Compositions and Methods for Inhibiting Bacterial Growth

ABSTRACT

The present disclosure provides, among other a things, compositions and methods useful for inhibiting bacteria such as  Mycobacterium tuberculosis . These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted with active or latent bacterial infections. The compositions described herein are also useful for decontaminating surfaces (e.g., surgical tools or implants).

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims priority to U.S. Provisional Application No. 62/156,733, filed May 4, 2015, the contents of which is incorporated herein by reference in its entirety.

STATEMENT OF GOVERNMENT SUPPORT

This disclosure was made with government support under grant nos. R21-AI105867 and U54-AI057153 from the National Institute of Allergy and Infectious Disease, National Institutes of Health. The government may have certain rights in the invention.

BACKGROUND

Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB) and is responsible for nearly two million deaths annually. In addition, a substantial proportion of the millions of people living with HIV/AIDS worldwide are co-infected with Mtb. And recently, multi-drug resistant (MDR) tuberculosis as well as extensively drug-resistant (XDR) tuberculosis have evolved, which further restricts treatment options for patients and threatens TB control and prevention efforts. Thus, there is a need in the art for new, effective treatments for TB.

SUMMARY

The disclosure is based, at least in part, on the discovery that the carbonic anhydrase antagonist, ethoxzolamide (ETZ), inhibits the PhoP/R regulon in Mycobacterium tuberculosis. This pH-dependent regulon controls, among other things, production of cell envelope lipids (such as sulfolipid) and is a virulence factor for the pathogenesis of tuberculosis. ETZ not only inhibits the PhoP/R regulon, but also inhibits growth of tuberculosis bacteria in macrophages in vivo. These observations indicate, among other things, that carbonic anhydrase inhibitors, as well as other compounds that inhibit the PhoP/R regulon, are useful for treating infections by bacteria in which the PhoPR regulon is conserved.

One of skill in the art would appreciate that there are several benefits to the use of the instantly-disclosed inhibitors and methods. For example, current treatment schedules for tuberculosis infection involve a regimen of at least four compounds (isoniazid, rifampicin, ethambutol, and pyrazinamide) coadministered over a prolonged period (e.g., 6-9 months). The instantly disclosed compositions, when used alone or in combination with one or more additional agents (e.g., isoniazid, rifampicin, ethambutol, and pyrazinamide), are believed to effectively treat an infection in a shorter period of time, e.g., less than 8 weeks (e.g., less than 7 weeks, 6 weeks, 5 weeks, 4 weeks, 3 weeks, or 2 weeks) or between 2 to 4 weeks. Thus, the instantly disclosed compositions offer the opportunity for increased patient compliance. The compositions are also useful for treating immunocompromised subjects (e.g., subjects afflicted with an HIV infection) and/or subjects with latent bacterial infections. Moreover, the compositions and methods described herein are useful for treating drug-resistant bacterial infections, such as infections with MDR and/or XDR tuberculosis.

Accordingly, in one aspect, the disclosure features a method for inhibiting growth or viability of one or more bacterial cells in which the PhoPR regulon is present or conserved. The method comprises contacting the one or more bacterial cells with an effective amount of an inhibitor of the PhoP/R regulon (e.g., an inhibitor of PhoP or PhoR) to thereby inhibit the growth or viability of the one or more bacterial cells. The contacting can occur in vitro (e.g., cultured bacteria), in macrophages or other immune cell hosts, or in vivo (e.g., in a human or non-human mammal).

In another aspect, the disclosure features a method for preventing or reducing the likelihood of a productive bacterial infection in a subject. The method comprises administering to a subject an effective amount of an inhibitor of the PhoP/R regulon to thereby prevent or reduce the likelihood of a productive bacterial infection in the subject. The subject can be one identified as being at risk of developing an infection with bacteria cells in which the PhoPR regulon is present or conserved.

In another aspect, the disclosure features a method for treating a subject who is infected with bacterial cells in which the PhoPR regulon is present or conserved, which method comprises administering to the subject an effective amount of an inhibitor of the PhoP/R regulon to thereby treat the infection.

In yet another aspect, the disclosure features a method for ameliorating the signs or symptoms of an infection of a subject by bacterial cells in which the PhoPR regulon is present or conserved. The method comprises administering to the subject an effective amount of an inhibitor of the PhoP/R regulon to thereby ameliorate the signs and symptoms of the infection.

In some embodiments, any of the methods described herein comprise identifying the subject as having an infection with bacterial cells in which the PhoPR regulon is present or conserved. In some embodiments, any of the methods described herein comprise identifying the subject as being at risk of developing an infection with bacterial cells in which the PhoPR regulon is present or conserved.

In some embodiments of any of the methods described herein, the bacteria or bacterial cells are of the genus Mycobacterium. In some embodiments, the Mycobacterium are Mycobacterium tuberculosis. In some embodiments, the Mycobacterium tuberculosis is multi-drug resistant Mycobacterium tuberculosis. In some embodiments, the Mycobacterium tuberculosis is extensively drug resistant Mycobacterium tuberculosis.

In some embodiments, the bacteria or bacterial cells are Clostridium (e.g., C. acetobutylicum) or Bacillus (e.g., B. subtilis).

One of skill in the art will appreciate that the PhoPR regulon is conserved in many other types of bacteria, such as Echerichia coli and Vibrio cholerae, in which the PhoPR system is encoded by the PhoBR operon (see, e.g., Diniz et al. (2011) J. Bacteriol 193(24):6929-6938), whereas the system is encoded by PhoRP in Streptomyces coelicolor. Such bacteria or bacterial cells are also amenable to treatment with the inhibitors described herein. In addition, The homologous pH- and Mg-sensing system PhoPQ exists in a variety of important pathogens belonging to the Enterobacteriaceae, including Salmonella spp., Yersinia pestis, Shigella spp., E. coli, Pseudomonas spp. and many others.

In another aspect, the disclosure features a method for eliminating dormant Mycobacterium tuberculosis cells in a subject afflicted with latent tuberculosis. The method comprises administering to the subject an effective amount of an inhibitor of PhoR or PhoP to thereby eliminate dormant Mycobacterium tuberculosis cells in the subject and treat latent tuberculosis. In some embodiments, the methods comprise determining that the subject has latent tuberculosis. In some embodiments, the Mycobacterium tuberculosis is multi-drug resistant Mycobacterium tuberculosis. In some embodiments, the Mycobacterium tuberculosis is extensively drug resistant Mycobacterium tuberculosis.

In some embodiments, the bacteria or bacterial cells are nontuberculous mycobacteria (NTM). The skilled artisan will appreciate that the PhoPR is conserved in many NTMs. The NTM can be, without limitation, M. avium, M. intracellulare, M. kansasii, M. abscessus, M. chelonae, M. fortuitum, M. terrae, M. xenopi, or M. simiae. In some embodiments, the NTM is M. leprae, M. ulcerans, or M. marinum.

Many species of NTM cause serious skin and ocular infections. In such embodiments, topical treatment with a compound described herein may be useful treatment as a monotherapy (e.g., as a cream, a salve, an ointment, an eye drop, or even applied to a bandage). Alternatively, one or more compounds described herein may synergize with traditional antibiotics by inhibiting survival in macrophages. NTM skin infections can be recalcitrant to treatment and sometimes very serious such as Buruli ulcer (caused by Mycobacterium ulcerans) and Mycobacterium abscessus, which causes skin and ear infections in immunocompromised individuals.

In some embodiments of any of the methods described herein, the inhibitor of PhoR or PhoP is a carbonic anhydrase inhibitor. The carbonic anhydrase inhibitor can be, e.g., a sulfonamide. For example, in some embodiments, the sulfonamide is ethoxzolamide (ETZ). In some embodiments, the carbonic anhydrase inhibitor is a ethoxzolamide analog. In some embodiments, the carbonic anhydrase inhibitor is acetazolamide, methazolamide, dorzolamide, or brinzolamide. In some embodiments, the carbonic anhydrase inhibitor is any one of those described herein (e.g., by reference) or those known in the art.

In another aspect, the disclosure features a method for treating tuberculosis in a subject, the method comprising administering to the subject a carbonic anhydrase inhibitor in an amount effective to treat tuberculosis. The carbonic anhydrase inhibitor can be, e.g., ethoxzolamide (ETZ). In some embodiments, the carbonic anhydrase inhibitor is a ethoxzolamide analog. In some embodiments, the carbonic anhydrase inhibitor is acetazolamide, methazolamide, dorzolamide, or brinzolamide. In some embodiments, the carbonic anhydrase inhibitor is any one of those described herein (e.g., by reference) or those known in the art. In some embodiments, the Mycobacterium tuberculosis is multi-drug resistant Mycobacterium tuberculosis. In some embodiments, the Mycobacterium tuberculosis is extensively drug resistant Mycobacterium tuberculosis. In some embodiments, the infection is a nosocomial infection.

In some embodiments of any of the methods described herein, the subject is a non-human primate.

In some embodiments of any of the methods described herein, the subject is a cow, a pig, a horse, a goat, a sheep, a bird (e.g., chicken, turkey, quail, or pheasant), or other domesticated livestock animal.

In some embodiments of any of the methods described herein, the subject is a human (e.g., a man or woman of any age: child, infant, toddler, or adult).

In some embodiments, the subject has a respiratory infection, e.g., a lung infection. In some embodiments, the subject has an eye infection. In some embodiments, the subject has an ear infection. In some embodiments, the subject has a gastrointestinal infection (e.g., an infection of the stomach or intestine). In some embodiments, the subject has a urinary tract infection. In some embodiments, the subject has a skin infection (e.g., an ulcer, a decubitus ulcer, or a chronic wound, such as one associated with diabetes, a cardiovascular disorder, or circulatory disorder).

In some embodiments, the subject is immunocompromised. For example, in some embodiments the subject (e.g., a human) has cancer, is being treated with immunosuppressive therapy, and/or is infected with HIV (e.g., a human infected with HIV-1).

In some embodiments of any of the methods described herein, the effective amount of the carbonic anhydrase inhibitor (e.g., ETZ or ETZ analog) is between 0.01 mg and 100 mg per kg body weight of the subject.

In some embodiments of any of the methods described herein, the inhibitor is administered as a short-term treatment, e.g., less than 8 weeks (e.g., less than 7 weeks, 6 weeks, 5 weeks, 4 weeks, 3 weeks, or 2 weeks), between 1 to 5 weeks, between 2 to 4 weeks, between 1 to 3 weeks, or between 2 to 5 weeks.

In some embodiments of any of the methods described herein, the inhibitor is orally administered to the subject. In some embodiments of any of the methods described herein, the inhibitor is parenterally administered to the subject. For example, the inhibitor can be administered intravenously.

In some embodiments, the inhibitor is administered as an aerosol, e.g., using a nebulizer or inhaler.

In some embodiments of any of the methods described herein, the inhibitor is administered with one or more antibiotics, such as isoniazid, rifampicin, ethambutol, and pyrazinamide (e.g., in the treatment of tuberculosis).

In another aspect, the disclosure features an aerosol composition comprising any one or more of the inhibitors described herein, e.g., for use in treating or preventing a bacterial infection, such as an active or latent bacterial infection described herein. The inhibitor is formulated in a composition suitable for aerosolization. The inhibitor may be formulated in combination with an additional active agent, and the combination formulation is suitable for aerosolization. Alternatively, the inhibitor and an additional active agent may be formulated separately, such that they will be combined after aerosolization occurs or after being administered to a subject.

In another aspect, the disclosure features a nebulization composition comprising one or more of any of the inhibitors described herein, e.g., for use in treating or preventing a bacterial infection, such as an active or latent bacterial infection described herein. The inhibitor can be formulated in a composition suitable for nebulization. Similarly, the inhibitor may be formulated in combination with an additional active agent, and the combination formulation is suitable for nebulization. Alternatively, the inhibitor and an additional active agent may be formulated separately, such that they will be combined after nebulization occurs or after being administered to a subject.

In another aspect, the disclosure provides a biopharmaceutical package comprising one or more of any of the inhibitors described herein, e.g., for use in treating or preventing a bacterial infection, such as an active or latent bacterial infection described herein. The biopharmaceutical package may further comprise an active agent in addition to the inhibitor(s). The biopharmaceutical package may also comprise instructions for use.

In yet another aspect, the disclosure provides a composition (e.g., a sterile aqueous or powdered (lyophilized) composition) comprising one or more of any of the inhibitors described herein, e.g., for use in inhibiting bacterial growth. For example, the composition can be a cleaning solution, or additive for a cleaning solution, used to decontaminate surfaces, e.g., surgical tools or tables. In another example, the compositions can be suitable as soaking solutions or perfusion solutions for transplant organs or implants to be transplanted or implanted in a subject.

In another aspect, the disclosure features a pharmaceutical composition for use in topical treatment of an infection with bacterial cells in which the PhoPR regulon is conserved, such as, but not limited to, any one of the nontuberculosis bacteria known in the art or described herein. The pharmaceutical composition can comprise, e.g., one or more carbonic anhydrase inhibitors. The carbonic anhydrase inhibitor can be any of those known in the art or described herein.

In some embodiments, the compositions are formulated as an eye drop. In some embodiments, the compositions are formulated as an ointment, lotion, gel, cream, aerosol, spray, or salve. In some embodiments, the compositions comprise one or more antibiotics for use in treating bacterial infections.

In another aspect, the disclosure features a sterile bandage or dressing for use in treating a wound or other cutaneous infection. The bandage or dressing comprises (or is impregnated with) a carbonic anhydrase inhibitor in an amount effective to inhibit the growth or viability of bacterial cells in which the PhoPR regulon is conserved. The carbonic anhydrase inhibitor can be any of those known in the art or described herein. In some embodiments, the bandage or dressing can be for surgical use and can contact cutaneous surfaces as well as internal surfaces.

In yet another aspect, the disclosure provides a screening method to identify a compound that inhibits the PhoP/R regulon. The method comprises screening a plurality of compounds for activity in a cell (e.g., a bacterial cell) that expresses a pH-inducible reporter gene (e.g., GFP) controlled by the PhoP/R regulon. A reduction in expression of the reporter gene (e.g., a reduction in detectable signal produced from the protein product of the gene) in the presence of the a candidate compound, as compared to the level of signal in the absence of the compound, indicates that a compound inhibits the PhoP/R operon. Such a screening method is exemplified in the working examples.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure pertains. In case of conflict, the present document, including definitions, will control. Preferred methods and materials are described below, although methods and materials similar or equivalent to those described herein can also be used in the practice or testing of the presently disclosed methods and compositions. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety.

Other features and advantages of the present disclosure, e.g., methods for treating bacterial infections, will be apparent from the following description, the examples, the drawings, and from the claims.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 includes four panels, A-D, and depicts ethoxzolamide (ETZ) inhibition of PhoPR-regulated aprA′::GFP fluorescence and Mtb carbonic anhydrase activity. (Panel A) Chemical structure of ethoxzolamide (ETZ) [6-ethoxy-1,3-benzothiazole-2-sulfonamide]. (Panel B) ETZ inhibits PhoPR-dependent CDC1551 (aprA′::GFP) fluorescence in a concentration dependent manner at pH 5.7 with an EC50 of 5.6 μM and little effect on growth. (Panel C) Mtb carbonic anhydrase activity is not detectable in whole cells when treated with ETZ (80 μM) compared to a DMSO control. (Panel D) Mtb treated with ETZ (80 μM) for 6 days exhibits no change of cytoplasmic pH at pH 7.0 and only slightly acidified cytoplasm (<0.1 pH units) at pH 5.7. Data are representative of at least two biological replicates, error bars are the standard deviation of at least three technical replicates, * p<0.05 calculated based on a two-tailed t-test.

FIG. 2 includes three panels, A-C, and depicts ETZ inhibition of the core PhoPR regulon. (Panel A) RNA-seq transcriptional profiling shows PhoPR-regulated genes are significantly down-regulated when treated with ETZ at acidic pH compared to the DMSO control pH 5.7. (Panel B) A complete overlap is observed between genes down-regulated (>2-fold, p<0.05) by ETZ treatment and the mock treated phoP::Tn mutant strain. Forty of these genes are also induced at pH 5.7 as compared to pH 7.0 (>2-fold, P<0.05). (Panel C) A list of the forty acidic pH induced and PhoPR and ETZ repressed (>2-fold, p<0.05) genes. CHP: conserved hypothetical protein; HP: hypothetical protein.

FIG. 3 includes three panels, A-C, and depicts Mtb lipid synthesis being modulated by ETZ. (Panel A) Radio-TLC showing Mtb treated with 80 μM ETZ and the ΔphoPR mutant strain exhibit a lack of accumulation of SL (*) and (Panel B) enhanced accumulation of TAG (*). (Panel C) 2-D radio-TLC demonstrating ETZ treatment increases the accumulation of TAG (spot 1) and phthiocerol dimycocerosate (PDIM) species (spots 2-4) at pH 5.7 compared to a DMSO control. Data are representative of two biological replicates with similar findings in both experiments.

FIG. 4 depicts ETZ treatment inhibits Esx-1 protein export. Western blot analysis of cell lysates (CL) and culture filtrates (CF) of wild-type (WT) M. tuberculosis Erdman and Δesat6 strains grown in Sauton's medium with or without addition of ETZ (80 μM). RNAP-β subunit served as a control for lysis and as a loading control for CL, MPT-32 served as loading control for CF and as a measure of Sec secretion. The CFP-10 and ESAT-6 antibodies detected the EsxB and EsxA protein respectively from WT M. tuberculosis Erdman strain. ETZ treatment inhibits the secretion of ESAT-6 and CFP-10. “−−” denotes no ETZ added, whereas “++” denotes ETZ added in both passages and “−+” denotes ETZ added only in second passage. Data are representative of three biological replicates.

FIG. 5 includes three panels A-C and depicts ETZ modulationg of Mtb gene expression and survival in macrophages. Primary murine BMDM were infected with Mtb CDC1551 (aprA′::GFP smyc′::mCherry) PhoPR regulon reporter at an MOI 1:1 and treated with DMSO or ETZ (100 μM) every two days for 9 days. (Panel A) Confocal microscopy images demonstrate that ETZ treatment inhibits the PhoPR regulon in infected macrophages. The merged images show GFP (PhoPR-inducible signal) and mCherry (constitutive signal) fluorescence. (Panel B) Single-cell quantification of reporter fluorescence shows ETZ significantly down-regulates PhoPR-dependent GFP fluorescence compared to a DMSO control. Statistical significance was calculated based on the Mann-Whitney rank test (p<0.001). (Panel C) Treatment of infected BMDMs with 80 μM ETZ reduces growth ˜1-log compared to the DMSO control. Data are representative of three biological replicates and statistical significance was calculated based on a two-tailed t-test (p<0.001). Error bars are the standard deviation of three technical replicates.

FIG. 6 includes three panels, A-C, and depicts ETZ modulation of PhoPR-regulated gene expression and Mtb survival in vivo. C57Bl/6 mice were infected with 1000 CFU of the Mtb Erdman (aprA′::GFP smyc′::mCherry) fluorescent reporter strain and treated with 100 mg/kg of ETZ for 4 weeks. (Panel A) ETZ down-regulates PhoPR-dependent GFP fluorescence in vivo. Images show reporter fluorescence in mouse lung tissue. (Panel B) Single-cell quantification of reporter fluorescence in infected mouse lungs shows ETZ significantly down-regulates PhoPR-dependent GFP fluorescence as compared to mock treated mice. GFP fluorescence was quantified for ˜3000 bacteria. Statistical significance was calculated based on the Mann-Whitney rank test (p<0.0001). (Panel C) Mtb survival is attenuated in ETZ treated lungs. Data presented are from seven animals per treatment group and statistical significance was calculated using a two-tailed t-test (p<0.01). Data are combined from two biological replicates.

FIG. 7 depicts a model linking ETZ, CA and stimulation of the PhoPR pathway. PhoPR is activated at a similar pH (˜6.3) as the dissolved inorganic carbon equilibrium favors CO2 to dissolve in water. CA will interconvert CO₂+H₂O to HCO³⁻+H⁺. Bicarbonate may be shuttled into the cytoplasm by a bicarbonate transporter (BT) to act in maintaining pH homeostasis or metabolism, while the proton produced in the reaction may promote the acidification of the extracellular environment surrounding PhoR, leading to induction of the PhoPR regulon. ETZ would inhibit this process by inhibiting CA and reducing the accumulation of protons in the pseudoperiplasm.

FIG. 8 includes three panels, A-C, and depicts ETZ inhibition of the phoPR regulated aprA′::GFP in a dose dependent manner, but does not alter the pH of the medium or macrophage phagosome acidification. (Panel A) ETZ inhibits PhoPR-dependent aprA′::GFP fluorescence in a concentration dependent manner at pH 7.0 with an EC50 of 4.7 μM and little effect on growth. (Panel B) The pH of the culture medium is not altered when Mtb is treated with ETZ (80 M) compared to a DMSO control after 6 days incubation at pH 5.7. (C) pHrodo labeled particles (Life Technologies) were fed to BMDMs pre-treated for 4 hours with: ETZ (100, 80, or 40 μM) or an equivalent volume of DMSO. Concanamycin A (CcA, 100 nM) inhibits phagosome acidification through inhibition of the vacuolar ATPase and added 30 minutes before feeding of labeled particles. pHrodo fluorescence increases as pH decreases and was monitored every 5 minutes for 100 minutes. Treatments were present throughout the assay. F0: fluorescence at time 0. F: fluorescence at each time point. Error bars represent the standard deviation from at least three technical replicates. Data are representative of at least two biological replicates. Error bars are the standard deviation of at least 3 technical replicates.

FIG. 9 depicts ETZ down-regulation of PhoPR regulon genes, but not phoP. Semi-quantitative RT-PCR validation of RNA-seq transcriptional profiling reveals that ETZ down-regulates PhoPR-regulated genes (aprA and pks2), but not phoP. Error bars are the standard deviation of three technical replicates. Data are representative of three biological replicates.

FIG. 10 includes three panels, A-C, and depicts the alteration of lipid species production by ETZ. (Panels A and B) Quantitation of lipid analysis as summarized in FIG. 3. (Panel C) Radio-TLC showing Mtb treated with 80 μM ETZ and the ΔphoPR mutant strain exhibit a lack of accumulation of sulfolipid (SL) (*), consistent with that of a SL standard. The unlabeled SL standard was resolved on the same TLC plate as radio-labeled lipids, and visualized by staining with phosphomolybdic acid and charring. Data are representative of two biological replicates with similar findings in each experiment.

FIG. 11 depicts a comparison of percent lung area affected of the section examined for each CMC and ETZ treated animal. There is no significant difference between the two groups.

DETAILED DESCRIPTION

The present disclosure provides, among other things, compositions and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted with active or latent bacterial infections. While in no way intended to be limiting, exemplary compositions and methods are elaborated on below.

Inhibitors of the PhoPR Regulon

The disclosure features, among other things, in vitro and in vivo methods for inhibiting the growth or viability of bacteria, such as Mycobacterium tuberculosis, using inhibitors of the PhoPR regulon. As used herein, “inhibition of the PhoPR regulon” or similar grammatical terms and phrases, includes direct and indirect inhibition of the regulon. For example, an inhibitor of the PhoPR regulon can be one that directly binds to PhoP protein or PhoR protein and inhibits the activity of the protein. In some embodiments, the inhibitor can be one that inhibits the expression or stability of PhoP or PhoR protein. In some embodiments, the inhibitor inhibits a protein regulator of the PhoPR regulon.

In some embodiments, the inhibitor can inhibit the ability of PhoP to bind to DNA (see, e.g., He and Wang (2014) Biochemistry 53(51):8008-8020 and Gupta et al. (2009) J Bacteriol 191(24):7466-7476, which describe DNA binding motifs for Mycobacterium tuberculosis PhoP). In some embodiments, the inhibitor inhibits the ability of PhoP to enhance or repress the expression of a target gene, such as any of those described in the tables provided herein. In some embodiments, an inhibitor can inhibit the kinase activity of PhoR. Methods for measuring DNA binding activity and kinase activity are well known in the art.

As used herein, the term “inhibiting” and grammatical equivalents thereof refer to a decrease, limiting, and/or blocking of a particular action, function, or interaction. In one embodiment, the term refers to reducing the level of a given output or parameter to a quantity which is at least 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 99% or less than the quantity in a corresponding control. A reduced level of a given output or parameter need not, although it may, mean an absolute absence of the output or parameter. The disclosure does not require, and is not limited to, methods that wholly eliminate the output or parameter.

The inhibitor can be, e.g., a small molecule, a protein, a protein fragment, a polypeptide, a peptide, a polypeptide analog, a peptidomimetic, a nucleic acid, a nucleic acid analog, a macrocyle compound, an aptamer including but not limited to an RNA aptamer including an L-RNA aptamer, a spiegelmer, a locked nucleic acid (LNA), a peptide nucleic acid (PNA), or an antibody.

In some embodiments of any of the methods described herein, the inhibitor of the PhoPR regulon is a carbonic anhydrase inhibitor. The carbonic anhydrase inhibitor can be, e.g., a sulfonamide. For example, in some embodiments, the sulfonamide is ethoxzolamide (ETZ). In some embodiments, the sulfonamide is a ethoxzolamide analog. In some embodiments, the sulfonamide is acetazolamide, methazolamide, dorzolamide, or brinzolamide (see, e.g., U.S. Pat. No. 4,221,783). In some embodiments, the carbonic anhydrase inhibitor is any one of those described herein (e.g., by reference) or those known in the art. In some embodiments, the carbonic anhydrase inhibitor is one identified in U.S. Patent Application Publication No. 20130053392 and 20030100594; International Patent Application Publication No. WO 1997/030704; and U.S. Pat. Nos. 5,095,026 and 4,629,738, the disclosures of each of the foregoing (as they relate to such compounds) is incorporated herein by reference in their entirety.

Methods for determining whether a compound has carbonic anhydrase activity are known in the art and described in, e.g., U.S. Patent Application Publication No. 20130053392 and 20030100594; International Patent Application Publication No. WO 1997/030704; and U.S. Pat. Nos. 5,095,026 and 4,629,738. Methods for identifying or designing additional useful carbonic anhydrase inhibitors are known in the art and described in, e.g., Ivanova et al. (2015) “X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors” Chem Commun (Camb) 51(33):7108-7111, the disclosure of which is incorporated herein by reference in its entirety.

For use in the identification of additional carbonic anhydrase inhibitors, skilled artisans would be well aware of the amino acid sequences of bacterial carbonic anhydrase enzymes, such as those from Mycobacterium tuberculosis. For example, Mycobacterium tuberculosis has three carbonic anhydrase genes (Rv3273, Rv1284, and Rv3588c), of which the latter two are required for survival of Mycobacterium tuberculosis in mice.

An exemplary amino acid sequence for Rv3273 Mycobacterium tuberculosis is as follows:

MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPLSL GIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELID ELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIA LQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSK LPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFFDAIGLPKLAEM SPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKLHHGPRTDFNRE MVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLF ASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITIV CVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDG TLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETR GGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVL DRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCADSRILPNVITASGPG DLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTA LLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPEADQLSI VNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVYEVGPNGIICP DEPADRPVDHESAQ (SEQ ID NO:1, Uniprot Id. No. P96878). An exemplary amino acid sequence for Rv1284 of Mycobacterium tuberculosis is as follows:

MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKE GEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDD FKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFV FDVATGKLNEVTP (SEQ ID NO:2, Uniprot Id. No. P9WPJ7). And an exemplary amino acid sequence for Rv3588c of Mycobacterium tuberculosis is as follows:

MPNTNPVAAWKALKEGNERFVAGRPQHPSQSVDHRAGLAAGQKPTAVIFG CADSRVAAEIIFDQGLGDMFVVRTAGHVIDSAVLGSIEYAVTVLNVPLIV VLGHDSCGAVNAALAAINDGTLPGGYVRDVVERVAPSVLLGRRDGLSRVD EFEQRHVHETVAILMARSSAISERIAGGSLAIVGVTYQLDDGRAVLRDHI GNIGEEV (SEQ ID NO:3, Uniprot Id. No. P9WPJ9). Methods for testing the activity of compounds against carbonic anhydrase proteins, such as these, are known in the art.

“Small molecule” as used herein, is meant to refer to an agent, which has a molecular weight of less than about 6 kDa and most preferably less than about 2.5 kDa. Many pharmaceutical companies have extensive libraries of chemical and/or biological mixtures comprising arrays of small molecules, often fungal, bacterial, or algal extracts, which can be screened with any of the assays of the application. This application contemplates using, among other things, small chemical libraries, peptide libraries, or collections of natural products. Tan et al. described a library with over two million synthetic compounds that is compatible with miniaturized cell-based assays (J Am Chem Soc (1998) 120:8565-8566). It is within the scope of this application that such a library may be used to screen for inhibitors (e.g., kinase inhibitors) of any one of the gene products described herein, e.g., cyclin dependent kinases. There are numerous commercially available compound libraries, such as the Chembridge DIVERSet. Libraries are also available from academic investigators, such as the Diversity set from the NCI developmental therapeutics program. Rational drug design may also be employed.

Compounds useful in the methods of the present invention may be obtained from any available source, including systematic libraries of natural and/or synthetic compounds. Compounds may also be obtained by any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive; see, e.g., Zuckermann et al., 1994, J. Med. Chem. 37:2678-85, which is expressly incorporated by reference); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the ‘one-bead one-compound’ library method, and synthetic library methods using affinity chromatography selection. The biological library and peptoid library approaches are limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, 1997, Anticancer Drug Des. 12:145, which is expressly incorporated by reference).

Examples of methods for the synthesis of molecular libraries can be found in the art, for example in: DeWitt et al. (1993) Proc. Natl. Acad. Sci. U.S.A. 90:6909; Erb et al. (1994) Proc. Natl. Acad. Sci. USA 91:11422: Zuckermann et al. (1994). J. Med. Chem. 37:2678: Cho et al. (1993) Science 261:1303; Carrell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2059; Carell et al. (1994) Angew. Chem. Int. Ed. Engl. 33:2061; and in Gallop et al. (1994) J. Med. Chem. 37:1233, each of which is expressly incorporated by reference.

Libraries of agents may be presented in solution (e.g., Houghten, 1992, Biotechniques 13:412-421), or on beads (Lam, 1991, Nature 354:82-84), chips (Fodor, 1993, Nature 364:555-556), bacteria and/or spores. (Ladner, U.S. Pat. No. 5,223,409), plasmids (Cull et al, 1992, Proc Natl Acad Sci USA 89:1865-1869) or on phage (Scott and Smith, 1990, Science 249:386-390; Devlin, 1990, Science 249:404-406, Cwirla et al, 1990, Proc. Natl. Acad. Sci. 87:6378-6382; Felici, 1991, J. Mol. Biol. 222:301-310; Ladner, supra., each of which is expressly incorporated by reference).

Peptidomimetics can be compounds in which at least a portion of a subject polypeptide is modified, and the three dimensional structure of the peptidomimetic remains substantially the same as that of the subject polypeptide. Peptidomimetics may be analogues of a subject polypeptide of the disclosure that are, themselves, polypeptides containing one or more substitutions or other modifications within the subject polypeptide sequence. Alternatively, at least a portion of the subject polypeptide sequence may be replaced with a non-peptide structure, such that the three-dimensional structure of the subject polypeptide is substantially retained. In other words, one, two or three amino acid residues within the subject polypeptide sequence may be replaced by a non-peptide structure. In addition, other peptide portions of the subject polypeptide may, but need not, be replaced with a non-peptide structure Peptidomimetics (both peptide and non-peptidyl analogues) may have improved properties (e.g., decreased proteolysis, increased retention or increased bioavailability). Peptidomimetics generally have improved oral availability, which makes them especially suited to treatment of humans or animals. It should be noted that peptidomimetics may or may not have similar two-dimensional chemical structures, but share common three-dimensional structural features and geometry. Each peptidomimetic may further have one or more unique additional binding elements.

Applications

As elaborated on in more detail below, the compositions described herein are useful in a number of in vitro and in vivo applications. For example, the compositions described herein can be used to treat bacterial infections, such as Mycobacterium tuberculosis infections. In some embodiments, the compositions can be used to decontaminate surfaces, e.g., surgical tools or tables, implants, or even donor organs for transplant (e.g., as an antibiotic component of a soaking or perfusion solution).

Pharmaceutical Compositions and Dosages

When employed as pharmaceuticals, the compounds provided herein can be administered in the form of pharmaceutical compositions. These compositions can be prepared in a manner well known in the pharmaceutical art, and can be administered by a variety of routes, depending upon whether local or systemic treatment is desired and upon the area to be treated. Administration may be topical (including transdermal, epidermal, ophthalmic and to mucous membranes including intranasal, vaginal and rectal delivery), pulmonary (e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal or intranasal), oral or parenteral. Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal, intramuscular or injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration. Parenteral administration can be in the form of a single bolus dose, or may be, for example, by a continuous perfusion pump. Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders. Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable.

This disclosure also provides pharmaceutical compositions which contain, as the active ingredient, a compound provided herein or a pharmaceutically acceptable salt thereof, in combination with one or more pharmaceutically acceptable carriers (excipients). In some embodiments, the composition is suitable for topical administration. In making the compositions provided herein, the active ingredient is typically mixed with an excipient, diluted by an excipient or enclosed within such a carrier in the form of, for example, a capsule, sachet, paper, or other container. When the excipient serves as a diluent, it can be a solid, semi-solid, or liquid material, which acts as a vehicle, carrier or medium for the active ingredient. Thus, the compositions can be in the form of tablets, pills, powders, lozenges, sachets, cachets, elixirs, suspensions, emulsions, solutions, syrups, aerosols (as a solid or in a liquid medium), ointments containing, for example, up to 10% by weight of the active compound, soft and hard gelatin capsules, suppositories, sterile injectable solutions, and sterile packaged powders.

In preparing a formulation, an active compound can be milled to provide the appropriate particle size prior to combining with the other ingredients. If an active compound is substantially insoluble, it can be milled to a particle size of less than 200 mesh. If an active compound is substantially water soluble, the particle size can be adjusted by milling to provide a substantially uniform distribution in the formulation, e.g. about 40 mesh.

The compounds provided herein may be milled using known milling procedures such as wet milling to obtain a particle size appropriate for tablet formation and for other formulation types. Finely divided (nanoparticulate) preparations of the compounds provided herein can be prepared by processes known in the art, e.g., see International App. No. WO 2002/000196.

Some examples of suitable excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, and methyl cellulose. The formulations can additionally include: lubricating agents such as talc, magnesium stearate, and mineral oil; wetting agents; emulsifying and suspending agents; preserving agents such as methyl- and propylhydroxy-benzoates; sweetening agents; and flavoring agents. The compositions provided herein can be formulated so as to provide quick, sustained or delayed release of the active ingredient after administration to the patient by employing procedures known in the art.

For preparing solid compositions such as tablets, the principal active ingredient is mixed with a pharmaceutical excipient to form a solid preformulation composition containing a homogeneous mixture of a compound provided herein. When referring to these preformulation compositions as homogeneous, the active ingredient is typically dispersed evenly throughout the composition so that the composition can be readily subdivided into equally effective unit dosage forms such as tablets, pills and capsules. This solid preformulation is then subdivided into unit dosage forms of the type described above containing from, for example, about 0.1 to about 1000 mg of the active ingredient provided herein.

The tablets or pills provided herein can be coated or otherwise compounded to provide a dosage farm affording the advantage of prolonged action. For example, the tablet or pill can comprise an inner dosage and an outer dosage component, the latter being in the form of an envelope over the former. The two components can be separated by an enteric layer which serves to resist disintegration in the stomach and permit the inner component to pass intact into the duodenum or to be delayed in release. A variety of materials can be used for such enteric layers or coatings, such materials including a number of polymeric acids and mixtures of polymeric acids with such materials as shellac, cetyl alcohol, and cellulose acetate.

The liquid forms in which the compounds and compositions provided herein can be incorporated for administration orally or by injection include aqueous solutions, suitably flavored syrups, aqueous or oil suspensions, and flavored emulsions with edible oils such as cottonseed oil, sesame oil, coconut oil, or peanut oil, as well as elixirs and similar pharmaceutical vehicles.

In some embodiments, the compounds provided herein are formulated for intravenous administration. Pharmaceutical compositions suitable for injectable use can include sterile aqueous solutions (where water soluble) or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. For intravenous administration, suitable carriers include physiological saline, bacteriostatic water, Cremophor EL™ (BASF, Parsippany, N.J.) or phosphate buffered saline (PBS). In all cases, the composition must be sterile and should be fluid to the extent that easy syringability exists. It should be stable under the conditions of manufacture and storage and must be preserved against the contaminating action of microorganisms such as bacteria and fungi. The carrier can be a solvent or dispersion medium containing, for example, water, ethanol, polyol (for example, glycerol, propylene glycol, and liquid polyethylene glycol, and the like), and suitable mixtures thereof.

The proper fluidity can be maintained, for example, by the use of a coating such as lecithin, by the maintenance of the required particle size in the case of dispersion and by the use of surfactants. Prevention of the action of microorganisms can be achieved by various antibacterial and antifungal agents, for example, parabens, chlorobutanol, phenol, ascorbic acid, thimerosal, and the like. In many cases, it will be preferable to include isotonic agents, for example, sugars, polyalcohols such as mannitol, sorbitol, sodium chloride in the composition. Prolonged absorption of the injectable compositions can be brought about by including in the composition an agent that delays absorption, for example, aluminum monostearate and gelatin.

Sterile injectable solutions can be prepared by incorporating the active compound in the required amount in an appropriate solvent with one or a combination of ingredients enumerated above, as required, followed by filter sterilization. Generally, dispersions are prepared by incorporating the active compound into a sterile vehicle, which contains a basic dispersion medium and the required other ingredients from those enumerated above. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum drying and freeze-drying, which yield a powder of the active ingredient plus any additional desired ingredient from a previously sterile-filtered solution thereof.

Compositions for inhalation or insufflation include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders. The liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as described supra. In some embodiments, the compositions are administered by the oral or nasal respiratory route for local or systemic effect. Compositions can be nebulized by use of inert gases. Nebulized solutions may be breathed directly from the nebulizing device or the nebulizing device can be attached to a face mask, tent, or intermittent positive pressure breathing machine. Solution, suspension, or powder compositions can be administered orally or nasally from devices which deliver the formulation in an appropriate manner.

A nebulizer of the present application can be a jet air nebulizer (e.g., Pari L C Jet Plus or Hudson T Up-draft II), an ultrasonicnebulizer (e.g., MABISMist II), a vibrating mesh nebulizer (e.g., Micro air by Omron) and a Shockwave nebulizer (EvitLabs Sonik LDI20). As used herein, an “aerosol composition” or like grammatical terms means an inhibitor described herein in a form or formulation that is suitable for pulmonary delivery. The aerosol composition may be in the dry powder form, it may be a solution, suspension or slurry to be nebulized, or it may be in admixture with a suitable low boiling point, highly volatile propellant. It is to be understood that more than one inhibitor and optionally other active agents or ingredients may be incorporated into the aerosolized formulation or aerosol composition.

In certain preferred embodiments, an active agent (e.g., an inhibitor described herein) retains more than 50% of its activity after nebulization, preferably more than 70%. In certain preferred embodiments, an active agent (e.g., an inhibitor described herein) more than 50% of its purity after nebulization, preferably more than 70%.

Active agent formulations suitable for use in the present application include dry powders, solutions, suspensions or slurries for nebulization and particles suspended or dissolved within a propellant. Dry powders suitable for use in the present application include amorphous active agents, crystalline active agents and mixtures of both amorphous and crystalline active agents. The dry powder active agents have a particle size selected to permit penetration into the alveoli of the lungs, that is, preferably 10 μm mass median diameter (MMD)₅ preferably less than 7.5 μm, and most preferably less than 5 μm, and usually being in the range of 0.1 μm to 5 μm in diameter. The delivered dose efficiency (DDE) of these powders is >300%, usually >40%, preferably >50 and often >60% and the aerosol particle size distribution is about 1.0-5.0 μm mass median aerodynamic diameter (MMAD), usually 1.5-4.5 μm MMAD and preferably 1.5-4.0 μm MMAD. These dry powder active agents have a moisture content below about 10% by weight, usually below about 5% by weight, and preferably below about 3% by weight. Such active agent powders are described in WO 95/24183 and WO 96/32149, which are incorporated by reference herein.

Dry powder active agent formulations are preferably prepared by spray drying under conditions which result in a substantially amorphous powder. Bulk active agent, usually in crystalline form, is dissolved in a physiologically acceptable aqueous buffer, typically a citrate buffer having a pH range from about 2 to 9. The active agent is dissolved at a concentration from 0.01% by weight to 1% by weight, usually from 0.1% to 0.2%. The solutions may then be spray dried in a conventional spray drier available from commercial suppliers such as Niro A/S (Denmark), Buchi (Switzerland) and the like, resulting in a substantially amorphous powder. These amorphous powders may also be prepared by lyophilization, vacuum drying, or evaporative drying of a suitable active agent solution under conditions to produce the amorphous structure. The amorphous active agent formulation so produced can be ground or milled to produce particles within the desired size range.

Dry powder active agents may also be in a crystalline form. The crystalline dry powders may be prepared by grinding or jet milling the bulk crystalline active agent. The active agent powders of the present application may optionally be combined with pharmaceutical carriers or excipients which are suitable for respiratory and pulmonary administration. Such carriers may serve simply as bulking agents when it is desired to reduce the active agent concentration in the powder which is being delivered to a patient, but may also serve to improve the dispersability of the powder within a powder dispersion device in order to provide more efficient and reproducible delivery of the active agent and to improve handling characteristics of the active agent such as flowability and consistency to facilitate manufacturing and powder filling. Such excipients include but are not limited to (a) carbohydrates, e.g., monosaccharides such as fructose, galactose, glucose, D-mannose, sorbose, and the like; disaccharides, such as lactose, trehalose, cellobiose, and the like; cyclodextrins, such as 2-hydroxypropyl-.beta.-cyclodextrin; and polysaccharides, such as raffmose, maltodextrins, dextrans, and the like; (b) amino acids, such as glycine, arginine, aspartic acid, glutamic acid, cysteine, lysine, and the like; (c) organic salts prepared from organic acids and bases, such as sodium citrate, sodium ascorbate, magnesium gluconate, sodium gluconate, tromethamin hydrochloride, and the like; (d) peptides and proteins such as aspartame, human serum albumin, gelatin, and the like; and (e) alditols, such as mannitol, xylitol, and the like. A preferred group of carriers includes lactose, trehalose, raffmose, maltodextrins, glycine, sodium citrate, human serum albumin and mannitol.

The dry powder active agent formulations may be delivered using Inhale Therapeutic Systems' dry powder inhaler as described in WO 96/09085 which is incorporated herein by reference, but adapted to control the flow rate at a desirable level or within a suitable range. The dry powders may also be delivered using a metered dose inhaler as described by Laube et al. in U.S. Pat. No. 5,320,094, which is incorporated by reference herein. Nebulized solutions may be prepared by aerosolizing commercially available active agent formulation solutions. These solutions may be delivered by a jet nebulizer such as the Raindrop, produced by Puritan Bennett, the use of which is described by Laube et al., supra. Other methods for delivery of solutions, suspensions of slurries are described by Rubsamen et al, U.S. Pat. No. 5,672,581. A device that uses a vibrating, piezoelectric member is described in Ivri et al., U.S. Pat. No. 5,586,550, which is incorporated by reference herein.

Propellant systems may include an active agent dissolved in a propellant or particles suspended in a propellant. Both of these types of formulations are described in Rubsamen et al., U.S. Pat. No. 5,672,581, which is incorporated herein by reference. In certain embodiments, an aerosol or nebulization composition can be combined with one or more other aerosol or nebulization treatments, such as sympathomimetics (e.g., albuterol), antibiotics (e.g., tobramycin), deoxyribonucleases (e.g., pulmozyme), anticholinergic drugs (e.g., ipratropium bromide), or corticosteroids.

As described herein, an active agent (e.g., an inhibitor described herein) may be formulated as microparticles. Microparticles having a diameter of between 0.5 and 10 microns can penetrate the lungs, passing through most of the natural barriers. A diameter of less than ten microns is generally required to bypass the throat; a diameter of 0.5 microns or greater is usually required to avoid being exhaled.

In certain embodiments, an active agent (e.g., an inhibitor described herein) is formulated in a supramolecular complex, which may have a diameter of between 0.5 and 10 microns, which can be aggregated into particles having a diameter of between 0.5 and 10 microns.

In other embodiments, an active agent (e.g., an inhibitor described herein) are provided in liposomes or supramolecular complexes appropriately formulated for pulmonary delivery.

Topical formulations can contain one or more conventional carriers. In some embodiments, ointments can contain water and one or more hydrophobic carriers selected from, for example, liquid paraffin, polyoxyethylene alkyl ether, propylene glycol, white Vaseline, and the like. Carrier compositions of creams can be based on water in combination with glycerol and one or more other components, e.g. glycerinemonostearate, PEG-glycerinemonostearate and cetylstearyl alcohol. Gels can be formulated using isopropyl alcohol and water, suitably in combination with other components such as, for example, glycerol, hydroxyethyl cellulose, and the like. In some embodiments, topical formulations contain at least about 0.1, at least about 0.25, at least about 0.5, at least about 1, at least about 2, or at least about 5 wt % of the compound provided herein. The topical formulations can be suitably packaged in tubes of, for example, 100 g which are optionally associated with instructions for the treatment of the select indication.

The formulations may be presented as, for instance, ointments, creams or lotions, gels, eye ointments and eye or ear drops, sprays, impregnated dressings (e.g., bandages or dressings for use in would healing), and aerosols, and may contain appropriate conventional additives such as preservatives, solvents to assist drug penetration and emollients in ointments and creams. The formulations may also contain compatible conventional carriers, such as cream or ointment bases and ethanol or oleyl alcohol for lotions. Such carriers may be present as from about 1% up to about 98% of the formulation. More usually they will form up to about 80% of the formulation. In some embodiments, the compounds are formulated for use in the eye. In some embodiments, the compounds are formulated for use in the ear. In some embodiments, the compounds are formulated for use on the skin, e.g., chronic wounds, such as those associated with diabetes or other cardiovascular/circulatory disorders.

In one embodiment, the compounds provided herein are prepared with carriers that will protect the compounds against rapid elimination from the body, such as a controlled release formulation, including implants and microencapsulated delivery systems. Biodegradable, biocompatible polymers can be used, such as ethylene vinyl acetate, polyanhydrides, polyglycolic acid, collagen, polyorthoesters, and polylactic acid. Such formulations can be prepared using standard techniques, or obtained commercially, e.g., from Alza Corporation and Nova Pharmaceuticals, Inc. Liposomal suspensions (including liposomes targeted to selected cells with monoclonal antibodies to cellular antigens) can also be used as pharmaceutically acceptable carriers. These can be prepared according to methods known to those skilled in the art, for example, as described in U.S. Pat. No. 4,522,811.

The compositions administered to a patient can be in the form of pharmaceutical compositions described above. These compositions can be sterilized by conventional sterilization techniques, or may be sterile filtered. Aqueous solutions can be packaged for use as is, or lyophilized, the lyophilized preparation being combined with a sterile aqueous carrier prior to administration. The pH of the compound preparations typically will be between 3 and 11, more preferably from 5 to 9 and most preferably from 7 to 8. It will be understood that use of certain of the foregoing excipients, carriers, or stabilizers will result in the formation of pharmaceutical salts.

The compositions can be formulated in a unit dosage form, each dosage containing from about 5 to about 1000 mg (1 g), more usually about 100 to about 500 mg, of the active ingredient. The term “unit dosage forms” refers to physically discrete units suitable as unitary dosages for human subjects and other mammals, each unit containing a predetermined quantity of active material calculated to produce the desired therapeutic effect, in association with a suitable pharmaceutical excipient.

In some embodiments, the compositions provided herein contain from about 5 to about 50 mg of the active ingredient. One having ordinary skill in the art will appreciate that this embodies compositions containing about 5 to about 10, about 10 to about 15, about 15 to about 20, about 20 to about 25, about 25 to about 30, about 30 to about 35, about 35 to about 40, about 40 to about 45, or about 45 to about 50 mg of the active ingredient.

In some embodiments, the compositions provided herein contain from about 50 to about 500 mg of the active ingredient. One having ordinary skill in the art will appreciate that this embodies compositions containing about 50 to about 100, about 100 to about 150, about 150 to about 200, about 200 to about 250, about 250 to about 300, about 350 to about 400, or about 450 to about 500 mg of the active ingredient.

In some embodiments, the compositions provided herein contain from about 500 to about 1000 mg of the active ingredient. One having ordinary skill in the art will appreciate that this embodies compositions containing about 500 to about 550, about 550 to about 600, about 600 to about 650, about 650 to about 700, about 700 to about 750, about 750 to about 800, about 800 to about 850, about 850 to about 900, about 900 to about 950, or about 950 to about 1000 mg of the active ingredient.

Similar dosages may be used of the compounds described herein in the methods and uses provided herein.

The active compound can be effective over a wide dosage range and is generally administered in a pharmaceutically effective amount. It will be understood, however, that the amount of the compound actually administered will usually be determined by a physician, according to the relevant circumstances, including the condition to be treated, the chosen route of administration, the actual compound administered, the age, weight, and response of the individual patient, the severity of the patient's symptoms, and the like.

The amount of compound or composition administered to a patient will vary depending upon what is being administered, the purpose of the administration, such as prophylaxis or therapy, the state of the patient, the manner of administration, and the like. In therapeutic applications, compositions can be administered to a patient already suffering from a disease in an amount sufficient to cure or at least partially arrest the symptoms of the disease and its complications. Effective doses will depend on the disease condition being treated as well as by the judgment of the attending clinician depending upon factors such as the severity of the disease, the age, weight and general condition of the patient, and the like.

The therapeutic dosage of a compound provided herein can vary according to, for example, the particular use for which the treatment is made, the manner of administration of the compound, the health and condition of the patient, and the judgment of the prescribing physician. The proportion or concentration of a compound provided herein in a pharmaceutical composition can vary depending upon a number of factors including dosage, chemical characteristics (e.g., hydrophobicity), and the route of administration. For example, the compounds provided herein can be provided in an aqueous physiological buffer solution containing about 0.1 to about 10% w/v of the compound for parenteral administration. Some typical dose ranges are from about 1 mg/kg to about 1 g/kg of body weight per day. In some embodiments, the dose range is from about 0.01 mg/kg to about 100 mg/kg of body weight per day. The dosage is likely to depend on such variables as the type and extent of progression of the disease or disorder, the overall health status of the particular patient, the relative biological efficacy of the compound selected, formulation of the excipient, and its route of administration. Effective doses can be extrapolated from dose-response curves derived from in vitro or animal model test systems.

Methods for Treatment

Also featured herein are therapeutic methods for treating subjects with a variety of infections, such as tuberculosis infections. The methods comprise administering to the subject an inhibitor of the PhoPR regulon, such as any of those described herein, in an amount effective to treat the infection. In some embodiments, the bacteria infecting the subject are identified as expressing one or both of PhoP or PhoR.

In some embodiments, the methods include receiving the results of a test determining that the bacteria infecting the subject are identified as bacteria in which the PhoPR regulon is conserved and, in view of this information, ordering administration of an effective amount of one or more of the inhibitors described herein to the subject. For example, a physician treating a subject can request that a third party (e.g., a CLIA-certified laboratory) to perform a test to determine whether the bacteria infecting the subject are bacteria in which the PhoPR regulon is conserved. The laboratory may provide such information, or, in some embodiments, provide an expression score or value, or a positive or negative result. If the bacteria have the conserved PhoPR regulon, or if the bacteria are identified as tuberculosis, the physician may then administer to the subject one or more of the inhibitors described herein. Alternatively, the physician may order the administration of the inhibitor to the subject, which administration is performed by another medical professional, e.g., a nurse.

In some embodiments, the method can include: requesting a test, or the results of a test, which determines that the bacteria infecting the subject are Mycobacterium tuberculosis or bacteria in which the PhoPR regulon is conserved; and administering or ordering administration of an effective amount of an inhibitor described herein to the subject.

A “subject,” as used herein, can be any mammal. For example, a subject can be a human, a non-human primate (e.g., monkey, baboon, or chimpanzee), a horse, a cow, a pig, a sheep, a goat, a dog, a cat, a rabbit, a guinea pig, a gerbil, a hamster, a rat, or a mouse. In some embodiments, the subject is an infant (e.g., a human infant).

As used herein, a subject “in need of prevention,” “in need of treatment,” or “in need thereof,” refers to one, who by the judgment of an appropriate medical practitioner (e.g., a doctor, a nurse, or a nurse practitioner in the case of humans; a veterinarian in the case of non-human mammals), would reasonably benefit from a given treatment.

The term “preventing” is art-recognized, and when used in relation to a condition, is well understood in the art, and includes administration of a composition which reduces the frequency of, or delays the onset of, symptoms of a medical condition in a subject relative to a subject which does not receive the composition. For example, treatment with an inhibitor described herein may delay the onset of, and/or reduce the severity of symptoms upon onset of, a Mycobacterium tuberculosis infection in a subject who has been exposed to Mycobacterium tuberculosis. Exposure to a bacterial infection, such as Mycobacterium tuberculosis, can be, e.g., close quarters exposure to an infected individual or exposure to bodily fluids (e.g., sputum, saliva, etc.) from an infected individual.

As used herein, “latent tuberculosis” refers to the presence of Mycobacterium tuberculosis in one or more cells of the infected individual (e.g., has a positive tuberculosis skin test), but the individual does not have an active infection (exhibits one or more signs or symptoms of a TB infection, such as cough, fever, night sweats, weight loss, fatigue, flu-like symptoms, chest pain, shortness of breath, blood in the sputum, etc.).

As used herein, “MDR tuberculosis” or “multi-drug resistant tuberculosis” refers to a form of tuberculosis that is resistant to two or more of the primary drugs (isoniazid and rifampicin) used for the treatment of tuberculosis. As used herein, “XDR tuberculosis” or “extensively multi-drug resistant tuberculosis” refers to a form of tuberculosis resistant to at least isoniazid and rifampicin among the first-line anti-TB drugs, is resistant to any fluoroquinolone and at least one of three injectable second-line drugs, such as amikacin, kanamycin or capreomycin.

The inhibitor compositions can be administered to a subject, e.g., a human subject, using a variety of methods that depend, in part, on the route of administration. The route can be, e.g., intravenous injection or infusion (IV), subcutaneous injection (SC), intraperitoneal (IP) injection, or intramuscular injection (IM).

Administration can be achieved by, e.g., local infusion, injection, or by means of an implant. The implant can be of a porous, non-porous, or gelatinous material, including membranes, such as sialastic membranes, or fibers. The implant can be configured for sustained or periodic release of the composition to the subject. See, e.g., U.S. Patent Application Publication No. 20080241223; U.S. Pat. Nos. 5,501,856; 4,863,457; and 3,710,795; EP488401; and EP 430539, the disclosures of each of which are incorporated herein by reference in their entirety. The composition can be delivered to the subject by way of an implantable device based on, e.g., diffusive, erodible, or convective systems, e.g., osmotic pumps, biodegradable implants, electrodiffusion systems, electroosmosis systems, vapor pressure pumps, electrolytic pumps, effervescent pumps, piezoelectric pumps, erosion-based systems, or electromechanical systems.

As used herein the term “effective amount” or “therapeutically effective amount”, in an in vivo setting, means a dosage sufficient to treat, inhibit, or alleviate one or more symptoms of the disorder being treated or to otherwise provide a desired pharmacologic and/or physiologic effect (e.g., modulate (e.g., enhance) an immune response to an antigen. The precise dosage will vary according to a variety of factors such as subject-dependent variables (e.g., age, immune system health, etc.), the disease, and the treatment being effected.

Suitable human doses of any of the compounds described herein can further be evaluated in, e.g., Phase I dose escalation studies. See, e.g., van Gurp et al. (2008) Am J Transplantation 8(8): 1711-1718; Hanouska et al. (2007) Clin Cancer Res 13(2, part 1):523-531; and Hetherington et al. (2006) Antimicrobial Agents and Chemotherapy 50(10): 3499-3500.

Toxicity and therapeutic efficacy of such compositions can be determined by known pharmaceutical procedures in cell cultures or experimental animals (e.g., animal models of infection). These procedures can be used, e.g., for determining the LD₅₀ (the dose lethal to 50% of the population) and the ED₅₀ (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD₅₀/ED₅₀. Agents that exhibits a high therapeutic index is preferred. While compositions that exhibit toxic side effects may be used, care should be taken to design a delivery system that targets such compounds to the site of affected tissue and to minimize potential damage to normal cells and, thereby, reduce side effects.

The data obtained from the cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of such compounds lies generally within a range of circulating concentrations of the compounds that include the ED₅₀ with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. A therapeutically effective dose can be estimated initially from cell culture assays. A dose can be formulated in animal models to achieve a circulating plasma concentration range that includes the IC₅₀ (i.e., the concentration of the inhibitor which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography. In some embodiments, e.g., where local administration is desired, cell culture or animal modeling can be used to determine a dose required to achieve a therapeutically effective concentration within the local site. Suitable dosages are described herein.

In some embodiments of any of the methods described herein, an agent can be administered to a mammal in conjunction with one or more additional therapeutic agents. For example, in some embodiments, it may be advantageous to administer an inhibitor described herein in combination with at least one additional pharmaceutical (or therapeutic) agent (e.g., first-line or second-line antituberculosis drugs, and for patients with HIV or AIDS an HIV/AIDS drug). The inhibitor may be administered either simultaneously with, or before or after, one or more other therapeutic agent(s). Alternatively, the compound of the present invention may be administered separately, by the same or different route of administration, or together in the same pharmaceutical composition as the other agent(s).

Suitable additional TB agents include first-line drugs (such as isoniazid, rifampicin, pyrazinamide, ethambutol and combinations thereof); second-line drugs (such as streptomycin, kanamycin, amikacin, capreomycin, ofloxacin, levofioxacin, moxifioxacin, cycloserine, para-aminosaicylic acid, ethioamide, prothionamide, thioacetazone and combinations thereof); and other antituberculosis drugs (such as clofazimine, amoxicilin with clavulanate, imipenem, linezolid, clarithromycin, thioridazine and combinations thereof). Other potential additional TB agents include compounds such as bicyclic nitroimidazoles (e.g., (S)-6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine (PA-824) and TBA-354, available from TB Alliance), bedaquiline (TMC-207), delamanid (OPC67683), oxazolidinone, 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one (BTZ043), imidazopyridines (e.g., Q201, available from Quro Science Inc.), and combinations thereof.

Suitable therapeutic agents for adjunct therapy include human immunodeficiency virus (HIV) drugs, immunotherapeutic agents, (e.g., anti-interleukin 4 neutralizing antibodies, high-dose intravenous immunoglobulin, 16a-bromoepiandosterone (HE2000), RUTI® vaccine, DNA vaccine with HSP65, Ag85, MPT-64, and MPT-83, dzherelo (plant extracts from the Ukraine), cytokines (such as Interleukin 2, Interleukin 7, Interleukin 15, Interleukin 27, Interleukin 12, Interferon γ), immunosuppressive agents (such as corticosteroids, thalidomide, and etanercept)), steroids, anti-inflammatory agents (e.g. prednisone), and other agents well-known to those of skill in art for use in improving the quality of care for patients being treated for the diseases, conditions, or disorders described herein.

Suitable HIV/AIDS drugs include non-nucleoside reverse transcriptase inhibitors (NNRTIs), such as efavirenz (Sustiva), etravirine (Intelence) and nevirapine (Viramune); Nucleoside reverse transcriptase inhibitors (NRTIs), such as Abacavir (Ziagen), and the combination drugs emtricitabine and tenofovir (Truvada), and lamivudine and zidovudine (Combivir); Protease inhibitors (Pis), such as atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva) and ritonavir (Norvir); Entry or fusion inhibitors, such enfuvirtide (Fuzeon) and maraviroc (Selzentry); and Integrase inhibitors, such as Raltegravir (Isentress).

Methods for diagnosing a subject has having tuberculosis are well known in the art and include, e.g., chest x-ray, testing of a sputum sample, tuberculin skin test, or a blood test (e.g., to test for the presence of microbial DNA or circulating anti-TB antibodies).

Likewise, methods for determining whether bacteria express PhoP and/or PhoR are known in the art and include, e.g., protein (e.g., Western blot, dot blot, or other immunoassays) and nucleic acid (e.g., RT-PCR) detection techniques.

The International Standards for Tuberculosis Care describes a widely accepted level of care that all practitioners, public and private, should follow in dealing with people who have, or are suspected of having, tuberculosis. The Standards are intended to facilitate the effective engagement of all care providers in delivering high-quality care for patients of all ages, including those with sputum smear-positive, sputum smear-negative, and extrapulmonary tuberculosis; tuberculosis caused by drug resistant Mycobacterium tuberculosis complex (M. tuberculosis) organisms; and tuberculosis combined with human immunodeficiency virus (HIV) infection, all of which are amenable to treatment using one or more of the inhibitors described herein.

Another aspect of the disclosure is a product comprising an inhibitor described herein and at least one other therapeutic agent (or pharmaceutical agent) as a combined preparation for simultaneous, separate or sequential use in therapy to treat a subject having sputum smear-positive, sputum smear-negative, and extrapulmonary tuberculosis; tuberculosis caused by drug resistant Mycobacterium tuberculosis complex (M. tuberculosis) organisms; or tuberculosis combined with human immunodeficiency virus (HIV) infection.

Embodiments of the present invention are illustrated by the following Examples. It is to be understood, however, that the embodiments of the invention are not limited to the specific details of these Examples, as other variations thereof will be known, or apparent in light of the instant disclosure, to one of ordinary skill in the art.

EXAMPLES Example 1. Materials and Methods

Bacterial Strains and Growth Conditions

Mtb experiments, unless otherwise stated, were performed with Mtb strain CDC1551. The phoP::Tn and ΔphoPR mutants have been previously described (5, 14). Cultures were maintained in standing tissue culture flasks in 7H9 Middlebrook medium supplemented with 10% OADC and 0.05% Tween-80 and incubated at 37° C. with 5% CO₂.

High-Throughput Screening Assay and Data Analysis

A compound library (of approximately 220,000 compounds) arrayed in 384-well optical microtiter plates was provided by the Institute of Chemistry and Cell Biology (ICCBL) at Harvard University. Two columns of each plate were left blank for positive and negative controls of 0.3 μM rifampicin and DMSO, respectively. The CDC1551 (aprA′::GFP) fluorescent reporter was grown in Middlebrook 7H9 medium, buffered at pH 7.0 with 100 mM MOPS, to mid- to late-log phase. The cultures were then pelleted, re-suspended in 7H9 buffered at pH 5.7 with 100 mM MES and dispensed into the 384-well assay plates at an OD of 0.2. The plates were incubated for 6 days at 37° C. and both fluorescence and optical density (OD) were measured on a plate reader. For analysis of hits, fluorescence and growth inhibition were normalized based on the rifampin (100%) and DMSO (0%) controls, respectively. Potential PhoPR regulon inhibitors were flagged as compounds that had: i) greater than 35% fluorescence inhibition, and ii) at least a 1.5-fold greater fluorescence inhibition as compared to growth inhibition.

For EC₅₀ determinations, Mtb CDC1551 aprA′::GFP was grown to mid- to late-log phase in non-inducing medium (7H9, pH 7.0), pelleted, and re-suspended in GFP inducing medium (7H9, pH 5.7) in the presence of a 14-point dilution series (2.5-fold) of ETZ at a final concentration ranging from 3 nM to 500 μM. E₅₀ values were calculated based on a variable slope, four-parameter non-linear least squares regression model in the GraphPad Prism software package (ver. 6).

Transcriptional Profiling and Data Analysis

For RNA-seq experiments, Mtb cultures were grown at 37° C. in T-25 vented, standing tissue culture flasks in 8 mL of buffered 7H9 medium seeded at an initial OD of 0.2. Three conditions were examined with two biological replicates: 1) DMSO treated, pH 7.0, 2) DMSO treated, pH 5.7, and 3) 40 μM ETZ treated, pH 5.7. The phoP::Tn mutant was grown in a similar manner and treated with DMSO at pH 5.7. Following six days incubation, total bacterial RNA was extracted as previously described (2). RNA-sequencing, data analysis and qPCR were performed as described by Baker et al. (15) with minor modifications (FIG. 8). The transcriptional profiling data have been submitted to the NCBI GEO database (accession number: GSE63917).

Cell Culture

Primary murine bone marrow derived macrophages (BMDMs) were isolated and grown as described (16). Briefly, BMDMs were isolated from WT C57Bl/6 mice (Charles River) and grown at 37° C. (5% CO₂) in DMEM (Corning CellGro) containing 10% fetal bovine serum (Thermo Scientific), 20% L-cell conditioned medium, 1 mM pyruvate, 2 mM L-glutamine, and 1 mM penicillin/streptomycin (Corning CellGro). Cells were grown until fully differentiated, scraped, and plated in medium lacking antibiotics at either 1×10 cells/mL for macrophage infections or 2×10⁵ cells/mL for measuring phagosome acidification. Cells were allowed to adhere overnight before addition of Mtb or experimental treatments.

Carbonic Anhydrase Activity Assay Carbonic anhydrase (CA) activity was measured using a modified Maren endpoint method (17) based on acidification of the media by CA conversion of CO₂. WT Mtb CDC1551 cultures were grown for six days at 37° C. in T-150 vented, standing tissue culture flasks in 50 mL of 7H9 medium seeded at an initial OD of 0.2. Two conditions were examined: 1) DMSO treated, pH 5.7, and 2) ETZ treated (80 μM), pH 5.7. Cells were then were pelleted, washed once in cold assay buffer (20 mM Tris, 20 mM NaCl, pH 8.3), re-suspended in 500 μL cold assay buffer and transferred to 2 mL screw cap tubes containing 200 μL of 0.1 mm glass beads. Cell lysis was achieved by bead beating at max speed for 2 minutes. Lysates were clarified by centrifugation at 21,000×g for 1 minute. Clarified lysates were transferred to new tubes and kept on ice. The CA assay apparatus utilized: 15×88 mm Pyrex glass tubes, 14 mm serum stoppers, 18 gauge 1.5 inch needles, 1 mL syringes, 1 mm tubing, sample evaporator needles, and 0.22 μm syringe filters (to prevent aerosol escape). All assay components were kept on ice before and during the assay. 450 μL of ddH₂O was added to the tube with 50 μL cell lysate. CO₂ was bubbled in at a constant rate and 500 μL of cold color indicator buffer (20 mM imidazole, 5 mM Tris, 0.2 mM 4-nitrophenol) was added, and timing was initiated. The color was monitored until clearing, comparing it to a previously cleared sample. Data are representative of at least two biological replicates with similar findings in each experiment.

Cytoplasmic pH and Phagosome Acidification Measurement

Cytoplasmic pH was measured as previously described by Purdy et al. (18). WT Mtb CDC1551 was grown in a similar manner as the transcriptional profiling experiments. Four conditions were examined: 1) DMSO treated, pH 7.0, 2) DMSO treated, pH 5.7, 3) 80 μM ETZ, pH 7.0, and 4) 80 μM ETZ, pH 5.7. Cytoplasmic pH was measured following 6 days incubation. Phagosome acidification was measured using pHrodo labeled beads (Life Technologies) fed to BMDMs in a 96-well black assay plate. One column did not contain any cells for a media and beads only control. Five conditions were examined: 1) 100 μM ETZ, 2) 80 μM ETZ, 3) 40 μM ETZ, 4) 100 nM Concanamycin A (CcA), and 5) an equivalent volume of DMSO. Cells were pre-treated for 4 hours with ETZ and DMSO before addition of particles. CcA was added 30 minutes prior to assay initiation. pHrodo green labeled particles (ex. 509 nm, em. 533 nm) were added to each well in pre-warmed live cell imaging solution (Life Technologies) at 1 mg/mL. The assay was carried out in a Perkin Elmer plate reader at 37° C. for 100 minutes taking readings at 5-minute intervals.

Analysis of Mycobacterial Lipids

Lipid analysis was conducted as previously described (15). Briefly, Mtb cultures were grown at 37° C. in standing, vented T-75 tissue culture flasks in 40 ml of minimal medium supplemented with 10 mM pyruvate and seeded at an initial OD of 0.1. Four conditions were examined: 1) DMSO treated, pH 7.0, 2) DMSO treated, pH 5.7, 3) 80 μM ETZ, pH 7.0, and 4) 80 μM ETZ, pH 5.7. Following 3 days incubation, lipids were radiolabeled by adding 8 μCi of [1,2 ¹⁴C] sodium acetate to each culture. Following 6 days of labeling, the lipids were extracted and analyzed by thin layer chromatography (TLC). Total extractable lipid C¹⁴ incorporation was determined using a scintillation counter. To analyze lipid species, 20,000 counts per minute (CPM) were loaded at the origin of a 100 cm² high performance TLC silica gel 60 aluminum sheet. To separate SL and TAG, TLCs were developed with the chloroform:methanol:water (90:10:1 v/v/v) and hexane:diethyl ether:acetic acid (80:20:1, v/v/v) solvent systems, respectively (15). To examine PDIM accumulation the 2D TLC was developed with 1) petroleum ether:ethyl acetate (98:2, v/v) and 2) petroleum ether:acetone (98:2, v/v) (5). Radiolabeled lipids were detected with a phosphor screen and Typhoon Imager and quantified using ImageJ software (19). Radiolabeling experiments, lipid extractions and analyses were repeated in two independent biological replicates with similar findings in both replicates. TAG and PDIM species were previously identified using these solvent systems and mass spectroscopy (5). SL identity was confirmed using a SL standard (provided by BEI resources) that was visualized by staining with phosphomolybdic acid followed by charring (FIG. 10, Panel C).

Analysis of Esx-1 Protein Export

Mycobacterium tuberculosis Erdman and Δesat-6 strains were a gift from Jeffery S. Cox (20). Mtb was cultured in 7H9 medium, collected by centrifugation, washed once with 5 mL of Sauton's broth and re-suspended in 50 mL of Sauton's broth in the presence or absence of 80 μM ETZ. After 5 days of growth at 37° C., the cells were diluted, washed and treated as above. The cultures were grown at 37° C. with gentle shaking for 4 days. Lysates were prepared as described previously (20). The secreted protein fraction was concentrated using Amicon filter systems with a 3 kDa molecular weight cut-off and total protein concentrations were determined by the MicroBCA assay (Promega). 13.5 μg of cell lysates and culture filtrates were separated on a 4-20% pre-cast gel (Bio-Rad) and transferred to nitrocellulose. Nitrocellulose membranes were incubated with antibodies against Esat-6 (Abcam, ab26246), CFP-10, MPT32, or RNAPβ(Abcam, 8RB13) and detected using chemiluminescence (LumiGLO®)(21). The following reagents were obtained through BET Resources, NIAID, NIH: Polyclonal Anti-Mycobacterium tuberculosis CFP10 (Gene Rv3874) (antiserum, Rabbit), NR-13801, Polyclonal Anti-Mycobacterium tuberculosis Mpt32 (Gene Rv1860) (antiserum, Rabbit), NR-13807.

Macrophage Infections

Macrophage infections were performed as described (16). Briefly, BMDMs were infected at an MO1 of 1:1 with Mtb CDC1551 in 24-well tissue culture treated plates. Infected BMDMs were treated with 80 μM ETZ or an equivalent volume of DMSO every two days for 9 days total. At days 3, 6 and 9, intracellular bacteria were quantified by lysing macrophage monolayers and performing serial dilution plating of lysates on 7H10 agar. For fluorescence microscopy experiments, macrophages were seeded on glass coverslips before infection with Mtb CDC1551 (aprA′::GFP smyc′::mCherry). Samples were treated every two days with 100 μM ETZ or an equal volume of DMSO for 9 days. Monolayers were then fixed in 4% paraformaldehyde and imaged by confocal microscopy. Survival assays and imaging experiments were repeated with three biological replicates with similar results.

Quantitative Single-Cell Imaging of Mtb Exposure to ETZ in Mice

C57BL/6 mice were infected via the intranasal route with 1000 CFU of the Erdman (aprA′::GFP smyc′::mCherry) dual fluorescent reporter. Mice were treated with 100 mg/kg of ETZ or an equal volume of 0.25% carboxymethyl cellulose (CMC) 5 days per week for 4 weeks via oral gavage. After 4 weeks, the right lung was homogenized and plated for enumeration of the bacterial load and the left lung was fixed in 4% paraformaldehyde before being transferred to 30% sucrose for confocal microscopy and pathology evaluation (FIG. 8). This experiment was repeated and the data from the two independent biological replicates were similar and therefore combined. Lungs were also examined for histopathological hallmarks of TB disease (FIG. 8), however, ETZ treated lungs did not have a significant reduction in the area of the lung showing Mtb-associated granulomatous pneumonia (FIG. 11). Mice were euthanized by carbon dioxide asphyxiation followed by cervical dislocation. Animal experiments were conducted following protocols approved by the Michigan State University Institutional Animal Care and Use Committee.

pH of Medium Determination

To examine whether ETZ alters the pH of the medium, WT Mtb CDC551 was grown in a similar manner as the transcriptional profiling experiments. Two conditions were examined: 1) DMSO treated, pH 5.7 or 2) 80 μM ETZ treated, pH 5.7. After 6 days incubation, cells were pelleted and supernatants were collected and filtered twice through 0.22 μm filters. The pH of the supernatants was then measured on a pH meter.

Data Analysis of RNA-Seq Transcriptional Profiling Experiments

Differential gene expression was calculated by normalizing data utilizing the trimmed mean of M-values normalization method (Robinson et al. (2010) Genome Biol:R25) and filtering genes that had >2 average normalized counts per million (CPM) within the edgeR package (Robinson et al. (2010) Bioinformatics 26:139-140). Statistical analysis was performed in RStudio (ver. 0.97.551) by fitting an additive generalized linear model (McCarthy et al. (2012) Nucleic Acids Res 40:4288-4297) or exact test (Robinson et al. (2008) Biostalistics 9:321-332) with the negative binomial distribution for each set of conditions and testing for differential gene expression utilizing the edgeR package. Differentially expressed genes were determined to be statistically significant based on >2-fold differentially regulated and an adjusted p<0.05.

Confocal Microscopy and Pathology of ETZ Treated Lungs

PFA fixed mouse lungs were frozen in a 30% sucrose PBS pH 7.4 solution, frozen in a dry ice, ethanol bath, and stored at −80° C. until imaging. At the time of imaging, lungs were thawed and hand-sectioned using a sterile scalpel. Sections were transferred to a microscope slide and 10 μL of ProLong® Gold antifade reagent (Invitrogen) was added. Samples were then mounted on a glass coverslip and imaged immediately. Images were obtained using an Olympus FV1000 confocal microscope. Settings for GFP and mCherry fluorescence were held constant through the image acquisition to allow for comparison between samples. For quantification of Mtb reporter fluorescence, bacilli were identified in the mCherry channel and the corresponding sum of GFP fluorescence was measured using the Volocity software package (Perkin Elmer). At least 1500 bacilli were counted across multiple fields of view and lungs.

For histopathology, transverse sections of each lung specimen was fixed in 4% paraformaldehyde for 48 hours, transferred to 50% ethanol for 4 hours, processed routinely, embedded in paraffin, and sectioned at 4 μm, followed by routine hematoxylin and eosin staining. Photomicrographs were acquired, and using Image-J the total area of each lung section was measured, as was the area of each lesion and a percentage of lung affected was calculated from this data.

Example 2. Results

Identification of Ethoxzolamide as an Inhibitor of the PhoPR Regulon

A whole-cell phenotypic screen was employed to identify inhibitors of the PhoPR regulon. The CDC1551 (aprA′::GFP) fluorescent reporter exhibits pH-inducible fluorescence that is fully dependent on PhoPR (5). Although PhoPR is required for growth in vivo, a PhoPR mutant grows well in rich medium at acidic pH; therefore, compounds that inhibit pH-inducible reporter fluorescence, but not growth, are anticipated to be inhibitors of the PhoPR pathway. To discover inhibitors of the PhoPR regulon a high throughput screen (HTS) of a ˜220,000 compound library composed of small molecules representing broad chemical diversity was performed. The reporter strain was grown in 384 well plates containing the compound library (at an concentration of ˜10 μM) in rich medium buffered at pH 5.7. Following 6 days of incubation, plates were examined for GFP fluorescence and growth. Ethoxzolamide (ETZ, FIG. 1, Panel A) was identified as a compound that inhibits Mtb reporter fluorescence but that does not reduce growth. ETZ inhibits CDC1551 (aprA′::GFP) reporter fluorescence with a half-maximal effective concentration (EC₅₀) of 5.6 μM at pH 5.7, (FIG. 1B). Growth was mostly unaffected at pH 5.7 across the range of ETZ concentrations tested (FIG. 1, Panel B). Basal aprA expression is also dependent on PhoPR at neutral pH and we observed inhibition of reporter fluorescence at pH 7.0 with a similar EC₅₀ of 4.7 μM (FIG. S1A). ETZ is a carbonic anhydrase (CA) inhibitor that has previously been shown to inhibit recombinant Mtb CA proteins (22).

Whether ETZ inhibits Mtb CA activity was examined, and full inhibition of CA activity in Mtb whole cells treated with ETZ for 6 days was observed (FIG. 1, Panel C). ETZ did not quench GFP fluorescence, alter the pH of the culture medium (FIG. 8, Panel B) and only caused a slight acidification of cytoplasmic pH (FIG. 1, Panel D). These data support two novel findings: 1) ETZ inhibits the PhoPR regulon, and 2) a previously unrecognized link may exist between Mtb CA activity and PhoPR signaling.

Prior transcriptional profiling and ChIP-seq studies have defined a core regulon that is directly regulated by PhoP and induced by acidic pH (2-5, 23, 24). To determine if ETZ inhibits the PhoPR regulon, RNA-seq transcriptional profiling was performed. Mtb CDC1551 was inoculated into rich medium buffered at pH 5.7 in the presence of either 40 μM ETZ or an equivalent volume of DMSO. As a positive control for PhoPR-regulated genes, a DMSO treated phoP transposon mutant strain (phoP::Tn) was cultured using the above described conditions. To identify genes regulated by acidic pH, the transcriptional profile of DMSO treated Mtb at pH 5.7 as compared to pH 7.0. After 6 days incubation, total RNA was isolated and subjected to RNA sequencing. ETZ treatment of Mtb caused the down-regulation (>2-fold, p<0.05) of 45 genes (FIG. 2, Table 2). All 45 of these genes were also down-regulated in the phoP::Tn mutant and 40 were induced by acidic pH (FIG. 2, Panels B and C). ETZ down-regulated genes include many genes previously shown to be directly controlled by PhoP and are involved in lipid synthesis, carbon metabolism, and virulence (FIG. 2, Panel C) (23, 24). Many of the remaining 137 genes downregulated in the phoP::Tn mutant but not by ETZ (>2-fold, p<0.05), are significantly downregulated by ETZ but less than 2-fold (e.g. espR, espA, esxA, FIG. 2, Pan). To confirm the RNA-seq results, semi-quantitative real-time PCR was conducted on the phoP gene and two well-characterized PhoP regulated genes, aprA and pks2. In ETZ treated Mtb, aprA and pks2 were down-regulated >5 fold at both pH 7.0 and 5.7 (FIG. 9). phoP did not exhibit substantial differential regulation by ETZ, demonstrating that ETZ is not acting by modulating phoP gene expression. These findings validate ETZ as an inhibitor of the core PhoPR regulon.

Lipid Synthesis and Esx-1 Protein Secretion are Modulated by Ethoxzolamide.

PhoPR controls cell envelope lipids and Esx-1 dependent secretion of ESAT-6 (EsxA)(25, 26). Therefore, whether ETZ modulates these virulence factors was investigated. The PhoPR-dependent mmpL8-pks2 operon (Rv3823c-Rv3825c) is responsible for the production of sulfolipid (SL) and is strongly induced at acidic pH (3, 15, 27, 28). Transcriptional profiling data demonstrated a ˜5-fold down-regulation of this operon when treated with ETZ at acidic pH (FIG. 2C), suggesting that similar to a phoPR knockout mutant (ΔphoPR), ETZ may downregulate the accumulation of SL. To test this hypothesis, ¹⁴C radiolabeled lipids were isolated from wild type (WT) and ΔphoPR mutant strains grown at pH 7.0 and pH 5.7 treated with either ETZ or an equal volume of DMSO. A lipid migrating with a position consistent with SL was induced ˜2.5 fold at pH 5.7 as compared to pH 7.0 in DMSO, whereas, this lipid was not detected in ETZ treated cells and the ΔphoPR mutant (FIG. 3, Panel A, FIG. 10, Panels A and C). It has been shown previously that mutant strains with reduced accumulation of PhoPR-regulated lipids compensate by over-accumulating other long chain fatty acids, such as triacylglycerol (TAG) and phthiocerol dimycoserate (PDIM) (5, 15, 29). At pH 5.7, as compared to the DMSO control, TAG was induced 5.5-fold and 6.5-fold in ETZ treated Mtb and the ΔphoPR mutant strain, respectively (FIG. 3, Panel B, FIG. 10, Panel A). Similarly, at pH 5.7, a 2-fold increase in the accumulation of PDIM species in the ETZ treated samples as compared to the DMSO treated cells (FIG. 3, Panel C) was observed. Therefore, ETZ treatment phenocopies the ΔphoPR mutant strain for alteration of lipid species production.

ESAT-6 protein is expressed in a phoP mutant strain but it is not exported from the bacterial cell (25). Therefore, ETZ treatment altered the secretion of Esx-1-exported proteins. Mtb Erdman was grown in rich medium and passaged twice in Sauton's minimal medium to measure Esx-1 export. During growth in Sauton's medium the cells were untreated, treated with ETZ during both passages (WT++, FIG. 4), or only treated with ETZ in the final passage (WT−+, FIG. 4). ETZ did not affect ESAT-6 and CFP-10 expression, but strongly and selectively reduced their secretion, as it did not alter that of Sec-secreted protein, Mpt-32 (FIG. 4). Moreover, transcriptional profiling revealed that espR and the espACD operon were significantly down-regulated (p<0.05, >1.5-fold) in ETZ treated cultures (Table 3). Recently, Cao and colleagues have shown that PhoPR directly regulates EspR-dependent expression of espACD (26). EspA and ESAT-6 secretion are mutually dependent and loss of espR and espA expression leads to reduced Esx-1 function, loss of ESAT-6 secretion, and attenuated virulence (23, 30). Therefore, both transcriptional profiling and biochemical approaches support that ETZ inhibits the Esx-1 secretion.

Ethoxzolamide Inhibits Mtb PhoPR Regulon Expression and Growth in Infected Macrophages and Mice

The PhoPR regulon is induced within 20 minutes of Mtb phagocytosis by macrophages and remains induced over a period of at least 14 days (32). To determine if ETZ modulates the PhoPR regulon in macrophages, murine bone marrow derived macrophages (BMDMs) were infected with the CDC1551 (aprA′::GFP, snmyc′::mCherry) reporter strain. This strain exhibits PhoPR-inducible expression of GFP and constitutive expression of mCherry (5). The infected macrophages were treated with ETZ or DMSO and single-cell reporter fluorescence was quantified 6 days post-infection. ETZ treatment caused >90% inhibition of reporter GFP fluorescence in infected macrophages (FIG. 5, Panel A and B). Moreover, in a 9-day macrophage survival assay, ETZ treatment significantly inhibited the ability of Mtb to grow intracellularly (FIG. 5, Panel C). Notably, both ETZ treated and untreated bacteria exhibited a similar initial decrease in growth during the first 3 days of infection. However, the untreated Mtb successfully adapted to the macrophage environment and grew ˜0.5 logs over the next six days while the ETZ treated cells could not transition into a growth phase. This phenotype is similar to that observed with a PhoPR mutant strain (6) and consistent with ETZ functioning as an anti-virulence agent targeting PhoPR-dependent macrophage adaptation.

ETZ is also a eukaryotic CA inhibitor. Therefore, it is possible that the observed intracellular Mtb phenotypes may, in part, be driven by ETZ targeting macrophage CA activity. Because PhoPR is induced by acidic pH in macrophages, whether ETZ inhibits phagosome acidification was also examined. BMDMs were treated with DMSO, ETZ or concanamycin A (an inhibitor of the vacuolar ATPase) four hours prior to being fed with beads coated with the pH-sensitive dye pHrodo. Phagosome acidification was monitored for one hundred minutes using a plate reader. Even at concentrations as high as 100 μM, ETZ did not alter phagosome acidification (FIG. 8, Panel C), supporting the idea that ETZ-induced inhibition of Mtb growth is mediated by PhoPR regulon inhibition, rather than by altering the environment within the macrophage phagosome.

Next experiments were performed to examiner whether ETZ can modulate the PhoPR regulon in vivo. C57Bl/6 mice were infected with the Erdman (aprA′::GFP smyc′::mCherry) dual fluorescent reporter strain and the mice were treated orally with either 100 mg/kg of ETZ or an equal volume of 0.25% carboxymethyl cellulose (as a mock treatment) 5 days per week for 4 weeks. In animals, ETZ is previously reported to have a short half-life (2.5-5.5 hours) and an LD₅₀ of ˜1000 mg/kg with no observable drug-related organ lesions observed at 100 mg/kg (33-35). Quantitative single-cell imaging was used to measure the induction of reporter fluorescence in lung tissues. For this approach, lung tissue was sectioned, imaged by confocal microscopy and bacterial fluorescence quantified using Volocity image analysis software (14, 36). Individual bacterial cells were identified using the constitutive mCherry signal and then GFP fluorescence was measured for ˜3000 bacterial cells across multiple fields of view from lungs of mice in the same treatment group. Two independent experiments were conducted with similar results; therefore, the data from both experiments were combined for analysis. The Erdman (aprA′::GFP smyc′::mCherry) reporter exhibited a strong induction of GFP fluorescence in infected mice in mock-treated mouse lungs (FIG. 6A). Notably, single cells in the mock treated samples exhibited substantial heterogeneity of GFP fluorescence providing additional evidence that Mtb experiences a variety of microenvironments during the course of infection (FIG. 6, Panel B). In contrast, ETZ strongly down-regulated GFP reporter fluorescence in mouse lungs with 3-fold inhibition of GFP signal as compared to the mock treated control (FIG. 6, Panel B). Importantly, the distribution of reporter fluorescence was dramatically altered by ETZ treatment, with a more homogeneous population of cells expressing low levels of GFP. For example, 49% of Mtb cells in ETZ treated lungs quantified for GFP fluorescence are in the bottom decile of fluorescence (<1000 GFP/μm²) as compared to 5% of cells in the mock-treated mice (FIG. 6, Panel B). This approach demonstrates that quantitative analysis of fluorescent Mtb reporter strains in host tissues can be applied as a biomarker for pathway-specific drug exposure in vivo. The effect of ETZ treatment on bacterial survival in vivo was also examined. A significant 0.72 log reduction of bacterial survival in the lungs of ETZ treated mice as compared to the mock-treated control was observed (FIG. 6, Panel C). Therefore, adequate ETZ exposure was achieved in mouse lungs to repress the PhoPR regulon and attenuate virulence. Together, these data support that ETZ functions by an anti-virulence mechanism and attenuates Mtb virulence in vivo by i) targeting Mtb inside macrophages and the mouse lung, ii) downregulating the PhoPR regulon, and iii) reducing the expression of virulence pathways such as lipid metabolism and Esx-1 secretion.

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TABLE 1 Gene expression tables of ETZ treated Mtb genes induced at pH 5.7 as compared to DMSO treated Mtb at pH 5.7 ETZ 5.7/ Counts per million (CPM) DMSO5.7 log2 Fold Gene DMSO5.7A DMSO5.7B ETZ5.7A ETZ5.7B Fold change change MT0468 42.731699 49.9501614 98.2060327 93.5145073 2.070860989 1.050230713 MT0543 1.87419733 2.17174615 3.54632896 4.99576667 2.104137421 1.07322893 MT1068 9.46469649 13.7543923 76.928059 58.8563761 5.824066213 2.542026757 MT1069 7.40307944 15.0212442 96.2055394 84.5377391 8.323756901 3.057234831 MT1567 10.495505 8.05355863 30.6439195 22.6370677 2.86585684 1.518966544 MT3830 101.956335 27.9612317 362.543937 36.2193083 2.18722507 1.129101685 Adjusted Rv Gene Gene logCPM p-value number name Proposed function MT0468 6.15584656 8.80E−15 Rv0452 Rv0452 putative transcriptional regulator MT0543 1.74399765 0.00401549  MT1068 5.32065862 8.24E−37 Rv1039c PPE PPE-family protein MT1069 5.67295552 2.77E−38 Rv1040c PE PE-family protein MT1567 4.18209787 2.33E−21 Rv1517 Rv1517 conserved hypothetical protein MT3830 7.04768187 0.000171968 Rv3727 Rv3727 similar to phytoene dehydrogenase precursor

TABLE 2 Gene expression tables of ETZ treated Mtb genes repressed at pH 5.7 as compared to DMSO treated Mtb at pH 5.7 ETZ 5.7/ Counts per million (CPM) DMSO5.7 log2 Fold Adjusted Rv Gene Gene DMSO5.7A DMSO5.7B ETZ5.7A ETZ5.7B Fold change change logCPM p-value number name Proposed function MT0121 169.333728 187.041637 71.3812367 95.6220964 0.465139248 −1.104265418 7.03342469 1.34E−18 Rv0112 gca probable GDP-mannose dehydratase MT0122 161.18097 181.974229 54.6498386 98.9005683 0.431612949 −1.212189946 6.9581013 3.99E−14 Rv0113 gmhA phosphoheptose isomerase MT0123 104.673921 101.710111 38.1003034 55.9681985 0.449781332 −1.152704311 6.23396912 5.30E−13 Rv0115 Rv0115 conserved hypothetical protein MT0124 31.6739348 62.5281912 9.82060327 19.826949 0.314329613 −1.6696499  4.95967908 1.61E−30 MT0266 2072.01885 895.573818 449.92912 213.490966 0.227440347 −2.136439889 9.82632863 3.95E−62 Rv0252 nirB nitrite reductase flavoprotein MT1216 33.4544223 54.1126749 10.6389869 21.6223026 0.362381577 −1.464418482 4.91246015 1.12E−21 MT1217 219.655927 248.212487 70.3809901 106.862571 0.372531337 −1.424566308 7.33475038 4.89E−26 Rv1179c Rv1179c hypothetical protein MT1218 1595.50418 2561.75556 315.077688 690.11833 0.230842913 −2.115016651 10.334003 1.39E−44 Rv1180 pks3 polyketide synthase MT1219 509.219413 1031.66991 90.2040597 290.535055 0.224387679 −2.155934636 8.90856975 1.10E−41 Rv1182 papA3 PKS-associated protein, unknown function MT1220 582.406819 908.875763 100.297458 333.15519 0.252195014 −1.98738834  8.9109085 4.40E−20 Rv1183 mmpL10 conserved large membrane protein MT1221 865.504325 892.13522 72.3814834 169.699949 0.126632779 −2.981277199 8.96594302 2.18E−37 Rv1184c Rv1184c conserved hypothetical protein MT1222 964.743073 1135.55177 272.612672 478.032423 0.345229335 −1.534373035 9.47752699 4.68E−23 Rv1185c fadD21 acyl-CoA synthase MT1586 628.980622 1585.37469 282.615139 815.558909 0.48114939  −1.055443195 9.6940307 5.54E−16 Rv1535 Rv1535 hypothetical protein MT1676 208.317033 355.261474 75.7459493 110.765514 0.336028627 −1.573343949 7.5520732 3.35E−38 MT1677 1156.56717 1458.32754 362.998595 479.5936 0.321310343 −1.637960672 9.7557478 2.22E−39 Rv1639c Rv1639c conserved hypothetical protein MT2345.1 77.779189 139.987137 31.28044 45.3521943 0.358773601 −1.478854357 6.20461948 7.79E−29 Rv2288 Rv2288 hypothetical protein MT2391 627.387555 704.822114 86.0212101 165.016418 0.179783783 −2.475665204 8.62915134 2.52E−47 Rv2329c narK1 probable nitrite extrusion protein MT2393 110.952482 143.968672 16.8223297 39.8100156 0.208578985 −2.261334285 6.28594525 1.91E−34 Rv2331 Rv2331 hypothetical protein MT2394 83.401781 120.169954 32.6444127 56.748787 0.432413656 −1.209516008 6.19775275 2.32E−20 Rv2332 mez probable malate oxidoreductase MT2445 324.610977 440.412021 124.212445 233.317915 0.451359652 −1.147650637 8.1334107 1.46E−16 MT2466 4373.8143 3300.42072 1080.17543 1181.3427 0.297335237 −1.749837649 11.2784899 5.97E−27 Rv2395a aprA conserved hypothetical protein M72467 768.608323 994.207289 220.963574 314.264947 0.301574806 −1.729412187 9.16655077 6.97E−48 Rv2395b aprB conserved hypothetical protein MT2467.1 1060.32714 887.701238 317.350976 385.376563 0.360595047 −1.471548515 9.37249515 8.21E−23 Rv2396 aprC PE_PGRS-family protein MT2837 10.2143754 22.8033346 4.81937012 6.71306146 0.358446923 −1.480168586 3.49749824 7.73E−12 MT2838 92.3042183 156.094254 42.9196736 53.6264328 0.397690542 −1.330281844 6.43277182 1.63E−21 Rv2768c PPE PPE-family protein MT2839 32.4236137 88.6796344 18.7318914 26.6961281 0.409860945 −1.28679357  5.38514347 3.82E−09 Rv2769c PE PE-family protein MT3220.2 959.307901 976.471362 225.964807 478.188541 0.340057328 −1.556150112 9.36661886 1.02E−12 MT3221 1765.58759 1906.9741 397.370706 958.953024 0.336663001 −1.570622914 10.2962015 9.56E−11 Rv3136 PPE PPE-family protein MT3223 40.4826622 46.6925422 7.27452094 22.0125969 0.301748667 −1.728580698 4.87148205 5.26E−10 MT3224 235.680314 191.475619 56.7412633 109.67269 0.372818544 −1.423454472 7.21474753 1.13E−08 Rv3137 Rv3137 probable monophosphatase MT3412 36.9216873 21.7174615 7.45638396 5.30800209 0.220692396 −2.17989117  4.16771802 5.99E−38 MT3413 197.634108 267.396244 21.3689053 47.5378422 0.140675641 −2.829555555 7.06193426 5.06E−65 MT3525 2548.3461 1407.20101 1243.57936 539.074447 0.432528515 −1.209132849 10.4865077 1.89E−17 Rv3416 whiB3 WhiB transcriptional activator homologue MT3580.2 66.8151347 191.837576 24.0968506 36.2973672 0.257737722 −1.956024393 6.32027386 8.33E−24 MT3581 687.549289 1054.20178 254.244507 436.114818 0.391333715 −1.353528686 9.24836584 1.74E−29 Rv3477 PE PE-family protein MT3582 488.603243 700.297643 226.692259 322.695303 0.462370156 −1.112879814 8.76397847 1.17E−22 Rv1361c PPE PPE-family protein MT3583 860.631412 1176.3625 367.272376 563.038515 0.452086135 −1.145330424 9.53524669 1.03E−19 Rv3479 Rv3479 hypothetical protein MT3589 162.399198 67.2336412 20.7323847 35.2045432 0.259820655 −1.944411968 6.16025338 8.44E−07 Rv3485c Rv3485c short-chain alcohol dehydrogenase family MT3591 1859.29746 1684.09865 151.219104 378.663502 0.135460473 −2.884056157 9.99215187 4.10E−24 Rv3487c lipF probable esterase MT3874 324.892106 540.583812 80.3834564 176.334952 0.285175589 −1.810077601 8.13288672 3.93E−43 Rv3767c Rv3767c conserved hypothetical protein MT3930 1317.46701 1436.24812 242.42341 468.743419 0.245335793 −2.027170366 9.75882391 1.23E−27 Rv3822 Rv3822 conserved hypothetical protein MT3931 632.635307 1086.77797 132.578144 440.486114 0.292331754 −1.774321545 9.16309759 3.10E−19 Rv3823c mmpL8 conserved large membrane protein MT3932 481.293873 804.450969 57.5596469 262.668044 0.198835431 −2.330353238 8.64978071 8.55E−18 Rv3824c papA1 PKS-associated protein, unknown function MT3933 3993.9145 5457.05513 476.844848 1547.51678 0.184125775 −2.4412365  11.4863194 1.78E−21 Rv3825c pks2 polyketide synthase MT3976 340.822784 586.823907 128.031569 221.452969 0.376547817 −1.409095015 8.31939981 1.02E−34 Rv3862c Rv3862c hypothetical protein

TABLE 3 Gene expression tables of ETZ treated Mtb at pH 5.7 as compared to DMSO treated Mtb at pH 5.7 ETZ 5.7/ Counts per million (CPM) DMSO5.7 log2 Fold Adjusted Rv Gene Gene DMSO5.7A DMSO5.7B ETZ5.7A ETZ5.7B Fold change change logCPM p-value number name Proposed function MT0001 614.549303 735.859986 865.031471 973.159735 1.364275142 0.448134631 9.63905618 0.002469029 Rv0001 dnaA chromosomal replication initiator protein MT0002 134.942207 193.466386 158.038967 220.594322 1.155275627 0.208237093 7.46724172 0.267913038 Rv0002 dnaN DNA polymerase III, [beta] subunit MT0003 78.8099975 103.5199 84.2935114 118.883635 1.109488944 0.149895291 6.59350057 0.499249286 Rv0003 recF DNA replication and 50S induction MT0004 42.6379892 48.1403729 46.4660025 53.8606094 1.104566359 0.143480094 5.58379825 0.591423487 Rv0004 Rv0004 conserved hypothetical protein MT0005 1550.992 1128.31261 1628.58338 1271.11038 1.087584465 0.121127449 10.4459637 0.641879751 Rv0005 gyrB DNA gyrase subunit B MT0006 1054.32971 853.043789 1087.54088 899.316059 1.042800576 0.060463285 9.92737302 0.840411204 Rv0006 gyrA DNA gyrase subunit A MT0007 270.915223 276.807144 272.976398 293.423233 1.033585921 0.047658323 8.1226204 0.870054573 MT0009 3.93581438 6.96768556 5.18309617 6.55694375 1.083319173 0.11545836 2.54788765 0.839018102 MT0010 32.7047433 43.7968807 35.6451526 43.8690761 1.042603203 0.060197116 5.29240324 0.857846065 Rv0008c Rv0008c hypothetical protein MT0011 1189.08449 1100.1704 1126.82329 1157.61281 0.998575231 −0.002056973 10.1593646 0.997032163 Rv0009 ppiA peptidyl-prolyl cis-trans isomerase MT0012 54.632852 33.3001076 54.5589071 48.0842542 1.196083639 0.258318277 5.57947294 0.347475973 MT0013 93.2413169 84.6076103 101.115841 98.1980386 1.12194598 0.166003214 6.56176789 0.429500238 Rv0010c Rv0010c hypothetical protein MT0014 300.152702 223.780343 289.980591 243.933919 1.025954877 0.036967281 8.04783468 0.89957148 Rv0011c Rv0011c hypothetical protein MT0015 256.390194 211.835739 237.058451 184.765308 0.898151032 −0.154970028 7.79879591 0.448807051 Rv0012 Rv0012 possible cell division protein MT0016 130.069294 150.936357 127.304117 144.252763 0.967018517 −0.048384579 7.11186704 0.870656307 Rv0013 pabA p-aminobenzoate synthase glutamine amidotransferase MT0017 379.712378 298.072159 380.275582 382.020032 1.132811983 0.179908431 8.49264796 0.419545994 Rv0014c pknB serine-threonine protein kinase MT0018 457.491567 263.867157 489.211533 341.195252 1.175056906 0.232730626 8.6003071 0.216628686 Rv0015c pknA serine-threonine protein kinase MT0019 536.114145 357.43322 555.955263 464.918536 1.160993332 0.215359686 8.90320936 0.300046275 Rv0016c pbpA penicillin-binding protein MT0020 291.906233 235.001031 324.170839 288.19329 1.166861541 0.222633382 8.15478513 0.225429598 Rv0017c rodA ftsW/RodA/SpovE family MT0021 461.989641 346.031553 493.030657 427.684462 1.1482782 0.199472214 8.75608115 0.308438093 Rv0018c ppp putative phosphoprotein phosphatase MT0022 282.160407 188.760936 311.167633 251.661746 1.211784706 0.277133403 8.01463294 0.110360429 Rv0019c Rv0019c conserved hypothetical protein MT0023 1385.96892 1071.1233 1559.74822 1347.99835 1.190039729 0.251009738 10.389507 0.230822487 Rv0020c Rv0020c conserved hypothetical protein MT0024 39.4518537 43.6159018 35.6451526 46.3669594 0.982933482 −0.024834307 5.37343866 0.942756952 Rv0021c Rv0021c conserved hypothetical protein MT0026 67.0962642 61.6232969 70.8356477 83.2887974 1.195813938 0.257992932 6.14767834 0.227492631 Rv0023 Rv0023 putative transcriptional regulator MT0027 92.491638 92.027743 94.4778407 105.847806 1.084590069 0.117149866 6.5908668 0.624704011 Rv0024 Rv0024 putative p60 homologue MT0028 55.1951112 40.9917085 59.0145511 57.6074344 1.224328967 0.29199125 5.73828296 0.198664225 Rv0025 Rv0025 conserved hypothetical protein MT0029 66.2528755 76.82552 66.9255927 87.4259167 1.073871638 0.102821556 6.2200541 0.704237224 Rv0026 Rv0026 conserved hypothetical protein MT0030 36.453138 50.8550556 38.4640295 48.0842542 0.996247811 −0.005423446 5.44787262 0.987820145 Rv0027 Rv0027 conserved hypothetical protein MT0030.1 21.5532692 32.1237451 20.9142477 24.1982448 0.847943966 −0.237959164 4.63657275 0.374521053 MT0031 18.7419733 25.9704644 15.3674255 17.6413011 0.741327137 −0.431817772 4.2929055 0.036164474 MT0032 2.90500585 1.44783077 1.72769872 2.02953021 0.89016066 −0.167862351 1.13749791 0.859814922 MT0033 8.6213077 12.3970509 12.5485486 12.0991224 1.176875627 0.234961863 3.53587467 0.52349722 MT0034 63.5352893 69.8578344 71.7449628 75.7170886 1.105934645 0.145266132 6.13741472 0.534991985 Rv0030 Rv0030 hypothetical protein MT0035 11.245184 15.2927125 14.9127679 17.8754776 1.237754151 0.307724788 3.90900628 0.226270181 Rv0031 Rv0031 conserved hypothetical protein MT0036 11.901153 7.51062209 12.5485486 7.33753229 1.01967113 0.028103921 3.31954745 0.952654537 MT0037 51.6341363 62.7996594 49.8304684 57.9977287 0.943464173 −0.08396036 5.80077411 0.778579543 Rv0032 bioF2 C-terminal similar to B. subtilis BioF MT0038 4.49807358 8.59649517 3.27353442 8.19617969 0.86656511 −0.206619944 2.66376222 0.659125261 Rv0033 Rv0033 possible acyl carrier protein MT0039 2.90500535 7.23915383 3.72819198 7.80588542 1.144620601 0.194869478 2.49099447 0.712080008 Rv0034 Rv0034 hypothetical protein MT0040 28.4877993 49.0452672 32.3716182 54.8753745 1.126727482 0.172138618 5.37140745 0.487704331 Rv0035 fadD34 acyl-CoA synthase MT0041 113.857438 138.810775 113.209732 123.957461 0.9415093 −0.08695275 6.93824525 0.733038419 Rv0036c Rv0036c conserved hypothetical protein MT0042 175.05003 163.695366 153.947049 146.594528 0.887474584 −0.172222292 7.32184579 0.39439271 Rv0037c Rv0037c probable membrane protein MT0043 296.029458 194.823727 290.889906 209.978318 1.028666143 0.040774827 7.95473751 0.886590154 Rv0038 Rv0038 conserved hypothetical protein MT0044 53.976883 72.3010488 74.3819766 90.1579766 1.308716492 0.388152599 6.18782106 0.012386351 MT0046 185.732955 318.794237 322.715935 462.810947 1.586341276 0.665703177 8.33415161 4.45E−07 Rv0040c Rv0040c conserved hypothetical protein MT0047 279.911371 350.194066 246.333465 311.532887 0.884853862 −0.176488889 8.2151586 0.375125762 Rv0041 leuS leucyl-tRNA synthase MT0048 82.652102 106.325072 92.6592105 112.560868 1.088651064 0.122541614 6.62550921 0.601975757 Rv0042c Rv0042c conserved hypothetical protein MT0049 50.1347735 79.9021604 52.4674823 76.4976771 0.99870985 −0.001862494 6.02106006 0.997032163 Rv0043c Rv0043c transcriptional regulator (GntR family) MT0050 90.2426012 75.5586681 93.5685256 79.3077959 1.043164757 0.060967034 6.40667201 0.8246528 Rv0044c Rv0044c possible monooxygenase MT0051 916.388732 403.673315 986.697834 443.218174 1.087201684 0.120619596 9.42551314 0.619926139 Rv0045c Rv0045c possible dihydrolipoamide acetyltransferase MT0052 3181.91851 1358.78917 3496.95315 1394.75561 1.062198086 0.087052835 11.2034991 0.779804726 Rv0046c Rv0046c conserved hypothetical protein MT0053 1690.24486 581.846989 1829.36015 739.685702 1.1725085 0.229598382 10.2413016 0.300046275 Rv0047c Rv0047c conserved hypothetical protein MT0054 49.6662291 62.9806383 48.0118382 65.1791433 1.001586668 0.002287264 5.82391847 0.996585457 Rv0048c Rv0048c hypothetical protein MT0055 232.962728 250.203254 216.780724 219.267321 0.902914236 −0.147339136 7.84534082 0.476182576 Rv0049 Rv0049 hypothetical protein MT0056 757.08201 756.672554 763.370041 765.679301 1.010104106 0.014503991 9.57151923 0.966783763 Rv0050 ponA penicillin-bonding protein MT0057 199.883145 191.20415 206.869189 210.368612 1.06718196 0.093806184 7.66006407 0.707679183 Rv0051 Rv0051 probable membrane protein MT0058 92.9601873 76.82552 100.024663 97.8858032 1.170649769 0.22730952 6.52518101 0.252418872 MT0059 239.897258 289.704195 213.961847 231.210326 0.844085802 −0.244538438 7.92920753 0.153630248 Rv0053 rpsf 30S ribosomal protein S6 MT0060 202.132132 228.395303 207.141984 215.052143 0.982026456 −0.026166203 7.73712878 0.924218684 Rv0054 ssb single strand binding protein MT0061 89.7740519 124.875404 107.299184 121.147342 1.074521646 0.103694546 6.79387579 0.694085957 Rv0055 rpsR 30S ribosomal protein S18 MT0062 271.664902 341.597571 286.616125 339.087663 1.023137275 0.032999726 8.27577601 0.904814009 Rv0056 rpll 50S ribosomal protein L9 MT0063 146.468521 174.825565 141.762227 196.318018 1.043661195 0.061653444 7.36661115 0.830576393 MT0064 336.886959 485.566243 382.276075 609.795769 1.194283661 0.25614554 8.82601642 0.127274038 Rv0058 dnaB DNA helicase (contains Intein) MT0065 30.4557065 46.1496056 31.4623031 56.0462573 1.127271004 0.172834392 5.3656361 0.505322279 MT0066 249.549374 352.365813 252.880534 367.266909 1.027893393 0.039690645 8.25600603 0.888779002 Rv0060 Rv0060 hypothetical protein MT0066.1 194.354263 221.427618 204.141244 207.948788 0.992835627 −0.010373209 7.69449653 0.973114765 MT0066.2 5.81001171 8.14404805 6.27427431 6.63500261 0.925816571 −0.11120171 2.78507213 0.830576393 MT0067 122.853635 234.277116 144.581104 246.041508 1.109937451 0.150478378 7.54796951 0.499431176 Rv0062 celA cellulase/endoglucanase MT0068 180.391493 224.413769 265.610946 279.919051 1.354344369 0.437594619 7.89344724 0.001801509 Rv0063 Rv0063 probable oxidoreductase MT0069 43.481378 40.6297509 48.8302218 46.601136 1.134938679 0.182614351 5.49390004 0.462931351 MT0070 744.618597 736.402923 748.27541 645.390606 0.938456073 −0.091638877 9.48952757 0.745984651 Rv0064 Rv0064 possible membrane protein MT0071 56.6944691 93.2041055 54.9226331 79.8542078 0.908281214 −0.138789053 6.15695487 0.574427351 Rv0065 Rv0065 conserved hypothetical protein MT0072 298.091085 317.346406 282.342344 332.999072 0.997196428 −0.00405038 8.26620601 0.988617034 Rv0066c lcd2 isocitrate dehydrogenase MT0073 34.9537801 25.6989961 33.6446594 24.1982448 0.952464543 −0.070262708 4.89655697 0.831756973 Rv0067c Rv0067c transcriptional regulator (TetR/AcrR family) MT0074 17.6174549 24.4321442 27.7341111 30.8332474 1.400423564 0.485863242 4.66375872 0.011125524 Rv0068 Rv0068 probable oxidoreductase MT0075 112.826679 101.167175 128.759021 103.740217 1.082049943 0.11376709 6.80470045 0.624685486 MT0076 72.9999858 82.9788007 74.9275657 67.8331443 0.915117472 −0.127971143 6.22603317 0.632483493 Rv0070c glyA2 serine hydroxymethyltransferase MT0077 11.4326037 7.1486644 7.63824699 7.49365 0.829923821 −0.268949178 3.10330718 0.505322279 Rv0071 Rv0071 group II intron maturase MT0078 122.197666 107.863392 114.755568 114.824575 0.999963333 −5.29E−05 6.846555 0.999874639 Rv0072 Rv0072 ABC-transporter transmembrane subunit MT0079 74.311924 86.7793565 80.2015934 92.0313891 1.069639074 0.097124073 6.38396131 0.706925211 Rv0073 Rv0073 ABC-transporter ATP-binding subunit MT0080 72.6251454 79.7211815 83.6569908 77.2002068 1.05537771 0.077759419 6.29419239 0.793843784 Rv0074 Rv0074 conserved hypothetical protein MT0081 80.0282258 77.8209036 82.2020866 85.6305631 1.063429717 0.088724688 6.35048868 0.740445414 Rv0075 Rv0075 probable aminotransferase MT0082 23.0526271 41.3536662 31.6441661 43.7910172 1.193927112 0.255714764 5.13571394 0.306839725 MT0083 33.3607124 48.4118412 50.8307151 56.9829636 1.332909217 0.414578523 5.57254931 0.032769559 Rv0077c Rv0077c probable oxidoreductase MT0084 10.5892149 27.9612317 11.0936444 24.0421271 0.927869492 −0.108006196 4.21889401 0.764687847 Rv0078 Rv0078 transcriptional regulator (TetR/AcrR family) MT0085 185.076986 167.314943 173.951982 166.811771 0.968046993 −0.046851012 7.43846899 0.875390859 MT0085.1 131.943492 124.332467 115.301157 116.776046 0.906120296 −0.1422255 6.93381022 0.497179783 MT0086 959.96387 1250.02089 862.667252 1023.5077 0.857713619 −0.221432067 10.0003051 0.289602189 Rv0079 Rv0079 hypothetical protein MT0087 622.233512 607.003048 531.858412 445.169645 0.791762 −0.336861267 9.10781271 0.036164474 Rv0080 Rv0080 hypothetical protein MT0088 74.1245042 103.338921 73.199867 95.7001552 0.955290642 −0.065988363 6.43921656 0.813012054 Rv0081 Rv0081 transcriptional regulator (ArsR family) MT0089 84.7137191 152.565167 91.1133748 122.474342 0.925187824 −0.112181816 6.81892669 0.692019534 Rv0082 Rv0082 probable oxidoreductase subunit MT0090 145.718842 202.24386 139.943597 166.811771 0.888990194 −0.16976059 7.35630586 0.436145896 Rv0083 Rv0083 probable oxidoreductase subunit MT0091 208.504452 206.496863 181.135571 192.337017 0.899695431 −0.152491398 7.62418774 0.465361366 Rv0084 hycO formate hydrogenlyase subunit 4 MT0092 111.421031 98.2715132 107.299184 102.803511 1.003716245 0.00535147 6.71592368 0.985131579 Rv0085 hycP putative formate hydrogen lyase hycP MT0093 245.707269 181.974229 224.509903 204.514198 1.012976554 0.018600783 7.74380305 0.951100432 Rv0086 hycQ probable formate hydrogenlyase subunit MT0096 191.261837 266.400861 178.498558 207.79267 0.852306838 −0.230555188 7.72222698 0.216905457 Rv0088 Rv0088 hypothetical protein MT0098 70.750949 91.4848065 63.8339213 69.082086 0.82376396 −0.279697086 6.20868669 0.135022698 Rv0089 Rv0089 possible bioC biotin synthesis gene MT0099 16.2118069 20.3601201 12.0029596 13.5822406 0.700254686 −0.514048362 3.97340813 0.008780397 Rv0090 Rv0090 hypothetical protein MT0099.1 11.245184 13.1209663 13.4578637 12.0210636 1.042923295 0.060633054 3.6594958 0.894157772 MT0100 32.236194 67.1431517 33.6446594 57.3732578 0.936729338 −0.094295845 5.57872443 0.776070416 Rv0091 Rv0091 conserved hypothetical protein MT0101 185.826665 233.100753 163.676721 193.976253 0.855850721 −0.224568913 7.60230327 0.209340621 Rv0092 ctpA cation-transporting ATPase MT0102 49.759939 37.1006634 39.9189337 32.5505422 0.838166465 −0.254691295 5.32169413 0.227492631 Rv0093c Rv0093c hypothetical protein MT0103 26.4261823 23.0748028 21.7326313 20.7636552 0.860354248 −0.216997288 4.53401924 0.392247273 Rv1588c Rv1588c REP-family protein MT0105 15.8369674 32.7571711 21.1870422 33.0188953 1.142382353 0.192045599 4.69478687 0.520660361 Rv0096 PPE PPE-family protein MT0106 24.9268244 43.9778595 34.3721114 48.0842542 1.217316809 0.283704681 5.24934722 0.212839227 Rv0097 Rv0097 conserved hypothetical protein MT0107 18.3671338 23.6177394 19.0956175 30.1307177 1.16207909 0.216708261 4.52357493 0.420522227 Rv0098 Rv0098 hypothetical protein MT0108 76.8420903 82.2548854 75.2003602 89.5335058 1.033094731 0.04697255 6.34235529 0.879854448 Rv0099 fadD10 acyl-CoA synthase MT0109 7.40307944 10.5872625 7.09265792 9.91347448 0.945696866 −0.080550279 3.15931023 0.870054573 Rv0100 Rv0100 hypothetical protein MT0110 256.015355 204.506096 313.622784 254.7841 1.23533313 0.304900143 8.00790584 0.041857944 Rv0101 nrp unknown non-ribosomal peptide synthase MT0111 232.025629 236.086904 210.051792 210.134436 0.897627106 −0.155811852 7.79601629 0.438953559 Rv0102 Rv0102 membrane protein MT0112 328.827921 335.353801 302.620071 308.332474 0.919863133 −0.120508877 8.31721697 0.595697538 Rv0103c ctpB cation transport ATPase MT0113 29.2374783 34.1145124 32.0078921 39.107486 1.121316617 0.165193698 5.07913267 0.525764889 Rv0104 Rv0104 hypothetical protein MT0115 92.5853479 154.646424 81.383703 154.088178 0.93849525 −0.091578651 6.9173473 0.724714072 Rv0106 Rv0106 conserved hypothetical protein MT0116 518.028141 511.355728 617.243102 587.627054 1.170127483 0.226665717 9.12604149 0.213869965 Rv0107c ctpl probable magnesium transport ATPase MT0117 527.680257 634.149875 593.782772 803.537845 1.194337576 0.256210668 9.32188753 0.160382194 MT0118 39.6392734 45.9686268 50.1941945 47.4597834 1.141512112 0.190946167 5.5234108 0.469324523 Rv0109 PE_PGRS PE_PGRS-family protein MT0119 32.7047433 33.8430441 32.1897552 34.9703667 1.009073642 0.013031466 5.07063839 0.973097519 Rv0110 Rv0110 transmembrane protein MT0120 154.05902 322.413814 183.408859 405.35963 1.224348907 0.292014746 8.05813026 0.063920171 Rv0111 Rv0111 possible acyltransferase MT0121 169.333728 187.041637 71.3812367 95.6220964 0.465139248 −1.104265418 7.03342469 1.34E−18 Rv0112 gca probable GDP-mannose dehydratase MT0122 161.18097 181.974229 54.6498386 98.9005683 0.431612949 −1.212189946 6.9581013 3.99E−14 Rv0113 gmhA phosphoheptose isomerase MT0123 104.673921 101.710111 38.1003034 55.9681985 0.449781332 −1.152704311 6.23396912 5.30E−13 Rv0115 Rv0115 conserved hypothetical protein MT0124 31.6739348 62.5281912 9.82060327 19.826949 0.314329613 −1.6696499 4.95967908 1.61E−30 MT0125 207.661064 202.24386 178.225763 162.206299 0.829636966 −0.269447918 7.55266881 0.105227729 Rv0116c Rv0116c conserved hypothetical protein MT0125.1 21.9281097 27.3278057 21.6416998 24.3543625 0.935261259 −0.096558667 4.58444329 0.767312271 Rv0117 oxyS transcriptional regulator (LysR family) MT0126 43.9499273 60.8993816 44.7383038 43.1665464 0.84639107 −0.240603688 5.59572718 0.389992495 Rv0118c oxcA oxalyl-CoA decarboxylase MT0127 37.2028169 63.7950431 40.0098652 50.6601964 0.917751688 −0.123824232 5.58796198 0.714554296 Rv0119 fadD7 acyl-CoA synthase MT0128 176.643098 320.423046 166.040941 216.144967 0.794466341 −0.331941996 7.78130254 0.079326745 Rv0120c fusA2 elongation factor G MT0129 37.2028169 48.1403729 34.7358375 39.2636037 0.870324251 −0.200375099 5.32235278 0.406290183 MT0131 28.6752191 46.1496056 26.824796 32.0041302 0.798892345 −0.323926989 5.06992568 0.165981297 Rv0123 Rv0123 hypothetical protein MT0132 9.93324532 13.5734134 16.5495351 14.9092412 1.339590778 0.421792349 3.79962734 0.118414684 Rv0124 PE_PGRS PE_PGRS-family protein MT0133 326.860014 402.9494 310.803907 377.960972 0.944365358 −0.082582975 8.47096282 0.718873933 Rv0125 pepA probable serine protease MT0134 248.705935 334.810864 215.053025 282.963346 0.854755012 −0.226417117 8.07982352 0.203348736 Rv0126 Rv0126 probable glycosyl hydrolase MT0135 180.860042 204.053649 161.767406 184.843367 0.902937984 −0.147301191 7.51812416 0.49400037 Rv0127 Rv0127 conserved hypothetical protein MT0136 55.7573704 85.1505469 60.3785238 77.4343834 0.989063301 −0.015865237 6.12651949 0.966222682 Rv0128 Rv0128 hypothetical protein MT0137 819.117941 1173.28586 1108.81885 1157.22251 1.15522487 0.208173707 10.0563609 0.433613807 Rv0129c fbpC2 antigen 85C mycolytransferase MT0138 25.4890836 48.9547778 29.3703783 44.9619 1.018635549 0.026637971 5.22448298 0.94190007 Rv0130 Rv0130 conserved hypothetical protein MT0139 70.750949 117.907718 67.2893187 93.3583896 0.864677903 −0.209765274 6.45137527 0.322018463 Rv0131c fadE1 acyl-CoA dehydrogenase MT0140 40.5763721 57.2798047 37.7365774 42.854311 0.830815626 −0.267399744 5.48500233 0.243200842 Rv0132c Rv0132c putative oxidoreductase MT0141 101.768915 107.410945 104.025649 120.132577 1.069863146 0.097426263 6.76178912 0.694453898 Rv0133 Rv0133 possible puromycin N-acetyltransferase MT0142 219.843346 145.416503 192.865736 148.780176 0.946689343 −0.079037014 7.46669458 0.778317939 Rv0134 ephF probable epoxide hydrolase MT0143 229.214333 220.613213 237.149383 228.556325 1.035310976 0.050064175 7.83957386 0.855750561 Rv0135c Rv0135c putative transcriptional regulator MT0144 93.0538972 110.668564 98.6606903 82.1179146 0.886256635 −0.174203572 6.58935143 0.518666881 Rv0136 Rv0136 cytochrome p450 MT0145 86.6816263 113.473736 83.2023333 108.111513 0.956202441 −0.064612007 6.61546765 0.813821128 Rv0137c Rv0137c putative peptide methionine sulfoxide MT0146 59.0372158 61.5328075 67.4711817 65.1010844 1.099191796 0.136443142 5.98786418 0.592162526 Rv0138 Rv0138 conserved hypothetical protein MT0147 114.982006 113.745205 123.394062 128.250697 1.100185803 0.137747192 6.91017417 0.514208848 Rv0139 Rv0139 putative oxidoreductase MT0148 93.0538972 167.224453 107.935705 155.961591 1.036743063 0.052058394 7.03602201 0.870656307 Rv0140 Rv0140 conserved hypothetical protein MT0149 122.853635 132.295536 121.4845 134.027053 1.001034408 0.001491564 6.99824741 0.997032163 Rv0141c Rv0141c hypothetical protein MT0150 70.09498 106.958498 94.4778407 124.113578 1.247582733 0.319135491 6.63091708 0.054134009 Rv0142 Rv0142 hypothetical protein MT0151 206.536545 190.299256 192.865736 192.024781 0.970783202 −0.04277895 7.61180141 0.880856541 Rv0143c Rv0143c probable chloride channel MT0152 594.589101 632.521066 323.534319 347.674137 0.546907465 −0.87063134 8.89097947 9.06E−14 Rv0144 Rv0144 putative transcriptional regulator MT0153 1582.75954 1318.15942 1282.04338 1011.79887 0.788522799 −0.342775625 10.3430173 0.050311626 Rv0145 Rv0145 conserved hypothetical protein MT0154 655.875354 479.051004 647.523295 492.239135 1.007140745 0.01026531 9.15187051 0.973641836 Rv0146 Rv0146 conserved hypothetical protein MT0155 575.472289 483.394497 579.961182 457.581003 0.976772116 −0.033906078 9.03416095 0.903824113 Rv0147 Rv0147 aldehyde dehydrogenase MT0156 411.761152 402.406463 396.006734 390.060094 0.96552798 −0.050610028 8.64469338 0.856419101 Rv0148 Rv0148 steroid dehydrogenase MT0157 260.326009 250.474722 238.604287 251.115334 0.958732071 −0.060800402 7.96754561 0.818068286 Rv0149 Rv0149 putative oxidoreductase MT0158 6.46598077 4.3434923 7.36545245 4.76159011 1.119679835 0.163086262 2.56066822 0.752487878 MT0160 48.6354206 55.8319739 67.1074557 65.1791433 1.267546948 0.342039184 5.89172969 0.061201987 MT0161 42.1694398 45.6971585 43.1924681 46.7572537 1.023711446 0.03380912 5.48006206 0.918364976 Rv0152c PE PE-family protein MT0162 76.0924114 100.533749 66.1072091 87.1917401 0.86802275 −0.20419524 6.36915366 0.291510728 Rv0153c Rv0153c putative protein-tyrosine-phosphatase MT0163 134.661078 190.751703 132.669076 160.410945 0.909024926 −0.13760824 7.27429441 0.554227608 Rv0154c fadE2 acyl-CoA dehydrogenase MT0165 141.314478 215.274337 163.858584 286.397936 1.243900012 0.314870523 7.65762581 0.046862744 Rv0157 pntB pyridine transhydrogenase subunit [beta] MT0167 68.0333629 116.369398 85.293758 134.027053 1.199357905 0.262262243 6.66009664 0.133609598 Rv0158 Rv0158 transcriptional regulator (TetR/AcrR family) MT0168 22.4903679 36.1052797 35.4632896 42.0737224 1.344065138 0.426603058 5.09709921 0.039753799 Rv0159c PE PE-family protein MT0169 6.09114131 15.3832019 8.18383606 12.333299 0.992249045 −0.011225826 3.4180397 0.983253476 Rv0160c PE PE-family protein MT0171 32.6110335 37.0101739 31.28044 32.3163656 0.913985494 −0.129756826 5.06517979 0.641879751 Rv0162c adhE alcohol dehydrogenase (Zn) MT0172 12.650832 15.6546702 12.0029596 14.1286526 0.923588377 −0.114678077 3.78537132 0.759946924 Rv0163 Rv0163 probable dehydrogenase MT0173 411.198893 550.899606 367.545171 495.673724 0.896813585 −0.157119963 8.83450975 0.450702308 Rv0164 Rv0164 conserved hypothetical protein MT0175 591.402966 587.819291 757.459493 704.481159 1.238913515 0.309075481 9.36735294 0.058746039 Rv0166 fadD5 acyl-CoA synthase MT0176 429.191138 581.756499 584.962415 694.333508 1.275048973 0.35055266 9.1617707 0.02496369 MT0177 14.8998637 17.1025009 12.9122747 14.9092412 0.869434571 −0.201850632 3.91951344 0.492818423 MT0178 459.084635 711.156374 550.772167 791.516782 1.155286442 0.208250598 9.29537564 0.285039845 Rv0169 mce1 cell invasion protein MT0179 204.756058 319.970599 231.056971 341.429428 1.096854064 0.133384742 8.10065384 0.544204735 Rv0170 Rv0170 part of mce1 operon MT0180 459.740604 784.000359 559.774386 893.383586 1.177648207 0.235908634 9.39751599 0.212410246 Rv0171 Rv0171 part of mce1 operon MT0181 482.137252 713.147141 587.781292 848.499745 1.204284351 0.268176076 9.36213959 0.118986382 Rv0172 Rv0172 part of mce1 operon MT0182 287.876709 404.035273 364.453499 544.226331 1.30623879 0.385418656 8.64511975 0.005175855 Rv0173 lprK part of mce1 operon MT0183 944.595452 1219.0735 1129.7331 1479.21529 1.204677696 0.268647214 10.2207991 0.163844836 Rv0174 Rv0174 part of mce1 operon MT0184 372.028169 384.580047 427.196242 506.055552 1.229491501 0.298061762 8.72333567 0.059861588 Rv0175 Rv0175 conserved hypothetical protein MT0185 245.51985 270.472885 260.609713 298.262882 1.082026774 0.113736198 8.0709269 0.622324844 Rv0176 Rv0176 conserved hypothetical protein MT0186 238.11677 279.340848 228.783684 303.648943 1.022537276 0.032153437 8.03705064 0.906994579 Rv0177 Rv0177 conserved hypothetical protein MT0187 428.441509 481.675198 429.560462 493.019723 1.013067162 0.018729822 8.84032366 0.949117634 Rv0178 Rv0178 conserved hypothetical protein MT0188 463.301579 409.464638 606.87691 580.523699 1.362745742 0.446516413 9.0090625 0.001187006 Rv0179c lpr0 lipoprotein MT0189 155.933218 194.37128 142.58061 168.607125 0.890292449 −0.167648776 7.37113294 0.420276212 MT0190 105.892149 85.4220151 101.206773 86.723387 0.984821922 −0.022065219 6.56954521 0.918576705 Rv0181c Rv0181c conserved hypothetical protein MT0191 271.383773 202.967775 253.971712 213.022613 0.99078641 −0.013354014 7.87960546 0.967251048 Rv0182c sigG sigma-70 factors ECF subfamily MT0192 164.835655 214.550422 174.588503 211.85173 1.022201036 0.031678959 7.58226382 0.90930602 Rv0183 Rv0183 Probable oxidoreductase MT0193 233.993536 230.657539 231.329766 244.480331 1.023784663 0.033912299 7.87831757 0.90313325 Rv0184 Rv0184 conserved hypothetical protein MT0194 69.5327208 83.4312478 76.928059 92.8900365 1.109932193 0.150471543 6.33775844 0.494261547 Rv0185 Rv0185 conserved hypothetical protein MT0195 303.713677 322.413814 298.891879 322.539186 0.992256057 −0.011215631 8.28571596 0.973097519 Rv0186 bgl5 [beta]-glucosidase MT0196 215.345273 686.543251 342.448073 734.455759 1.301077757 0.379707185 8.95103219 0.059185172 MT0197 51.4467166 53.0268018 48.9211533 58.9344349 1.029667325 0.042178293 5.7351224 0.901225662 Rv0187 Rv0187 probable o-methyltransferase MT0198 179.922943 315.808086 222.600341 288.739702 1.061538038 0.086156068 7.97703521 0.777198586 Rv0188 Rv0188 putative methyltransferase MT0199 313.272033 286.94196 319.806127 295.062469 1.024571742 0.035021007 8.24766112 0.900323347 Rv0189c ilvD dihydroxy-acid dehydratase MT0200 203.35041 258.61877 227.328779 241.748271 1.021557323 0.030770161 7.86382469 0.917388404 Rv0190 Rv0190 conserved hypothetical protein MT0201 217.31318 281.693573 270.612179 309.26918 1.16865331 0.224847007 8.0763335 0.226907254 Rv0191 Rv0191 probable chloramphenicol resistsance protein MT0202 281.504438 273.097078 273.06733 277.889521 0.993561337 −0.009319061 8.11147618 0.975415001 Rv0192 Rv0192 conserved hypothetical protein MT0203 34.2041012 31.671298 23.278467 22.9493031 0.702585748 −0.509253783 4.81700634 0.002860386 Rv0193c Rv0193c hypothetical protein MT0204 22.4903679 24.8845913 24.2787136 24.9788333 1.039706595 0.056176458 4.6050678 0.878360152 Rv0194 Rv0194 Probable ABC transporter MT0205 7.02823997 7.1486644 9.54780873 8.04006198 1.235243689 0.304795685 3.02123778 0.392247273 Rv0195 Rv0195 transcriptional regulator (LuxR/UhpA family) MT0206 22.9589172 53.6602277 27.8250426 56.748787 1.122171781 0.166293539 5.34004407 0.523182712 Rv0196 Rv0196 transcriptional regulator (TetR/AcrR family) MT0207 85.463398 200.70554 97.8423067 184.062778 1.019983791 0.028546226 7.15197373 0.928669788 Rv0197 Rv0197 conserved hypothetical protein MT0208 641.444035 582.027968 589.963648 549.924628 0.932210859 −0.101271777 9.2070385 0.686874544 Rv0198c Rv0198c probable zinc metalloprotease MT0209 61.5673821 57.0083364 54.2861125 50.8163141 0.886579959 −0.173677344 5.8096259 0.461999184 MT0210 119.01153 105.691646 105.298691 100.305628 0.916377164 −0.125986587 6.7515009 0.572355347 Rv0200 Rv0200 probable membrane protein MT0211 182.640529 155.460828 205.68708 191.946723 1.179105216 0.237692461 7.52443959 0.191125613 MT0212 757.925398 740.565436 881.581007 788.472486 1.112820122 0.154220412 9.62992424 0.508314982 Rv0202c mmpL11 conserved large membrane protein MT0213 189.20022 205.772948 210.597381 223.950853 1.100561488 0.13823975 7.69740042 0.515423572 Rv0203 Rv0203 hypothetical protein MT0214 158.838223 147.135802 192.047353 194.366547 1.263892301 0.337873534 7.43697181 0.027928192 Rv0204c Rv0204c probable membrane protein MT0215 54.0705928 66.6907046 69.5626065 84.069386 1.273071015 0.348312898 6.10414672 0.035875425 Rv0205 Rv0205 probable membrane protein MT0216 1387.56199 1434.98127 1643.76894 1659.45318 1.170444199 0.227056155 10.5808456 0.280503699 Rv0206c mmpL3 conserved large membrane protein MT0217 290.125746 299.248521 381.184897 403.408159 1.330897679 0.412399659 8.42492397 0.001573521 Rv0207c Rv0207c conserved hypothetical protein MT0218 178.798425 181.702761 294.345304 247.914921 1.498568109 0.583584655 7.81937888 1.03E−05 MT0219 63.1604499 43.8873701 65.8344145 48.5526073 1.072934629 0.101562179 5.79505006 0.725019493 Rv0209 Rv0209 hypothetical protein MT0220 41.7946004 46.6925422 40.4645227 46.7572537 0.985114956 −0.021636008 5.46295802 0.949581487 Rv0210 Rv0210 hypothetical protein MT0221 2877.73628 1871.50224 3266.2599 1908.85122 1.075998787 0.105676451 11.2768483 0.728805944 Rv0211 pckA phosphoenolpyruvate carboxykinase MT0222 50.9781673 44.520796 45.1020298 39.107486 0.881610255 −0.18178709 5.49483109 0.464084488 Rv0212c nadR similar to E. coli NadR MT0223 24.9268244 27.3278057 28.9162207 30.5990708 1.139025994 0.187800671 4.81379533 0.472451693 Rv0213c Rv0213c some similarity to methyltransferases MT0224 34.8600703 55.650995 37.8275089 58.5441406 1.067282744 0.093942425 5.55200283 0.760272935 Rv0214 fadD4 acyl-CoA synthase MT0225 49.1039699 55.3795268 48.7392903 53.4703151 0.978654876 −0.031127914 5.69632616 0.923772833 Rv0215c fadE3 acyl-CoA dehydrogenase MT0226 29.7997375 46.6020528 32.8262757 42.4640167 0.996031622 −0.005736549 5.25207387 0.98750337 Rv0216 Rv0216 conserved hypothetical protein MT0227 31.1116756 34.024023 28.5524947 30.3648943 0.904668846 −0.144538305 4.96291246 0.600343889 Rv0217c lipW probable esterase MT0228 20.2413311 29.4995518 22.3691519 27.867011 1.015773033 0.022578079 4.65418715 0.951832088 Rv0218 Rv0218 some similarity with sulphitesulfite oxidases MT0229 4.40436371 6.96768556 5.27402768 6.08859063 1.002367741 0.003411891 2.55225484 0.997032163 Rv0219 Rv0219 hypothetical protein MT0230 674.992167 738.665159 695.262339 771.377597 1.03714595 0.052618929 9.4923645 0.864790438 Rv0220 lipC probable esterase MT0231 124.446702 144.149651 134.12398 157.678886 1.085880055 0.118864754 7.13221723 0.611538154 Rv0221 Rv0221 conserved hypothetical protein MT0232 68.9704616 89.5845286 75.0184972 93.3583896 1.063968445 0.089455364 6.35614251 0.73754497 Rv0222 echA1 enoyl-CoA hydratase/isomerase superfamily MT0233 48.7291305 80.7165652 48.5574273 68.3014974 0.91449738 −0.128949058 5.94865078 0.633618212 Rv0223c Rv0223c aldehyde dehydrogenase (possible betB) MT0234 31.0179657 38.2770259 32.4625497 38.6391328 1.027014467 0.033456504 5.14089114 0.905696211 MT0235 161.08726 210.749866 164.313242 222.545793 1.038120694 0.053974184 7.5688153 0.849425114 Rv0225 Rv0225 possible Involved in LPS synthesis MT0236 87.4313052 104.877241 86.9305252 124.113578 1.086969306 0.120311202 6.65864457 0.633618212 Rv0226c Rv0226c probable membrane protein MT0237 439.967822 576.236645 431.470023 601.053177 1.01157938 0.016609534 9.00104444 0.95527257 Rv0227c Rv0227c possible membrane protein MT0238 51.165587 38.0055576 54.195181 48.708725 1.163594993 0.218588994 5.59078253 0.379168823 MT0239 221.342704 152.02223 229.056478 166.187301 1.063298258 0.088546333 7.5873399 0.733038419 Rv0229c Rv0229c conserved hypothetical protein MT0240 144.969153 260.700027 115.392088 178.208364 0.736217439 −0.441796171 7.45119222 0.002457632 Rv0230c Rv0230c conserved hypothetical protein MT0241 132.786831 226.585515 156.493132 203.577492 1.026652423 0.037947834 7.49224548 0.904814009 Rv0231 fadE4 acyl-CoA dehydrogenase MT0242 557.386235 394.986331 616.970307 438.612702 1.108663455 0.148821488 8.97198705 0.484421074 Rv0232 Rv0232 transcriptional regulator (TetR/AcrR family) MT0244 248.237436 302.234672 303.347523 319.963243 1.136946401 0.185164243 8.1978521 0.37069486 Rv0233 nrdB ribonucleoside-diphosphate reductase B2 MT0245 231.55708 205.139522 221.872889 182.813837 0.924153395 −0.113795759 7.7177564 0.618065109 MT0246 38.8895945 30.2234672 40.7373173 35.360661 1.105977844 0.145322485 5.18885885 0.595039324 Rv0235c Rv0235c conserved hypothetical protein MT0247 403.608394 323.409197 461.386491 393.182449 1.178803369 0.237323089 8.62779342 0.164011326 Rv0236c Rv0236c possible membrane protein MT0250 201.288793 271.558758 205.868943 209.588024 0.887581669 −0.172048223 7.79603924 0.472451693 MT0251 109.265704 138.448817 109.026883 150.263294 1.04166787 0.058895356 6.98801083 0.828256087 Rv0237 lpql beta-hexosaminidase precursorBETA-HEXOSAMINIDASE A MT0252 184.889556 145.054545 198.412559 163.377182 1.099240736 0.136507374 7.43549765 0.531839075 Rv0238 Rv0238 transcriptional regulator (TetR/AcrR family) MT0253 651.002441 360.328882 653.070117 453.756119 1.12330667 0.167751847 9.04903674 0.476182576 Rv0239 Rv0239 conserved hypothetical protein MT0254 82.2772626 47.1449893 97.023923 61.6664948 1.239238787 0.309454205 6.17377005 0.071839145 Rv0240 Rv0240 hypothetical protein MT0255 154.714989 156.72768 178.0439 203.577492 1.223072513 0.29050994 7.43840985 0.081568603 Rv0241c Rv0241c hypothetical protein MT0256 227.621265 195.004706 232.875602 244.480331 1.132625052 0.179670345 7.81491042 0.401378813 Rv0242c fabG4 3-oxoacyl-[ACP] reductase MT0257 551.201433 651.071397 606.33132 757.405062 1.131326352 0.178015162 9.32573575 0.395808521 Rv0243 fadA2 acetyl-CoA C-acetyltransferase MT0258 301.933189 528.639208 422.376872 637.038309 1.297436041 0.375663421 8.88478111 0.012386351 Rv0244c fadE5 acyl-CoA dehydrogenase MT0259 142.907546 145.326013 137.12472 129.889933 0.925948945 −0.110995447 7.11876799 0.641879751 Rv0245 Rv0245 probable monooxygenase MT0260 58.6623763 47.0544999 58.5598936 50.8163141 1.03787075 0.05362679 5.75339198 0.873642922 Rv0246 Rv0246 probable membrane transport protein MT0261 224.622549 272.282673 191.501764 286.241818 0.947823637 −0.077309455 7.92985206 0.786545243 Rv0247c Rv0247c probable iron-sulphur protein MT0262 447.839451 531.353891 386.640788 530.878267 0.929107341 −0.106082812 8.88984567 0.669457314 Rv0248c Rv0248c probable flavoprotein subunit of Rv0247c MT0263 308.961419 366.663141 250.698178 381.317503 0.919500456 −0.121077805 8.35357619 0.64128703 MT0264 404.732912 340.964145 333.082128 340.024369 0.905962293 −0.14247709 8.47115408 0.52349722 Rv0250c Rv0250c hypothetical protein MT0265 133.817639 267.758202 200.32212 240.109036 1.155388536 0.208378085 7.71899156 0.492818423 Rv0251c hsp possible heat shock protein MT0266 2072.01835 895.573818 449.92912 213.490966 0.227440347 −2.136439889 9.82632863 3.95E−62 Rv0252 nirB nitrite reductase flavoprotein MT0267 18.8356831 22.5318663 20.1867956 26.6961281 1.130756401 0.177288163 4.47590912 0.518774989 MT0268 55.2888211 74.9252421 56.6503318 77.0440891 1.026518723 0.037759941 6.04801347 0.90313325 Rv0255c cobQ cobyric acid synthase MT0269 53.4146238 83.9741844 64.5613734 78.683325 1.059626838 0.08355629 6.13638265 0.79743892 Rv0256c PPE PPE-family protein MT0270 34.6726505 40.448772 39.2824131 44.1813115 1.111712972 0.152784353 5.31580964 0.547156289 MT0270.1 15.9306773 11.3111779 18.0044393 14.1286526 1.184586888 0.244384022 3.90836301 0.381485881 MT0270.2 10.495505 13.7543923 11.548302 12.0210636 0.973141577 −0.039278385 3.60081143 0.930326316 MT0271 22.3029482 26.0609538 20.8233162 22.7931854 0.90230725 −0.148309317 4.53424399 0.609190582 Rv0258c Rv0258c conserved hypothetical protein MT0272 83.0269415 53.5697383 79.1104152 42.9323698 0.876916723 −0.189488253 6.01815134 0.431406208 Rv0259c Rv0259c conserved hypothetical protein MT0273 86.213077 71.2151758 84.8391005 51.3627261 0.844903021 −0.243142338 6.20088695 0.296211359 Rv0260c Rv0260c two-component response regulator MT0274 22.7714975 62.0757441 25.0061657 42.5420755 0.85043117 −0.233733619 5.25883342 0.471498466 Rv0261c narK3 nitrite extrusion protein1 MT0275 154.34015 154.374955 195.775545 160.957357 1.150014662 0.201652255 7.37969387 0.337254574 Rv0262c Rv0262c aminoglycoside 2′-N-acetyltransferase MT0276 202.507021 220.613213 299.255605 232.927621 1.248949218 0.320714819 7.9008779 0.097467777 Rv0263c Rv0263c conserved hypothetical protein MT0277 99.519878 107.139477 156.765926 114.902633 1.29977214 0.37825873 6.9039689 0.048861987 Rv0264c Rv0264c conserved hypothetical protein MT0278 129.132196 101.800601 124.121514 102.257099 0.98240742 −0.025606638 6.83913856 0.925428316 Rv0265c fecB2 Iron transport protein FeIII dicitrate transporter MT0280 22.3029432 32.9381499 23.096604 22.8712443 0.841423834 −0.249095411 4.67097039 0.415865749 Rv0267 narU similar to nitrite extrusion protein 2 MT0281 308.30546 251.651085 358.452019 295.452763 1.168316725 0.224431435 8.24621162 0.198891918 Rv0268c Rv0268c hypothetical protein MT0282 56.0335 65.8762998 57.4687154 60.0272589 0.965543346 −0.050587068 5.90760292 0.879854448 Rv0269c Rv0269c conserved hypothetical protein MT0283 622.795771 524.476695 619.152664 472.09995 0.946056245 −0.080002138 9.12875491 0.764687847 Rv0270 fadD2 acyl-CoA synthase MT0284 285.065413 310.37872 324.625497 310.049769 1.066374388 0.092714035 8.26541346 0.725019493 Rv0271c fadE6 acyl-CoA dehydrogenase MT0285 125.196331 130.12379 133.578391 130.202169 1.033046338 0.046904969 7.02182993 0.873231353 Rv0272c Rv0272c hypothetical protein MT0286 47.9794515 69.767345 51.7400302 62.3690245 0.978411735 −0.031486387 5.86163626 0.923772833 Rv0273c Rv0273c putative transcriptional regulator MT0286.1 87.9935644 87.2318036 67.4711817 80.7909141 0.84391727 −0.244826517 6.34067724 0.216905457 Rv0274 Rv0274 hypothetical protein MT0287 197.259269 216.631678 203.686586 211.695613 1.004346206 0.006256663 7.69693995 0.982651332 Rv0275c fadD27 acyl-CoA synthase MT0288 629.261752 536.330809 600.966361 517.76438 0.960190741 −0.05860707 9.15797541 0.831756973 Rv0276 Rv0276 conserved hypothetical protein MT0289 329.765019 283.955809 389.18687 358.602376 1.220794368 0.287820211 8.41175078 0.058746039 MT0290 220.124476 231.652922 293.52692 256.891689 1.215837004 0.281949833 7.96997785 0.094091612 MT0291 42.9191288 30.4949355 60.8331814 38.4830151 1.340479979 0.422749672 5.43799296 0.0158751 MT0291.3 1.68677759 1.44783077 2.90980838 2.26370677 1.641707987 0.715197536 1.17427681 0.202085662 MT0291.4 14.6187391 9.68236824 13.7306583 11.3185339 1.041146316 0.05817283 3.6445518 0.894736554 MT0292 363.969121 227.671388 466.660518 259.467631 1.209547706 0.274467672 8.36458133 0.096977774 Rv0280 PPE PPE-family protein MT0293 347.195055 278.164486 374.637828 307.317709 1.091805144 0.1267154 8.35314397 0.563048544 Rv0281 Rv0281 conserved hypothetical protein MT0294 16.7740651 6.3342596 15.3674255 6.79112032 0.973301366 −0.039041515 3.51899586 0.930747689 MT0295 2913.81458 1587.99888 3373.37722 1910.49046 1.180152049 0.238972746 11.2565493 0.273603377 Rv0282 Rv0282 conserved hypothetical protein MT0296 1566.26671 756.401085 1806.44541 922.967892 1.186195356 0.246341629 10.3028377 0.230822487 Rv0283 Rv0283 conserved hypothetical protein MT0297 2523.13815 1388.56019 2695.57374 1761.78834 1.164136553 0.219260296 11.0309611 0.357876722 Rv0284 Rv0284 conserved hypothetical protein MT0298 121.541697 80.4450969 130.486719 97.2613323 1.137973328 0.186466744 6.74954836 0.355489385 MT0299 502.847142 443.217193 561.683948 492.004958 1.11353609 0.155148317 8.96610884 0.462931351 Rv0286 PPE PPE-family protein MT0300 160.150151 264.591072 176.498064 271.254518 1.062101976 0.086922291 7.77029227 0.730503677 Rv0287 Rv0287 conserved hypothetical protein MT0301 312.616114 375.712084 316.532592 434.709759 1.082902009 0.1149027 8.49218745 0.619926139 Rv0288 Rv0288 conserved hypothetical protein MT0302 511.65587 480.860793 541.769947 541.884566 1.09237618 0.127469761 9.02020541 0.577828942 Rv0289 Rv0289 conserved hypothetical protein MT0303 539.76833 418.061133 579.870251 485.05772 1.116357902 0.158799626 8.98259744 0.459370243 MT0304 440.623791 343.045402 477.208574 379.44409 1.094468078 0.130229876 8.680359 0.544489057 Rv0291 Rv0291 secreted protease MT0305 199.695725 164.871728 197.957901 193.664017 1.078991909 0.109684046 7.56394736 0.664400777 Rv0292 Rv0292 unknown possible membrane protein MT0306 311.585305 339.968762 295.527413 298.653176 0.912676887 −0.131823899 8.28358304 0.552927263 Rv0293c Rv0293c conserved hypothetical protein MT0307 11.8074432 18.9122894 13.0941377 16.7826537 0.97945118 −0.02995451 3.93868183 0.942574017 Rv0294 Rv0294 conserved hypothetical protein MT0308 143.001256 152.474678 136.306336 172.978421 1.040869767 0.057789571 7.24199033 0.846098817 Rv0295c Rv0295c hypothetical protein MT0310 120.979437 163.514387 147.127186 182.033248 1.162656675 0.217425141 7.26307316 0.245906231 Rv0296c atsG proable arylsulfatase MT0311 307.087232 327.028774 363.362321 315.43583 1.068186883 0.095164073 8.35932137 0.729227404 Rv0297 PE_PGRS PE_PGRS-family protein MT0312 288.626338 173.649202 277.432042 201.782138 1.055816164 0.078358658 7.87979924 0.778317939 Rv0298 Rv0298 hypothetical protein MT0313 131.287523 84.2456527 155.492885 110.687455 1.246024849 0.31733284 6.91405056 0.036028318 MT0314 160.337531 99.719344 166.040941 126.923697 1.146367167 0.197069195 7.11294036 0.366108488 Rv0301 Rv0301 conserved hypothetical protein MT0315 157.338856 114.107162 166.950256 140.505938 1.142337276 0.191988671 7.17889091 0.357876722 Rv0302 Rv0302 transcriptional regulator (TetR/AcrR family) MT0316 70.0012701 53.4792489 77.2008535 58.7002584 1.100264847 0.137850839 6.02267207 0.579941699 MT0318 137.940923 225.228173 189.955928 239.172329 1.206841113 0.27123575 7.63130573 0.154596928 Rv0304c PPE PPE-family protein MT0319 7.87162877 12.3970509 11.0936444 12.8797109 1.190853111 0.251995471 3.49171222 0.475650168 MT0320 31.3928052 55.0175691 28.6434262 38.9513682 0.796885694 −0.327555297 5.27355455 0.124578411 Rv0307c Rv0307c hypothetical protein MT0321 153.8716 246.674167 157.038721 228.087972 0.970423267 −0.043313954 7.61917508 0.880856541 Rv0308 Rv0308 conserved hypothetical protein MT0322 276.537815 494.615185 380.457445 563.194633 1.250403193 0.322393368 8.74450483 0.048221248 Rv0309 Rv0309 hypothetical protein MT0323 18.5545535 24.7036124 15.7311515 21.6223026 0.862801649 −0.212899161 4.34584798 0.420522227 Rv0310c Rv0310c conserved hypothetical protein MT0324 67.0962642 73.839369 52.5584138 62.2909656 0.813626327 −0.297561732 6.0027022 0.103888947 Rv0311 Rv0311 hypothetical protein MT0325 5.62259198 8.41551632 5.27402768 5.30800209 0.755455737 −0.404580866 2.66115188 0.286557916 MT0326 226.590457 441.226426 317.260045 518.388851 1.280976231 0.357243706 8.55486576 0.019386895 Rv0312 Rv0312 conserved hypothetical protein MT0327 364.7188 363.857969 432.47027 412.619103 1.159559155 0.213576421 8.62057202 0.230136358 Rv0313 Rv0313 hypothetical protein MT0328 75.5301522 84.1551632 82.2930181 95.309861 1.111231232 0.152159053 6.40100486 0.484772308 MT0328.1 66.9088445 48.4118412 76.7461959 62.5251422 1.215784714 0.281887785 5.99596799 0.143510225 MT0328.2 125.758641 142.61133 147.490912 148.311823 1.103840501 0.142531725 7.14183756 0.523994239 MT0329 230.057722 457.062075 258.154562 463.591535 1.065858086 0.092015363 8.46114277 0.709401593 Rv0315 Rv0315 probable [beta]-1,3-glucanase MT0330 53.7894632 96.4617247 57.4687154 99.1347448 1.046556288 0.065649907 6.26514267 0.817077148 MT0332 125.477511 102.886474 121.666363 99.056686 0.966226577 −0.049566559 6.81298823 0.859858221 Rv0317c glpQ2 glycerophosphoryl diester phosphodiesterase MT0333 20.7098804 23.7987182 20.9142477 22.3248323 0.971746465 −0.041348141 4.46692408 0.904814009 MT0334 47.9794515 28.7756365 38.554961 37.3121323 1.01655966 0.023694887 5.26025053 0.95867864 MT0335 12.7445418 8.86796344 13.9125213 17.5632422 1.467644338 0.553502395 3.75124148 0.056753569 Rv0320 Rv0320 conserved hypothetical protein MT0336 87.4313052 90.1274651 86.6577307 98.8225094 1.0431851 0.060995169 6.50686717 0.830576393 MT0337 45.6367049 43.7968807 41.4647694 44.8057823 0.964898435 −0.051551002 5.46278663 0.880856541 Rv0322 udgA UDP-glucose dehydrogenase/GDP- mannose MT0338 21.2721396 22.9843134 23.9149876 21.6223026 1.026833632 0.038202454 4.49969634 0.916845409 Rv0323c Rv0323c conserved hypothetical protein MT0339 20.5224607 11.0397096 21.7326313 13.5041818 1.128344833 0.174208036 4.07560275 0.572054672 Rv0324 Rv0324 putative transcriptional regulator MT0340 11.5263136 10.3157942 13.7306583 9.3670625 1.045748001 0.06453524 3.51108415 0.89125591 Rv0325 Rv0325 hypothetical protein MT0341 11.3388938 8.23453748 12.7304117 8.89870938 1.102942078 0.141357029 3.38782278 0.733038419 Rv0326 Rv0326 hypothetical protein MT0342 10.6829248 12.9399875 12.4576171 12.4113578 1.052296182 0.073540827 3.6207672 0.870122152 Rv0327c Rv0327c cytochrome P-450 monooxygenasemonoxygenase MT0343 63.8164189 31.4903191 66.1072091 36.921838 1.097661676 0.134433452 5.63631035 0.633618212 Rv0328 Rv0328 transcriptional regulator (TetR/AcrR family) MT0344 7.68420903 6.78670671 7.36545245 7.64976771 1.040602945 0.057419695 2.91620352 0.906626924 Rv0329c Rv0329c conserved hypothetical protein MT0345 10.3080853 6.51523844 10.7299184 9.60123907 1.225664484 0.293564107 3.24250432 0.412841331 MT0346 17.8048746 19.4552259 22.4600834 21.3100672 1.173309127 0.230583164 4.35316647 0.379503003 Rv0331 Rv0331 putative dehydrogenase MT0348 51.2592969 79.4497132 53.1949344 72.6727933 0.971527354 −0.041673479 6.0074513 0.898498494 Rv0334 rmlA glucose-1-phosphate thymidyltransferase MT0349 9.93324582 7.05817498 8.09290455 4.91770781 0.760007302 −0.395914815 2.93633613 0.225429598 Rv0335c PE PE-family protein MT0350 381.399156 156.275233 317.078182 166.811771 0.939789899 −0.089589834 7.99738772 0.751735413 Rv0336 Rv0336 conserved hypothetical protein MT0351 335.575031 412.26981 335.901004 445.481881 1.04028726 0.056981962 8.57929689 0.831756973 Rv0337c aspC aspartate aminotransferase MT0352 699.075602 809.608866 625.881595 862.160045 0.976658138 −0.034074434 9.5495301 0.914315517 Rv0338c Rv0338c conserved hypothetical protein MT0353 219.468507 174.01116 224.418971 198.581725 1.080037483 0.111081382 7.6744934 0.617012172 Rv0339c Rv0339c conserved hypothetical protein MT0355 62.9730301 52.3028864 65.0160309 53.2361386 1.025193534 0.035896285 5.87162008 0.905590819 Rv0340 Rv0340 hypothetical protein MT0356 104.111651 64.3379796 146.303802 54.1728448 1.095521808 0.131618204 6.52950912 0.725085375 Rv0341 Rv0341 conserved hypothetical protein MT0357 143.094956 130.938195 150.764447 127.860403 1.014384162 0.020604125 7.11202053 0.945594161 Rv0342 Rv0342 conserved hypothetical protein MT0357.1 210.19123 146.411886 192.592942 132.231699 0.909777579 −0.136414215 7.41375327 0.531692592 Rv0343 Rv0343 conserved hypothetical protein MT0359 15.8369674 60.6279133 15.5492885 58.1538464 0.967693799 −0.047377478 5.2387974 0.894346121 Rv0344c lpqJ lipoprotein MT0360 32.7984532 28.4136788 27.0975905 24.1982448 0.83879955 −0.253602008 4.82232771 0.266655454 Rv0345 Rv0345 unknown possible membrane protein MT0361 450.088488 591.800825 451.929613 535.48374 0.952942553 −0.069538849 8.98728301 0.801831984 Rv0346c aroP2 probable aromatic amino acid permease MT0362 65.0346472 86.5983776 62.197154 72.5166755 0.893228011 −0.162899601 6.16520643 0.489270244 Rv0347 Rv0347 conserved hypothetical protein MT0363 36.8279774 42.4395393 36.7363308 38.7952505 0.953750877 −0.068315616 5.28082494 0.831756973 MT0364 65.878036 64.0665114 58.5598936 66.1939084 0.959286385 −0.059966513 5.9966666 0.855739038 Rv0349 Rv0349 hypothetical protein MT0365 1128.54792 1717.0368 1473.81794 1682.32443 1.130960125 0.177548064 10.5513415 0.518774989 Rv0350 dnaK 70 kD heat shock protein, chromosome replication MT0366 145.906262 248.664934 183.499791 225.746206 1.066162626 0.092427515 7.65207119 0.764687847 Rv0351 grpE stimulates DnaK ATPase activity MT0367 350.38119 502.035318 404.736159 509.099847 1.081824693 0.113466733 8.78709168 0.632483493 Rv0352 dnaJ acts with GrpE to stimulate DnaK ATPase MT0368 57.1630184 85.7839728 61.0150444 84.069386 1.020846194 0.029765519 6.17387194 0.922310673 Rv0353 hspR heat shock regulator MT0369 18.1797141 22.4413769 20.4595902 25.2130099 1.124322376 0.169055758 4.44368719 0.533790532 Rv0354c PPE PPE-family protein MT0370 247.581457 293.18573 266.974919 289.910585 1.03233383 0.045909577 8.10115574 0.877734451 MT0372 44.6996052 51.578971 33.9174539 50.8943729 0.869772459 −0.201290067 5.50641285 0.462931351 Rv0356c Rv0356c hypothetical protein MT0373 87.0564658 93.2041055 88.7491555 96.5588026 1.027793662 0.039550661 6.51683561 0.894346121 Rv0357c purA adenylosuccinate synthase MT0374 18.7419733 27.8707422 17.0951242 24.9788333 0.903323117 −0.146685966 4.48267965 0.615784806 Rv0358 Rv0358 hypothetical protein MT0375 21.0847199 26.0609538 16.0948776 25.1349511 0.866773 −0.20627388 4.47759374 0.465361366 Rv0359 Rv0359 conserved hypothetical protein MT0376 11.901153 19.9981624 11.912028 13.6602995 0.812387523 −0.299760013 3.86231576 0.324583393 MT0377 200.164274 223.418385 213.416258 205.997316 0.991153859 −0.012819067 7.72057996 0.969605889 MT0378 56.6007592 46.3305845 57.1049894 53.1580797 1.075518311 0.105032087 5.74073927 0.727349312 Rv0362 mgtE putative magnesium ion transporter MT0379 216.657211 240.882844 212.052285 242.450801 0.992637888 −0.010660573 7.83409976 0.973097519 Rv0363c fba fructose bisphosphate aldolase MT0380 107.672636 195.547643 123.121267 228.087972 1.155273589 0.208234548 7.35590808 0.267643338 Rv0364 Rv0364 conserved hypothetical protein MT0381 104.767631 55.1985479 104.934965 69.4723802 1.118283601 0.161286107 6.38809042 0.505322279 Rv0365c Rv0365c conserved hypothetical protein MT0382 69.2515912 32.2142345 76.8371274 33.7994839 1.081460511 0.112980987 5.73264324 0.69712285 Rv0366c Rv0366c conserved hypothetical protein MT0384 11.8074432 12.4875404 9.00221966 11.6307693 0.848745116 −0.236596728 3.5121354 0.484283855 Rv0368c Rv0368c conserved hypothetical protein MT0384.1 24.2708554 20.9030567 21.2779738 19.7488901 0.910002411 −0.136057727 4.44090341 0.641879751 Rv0369c Rv0369c putative CO dehydrogenase gene cluster MT0385 22.6777876 20.8125673 17.8225763 16.2362417 0.783109269 −0.35271447 4.28920222 0.094091612 Rv0370c Rv0370c putative CO dehydrogenase gene cluster MT0386 2.43645652 3.34810864 1.81863024 3.51264844 0.917521974 −0.124185385 1.56861942 0.87947654 Rv0371c Rv0371c Possible membrane protein MT0387 3.37355519 5.1578971 3.36446594 3.12235417 0.760648876 −0.394697452 1.9724599 0.45709859 Rv0372c Rv0372c conserved hypothetical protein MT0388 26.613602 36.4672374 22.3691519 27.2425401 0.789510367 −0.340969885 4.82518284 0.091229323 Rv0373c Rv0373c putative CO dehydrogenase gene cluster MT0389 2.06161706 3.34810864 2.36421931 3.51264844 1.08697636 0.120320564 1.58945103 0.880350648 Rv0374c Rv0374c putative CO dehydrogenase gene cluster MT0390 5.15404254 10.4967731 6.45613734 9.60123907 1.038055154 0.053883099 3.02116468 0.916845409 Rv0375c Rv0375c putative CO dehydrogenase gene cluster MT0391 47.4171923 49.0452672 50.6488521 40.5906042 0.940231491 −0.088912093 5.5574332 0.798512961 Rv0377 Rv0377 transcriptional regulator (LysR family) MT0392 19.2105226 8.59649517 21.0961107 10.0695922 1.127042577 0.172542018 3.89686886 0.592526502 MT0393 37.3902366 27.3278057 51.1944411 32.4724833 1.279359433 0.355421643 5.2196961 0.062084717 Rv0380c Rv0380c some similarity with methyltransferases MT0394 48.9165502 31.9427663 61.2878389 37.1560146 1.209329001 0.274206787 5.4915027 0.193163968 Rv0381c Rv0381c hypothetical protein MT0395 267.635378 157.723064 296.618591 202.484668 1.191669567 0.252934252 7.85349837 0.140711849 Rv0382c umpA probable uridine 5′-monophosphate synthase MT0396 759.331046 471.721361 791.55881 574.357049 1.126310515 0.171604622 9.34297955 0.448807051 Rv0383c Rv0383c unknown possible membrane protein MT0397 361.626374 535.516404 438.198955 487.867839 1.049986566 0.070370869 8.83284475 0.819552181 Rv0384c clpB heat shock protein MT0398 45.0744457 59.3610614 48.5574273 49.4112547 0.944165009 −0.082889077 5.66610607 0.808331268 Rv0385 Rv0385 similar to oxidoreductases MT0399 183.296498 118.541144 236.96752 211.617554 1.517362505 0.601565793 7.55296867 0.000115169 Rv0386 Rv0386 transcriptional regulator (LuxR/UhpA family) MT0400 46.1052542 38.2770259 65.2888254 57.3732578 1.456382231 0.542389044 5.69889711 0.000420644 Rv0387c Rv0387c conserved hypothetical protein MT0401 47.6046121 33.4810864 45.3748244 36.6876615 1.020064069 0.028659769 5.35593086 0.930747689 Rv0389 purT phosphoribosylglycinamide formyltransferase II MT0401.1 139.252861 121.979742 115.028362 106.628395 0.849754336 −0.234882276 6.91753351 0.167597174 MT0402 151.622554 136.820007 133.123733 127.626227 0.905024042 −0.143971977 7.10295076 0.51545697 Rv0391 metZ o-succinyl homoserine sulfhydrylase MT0403 125.196331 124.694425 113.391595 109.594631 0.892146111 −0.164648088 6.88739868 0.406290183 Rv0392c Rv0392c possible dehydrogenasedehydrogemase MT0404 2.99871572 5.42936537 2.90980838 3.04429531 0.711136681 −0.491801222 1.91335223 0.318868558 Rv0393 Rv0393 conserved hypothetical protein MT0404.1 93.5224455 95.3758517 86.6577307 86.8014459 0.918249757 −0.123041486 6.50401775 0.59824312 Rv0394c Rv0394c hypothetical protein MT0407 12.0885728 14.7497759 8.18383606 13.1138875 0.78826268 −0.343251623 3.61059605 0.232719377 MT0407.1 128.944776 165.143197 97.2967176 141.05235 0.80395157 −0.314819498 7.05842107 0.051241944 MT0408 21.0847199 22.4413769 20.8233162 21.6223026 0.975090403 −0.036392114 4.43758165 0.917488009 Rv0398c Rv0398c hypothetical protein MT0409 64.7535176 70.400771 59.9238663 65.9597318 0.931264295 −0.102737428 6.03201488 0.712830382 Rv0399c lpqK possible PBP MT0410 129.881875 126.95666 113.209732 104.989159 0.848950946 −0.236246901 6.8939269 0.162234186 Rv0400c fadE7 acyl-CoA dehydrogenase MT0411 10.495505 12.4875404 12.8213432 12.2552401 1.089749472 0.123996505 3.60801661 0.760272935 Rv0401 Rv0401 probable membrane protein MT0412 54.9139816 60.8088921 46.011345 63.696025 0.939941652 −0.089356893 5.82124798 0.780755352 Rv0402c mmpL1 conserved large membrane protein MT0413 12.1822826 9.86334709 9.54780873 10.147651 0.898715895 −0.154062977 3.40700236 0.71643291 MT0414 7.30936957 5.33887595 7.27452094 7.72782657 1.196399669 0.258699417 2.82647301 0.538270037 MT0415 15.9306773 18.188374 26.1882754 27.0083636 1.558966929 0.640590324 4.46086116 0.000112511 Rv0403c mmpS1 conserved small membrane protein MT0416 2.62387626 1.08587307 3.72819198 1.79535365 1.497930723 0.582970903 1.30704262 0.322355421 MT0417 48.354231 72.2105594 62.1062225 82.7423854 1.210190592 0.275234274 6.0563313 0.15095801 MT0418 130.537844 123.518062 152.037488 167.904595 1.258705438 0.331940703 7.1667847 0.040459863 Rv0405 pks6 polyketide synthase MT0419 38.7958846 56.4653998 40.0098652 47.5378422 0.927921428 −0.107925445 5.51988565 0.737885134 MT0420 159.869032 198.714773 154.58357 176.334952 0.925838399 −0.111167695 7.43090428 0.641125319 Rv0407 Rv0407 probable coenzyme F420-dependent enzyme MT0421 228.652074 222.60398 198.50349 211.929789 0.909311849 −0.137152943 7.75218766 0.521875569 Rv0408 pta phosphate acetyltransferase MT0422 126.695739 104.515283 111.572965 116.307693 0.990030465 −0.014455175 6.84483533 0.967251048 Rv0409 ackA acetate kinase MT0423 695.046078 417.156239 659.162529 415.507281 0.971781986 −0.041295405 9.09506433 0.887972618 Rv0410c pknG serine-threonine protein kinase MT0424 388.614815 215.636295 365.271883 226.292618 0.992519602 −0.0108325 8.22452849 0.973097519 Rv0411c glnH putative glutamine binding protein MT0425 461.708511 271.468269 423.46805 251.817864 0.922325549 −0.116652033 8.46053049 0.590768039 Rv0412c Rv0412c unknown probable membrane protein MT0426 123.790733 88.1366978 114.119047 88.1284464 0.959516087 −0.059621101 6.69636941 0.831756973 Rv0413 mutT3 MutT homologue MT0427 23.802306 22.7128451 21.9144943 23.4957151 0.977168379 −0.033320916 4.53343234 0.925428316 Rv0414c thiE thiamine synthesis, thiazole moiety MT0428 87.3375954 93.9280209 97.4785806 86.4892104 1.013268949 0.019017155 6.51540571 0.952431559 Rv0415 Rv0415 conserved hypothetical protein MT0429 2.62387626 5.1578971 3.81912349 5.07382552 1.15127637 0.203234202 2.12363462 0.738873933 Rv0416 Rv0416 conserved hypothetical protein MT0430 26.3324724 41.8061133 27.6431796 27.7108932 0.82750491 −0.273160223 4.95630185 0.375157468 Rv0417 thlG thiamine synthesis, thiazole moiety MT0431 2.71758612 3.9815346 2.72794535 3.59070729 0.943774108 −0.083486503 1.78078329 0.904814009 MT0432 201.569922 245.226336 170.860311 219.189263 0.87072105 −0.199717494 7.71005572 0.281405936 Rv0418 lpqL probable aminopeptidase Y MT0433 322.17452 407.926318 323.807113 400.207745 0.992910957 −0.010263751 8.50665591 0.973097519 Rv0419 lpqM possible zinc metallopeptidase MT0434 65.4094857 84.5171209 62.1062225 79.229737 0.943255785 −0.084279051 6.18979639 0.760272935 MT0435 65.5031955 61.1708498 76.2006069 64.0863193 1.104113612 0.142888632 6.0642255 0.56234972 Rv0421c Rv0421c hypothetical protein MT0436 241.958875 231.381454 250.152589 246.744038 1.050033943 0.070435965 7.92324366 0.78906084 Rv0422c thiD phosphomethylpyrimidine kinase MT0437 761.392663 912.585829 798.19681 844.440685 0.984813224 −0.02207796 9.69580586 0.946240485 MT0438 113.388938 151.569783 123.575925 163.611358 1.084514956 0.117049948 7.11089133 0.619926139 MT0440 983.016497 1178.71522 1025.88932 1196.33 1.029156839 0.04146286 10.0982566 0.896513559 Rv0425c ctpH C-terminal region putative cation-transporting MT0441 98.2079398 185.684296 111.118307 160.09871 0.984155487 −0.023041829 7.11860339 0.946240485 Rv0426c Rv0426c hypothetical protein MT0442 82.9332316 105.963114 81.1109085 106.706454 0.992832678 −0.010377494 6.56017071 0.973145504 Rv0427c xthA exodeoxyribonuclease III MT0443 32.9858729 63.6140642 29.9164674 58.3880229 0.912936516 −0.131413554 5.53675831 0.633618212 Rv0428c Rv0428c hypothetical protein MT0444 31.3928052 62.2567229 34.463043 56.4365516 0.99002154 −0.014468181 5.53393023 0.972119393 Rv0429c def polypeptide deformylase MT0445 117.043623 329.652967 134.942363 302.321942 1.024051573 0.034288374 7.78918733 0.906734963 Rv0430 Rv0430 hypothetical protein MT0446 145.344003 241.606759 162.585543 275.079402 1.128780723 0.174765255 7.68898685 0.375125762 Rv0431 Rv0431 tuberculin related peptide (AT103) MT0447 251.517281 315.265149 264.156042 325.895716 1.041879421 0.059188321 8.1768925 0.825902812 Rv0432 sodC superoxide dismutase precursor (Cu—Zn) MT0448 271.852322 328.024158 278.159495 318.480125 0.996531644 −0.005012477 8.22549781 0.985374119 Rv0433 Rv0433 conserved hypothetical protein MT0449 110.109093 101.89109 112.936938 111.624162 1.060131577 0.084243334 6.77237614 0.741632985 MT0450 10.3080853 7.69160094 11.8210965 9.91347448 1.212250681 0.277688064 3.33747007 0.401746068 MT0451 356.940831 274.273441 335.810073 306.53712 1.025231025 0.035949042 8.31542863 0.90313325 Rv0435c Rv0435c ATPase of AAA-family MT0452 124.071863 131.209663 134.942363 134.807641 1.056875907 0.079805993 7.03821676 0.763576794 Rv0436c pssA CDP-diacylglycerol-serine o-phosphatidyltransferase MT0453 91.7419591 101.348154 100.115594 102.413217 1.04964595 0.069902783 6.63057561 0.801831984 Rv0437c psd putative phosphatidylserine decarboxylase MT0454 108.234896 102.976963 100.843047 108.892102 0.993020606 −0.01010444 6.71992521 0.974671036 Rv0438c moaA3 molybdenum cofactor biosynthesis, protein A MT0455 67.3773938 90.8513805 62.6518116 80.9470318 0.909548937 −0.136776833 6.24105924 0.558074612 Rv0439c Rv0439c Probable oxidoreductase MT0456 1271.92402 3979.9058 1399.16317 3715.5234 1.013155791 0.018856032 11.339761 0.958687248 Rv0440 groEL2 60 kD chaperonin 2 MT0457 166.147593 133.471899 167.586776 141.364585 1.033451945 0.047471306 7.25088893 0.871597492 Rv0441c Rv0441c 65 kDa antigen MT0458 87.8998546 61.0803604 118.392828 76.3415594 1.298786583 0.377164386 6.42788028 0.010995444 Rv0442c PPE PPE-family protein MT0459 279.536531 131.431131 234.057711 159.474239 1.005295479 0.007619604 7.65315326 0.983253476 Rv0443 Rv0443 hypothetical protein MT0460 268.385057 224.685237 241.514095 227.853795 0.955237571 −0.066068513 7.91157203 0.806148616 Rv0444c Rv0444c conserved hypothetical protein MT0461 127.820258 127.952044 111.936691 126.299226 0.930294143 −0.104241143 6.9504539 0.660006357 Rv0445c sigK ECF-type sigma factor MT0462 70.1886898 75.2871998 70.1991271 75.482912 1.001392627 0.002007738 6.18919288 0.996920859 Rv0446c Rv0446c conserved hypothetical protein MT0463 109.734253 107.682413 95.9327449 97.8077443 0.891229392 −0.166131282 6.68595524 0.431434762 Rv0447c ufaA1 unknown fatty acid methyltransferase MT0464 3.56097492 7.42013267 6.09241129 7.49365 1.256864685 0.329329336 2.66291842 0.457938723 Rv0448c Rv0448c conserved hypothetical protein MT0465 74.4056338 67.1431517 95.5690189 82.0398558 1.25283542 0.325196906 6.32134082 0.039298204 Rv0449c Rv0449c putative dehyodrogenase MT0466 785.288679 433.263357 1054.35088 660.221789 1.429946035 0.515960702 9.51855155 0.000359088 Rv0450c mmpL4 conserved large membrane protein MT0467 119.38637 49.226246 181.953955 82.7423854 1.595490947 0.674000423 6.76135676 5.82E−08 MT0468 42.731699 49.9501614 98.2060327 93.5145073 2.070860989 1.050230713 6.15584656 8.80E−15 Rv0452 Rv0452 putative transcriptional regulator MT0469 20.335041 27.2373163 38.554961 36.2193083 1.578878634 0.658900278 4.94381223 0.000439557 Rv0453 PPE PPE-family protein MT0470 240.459517 182.426676 301.256098 228.009913 1.25134932 0.323484581 7.89609217 0.02572891 MT0471 422.818917 373.540337 456.112463 402.939805 1.078721229 0.109322081 8.69357839 0.630293904 Rv0455c Rv0455c hypothetical protein MT0472 24.3645652 27.4182951 25.4608233 27.0864224 1.015036609 0.021531762 4.71487707 0.952431559 Rv0456c echA2 enoyl-CoA hydratase/isomerase superfamily MT0472.1 2.15532692 2.80517211 2.54608233 2.88817761 1.094364666 0.130093555 1.47510605 0.875390859 MT0473 79.184837 92.7516584 66.1981406 83.9132683 0.870603608 −0.199912096 6.33433346 0.31733205 Rv0457c Rv0457c probable peptidase MT0474 99.6135878 109.854159 102.934471 93.2803308 0.936165268 −0.095164854 6.66663808 0.735519493 MT0475 23.8960159 21.8079509 27.188522 24.0421271 1.119988009 0.163483286 4.60933257 0.548403779 Rv0459 Rv0459 conserved hypothetical protein MT0476 100.925526 194.914217 91.0224433 195.225194 0.952619408 −0.070028153 7.18709616 0.801831984 MT0477 80.4967751 175.187523 80.7471824 166.187301 0.973912919 −0.038135313 6.97563695 0.894346121 Rv0461 Rv0461 unknown possible membrane protein MT0478 608.926711 542.48409 550.408441 528.848737 0.938719561 −0.091233873 9.12370204 0.727349312 Rv0462 Rv0462 probable dihydrolipoamide dehydrogenase MT0479 30.7368351 25.6085067 32.2806867 28.7256583 1.0849495 0.117627892 4.83320395 0.698416576 MT0480 205.505737 194.009323 221.145437 192.649252 1.033718978 0.047844034 7.66868126 0.870054573 Rv0464c Rv0464c conserved hypothetical protein MT0481 515.685394 289.475664 564.684688 293.891586 1.054808254 0.076980766 8.70074177 0.764687847 Rv0465c Rv0465c transcriptional regulator (PbsX/Xre family) MT0482 233.056437 209.844972 246.60626 226.448736 1.068574314 0.095687244 7.84023404 0.687203723 Rv0466 Rv0466 conserved hypothetical protein MT0483 1850.2076 1460.22782 2448.24002 1295.40145 1.084041326 0.116419757 10.7845745 0.74702628 Rv0467 aceA isocitrate lyase MT0484 295.186079 361.052797 405.099885 359.382965 1.168293891 0.224403238 8.473134 0.311717327 MT0486 624.388839 665.821173 681.713544 715.409399 1.083093367 0.115157615 9.39234712 0.636705647 Rv0470c umaA2 unknown mycolic acid methyltransferase MT0487 42.2631497 30.1329778 51.5581672 34.3458958 1.180823107 0.239792858 5.31256369 0.271793205 MT0488 89.1180828 64.2474902 99.2062793 73.2192052 1.12604486 0.171264304 6.35076858 0.414134607 Rv0471c Rv0471c hypothetical protein MT0489 249.924213 195.185685 283.251659 265.322045 1.240910774 0.311399384 7.95768431 0.053914997 Rv0472c Rv0472c transcriptional regulator (TetR/AcrR family) MT0490 168.39663 125.146872 176.952722 143.08188 1.095688995 0.131838356 7.26269773 0.559675434 Rv0473 Rv0473 possible membrane protein MT0491 122.385085 79.178245 144.762967 104.20857 1.246223365 0.317562671 6.81765931 0.037608838 Rv0474 Rv0474 transcriptional regulator (PbsX/Xre family) MT0493 714.350311 736.85537 900.311898 845.299332 1.202378179 0.265890732 9.64274652 0.15276274 Rv0475 Rv0475 possible exported protein MT0495 355.722652 258.890239 343.993909 281.714405 1.02555453 0.036404204 8.27727648 0.901108236 Rv0476 Rv0476 unknownunkown hydrophobic protein MT0496 161.555809 118.360165 169.405406 122.396283 1.041404603 0.058530688 7.16081716 0.832160187 Rv0478 deoC deoxyribose-phosphate aldolase MT0497 506.220698 587.004886 434.925421 478.969129 0.83720956 −0.25633931 8.97140819 0.127231317 Rv0479c Rv0479c unknown hydrophobic protein MT0498 95.0218044 101.98158 103.843786 106.472277 1.067901082 0.094778019 6.67255729 0.715091434 MT0499 103.736822 95.013894 116.574198 104.364688 1.111007115 0.151868056 6.71558706 0.483874815 MT0500 37.6713652 38.5484941 32.5534812 37.46825 0.917902567 −0.123587071 5.19917488 0.667813113 Rv0482 murB UDP-N-acetylenolpyruvoylglucosamine reductase MT0501 1376.12939 1404.66731 1385.06879 1422.38844 1.009552858 0.013716449 10.4483642 0.969989124 Rv0483 Rv0483 conserved hypothetical protein MT0502 90.5237308 91.5752959 89.2947445 87.1136813 0.968571714 −0.046069224 6.48865447 0.87947654 Rv0484c Rv0484c oxidoreductase MT0503 950.874013 810.875718 989.425779 706.666807 0.952363145 −0.070416303 9.75592696 0.818068286 Rv0485 Rv0485 transcriptional regulator (ROX family) MT0504 682.114117 362.22916 702.173134 368.906145 1.023950932 0.034146583 9.04714315 0.90313325 Rv0486 Rv0486 conserved hypothetical protein MT0505 113.670058 67.41462 109.43154 66.4280849 0.973800255 −0.038302217 6.48226542 0.897840055 Rv0487 Rv0487 conserved hypothetical protein MT0506 14.2438997 11.130199 15.458357 11.8649458 1.075982955 0.105655224 3.73802716 0.785634149 MT0507 14.0564799 10.3157942 16.3676721 15.6898297 1.325754576 0.406813728 3.8368406 0.091661991 Rv0488 Rv0488 probable membrane protein MT0508 119.761209 79.7211815 124.48524 84.6938568 1.050575845 0.071180319 6.67704874 0.79743892 Rv0489 gpm phosphoglycerate mutase I MT0509 1062.57617 452.266135 987.06156 515.969026 1.028841911 0.041021319 9.55960046 0.900323347 MT0510 293.124452 134.014835 285.434015 156.820238 1.065328001 0.091297686 7.76487558 0.734697142 Rv0491 regX3 two-component response regulator MT0511 51.165537 53.931696 47.2843861 52.2213735 0.946392346 −0.079489689 5.68167028 0.801337286 Rv0492c Rv0492c gmc-type oxidoreductase MT0512 8.6213077 10.8587307 10.5480554 11.1624162 1.114742214 0.156710123 3.38955444 0.698960949 MT0513 18.0850042 31.2188509 18.7318914 25.9935985 0.918241087 −0.123055107 4.56640201 0.714554296 Rv0493c Rv0493c conserved hypothetical protein MT0514 2.81129599 4.79593941 2.90980838 4.37129584 0.95908566 −0.06026842 1.96640648 0.93032752 Rv0494 Rv0494 transcriptional regulator (GntR family) MT0515 217.03205 137.181965 203.686586 186.326485 1.127856793 0.173583897 7.54093893 0.52349722 Rv0495c Rv0495c conserved hypothetical protein MT0516 218.812538 206.134905 193.138531 219.111204 0.969008812 −0.045418309 7.71064984 0.880856541 Rv0496 Rv0496 conserved hypothetical protein MT0517 138.128343 176.092417 133.214665 179.769541 0.992759914 −0.010483232 7.29451153 0.973114765 Rv0497 Rv0497 probable membrane protein MT0518 76.5609607 78.6353084 76.5643329 95.309861 1.102672626 0.141004531 6.35675133 0.562810168 MT0519 47.0423529 55.1985479 46.1022765 64.3985547 1.072476845 0.1009465 5.73811575 0.745116768 Rv0499 Rv0499 hypothetical protein MT0520 97.0834215 101.710111 110.208992 108.111513 1.098192202 0.135130572 6.70677077 0.548403779 Rv0500 proC pyrroline-5-carboxylate reductase MT0521 145.625132 139.082243 164.404173 181.018483 1.212559965 0.278056095 7.30120742 0.103888947 MT0522 721.284841 672.60788 797.105632 661.782966 1.042771675 0.0604233 9.47849839 0.829018102 Rv0501 galE1 UDP-glucose 4-epimerase MT0523 1106.24497 873.494399 1269.4039 927.417247 1.103825495 0.142512113 10.0283303 0.562810186 Rv0502 Rv0502 conserved hypothetical protein MT0524 314.396601 509.817408 372.637335 504.182139 1.08181849 0.113458461 8.73284532 0.641879751 MT0525 11.6200234 10.3157942 11.0936444 9.44512136 0.935279724 −0.096530184 3.43123667 0.819552181 MT0526 292.468493 273.820994 335.537278 288.973878 1.100355433 0.137969613 8.21855817 0.52349722 Rv0505c serB probable phosphoserine phosphatase MT0527 70.4698194 116.369398 86.2030732 152.761178 1.269196967 0.343915979 6.73686015 0.02607446 Rv0506 mmpS2 conserved small membrane protein MT0528 154.714939 168.038858 173.588256 217.31585 1.205363983 0.269468862 7.48063449 0.123157185 Rv0507 mmpL2 conserved large membrane protein MT0529 19.6790719 19.7266942 22.914741 25.9935985 1.240992303 0.311494168 4.47676661 0.153142687 MT0530 1207.35792 801.012371 1114.91127 832.029327 0.979283926 −0.030200891 9.94981126 0.923772833 Rv0509 hemA glutamyl-tRNA reductase MT0531 638.539029 388.018645 664.527488 454.38059 1.103611084 0.142231851 9.06751209 0.52349722 Rv0510 hemC porphobilinogen deaminase MT0532 1436.66596 746.26627 1424.44213 851.856276 1.063635323 0.089003594 10.1227802 0.764687847 Rv0511 cysG uroporphyrin-III c-methyltransferase MT0533 542.298996 259.523665 557.137373 332.764895 1.146524803 0.197267565 8.72481523 0.351739042 Rv0512 hemB [delta]-aminolevulinic acid dehydratase MT0534 221.436414 138.448817 245.515082 160.020651 1.131664343 0.178446111 7.58133372 0.37638467 Rv0513 Rv0513 probable membrane protein MT0535 86.9627559 41.9870922 103.752855 57.3732578 1.271849801 0.346928306 6.18344592 0.038301997 Rv0514 Rv0514 possible membrane protein MT0536 424.130855 176.182906 347.449306 190.77584 0.939887445 −0.089440096 8.15371235 0.764687847 MT0537 537.238653 742.827672 669.710584 672.242852 1.06176568 0.086465414 9.35685875 0.79545701 Rv0516c Rv0516c conserved hypothetical protein MT0538 105.798439 104.605773 115.755815 113.263397 3.088385602 0.122189777 6.7818041 0.579199472 Rv0517 Rv0517 possible acyltransferase MT0539 37.9524958 81.0785229 40.5554542 69.2382037 0.947291504 −0.078119649 5.84298831 0.808331268 Rv0518 Rv0518 hypothetical protein MT0540 65.4094857 91.0323594 85.9302786 108.34569 1.248487476 0.320181349 6.4573566 0.048861987 MT0541 93.897286 158.989916 106.208006 169.62189 1.097376129 0.134058099 7.04851218 0.548110991 Rv0519c Rv0519c conserved hypothetical protein MT0542 17.6174549 20.2696307 29.9164674 26.9303047 1.49768043 0.582729819 4.57714699 0.001342685 Rv0520 Rv0520 similar to methyltransferases MT0543 1.87419733 2.17174615 3.54632896 4.99576667 2.104137421 1.07322893 1.74399765 0.00401549 MT0544 101.487735 101.619622 114.209979 114.824575 1.12765046 0.173319942 6.7577678 0.379168823 Rv0522 gabP probable 4-amino butyrate transporter MT0545 11.0577642 22.0794192 15.0036994 19.0463604 1.056647796 0.079494575 4.08620046 0.865552121 Rv0523c Rv0523c conserved hypothetical protein MT0546 543.610934 317.617874 483.300985 298.340941 0.913625786 −0.130324725 8.68254078 0.547666257 Rv0524 hemL glutamate-1-semialdehyde aminotransferase MT0547 138.503132 84.969568 125.667349 90.7824474 0.982833135 −0.024981598 6.78321067 0.930747689 MT0548 194.635392 114.650099 165.040694 123.098813 0.952592953 −0.070068219 7.22415666 0.814508736 Rv0526 Rv0526 conserved hypothetical protein MT0549 138.878022 74.3823056 123.394062 83.3668563 0.994913641 −0.007356791 6.71648218 0.98219487 MT0550 468.830461 258.347302 405.554542 279.762933 0.966972065 −0.048453883 8.46467224 0.877295001 Rv0528 Rv0528 probable membrane protein MT0551 203.818959 143.335246 185.954942 158.537533 1.003900665 0.005616523 7.43528849 0.985131579 Rv0529 ccsB cytochrome c-type biogenesis protein MT0552 437.010175 526.376973 436.198462 478.032423 0.901909825 −0.148944898 8.91312753 0.483174937 Rv0530 Rv0530 conserved hypothetical protein MT0553 96.1463228 83.7027161 82.6567442 63.696025 0.809305737 −0.305243273 6.35244024 0.068302674 MT0554 46.7612233 51.0360345 40.5554542 41.6834281 0.84119215 −0.249492708 5.49760975 0.249987045 Rv0531 Rv0531 unknown, membrane protein. MT0555 33.7355519 35.8338114 33.0990703 31.3796594 0.926140803 −0.110696549 5.07398673 0.723313141 MT0556 57.5378579 49.4072249 61.9243595 55.8120808 1.102466964 0.140735425 5.81621792 0.577509587 Rv0532 PE_PGRS PE_PGRS-family protein MT0557 110.390223 134.195814 115.028362 132.309758 1.013101936 0.018779342 6.94442641 0.948443219 Rv0533c fabH [beta]-ketoacyl-ACP synthase III MT0558 41.8883102 56.1939316 42.828742 48.7867839 0.939560317 −0.089942314 5.5730066 0.783069965 Rv0534c menA 4-dihydroxy-2-naphthoate octaprenyltransferase MT0559 46.1052542 37.1006634 41.4647694 40.7467219 0.993498175 −0.009410778 5.37599173 0.978929348 Rv0535 pnp phosphorylase from Pnp/MtaP family 2 MT0560 32.4236137 32.5761922 34.1902484 30.8332474 0.998647091 −0.001953157 5.03026628 0.997032163 Rv0536 galE2 UDP-glucose 4-epimerase MT0562 398.735481 354.26609 400.280515 396.070626 1.059425257 0.083281809 8.59810685 0.74546569 Rv0537c Rv0537c unknown, possible membrane protein, MT0563 163.055167 139.806158 171.224037 145.657822 1.045979764 0.064854941 7.27711726 0.809132929 Rv0538 Rv0538 possible transmembrane protein MT0564 42.07573 40.0868143 52.3765508 48.162313 1.222824015 0.290216791 5.51901352 0.146124782 MT0565 12.3697024 12.1255827 15.7311515 14.3628292 1.226754304 0.294846333 3.7894072 0.267751697 Rv0540 Rv0540 conserved hypothetical protein MT0566 158.557094 88.4986555 159.221077 103.5841 1.082028743 0.113738823 6.99576716 0.637012172 Rv0541c Rv0541c unknown membrane protein MT0567 267.635378 170.753541 279.341604 221.140734 1.161620659 0.216139017 7.87582438 0.280503699 Rv0542c menE o-succinyl benzoic acid-CoA ligase MT0569 75.8112818 70.7627287 79.5650728 91.016624 1.16288404 0.217707242 6.31241607 0.300046275 MT0570 1217.19745 1115.64409 1196.20404 1153.63181 1.008078746 0.011608339 10.193332 0.973114765 Rv0545c pitA low-affinity inorganic phosphate transporter MT0571 47.1360627 47.3259681 47.5571807 53.6264328 1.070246686 0.097943368 5.61746012 0.752487878 Rv0546c Rv0546c conserved hypothetical protein MT0572 101.019236 92.027743 97.023923 97.963862 1.011318772 0.016237813 6.60265155 0.958182745 Rv0547c Rv0547c putative oxidoreductase MT0573 224.06029 258.799749 182.86327 219.189263 0.831557504 −0.266112063 7.79053343 0.088951926 MT0573.1 14.9935736 18.0978846 16.0948776 16.8607125 0.996255548 −0.005412241 4.06091318 0.988617034 MT0574 44.2310559 30.7664038 40.7373173 27.2425401 0.90390153 −0.14576248 5.16599352 0.589625478 MT0575 5.15404254 7.78209036 6.09241129 5.07382552 0.863403902 −0.211892482 2.63120328 0.694085957 MT0577 49.759939 54.4746325 48.0118382 63.9302016 1.066941935 0.093481664 5.76108075 0.76492809 Rv0551c fadD8 acyl-CoA synthase MT0578 40.4826622 51.1265239 46.8297286 50.347961 1.064898417 0.090715815 5.56616417 0.778317939 Rv0552 Rv0552 putative transcriptional regulator MT0579 21.0847199 19.7266942 21.0961107 20.4514198 1.018645068 0.026651453 4.37605769 0.94190007 MT0580 63.8164139 83.4312478 60.3785238 69.7065568 0.887588385 −0.172037306 6.11916351 0.465361366 MT0581 347.476184 313.274382 338.265224 329.096129 1.011286074 0.016191166 8.37591798 0.955286813 Rv0555 menD 2-succinyl-6-hydroxy-2,4-cy- clohexadiene-1-carboxylate MT0582 100.456977 96.5522142 100.206526 99.2128037 1.012493832 0.017913119 6.6334694 0.951100432 Rv0556 Rv0556 possible membrane protein MT0583 231.18224 177.540248 234.239574 194.288488 1.052777157 0.074200091 7.71068193 0.775538143 Rv0557 Rv0557 conserved hypothetical protein MT0584 153.684131 127.952044 146.854392 119.430047 0.944480836 −0.082406571 7.09956739 0.755051206 MT0585 483.73033 356.890284 505.670137 439.315231 1.134140716 0.131599651 8.80275684 0.381485881 Rv0559c Rv0559c possible exported MT0586 50.9781673 44.7922643 73.4726615 65.9597318 1.456654544 0.542658773 5.88228285 0.000221256 Rv0560c Rv0560c methyl transferase MT0587 70.6572392 55.4700162 64.4704418 58.0757875 0.976855249 −0.033783297 5.96203699 0.916845409 Rv0561c Rv0561c similar to squalene monooxygenase MT0588 339.417136 242.692632 312.622537 252.286217 0.978213177 −0.031779197 8.1645031 0.91003342 Rv0562 grcC1 heptaprenyl diphosphate synthase II MT0589 283.847185 353.813643 330.536045 356.885081 1.083356271 0.115507763 8.37266117 0.628146178 Rv0563 htpX probable (transmembrane) heat shock protein MT0590 44.7933151 78.6353084 46.193208 59.0905526 0.874390166 −0.193650919 5.84196238 0.477179718 Rv0564c gpdA1 glycerol-3-phosphate dehydrogenase MT0591 37.3902366 83.883695 45.2838929 71.8922047 1.008379517 0.012038718 5.9022403 0.975577295 Rv0565c Rv0565c Probable monooxygenasemonoxygenase MT0592 27.8318303 36.376748 32.2806867 35.360661 1.057812223 0.081083551 5.05071348 0.80719169 Rv0566c Rv0566c conserved hypothetical protein MT0593 198.008947 265.134009 176.679927 239.250388 0.897395715 −0.156183799 7.78104111 0.438894255 Rv0567 Rv0567 Probable methyltransferase MT0594 600.867653 464.301229 583.143785 499.654726 1.02187151 0.031213804 9.06921066 0.914025115 Rv0568 Rv0568 similar too MTCY63.32c cytochrome P-450 MT0595 57.0693036 112.84031 64.2885788 79.6980901 0.886038476 −0.174558746 6.29747329 0.583058152 Rv0569 Rv0569 conserved hypothetical protein MT0596 298.184794 916.024427 256.972452 563.741045 0.726686469 −0.460595052 8.99129687 0.007894232 Rv0570 nrdZ ribonucleotide reductase, class II MT0597 183.952458 502.940212 157.038721 316.528654 0.73060891 −0.452828746 8.18141616 0.00611845 Rv0571c Rv0571c conserved hypothetical protein MT0598 93.897286 633.878407 83.2023333 275.703873 0.61545248 −0.700280626 8.08671468 0.004369491 MT0599 48.1668713 220.432234 39.0096185 137.539701 0.700442727 −0.513661004 6.8007391 0.000649691 Rv0572c Rv0572c hypothetical protein MT0600 55.6636606 323.228218 41.5557009 200.064843 0.672509253 −0.572373978 7.27922367 6.03E−05 MT0601 40.0141129 86.1459305 33.0990703 59.5589058 0.750659175 −0.413770071 5.77848558 0.019386895 Rv0573c Rv0573c conserved hypothetical protein MT0602 106.641828 268.844075 106.208006 184.60919 0.822764891 −0.281447863 7.3816692 0.212839227 Rv0574c Rv0574c conserved hypothetical protein MT0603 7.68420903 5.97230191 6.00147978 4.99576667 0.807435383 −0.308581285 2.66153754 0.438104303 MT0604 46.7612233 46.0591162 49.1939479 33.4872485 0.876217767 −0.190638626 5.46060044 0.530550672 Rv0575c Rv0575c possible oxidoreductase MT0605 435.282329 191.29464 514.581425 229.57109 1.190913307 0.252068396 8.42135847 0.112872066 Rv0576 Rv0576 putative transcriptional regulator MT0606 393.675148 174.735076 435.289147 189.292721 1.094691905 0.130524888 8.2210792 0.548791269 Rv0577 Rv0577 conserved hypothetical protein MT0607 1181.11915 531.44438 1289.31791 560.133404 1.091610293 0.116457903 9.80679313 0.617184719 Rv0578c PE_PGRS PE_PGRS-family protein MT0608 23.3337567 26.332422 22.4600834 20.0611255 0.854531843 −0.226793842 4.53698145 0.401319679 MT0608.1 108.609735 95.8282988 107.935705 91.2508006 0.972877734 −0.039669589 6.65927677 0.894346121 Rv0579 Rv0579 conserved hypothetical protein MT0609 102.987143 139.53469 115.48302 132.075581 1.02855886 0.040624355 6.93902905 0.89125591 Rv0580c Rv0580c hypothetical protein MT0610 13.2130911 27.0563374 15.094631 22.0125969 0.944012682 −0.083106571 4.28782327 0.839018102 MT0611 38.4210452 80.5355863 39.4642761 61.1200828 0.874629811 −0.193255573 5.78327389 0.480578669 Rv0583c lpqN equivalent to MXU20446_1 MK35 MT0612 50.6970377 42.6205182 58.0143045 53.3141974 1.196100602 0.258338737 5.68199976 0.224243439 Rv0584 Rv0584 hypothetical protein MT0613 27.6444106 34.8384278 28.8252892 32.0821891 0.977224118 −0.033238625 4.95546756 0.923772833 Rv0585c Rv0585c possible membrane protein MT0614 2.15532692 3.34810864 2.90980838 3.20041302 1.110253297 0.150888855 1.62548427 0.839868787 MT0615 180.297733 153.198593 168.223297 166.733713 1.007707024 0.011076257 7.38618658 0.973114765 Rv0586 Rv0586 transcriptional regulator (GntR family) MT0616 158.275954 133.381409 136.215405 131.294993 0.920384248 −0.119691803 7.1288896 0.622290708 Rv0587 Rv0587 part of mce2 operon MT0617 138.878022 130.304769 117.665376 125.674755 0.904299176 −0.145127945 7.00342308 0.513096782 Rv0588 Rv0588 part of mce2 operon MT0618 96.6148721 103.157942 78.3829631 98.5883328 0.881855173 −0.181386353 6.56017245 0.401489333 Rv0589 mce2 cell invasion protein MT0619 103.549402 112.568842 86.7486622 117.322458 0.936189766 −0.0951271 6.7174126 0.741445842 Rv0590 Rv0590 part of mce2 operon MT0620 10.495505 12.5780298 9.91153478 14.3628292 1.048315664 0.0680732 3.58809087 0.880578033 MT0621 17.6174549 17.2834798 17.7316448 18.3438307 1.034195295 0.048508647 4.16364494 0.898498494 Rv0591 Rv0591 part of mce2 operon MT0622 15.5558378 16.8310326 15.276494 16.080124 0.968085183 −0.046794097 4.01010843 0.90313325 Rv0592 Rv0592 part of mce2 operon MT0623 15.4621279 12.7590086 15.8220831 14.7531234 1.086879042 0.120191393 3.89473156 0.740705091 Rv0593 lprL part of mce2 operon MT0624 55.9447902 49.5882037 48.0118382 44.8057823 0.880612693 −0.183420455 5.63678825 0.461612363 Rv0594 Rv0594 part of mce2 operon MT0625 17.8985815 20.1791413 19.004686 18.4999484 0.984309564 −0.022815983 4.25329756 0.952654537 Rv0595c Rv0595c conserved hypothetical protein MT0626 13.5879306 12.2160721 10.0024663 12.2552401 0.864402085 −0.210225542 3.60771289 0.551198699 MT0627 317.114137 157.451596 381.184897 208.729376 1.261228988 0.334830234 8.05679106 0.027353454 Rv0597c Rv0597c conserved hypothetical protein MT0628 107.672636 74.2918161 118.939417 93.1242131 1.175433454 0.233192865 6.62464474 0.217679742 Rv0598c Rv0598c conserved hypothetical protein MT0629 23.2400458 19.0932682 22.4600834 23.7298917 1.096202602 0.132514464 4.47961279 0.69018019 Rv0599c Rv0599c conserved hypothetical protein MT0630 4.49807358 7.96306921 4.45564408 6.94723802 0.917675511 −0.123943986 2.62127018 0.813016449 Rv0601c Rv0601c sensor histidine kinase MT0631 4.21694398 4.70544999 4.45564408 5.77635521 1.146644991 0.197418793 2.31471816 0.720045953 Rv0602c tcrA two-component response regulator MT0632 65.5031955 73.0249642 61.5606335 62.2129068 0.894167849 −0.161382422 6.0388785 0.501164035 Rv0604 lpqO lipoprotein MT0633 43.481378 37.0101739 50.7397836 44.8057823 1.188364341 0.24897722 5.46551459 0.248144201 Rv0605 Rv0605 resolvase MT0635 91.2734097 68.1385354 93.2957311 80.0883844 1.095181112 0.131169471 6.38146735 0.584969964 Rv0606 Rv0606 transposase MT0636 16.0243871 11.4921567 16.7313982 13.6602995 1.11035995 0.151027437 3.87261535 0.648617706 Rv0607 Rv0607 hypothetical protein MT0637 56.0385 46.873521 53.2858659 50.0357255 1.007278946 0.010463265 5.69295443 0.976466231 Rv0608 Rv0608 conserved hypothetical protein MT0638 102.893433 85.6934834 107.935705 101.632628 1.115195631 0.157296814 6.63973942 0.477700205 Rv0609 Rv0609 conserved hypothetical protein MT0638.1 41.7008905 36.0147903 47.1025231 44.8838412 1.186285919 0.246451771 5.41294031 0.26559805 MT0639 7.12194934 7.60111152 7.7291785 8.3522974 1.092243021 0.127293888 2.97857075 0.785093466 MT0640 84.7137191 86.5078882 92.4773475 97.7296855 1.110701213 0.151470773 6.50046333 0.49025808 Rv0610c Rv0610c possible monooxygenase MT0641 145.625132 122.160721 131.668829 117.712752 0.933315711 −0.099562913 7.01636245 0.68329091 Rv0611c Rv0611c hypothetical protein MT0642 47.9794515 33.0286393 49.6486054 29.5062469 0.965017703 −0.051372686 5.32902402 0.880856541 Rv0612 Rv0612 hypothetical protein MT0643 622.795771 655.957826 530.767234 608.39071 0.889152464 −0.169497274 9.23996498 0.426706136 Rv0613c Rv0613c hypothetical protein MT0644 6.37227091 11.0397096 8.00197304 10.3037688 1.059787735 0.083775336 3.18856202 0.870054573 Rv0614 Rv0614 conserved hypothetical protein MT0645 39.8266932 29.4995518 32.2806867 30.2868354 0.910875246 −0.13467462 5.05055513 0.657330385 Rv0615 Rv0615 possible membrane protein MT0645.1 3.37355519 2.80517211 3.18260291 3.82488386 1.139716839 0.188688092 1.79847977 0.783679782 Rv0616c Rv0616c hypothetical protein MT0645.2 93.0538972 60.1754662 91.0224433 63.9302016 1.018207701 0.026031882 6.27066331 0.93054576 MT0646 65.7843251 31.3093403 64.7432364 42.7762521 1.150862812 0.202715868 5.68128475 0.477179718 Rv0617 Rv0617 conserved hypothetical protein MT0648 2.81129539 0.99538365 1.63676721 2.18564792 1.061369887 0.085927523 1.05948459 0.932981823 Rv0620 galK gala ctokinase MT0649 67.5648136 47.1449893 54.6498386 46.054724 0.887487287 −0.172201641 5.75533056 0.50848409 Rv0621 Rv0621 membrane spanning ATP/GTP-binding protein MT0650 21.9281097 25.246549 20.7323847 20.2953021 0.869548965 −0.201660825 4.47391087 0.459370243 Rv0622 Rv0622 potential membrane spanning protein MT0651 30.9242559 24.3416547 26.2792069 22.0125969 0.876083407 −0.190859867 4.70340448 0.47283403 MT0652 54.5391422 44.520796 52.4674823 44.5716057 0.981177991 −0.027413222 5.6203844 0.933447653 MT0653 70.6572392 71.8486017 62.3790171 66.7403203 0.905896469 −0.142581915 6.08916929 0.552927263 Rv0625c Rv0625c probable integral membrane protein MT0654 149.186107 98.9049391 126.576664 86.9575636 0.863368654 −0.211951381 6.85252394 0.231667181 Rv0626 Rv0626 conserved hypothetical protein MT0655 20.0539114 18.5503317 17.0951242 16.3923594 0.868137917 −0.204003839 4.18523139 0.464084488 MT0656 211.128329 227.037962 206.141737 178.832835 0.876793772 −0.189690545 7.68616686 0.37678538 Rv0628c Rv0628c conserved hypothetical protein MT0657 66.5340051 62.3472123 56.1956743 62.5251422 0.921204328 −0.118406906 5.95595985 0.672240715 Rv0629c recD exodeoxyribonuclease V MT0658 64.5660979 84.0646738 71.2903052 94.4512136 1.114121012 0.155905942 6.29983097 0.477357404 Rv0630c recB exodeoxyribonuclease V MT0659 69.1578813 89.2225709 66.6527981 87.7381521 0.973851438 −0.03822639 6.29237827 0.897921476 Rv0631c recC exodeoxyribonuclease V MT0660 334.450513 334.358417 309.439935 342.600311 0.973832416 −0.038254571 8.36802681 0.894346121 Rv0632c echA3 enoyl-CoA hydratase/isomerase superfamily MT0661 141.595608 135.643645 134.942363 140.271761 0.992929723 −0.010236484 7.11154897 0.974110692 Rv0633c Rv0633c hypothetical protein MT0662 224.154 220.522723 202.595408 216.301085 0.941723188 −0.086625042 7.75534546 0.733038419 Rv0634c Rv0634c putative glyoxylase II MT0662.1 59.4120552 88.6796344 58.3780306 82.1959735 0.9530772 −0.069335017 6.17699507 0.808331268 MT0663 81.7150034 136.639029 88.2944979 145.501704 1.072299491 0.100707904 6.82318443 0.667131289 MT0664 169.521148 273.911483 169.223543 271.80093 0.995198897 −0.006943208 7.78991358 0.980042284 Rv0635 Rv0635 conserved hypothetical protein MT0665 135.317047 197.176452 131.214172 196.396077 0.983076925 −0.024623784 7.36821469 0.930747689 Rv0636 Rv0636 hypothetical protein MT0666 422.256657 598.406553 425.650407 659.128965 1.054044982 0.075936436 9.04044148 0.781643628 Rv0637 Rv0637 conserved hypothetical protein MT0667 370.435101 298.434117 593.187857 336.980074 1.09468218 0.130512072 8.45092829 0.534991985 Rv0638 secE SecE preprotein translocase MT0668 1178.87012 802.64118 1216.5727 946.307489 1.102934289 0.14134684 10.0171776 0.578518157 Rv0639 nusG transcription antitermination protein MT0669 678.084592 465.477591 691.988805 524.945794 1.072627445 0.101149073 9.20528028 0.693077501 Rv0640 rplK 50S ribosomal protein L11 MT0669.1 2285.77106 1342.68206 2250.46398 1558.13279 1.068793914 0.095983698 10.8606395 0.757937303 Rv0641 rplA 50S ribosomal protein L1 MT0670 767.296335 1209.30065 882.581253 1369.62066 1.141344395 0.190734184 10.046303 0.389992495 Rv0642c mmaA4 methoxymycolic acid synthase 4 MT0671 226.590457 372.544954 293.890646 420.581106 1.209016059 0.273833408 8.36018833 0.103738237 Rv0643c mmaA3 methoxymycolic acid synthase 3 MT0672 187.607152 313.63634 188.501024 275.313579 0.938031105 −0.092292332 7.91559787 0.723313141 Rv0644c mmaA2 methoxymycolic acid synthase 2 MT0673 84.6200092 102.343537 81.20184 109.594631 1.015147771 0.02168975 6.56418619 0.942315875 Rv0645c mmaA1 methoxymycolic acid synthase 1 MT0674 156.120637 168.491305 159.039214 184.531131 1.056599052 0.07942802 7.38567953 0.764687847 Rv0646c lipG probable hydrolase MT0675 201.382503 242.059206 207.960367 248.461333 1.029518563 0.041969843 7.81474112 0.880856541 Rv0647c Rv0647c conserved hypothetical protein MT0676 122.103956 145.597481 115.301157 119.430047 0.879370754 −0.185456542 6.97477512 0.360424011 Rv0648 Rv0648 conserved hypothetical protein MT0677 9.08985703 14.4783077 13.0941377 12.8016521 1.11006169 0.150639854 3.64928655 0.740445414 MT0679 10.1206656 10.4967731 10.2752608 11.0843573 1.036263057 0.05139028 3.41595744 0.905590819 MT0680 159.962742 256.808982 160.857844 294.828292 1.076120169 0.105839191 7.77027804 0.657330385 Rv0651 rpll 50S ribosomal protein L10 MT0681 91.2734097 156.365723 81.7474291 153.073413 0.938317999 −0.091851156 6.91661622 0.719637416 Rv0652 rplL 50S ribosomal protein L7/L12 MT0682 20.1476213 21.1745249 21.0961107 19.9830667 0.992990515 −0.010148157 4.37674803 0.977936408 Rv0653c Rv0653c putative transcriptional regulator MT0683 101.019236 164.69075 94.9324983 145.970057 0.911687849 −0.133388147 6.98688753 0.536295734 Rv0654 Rv0654 putative dioxygenase MT0684 1729.13445 1161.43174 1866.73301 1552.51255 1.201186115 0.264459703 10.6235388 0.227492631 Rv0655 Rv0655 ABC transporter MT0685 25.957633 21.3555038 29.0980838 21.2320083 1.05775944 0.081011561 4.61927377 0.812642214 Rv0656c Rv0656c similar to beta dioxygenases MT0686 42.3568596 46.3305845 42.828742 39.8100156 0.931178798 −0.102869885 5.4263722 0.745116768 Rv0657c Rv0657c conserved hypothetical protein MT0687 39.7329833 37.6435999 44.1017832 47.5378422 1.184774602 0.244612619 5.40728556 0.277296766 Rv0658c Rv0658c probable membrane protein MT0688 232.119339 247.488571 232.057218 253.535158 1.012076108 0.017317785 7.91575699 0.951100432 Rv0659c Rv0659c conserved hypothetical protein MT0689 222.560932 224.504258 186.682394 196.318018 0.85653153 −0.223421741 7.69827247 0.201838154 Rv0660c Rv0660c conserved hypothetical protein MT0690 7.4967893 6.06279133 6.81986338 6.16664948 0.960806734 −0.057681833 2.76704508 0.910324084 Rv0661c Rv0661c conserved hypothetical protein MT0691 7.30936957 7.23915383 6.54706885 5.6202375 0.833870519 −0.262104712 2.7752089 0.5176178 Rv0662c Rv0662c hypothetical protein MT0692 424.599404 320.061089 366.453992 316.528654 0.923702293 −0.114500145 8.48008847 0.621541633 Rv0663 atsD proable arylsulfatase MT0692.1 17.4300351 21.8934403 13.2760007 16.3143005 0.752746845 −0.409763339 4.12123829 0.04646735 Rv0664 Rv0664 hypothetical protein MT0693 13.1193813 13.482924 10.0933978 11.0062984 0.793708923 −0.33331807 3.59645238 0.222687869 Rv0665 Rv0665 conserved hypothetical protein MT0694 8.80872743 8.86796344 8.91128815 10.6160042 1.105173515 0.144272894 3.24562341 0.741445842 MT0695 9521.7658 5795.75704 9893.53034 6591.28965 1.087032314 0.120394828 12.9568742 0.714079818 Rv0667 rpoB [beta] subunit of RNA polymerase MT0696 5406.59073 2734.86183 5725.59357 3643.78731 1.1877626 0.248246511 12.0960126 0.328614459 Rv0668 rpoC [beta]′ subunit of RNA polymerase MT0697 93.3350268 77.3684565 78.6557577 66.1939084 0.849090552 −0.236009676 6.30471761 0.197755898 MT0699 446.996062 312.731445 383.185391 266.570987 0.854837618 −0.226277699 8.46158997 0.171381035 Rv0670 end endonuclease IV (apurinase) MT0700 275.881846 239.254034 276.431796 222.311617 0.965008507 −0.051386434 7.9866171 0.854044262 Rv0671 lpqP probable esterase MT0701 312.053855 345.669595 354.451033 345.800724 1.065760384 0.091883112 8.40799736 0.719637416 Rv0672 fadE8 acyl-CoA dehydrogenase (aka aid8) MT0702 73.562245 67.7765777 82.3839497 71.2677339 1.085237154 0.118010346 6.20791342 0.632028653 Rv0673 echA4 enoyl-CoA hydratase/isomerase superfamily MT0703 55.8510833 60.8993816 59.2873457 53.3922563 0.963942434 −0.052981102 5.8462268 0.878360152 Rv0674 Rv0674 hypothetical protein MT0704 30.3619957 39.9963249 31.5532346 34.3458958 0.942134542 −0.087527113 5.09770974 0.798636571 Rv0675 echA5 enoyl-CoA hydratase/isomerase superfamily MT0705 903.92537 546.646603 859.302786 536.030152 0.965430785 −0.050755263 9.47498675 0.870054573 Rv0676c mmpL5 conserved large membrane protein MT0706 274.757328 167.586411 266.702124 166.577595 0.982085724 −0.026079135 7.7751968 0.924190318 Rv0677c mmpS5 conserved small membrane protein MT0706.1 122.759925 98.0000449 132.487213 89.1432115 0.99203486 −0.011537277 6.79128314 0.973097519 Rv0678 Rv0678 hypothetical protein MT0707 80.6841949 94.8329151 97.6604436 100.539804 1.131718041 0.178514566 6.54861703 0.407497409 MT0708 97.5519708 96.6427036 116.483267 108.579866 1.158110315 0.211772683 6.71415167 0.267751697 MT0709 236.804832 154.917892 225.782944 191.400311 1.084379118 0.116869236 7.66103591 0.658487479 Rv0681 Rv0681 transcriptional regulator (TetR/AcrR family) MT0710 127.632838 162.338025 139.852665 188.746309 1.129299005 0.17542752 7.2745845 0.389992495 Rv0682 rpsL 30S ribosomal protein S12 MT0711 353.661035 374.083274 394.733693 425.967167 1.127392923 0.172990416 8.59728688 0.372493132 Rv0683 rpsG 30S ribosomal protein S7 MT0712 1416.89318 1408.73933 1576.47962 1695.82861 1.157334396 0.210805772 10.5742798 0.337732372 Rv0684 fusA elongation factor G MT0713 1458.59407 1448.28321 1545.10825 1676.07972 1.107240325 0.146968391 10.5813871 0.558568415 Rv0685 tuf elongation factor EF-Tu MT0714 155.183539 155.27985 153.856118 174.305421 1.055398442 0.077787759 7.32046705 0.775693751 Rv0686 Rv0686 potential membrane protein MT0715 68.2207826 80.1736286 59.1054826 72.6727933 0.886745598 −0.173407831 6.13384854 0.438894255 Rv0687 Rv0687 putative dehydrogenase, SDR family MT0716 143.750935 179.802483 126.485733 155.571296 0.872425402 −0.196896318 7.24394625 0.30379452 Rv0688 Rv0688 putative oxidoreductase MT0717.1 6.84082024 4.70544999 5.72868524 4.91770781 0.929684892 −0.105186284 2.51494037 0.857846065 MT0718 486.166786 401.501569 430.833503 393.572743 0.931992738 −0.101609382 8.7420973 0.675826015 Rv0690c Rv0690c hypothetical protein MT0719 241.865165 206.677842 183.499791 195.381312 0.847056872 −0.239469259 7.69366671 0.218180025 Rv0691c Rv0691c transcriptional regulator (TetR/AcrR family) MT0719.1 28.6752191 106.59654 20.4595902 41.761487 0.516728468 −0.952521726 5.63073654 1.21E−05 MT0719.2 167.553241 402.406463 138.034035 356.416728 0.855256156 −0.225571511 8.05694196 0.213777965 Rv0692 Rv0692 hypothetical protein MT0720 351.411999 750.519273 272.976398 707.83769 0.857091966 −0.222478081 9.024836 0.272558158 Rv0693 pqqE coenzyme pqq synthesis protein E MT0721 410.542924 816.395573 326.535059 717.985341 0.836862328 −0.25693779 9.14990456 0.143510225 Rv0694 lldD1 l-lactate dehydrogenase (cytochrome) MT0722 300.527541 371.821038 264.701631 388.889212 0.960513039 −0.058122896 8.37361815 0.839820353 Rv0695 Rv0695 conserved hypothetical protein MT0723 184.702146 223.056427 164.858831 227.619619 0.955222673 −0.066091014 7.64562231 0.808331268 Rv0696 Rv0696 glycosyltransferase MT0724 43.2002484 41.8966028 41.1919748 42.9323698 0.988931079 −0.016058116 5.4087664 0.966783763 Rv0697 Rv0697 gmc-type oxidoreductase MT0724.1 4.40436371 3.34810864 4.00098652 5.07382552 1.17827973 0.236682084 2.1345761 0.690972131 MT0725 6.55969054 5.06740768 4.91030164 4.6054724 0.823437314 −0.28028679 2.44698786 0.534991985 MT0726 4.77920318 3.71006634 2.54608233 3.20041302 0.68441347 −0.547059941 1.89816604 0.236664882 MT0726.1 4.49807358 4.3434923 4.00098652 3.59070729 0.857598453 −0.221625791 2.09679433 0.698006418 MT0727 1187.49143 1062.25534 1299.50224 1348.70088 1.178750866 0.237258831 10.2581766 0.275877367 Rv0700 rpsl 30S ribosomal protein S10 MT0728 2146.79933 1604.46796 2137.9817 1966.30254 1.104719361 0.143679919 10.9396242 0.612425659 Rv0701 rplC 50S ribosomal protein L3 MT0729 1420.9227 1096.09838 1491.09493 1211.55148 1.076974609 0.106984237 10.3499291 0.707679183 Rv0702 rplD 50S ribosomal protein L4 MT0730 745.930536 505.926363 731.089355 619.475067 1.095243422 0.13125155 9.3460155 0.617543876 Rv0703 rplW 50S ribosomal protein L23 MT0731 1896.59398 1177.08641 1891.28451 1447.91369 1.107416609 0.147198065 10.6469056 0.593366813 Rv0704 rplB 50S ribosomal protein L2 MT0732 971.771313 602.659556 936.412708 758.341769 1.100885772 0.138664783 9.67501126 0.620486305 MT0733 320.206613 213.012101 368.09076 287.022407 1.243922451 0.314896547 8.21555586 0.05143078 MT0734 907.486345 528.910676 968.147806 758.419827 1.236423013 0.306172412 9.6273719 0.140711849 Rv0707 rpsC 30S ribosomal protein S3 MT0735 272.602001 170.753541 302.438208 228.868561 1.218383997 0.284968898 7.92976157 0.094111123 Rv0708 rplP 50S ribosomal protein L16 MT0736 366.405577 204.958543 375.729007 270.005577 1.161045308 0.215424272 8.25001191 0.306913002 Rv0709 rpmC 50S ribosomal protein L29 MT0737 313.459503 240.249418 369.90939 290.613114 1.194691416 0.256638024 8.24664475 0.11377177 Rv0710 rpsQ 30S ribosomal protein S17 MT0738 325.548075 298.615095 264.792562 235.347445 0.800661891 −0.320734955 8.13565262 0.031366926 MT0739 92.0230837 107.139477 65.8344145 72.5166755 0.695506574 −0.523863943 6.40164043 8.28E−05 Rv0712 Rv0712 conserved hypothetical protein MT0740 102.143754 177.449758 109.754335 158.771709 0.977978728 −0.032125009 7.10034436 0.916845409 Rv0713 Rv0713 potential membrane protein MT0741 583.625047 442.855235 556.682715 488.49231 1.025612988 0.036486437 9.0170412 0.90313325 MT0741.1 427.4107 349.741619 429.196736 388.030564 1.055447469 0.077854776 8.63940404 0.764687847 Rv0715 rplX 50S ribosomal protein L24 MT0742 710.039657 526.015015 730.725629 648.747137 1.126474732 0.171814953 9.35326862 0.459370243 Rv0716 rplE 50S ribosomal protein L5 MT0742.1 249.830504 207.130289 278.068563 234.488798 1.122479879 0.166689584 7.92215227 0.400849834 Rv0717 rpsN 30S ribosomal protein S14 MT0743 749.49151 610.079689 750.457767 698.704804 1.07082297 0.098719992 9.45606146 0.723313141 Rv0718 rpsH 30S ribosomal protein S8 MT0744 561.978058 432.810909 597.329101 550.393981 1.162477826 0.217203197 9.0655614 0.277883875 Rv0719 rplF 50S ribosomal protein L6 MT0745 238.58532 206.134905 257.518041 225.355912 1.086259939 0.119369378 7.85842696 0.584969964 Rv0720 rplR 50S ribosomal protein L18 MT0746 604.990897 489.638267 636.97524 538.059682 1.075600003 0.105141665 9.14869771 0.664133224 Rv0721 rpsE 30S ribosomal protein S5 MT0747 241.021776 181.521782 245.515082 207.324317 1.078307308 0.108768392 7.77489404 0.641869092 Rv0722 rpmD 50S ribosomal protein L30 MT0748 1076.91378 815.762147 1069.44551 972.535264 1.088012297 0.121694863 9.94227568 0.656145138 Rv0723 rplO 50S ribosomal protein L15 MT0749 1268.55046 894.940392 1104.99973 861.067221 0.915422453 −0.127490417 10.0119969 0.620935457 Rv0724 sppA protease IV, signal peptide peptidase MT0751 277.287494 291.013984 296.618591 332.999072 1.106527465 0.14603926 8.2271996 0.492164878 Rv0726c Rv0726c conserved hypothetical protein MT0752 8.9024373 8.68698459 8.54756211 10.2257099 1.068371273 0.095413089 3.21307355 0.838597999 Rv0727c fucA L-fuculose phosphate aldolase MT0753 10.6829218 11.5826461 12.8213432 14.9873 1.248627938 0.320343651 3.66754606 0.234813722 Rv0728c Rv0728c similar to D-3-phosphoglycerate dehydrogenases MT0754 39.6392734 59.4515508 45.6476189 59.8711412 1.073457136 0.102264585 5.68206841 0.740705091 Rv0729 xylB xylulose kinase MT0755 201.757342 191.747087 200.86771 184.531131 0.978822679 −0.030880566 7.60657242 0.91003342 Rv0730 Rv0730 conserved hypothetical protein MT0756 23.9897258 36.376748 23.3693985 29.7404235 0.886784352 −0.173344782 4.83543274 0.530737399 Rv0731c Rv0731c conserved hypothetical protein MT0756.1 454.961401 780.109314 454.021038 822.428088 1.025932416 0.036935696 9.29480378 0.900323347 Rv0732 secY SecY subunit of preprotein translocase MT0757 251.236152 380.508023 226.510396 385.220445 0.956161644 −0.064673561 8.28106204 0.814508736 Rv0733 adk probable adenylate kinase MT0758 253.578838 315.08417 236.785657 350.17202 1.019568265 0.027958374 8.17540604 0.924552662 Rv0734 map* probable methionine aminopeptidase MT0759 55.5699507 50.9455451 50.0123315 50.5040787 0.944840394 −0.081857451 5.69852803 0.797430088 Rv0735 slgL sigma-70 factors ECF subfamily MT0760 27.5507007 32.304724 28.0069056 32.7847188 1.015664773 0.02242431 4.92333995 0.94941324 Rv0736 Rv0736 hypothetical protein MT0761 1.87419733 2.71468269 3.0916714 2.49788333 1.208902968 0.273698452 1.44451038 0.71643291 MT0762 17.1489055 18.3693528 19.550275 20.6855964 1.132703492 0.179770256 4.25706923 0.52349722 Rv0737 Rv0737 putative transcriptional regulator MT0763 164.648235 142.158883 186.136805 143.940527 1.070193176 0.097871235 7.31641689 0.706296887 Rv0738 Rv0738 possible membrane protein MT0764 35.7034591 33.8430441 45.1020298 35.8290141 1.157076989 0.210484861 5.24003247 0.395282082 Rv0739 Rv0739 conserved hypothetical protein MT0765 30.9242559 38.096047 32.3716182 42.6981932 1.085036902 0.117744109 5.1783784 0.689462082 Rv0740 Rv0740 conserved hypothetical protein MT0766 732.998574 308.8404 734.635684 347.518019 1.061273955 0.085797119 9.05296287 0.748063474 MT0767 69.7201405 78.7257979 84.0207169 84.3035625 1.135048333 0.182753732 6.31059281 0.38833378 Rv0741 Rv0741 truncated copy of IS1557 MT0768 17.6174549 20.4506096 22.8238095 20.7636552 1.143243831 0.193133134 4.36403477 0.511878715 Rv0742 PE_PGRS PE_PGRS-family protein MT0768.1 4.40436371 2.26223557 2.81887686 2.88817761 0.881839234 −0.181412429 1.7059982 0.808331268 MT0769 31.6739348 26.1514432 33.3718648 27.6328344 1.055076779 0.077347989 4.90100534 0.812642214 Rv0743c Rv0743c hypothetical protein MT0770 48.2605811 35.8338114 44.9201668 35.9851318 0.965939477 −0.049995298 5.37208902 0.880856541 Rv0744c Rv0744c putative transcriptional regulator MT0772.1 72.2503059 94.380468 75.0184972 85.0841511 0.965817434 −0.050177589 6.35514942 0.871424661 MT0772.2 1.68677759 3.9815346 1.72769872 1.95147136 0.65931719 −0.600955399 1.3273574 0.318868558 MT0772.5 209.628971 168.943752 236.330999 144.877233 0.984354928 −0.022749494 7.57064571 0.946497216 Rv0747 PE_PGRS PE_PGRS-family protein MT0772.6 32.236294 39.815346 39.8280022 41.3711927 1.130024685 0.176354288 5.26661624 0.500027581 MT0773 52.6649448 72.4820277 63.9248528 83.522974 1.18147901 0.240593999 6.09469477 0.224922789 Rv0749 Rv0749 conserved hypothetical protein MT0773.1 25.957633 25.3370384 25.0061657 19.9050078 0.870559879 −0.199984562 4.59788412 0.470163095 MT0774 2475.62725 1077.27658 2365.49235 1173.77099 1.020179868 0.028823537 10.7921304 0.93032752 Rv0750 Rv0750 conserved hypothetical protein MT0775 110.483932 97.9095555 112.300417 76.3415594 0.891401387 −0.165852889 6.63544055 0.503200664 Rv0751c mmsB methylmalmonate semialdehyde oxidoreductase MT0776 122.385035 76.82552 118.756554 61.8226125 0.886526101 −0.173764988 6.57132382 0.438953559 Rv0752c fadE9 acyl-CoA dehydrogenase MT0777 245.33243 139.625179 244.605767 113.263397 0.901339929 −0.149856792 7.53801436 0.526487392 Rv0753c mmsA methylmalmonate semialdehyde dehydrogenase MT0778 96.6148721 53.931696 111.754828 40.1222511 0.936388313 −0.094821167 6.2431301 0.801831984 Rv0754 PE_PGRS PE_PGRS-family protein MT0779 82.3709725 107.048987 82.1111551 100.773981 0.967992554 −0.046932145 6.54317194 0.877295001 Rv0755c PPE PPE-family protein MT0780 102.893433 105.420178 105.935211 100.14951 0.988766037 −0.016298906 6.69729117 0.957093799 MT0781 348.975542 263.505199 301.074235 196.786371 0.803096043 −0.316355564 8.11798426 0.047051878 MT0782 336.51213 295.990902 313.168127 363.754261 1.069676534 0.097174597 8.35552054 0.741632985 Rv0757 phoP two-component response regulator MT0783 249.268244 220.341745 246.788123 263.916986 1.089121732 0.123165214 7.93816138 0.611538154 Rv0758 phoR sensor histidine kinase MT0784 72.3440158 98.6334709 62.197154 85.3183276 0.862487682 −0.213424242 6.3184104 0.266739001 Rv0759c Rv0759c conserved hypothetical protein MT0785 63.9101288 107.682413 58.3780306 96.7149203 0.905340083 −0.143468265 6.35512698 0.521875569 Rv0760c Rv0760c conserved hypothetical protein MT0786 170.364537 295.086008 158.038967 278.123698 0.935245534 −0.096582924 7.81760984 0.687906803 Rv0761c adhB zinc-containing alcohol dehydrogenase MT0787 30.4557055 29.2280836 23.6421931 27.7889521 0.861468428 −0.215130171 4.80494753 0.418561222 Rv0762c Rv0762c hypothetical protein MT0787.1 7.2156597 12.3065615 8.91128815 12.8797109 1.122104207 0.166206661 3.39525016 0.673053573 MT0788 62.4107709 61.0803604 48.1937012 55.4998453 0.838787642 −0.253622488 5.83211198 0.227492631 Rv0764c Rv0764c possible lanosterol 14-demethylase cytochrome P450 MT0789 33.3607124 29.318573 23.7331246 26.8522458 0.80887892 −0.306004331 4.83220644 0.193163968 Rv0765c Rv0765c short-chain alcohol dehydrogenase family MT0790 71.2194934 67.7765777 55.8319482 61.3542594 0.843123473 −0.24618417 6.0048888 0.236664882 Rv0766c Rv0766c cytochrome p-450 MT0791 27.2695711 24.7036124 20.7323847 21.2320083 0.809077712 −0.305649815 4.56391498 0.161479621 Rv0767c Rv0767c hypothetical protein MT0792 48.354291 66.5097258 44.3745777 59.8711412 0.908519959 −0.138409885 5.78033481 0.592526502 Rv0768 aldA aldehyde dehydrogenases MT0793 27.6444106 33.8430441 21.8235628 27.3986578 0.800110603 −0.321728651 4.79975984 0.114693413 Rv0769 Rv0769 similar to 7-alpha-hydroxysteroid dehydrogenase MT0794 13.306801 24.613123 14.4581104 21.5442438 0.960869421 −0.057587708 4.22266089 0.885389982 Rv0770 Rv0770 similar to 3-hydroxyisobutyrate dehydrogenase MT0795 10.9640544 21.8079509 10.6389869 16.6265359 0.843071899 −0.246272423 3.92556639 0.407497409 Rv0771 Rv0771 probable 4-carboxymuconolactone decarboxylase MT0796 95.2092241 116.731355 73.9273191 108.814043 0.852895972 −0.229558309 6.62722057 0.247788027 Rv0772 purD phosphoribosylamine-glycine ligase MT0797 110.952482 144.330629 121.120774 158.303356 1.09426946 0.12996804 7.06465297 0.564270992 Rv0773c ggtA putative [gamma]-glutamyl transpeptidase MT0798 133.817689 170.210604 132.396281 167.280125 0.986019537 −0.020311863 7.2394606 0.944598499 Rv0774c Rv0774c conserved hypothetical protein MT0799 207.379934 152.927125 215.96234 150.185236 1.011596697 0.016634231 7.50601774 0.95527257 Rv0775 Rv0775 conserved hypothetical protein MT0800 12.1822826 21.8984403 13.5487953 17.0948891 0.914267683 −0.12931147 4.03243632 0.742345018 Rv0776c Rv0776c conserved hypothetical protein MT0801 237.92935 228.576282 226.874122 228.634384 0.976679629 −0.034042688 7.84973774 0.90313325 Rv0777 purB adenylosuccinate lyase MT0802 149.279817 171.658435 140.216391 168.29489 0.959884075 −0.059067913 7.29960512 0.830576393 Rv0778 Rv0778 similar linalool 8-monooxygenase, cytochrome p-450 MT0803 8.0590485 9.86334709 6.54706885 8.58647396 0.844258486 −0.244243319 3.07764805 0.511878715 Rv0779c Rv0779c conserved hypothetical protein MT0804 78.7162877 95.3758517 68.8351544 99.056686 0.955444091 −0.06575664 6.42093699 0.819552181 MT0805 257.608422 325.038007 230.784177 292.642644 0.898125298 −0.155011364 8.11217351 0.459756536 Rv0781 ptrBb protease II, [beta] subunit MT0806 14.0564799 15.1117336 12.7304117 14.5970057 0.937039138 −0.093818787 3.83811631 0.802899283 MT0807 157.526235 183.964997 139.398008 164.15777 0.888670551 −0.170279415 7.33484697 0.403024333 Rv0783c Rv0783c multidrug resistance protein MT0808 142.907546 79.7211815 147.854638 89.9238 1.078752268 0.109363593 6.84874346 0.637012172 Rv0784 Rv0784 conserved hypothetical protein MT0809 77.3106337 91.3943171 84.0207169 93.5925662 1.054343068 0.076344375 6.43899 0.783069965 Rv0785 Rv0785 putative dehydrogenases MT0810 33.0795828 44.7922643 29.3708783 35.7509552 0.839514845 −0.252372258 5.16694144 0.255022855 Rv0786c Rv0786c conserved hypothetical protein MT0811 15.1809933 29.4995518 15.9130146 28.0231287 0.990095027 −0.014361096 4.48222202 0.973097519 Rv0787 Rv0787 hypothetical protein MT0812 140.47109 146.683354 112.118554 124.347755 0.822835495 −0.281324065 7.03426999 0.084096184 MT0813 178.142456 178.354652 166.222804 166.109242 0.932215861 −0.101264036 7.42945096 0.67738269 Rv0788 purQ phosphoribosylformylglycinamidine synthase I MT0814 51.2592969 79.8116709 37.9184404 43.1665464 0.629299989 −0.668180177 5.73347931 8.86E−05 Rv0789c Rv0789c hypothetical protein MT0815 47.9794515 66.0572787 50.9216466 60.7297886 0.985245932 −0.021444207 5.82285399 0.94941324 Rv0790c Rv0790c hypothetical protein MT0816 67.3773938 88.7701238 70.0172641 79.3858547 0.962164254 −0.055644893 6.25866498 0.858854075 MT0817 133.536559 185.684296 139.034282 154.868767 0.930502703 −0.103917753 7.26171428 0.709433693 MT0818 6.74711037 8.41551632 6.1833428 8.66453282 0.978260673 −0.031709149 2.94254678 0.950936475 MT0819 113.763778 119.898485 101.388636 126.143108 0.969486096 −0.044707887 6.85150416 0.880856541 Rv0798c Rv0798c similar to bacteriocins MT0820 167.084692 166.22907 149.036748 166.031183 0.944241018 −0.082772939 7.34227252 0.759681853 Rv0799c Rv0799c conserved hypothetical protein MT0821 74.4993437 90.308444 63.5611267 75.6390297 0.845149075 −0.242722256 6.25130323 0.19179714 Rv0800 pepC aminopeptidase I MT0822 23.0526271 32.7571711 18.2772339 27.0864224 0.811359342 −0.301587086 4.67101371 0.167258959 Rv0802c Rv0802c acetyltransferase MT0823 287.689289 378.245787 257.881767 364.378731 0.929592755 −0.10532927 8.3319683 0.658932265 Rv0803 purL phosphoribosylformylglycinamidine synthase II MT0824 41.9820201 62.3472123 44.2836462 57.841611 0.986289 −0.019917652 5.69487318 0.953339877 Rv0804 Rv0804 conserved hypothetical protein MT0825 630.76111 889.872984 643.340446 859.349926 0.992348176 −0.011081701 9.56227684 0.973114765 Rv0805 Rv0805 conserved hypothetical protein MT0826 113.670068 147.859717 109.299677 123.645225 0.895593246 −0.159084447 6.95181943 0.456226727 Rv0806c cpsY probable UDP-glucose-4-epimerase MT0828 26.3324724 29.2280836 26.824796 21.0758906 0.856615939 −0.223279574 4.70209739 0.461423825 Rv0807 Rv0807 conserved hypothetical protein MT0829 732.155135 521.128586 689.988311 507.928964 0.958357879 −0.061363594 9.25965323 0.8246528 Rv0808 purf amidophosphoribosyltransferase MT0830 282.535247 296.171881 264.610699 278.982345 0.939269053 −0.090389618 8.13314383 0.720045953 Rv0809 purM 5′-phosphoribosyl-5-aminoimidazole synthase MT0831 414.291319 310.831167 376.638322 303.570884 0.942146961 −0.085975978 8.45736886 0.729397047 Rv0810c Rv0810c hypothetical protein MT0832 244.770171 175.820949 203.777518 156.820238 0.861480233 −0.215110401 7.61070442 0.233300069 Rv0811c Rv0811c conserved hypothetical protein MT0833 102.237454 67.9575565 86.1121416 83.4449151 1.015428597 0.022088796 6.4112465 0.952431559 MT0834 112.639259 149.036079 128.940884 155.961591 1.093605327 0.129092176 7.09625862 0.577977324 Rv0813c Rv0813c conserved hypothetical protein MT0835 22.6777876 44.0683489 36.0088787 43.4787818 1.236293844 0.306021686 5.19971821 0.292971938 MT0836 193.510874 306.125717 226.874122 276.094167 1.026796322 0.038150033 7.97060608 0.90313325 Rv0814c sseC2 thiosulfate sulfurtransferase MT0837 697.482535 866.526713 723.087382 823.833147 0.992689875 −0.010585017 9.60346568 0.974136607 Rv0815c cysA2 thiosulfate sulfurtransferase MT0838 7.96533853 13.2114557 11.8210965 17.2510068 1.378322509 0.462913499 3.67393645 0.046537529 Rv0816c thiX equivalent to M. leprae ThiX MT0839 24.6456948 28.3231893 22.3691519 26.3058339 0.918684311 −0.122358904 4.67747461 0.692019534 Rv0817c Rv0817c probable exported protein MT0840 436.032008 276.445187 433.743311 277.655344 0.999510468 −0.000706418 8.47624743 0.999286081 Rv0818 Rv0818 two-component response regulator MT0841 217.03205 151.750762 212.961601 158.06918 1.010690027 0.015340599 7.53229357 0.959849725 Rv0819 Rv0819 conserved hypothetical protein MT0842 138.503182 93.1136161 126.031075 98.6663917 0.980789453 −0.02798463 6.83595376 0.923419401 Rv0820 phoT phosphate transport system ABC transporter MT0843 512.686678 350.375045 260.245987 216.144967 0.559413668 −0.838012591 8.38805531 2.66E−11 Rv0821c phoY2 phosphate transport system regulator MT0844 1075.60185 591.438868 1153.28436 562.257927 1.009891422 0.014200191 9.72416457 0.969278389 Rv0822c Rv0822c conserved hypothetical protein MT0845 2370.29736 1460.77075 2731.40075 1460.48116 1.073471108 0.102283362 10.9700282 0.738873933 Rv0823c Rv0823c transcriptional regulator (NifR3/Smm1 family) MT0846 4642.38678 3106.4114 4742.71486 3061.7805 1.003469007 0.004996059 11.9249909 0.988617034 Rv0824c desA1 acyl-[ACP] desaturase MT0847 26.613602 33.1191288 24.9152342 34.267837 0.987322799 −0.018406253 4.90282162 0.960434627 Rv0825c Rv0825c conserved hypothetical protein MT0848 779.010118 628.358552 709.902312 737.656172 1.034303472 0.048659545 9.47959409 0.886067917 Rv0826 Rv0826 conserved hypothetical protein MT0849 21.0847199 9.77285767 21.9144943 10.147651 1.038915178 0.05507787 3.9891549 0.89125591 Rv0827c Rv0827c transcriptional regulator (ArsR family) MT0850 1.40564799 1.9907673 1.63676721 2.26370677 1.147412207 0.198383772 1.00669558 0.819552181 Rv0829 Rv0829 probable transposase fragment, highly similarsim MT0851 105.32989 90.2179546 131.941624 130.202169 1.344427563 0.426992026 6.84056317 0.002043666 Rv0830 Rv0830 conserved hypothetical protein MT0852 572.005024 553.885757 679.440256 762.32277 1.278710718 0.354689921 9.32665908 0.027353454 Rv0831c Rv0831c conserved hypothetical protein MT0854 61.4736723 52.212397 67.7439763 55.3437276 1.080974439 0.112332409 5.89152362 0.679870362 Rv0832 PE_PGRS PE_PGRS-family protein MT0854.1 52.3838152 46.6925422 72.7452094 66.7403203 1.408740767 0.494406155 5.90267089 0.000960844 MT0855 583.625047 397.701013 690.988558 325.037069 0.984598467 −0.022392601 8.96430702 0.950820746 Rv0834c PE_PGRS PE_PGRS-family protein MT0856 56.1322099 61.6232969 90.9315118 98.3541563 1.607650322 0.684953642 6.26597823 9.33E−08 Rv0835 lpqQ lipoprotein MT0856.1 12.2759925 15.7451596 11.730165 15.1434177 0.958991919 −0.060409436 3.79772133 0.881775651 MT0857 7.68420933 7.96306921 5.72868524 5.93247292 0.745601033 −0.423524236 2.80633941 0.192254636 Rv0836c Rv0836c hypothetical protein MT0858 11.0577612 12.849498 10.7299184 14.2847703 1.044663234 0.063037938 3.63422676 0.885389982 Rv0837c Rv0837c hypothetical protein MT0860 65.9717459 48.9547778 61.1969074 52.0652557 0.992247435 −0.011228167 5.83832174 0.974136607 Rv0838 lpqR lipoprotein MT0861 265.854891 124.875404 301.983551 116.776046 1.033547595 0.047604826 7.66189185 0.87947654 Rv0839 Rv0839 conserved hypothetical protein MT0862 29.7060276 19.5457153 26.6429329 20.5294787 0.966769633 −0.048755938 4.60107177 0.894346121 MT0864 21.9281087 28.3231893 21.8235628 21.7003615 0.868690105 −0.20308649 4.5617113 0.477357404 Rv0842 Rv0842 Unknown integral membrane protein MT0865 11.3388938 15.3832019 11.730165 14.0505938 0.966471142 −0.04920144 3.73415285 0.903351005 Rv0843 Rv0843 similar to various dehydrogenases MT0866 116.481354 88.2271873 116.574198 112.638927 1.129681522 0.175916108 6.7636387 0.444930734 Rv0844c narL two-component response regulator MT0867 42.4505694 55.3795268 45.1929613 65.1791433 1.121846041 0.165874698 5.70720797 0.51545697 Rv0845 Rv0845 sensor histidine kinase MT0868 2.71758612 7.32964325 1.90956175 5.07382552 0.696151248 −0.52252731 2.15265643 0.20900061 MT0869 37.2028169 110.216117 44.9201668 88.9090349 0.973456729 −0.038811243 6.13979443 0.920168489 Rv0846c Rv0846c similar to several L-ascorbate oxidases MT0870 66.2528755 197.53841 88.2944979 166.499536 1.051062827 0.071848908 7.02067839 0.852815959 Rv0847 lpqS lipoprotein MT0873 3.09242559 11.8541144 6.27427431 12.0210636 1.307791495 0.387132546 3.09041973 0.347475973 Rv0850 Rv0850 transposase fragment MT0874 26.2387626 35.2003855 22.5510149 23.1011875 0.826404974 −0.275079158 4.81762602 0.218180025 Rv0851c Rv0851c Short-chain dehydrogenases/reductase MT0875 27.2695711 41.8966028 25.2789603 37.1560146 0.905020498 −0.143977626 5.04817858 0.597944258 Rv0852 fad016 acyl-CoA synthase MT0876 94.5532551 163.242919 101.66143 127.470109 0.912869943 −0.131518762 6.9297244 0.628146178 Rv0853c pdc pyruvate (or Indolepyruvate) decarboxylase MT0877 42.07573 62.70917 47.6481122 57.3732578 1.013679013 0.019600888 5.71798214 0.956900362 Rv0854 Rv0854 conserved hypothetical protein MT0878 60.3491539 82.5263536 62.4699486 71.1116162 0.942083381 −0.086073341 6.11465624 0.777753655 Rv0855 far fatty acyl-CoA racemase MT0879 81.4338738 94.380468 113.300664 119.351988 1.32551372 0.406551603 6.67674253 0.005001266 Rv0856 Rv0856 conserved hypothetical protein MT0880 71.3132082 57.8227412 66.8346611 66.7403203 1.039861549 0.056391455 6.04117767 0.870054573 Rv0857 Rv0857 conserved hypothetical protein MT0881 36.453138 58.7276354 34.644906 55.0314922 0.943244406 −0.084296456 5.53621396 0.790412569 Rv0858c Rv0858c possible aminotransferase MT0882 579.314393 918.467642 753.09478 934.67672 1.149729886 0.201294959 9.63767378 0.402279637 Rv0859 fadA [beta] oxidation complex, subunit (acetyl-CoA MT0883 733.092284 1256.89808 998.791725 1337.30429 1.203594623 0.267349567 10.0791073 0.22614993 Rv0860 fadB hypothetical protein MT0884 195.385071 156.72768 182.86327 159.552298 0.975949381 −0.035121773 7.44128948 0.90313325 Rv0861c Rv0861c probable DNA helicase MT0885 152.559662 127.228129 131.577898 125.986991 0.924091357 −0.11389261 7.07154721 0.641879751 Rv0861c Rv0862c conserved hypothetical protein MT0886 230.526271 161.885577 211.324833 165.953124 0.968962922 −0.045486634 7.58936089 0.879854448 Rv0863 Rv0863 conserved hypothetical protein MT0887 651.5647 373.268869 599.875183 389.747859 0.980088707 −0.029015762 8.97662297 0.921284174 MT0888 160.99355 76.9160094 129.759267 72.1263813 0.866708435 −0.20638135 6.78261426 0.286557916 Rv0865 mog molybdopterin biosynthesis MT0889 84.9011338 43.7968807 74.4729081 47.7720188 0.973658724 −0.038511912 5.97478382 0.905696211 MT0890 352.255337 753.776892 500.850767 768.723596 1.202817347 0.266429574 9.2145675 0.230822487 Rv0867c Rv0867c probable exported protein MT0891 30.3619957 45.154222 35.4632896 37.0779557 0.973239769 −0.039132822 5.21695876 0.921052928 Rv0868c moaD2 molybdopterin converting factor subunit 1 MT0892 347.663634 262.962263 386.73172 257.672278 1.044423577 0.062706931 8.2941511 0.819552181 Rv0869c moaA2 molybdenum cofactor biosynthesis, protein A MT0892.1 191.917806 167.948369 193.68412 176.178834 1.028889603 0.041088193 7.51258129 0.887972618 Rv0870c Rv0870c unknown hydrophobic protein MT0893 156.870316 178.8071 171.951489 192.80537 1.087086996 0.120467399 7.4536174 0.606500069 Rv0871 cspB probable cold shock protein MT0894 472.766275 317.074938 620.425705 284.836759 1.087044653 0.120411204 8.7276765 0.698155929 Rv0872c PE_PGRS PE_PGRS-family protein MT0896 327.609693 405.664083 341.447827 399.114922 1.01244662 0.017845845 8.52607582 0.950509824 Rv0873 fadE10 acyl-CoA dehydrogenase MT0897 75.5301522 80.7165652 75.9278123 75.3267943 0.968176438 −0.04665811 6.2677247 0.879854448 MT0898 112.17071 70.8532181 96.1146079 77.5905011 0.966651962 −0.048931546 6.48132783 0.880856541 Rv0875c Rv0875c possible exported protein MT0899 436.687977 37.992785 413.283721 349.937843 0.941036815 −0.08767693 8.62074194 0.726511707 Rv0876c Rv0876c possible membrane protein MT0900 222.279803 245.045357 220.599848 220.204028 0.944137593 −0.08293097 7.82785984 0.745155862 Rv0877 Rv0877 conserved hypothetical protein MT0901 19.3979423 14.3878182 23.9149876 20.7636552 1.330158565 0.411598236 4.30705371 0.046135845 Rv0878c PPE PPE-family protein MT0902 124.634122 109.944649 135.94261 121.303459 1.096982948 0.1335411 6.94404558 0.52349722 Rv0879c Rv0879c hypothetical protein MT0904 27.0821514 41.082198 29.3708783 42.1517813 1.052636348 0.074007118 5.13395084 0.819551181 Rv0881 Rv0881 possible rRNA methyltransferase MT0905 16.0243871 23.5272499 17.0951242 21.3881261 0.977755806 −0.032453897 4.29959268 0.930747689 Rv0882 Rv0882 unknown hydrophobic protein MT0906 185.732955 464.482207 254.244507 501.137844 1.212441127 0.277914696 8.45783009 0.119963819 Rv0883c Rv0883c conserved hypothetical protein MT0907 189.856139 232.01488 162.858338 203.265256 0.867019326 −0.205863943 7.62334907 0.250978723 Rv0884c serC phosphoserine aminotransferase MT0908 89.024373 414.713025 86.2030732 281.402169 0.8036181 −0.315418036 7.76844922 0.116754925 Rv0885 Rv0885 unknown transmembrane protein MT0909 47.3234825 171.477456 47.9209067 121.069283 0.834233107 −0.261477527 6.60210937 0.266833027 Rv0886 fprB ferredoxin, ferredoxin-NADP reductase MT0910 20.2413311 33.2096182 17.3679188 30.5990703 0.893133612 −0.163052077 4.67501591 0.562810186 Rv0887c Rv0887c hypothetical protein MT0910.3 3.09242559 1.53832019 3.54632896 4.44935469 1.762455095 0.8175865 1.74354106 0.084604125 MT0910.4 4.02952425 5.79132306 3.18260291 4.21517813 0.75412422 −0.407125909 2.16366988 0.365331314 MT0911 130.631554 209.211546 176.952722 230.27362 1.218884861 0.285561852 7.54660313 0.114693413 Rv0888 Rv0888 possible membrane protein MT0912 323.767598 194.642749 252.880534 166.187301 0.816160325 −0.293075515 7.87357305 0.058267085 Rv0889c citA citrate synthase 2 MT0914 139.319615 189.484851 101.02491 165.016418 0.826076713 −0.275652333 7.19374719 0.104390741 Rv0890c Rv0890c transcriptional regulator (LuxR/UhpA family) MT0915 98.3016497 147.950206 76.1096753 117.946929 0.786123184 −0.347172698 6.78475936 0.015311052 Rv0891c Rv0891c putative transcriptional regulator MT0915.1 7.02823997 10.7682413 6.45613734 7.25947344 0.773805284 −0.369957515 3.00924598 0.276259849 MT0916 109.171994 161.252152 66.5618666 110.765514 0.648778798 −0.624201421 6.80882493 6.29E−07 Rv0892 Rv0892 putative monooxygenase MT0917 24.2708554 19.7266942 21.6416998 22.2467734 1.002739517 0.003946884 4.4690014 0.993327109 Rv0893c Rv0893c conserved hypothetical protein MT0918 5.15404284 5.88181248 4.91030164 5.46411979 0.940011321 −0.089249963 2.46722911 0.880578033 Rv0894 Rv0894 putative transcriptional regulator MT0919 11.7137333 13.3924346 11.2755075 17.0168302 1.119640809 0.163035977 3.75940904 0.651061634 Rv0895 Rv0895 conserved hypothetical protein MT0920 1375.00437 1171.2046 1293.50076 1278.60403 1.013404785 0.019210546 10.3216492 0.95527257 Rv0896 gltA2 citrate synthase 1 MT0921 178.798425 169.124731 168.677954 154.556531 0.928501476 −0.107023892 7.39196661 0.651061634 Rv0897c Rv0897c possible oxidoreductase MT0921.1 152.372243 122.613168 126.30387 117.400517 0.890714509 −0.166965 7.02058654 0.438943559 Rv0898c Rv0898c hypothetical protein MT0922 79.4659656 86.7793565 71.1084422 71.4238516 0.857745216 −0.221378921 6.27361381 0.250978723 Rv0899 ompA member of OmpA family MT0923 22.2092333 20.0886519 19.550275 19.2024781 0.917648558 −0.12398636 4.3529025 0.700160804 Rv0900 Rv0900 hypothetical protein MT0924 60.255444 72.9344748 62.197154 68.6917917 0.984956772 −0.021867686 6.04874484 0.946497216 Rv0901 Rv0901 conserved hypothetical protein MT0925 387.396537 324.676049 368.909143 323.866186 0.974596014 −0.037123773 8.45689237 0.894346121 Rv0902c Rv0902c sensor histidine kinase MT0926 324.048718 235.724947 291.890153 230.585855 0.938478637 −0.09160419 8.08068737 0.723313141 Rv0903c Rv0903c two-component response regulator MT0927 35.3286196 50.0406508 39.1005501 45.1180177 0.994768915 −0.007566668 5.41207697 0.983253476 Rv0904c accD3 acetyt/propionyl CoA carboxylase [beta] subunit MT0928 349.537801 230.838518 289.707797 222.467734 0.89330298 −0.162778521 8.09432853 0.459620011 Rv0905 echA6 enoyl-CoA hydratase/isomerase superfamily (aka MT0929 264.917792 192.380513 219.781464 183.828602 0.890017352 −0.168094631 7.75080748 0.415865749 Rv0906 Rv0906 probable membrane protein MT0930 134.192529 132.928962 115.846746 130.670522 0.921730759 −0.1175827 7.00658698 0.620486305 Rv0907 Rv0907 probable penicillin binding protein MT0931 179.173264 179.621504 150.127926 186.716779 0.934033467 −0.098453852 7.44368838 0.727349312 MT0932 2.62387626 2.89566153 2.90980838 2.88817761 1.048693473 0.068593048 1.58809161 0.929988815 MT0933 88.1809842 79.178245 65.379757 74.7803823 0.837722116 −0.255456334 6.26775827 0.219545748 Rv0909 Rv0909 hypothetical protein MT0934 226.777876 172.382351 195.593682 196.474136 0.991268738 −0.012651862 7.62921033 0.973097519 Rv0910 Rv0910 conserved hypothetical protein MT0934.1 80.3093554 75.5586681 73.0180039 77.2782657 0.964769478 −0.051743829 6.26146811 0.869506445 Rv0911 Rv0911 conserved hypothetical protein MT0936 29.7060276 31.8522768 28.6434262 35.7509552 1.043284843 0.061133104 4.98517572 0.865029216 Rv0912 Rv0912 conserved hypothetical protein MT0937 17.8985845 36.376748 19.2774805 40.2783688 1.094348343 0.130072037 4.84116745 0.658345643 MT0938 54.1643027 82.616843 48.0118382 85.5525042 0.962186631 −0.055611341 6.08282754 0.867153389 Rv0913c Rv0913c probable dioxygenase MT0939 121.729116 90.4894228 107.117321 87.8942698 0.924015611 −0.114010869 6.67202436 0.637012172 Rv0914c Rv0914c lipid transfer protein MT0940 19.2105226 18.6408211 25.0970972 18.5780073 1.143154017 0.193019791 4.36125088 0.519306729 Rv0915c PPE PPE-family protein MT0941 23.2400458 12.1255827 26.4610699 14.7531234 1.171842082 0.228778165 4.27080772 0.393053826 Rv0916c PE PE-family protein MT0942 70.1886898 73.0249642 64.8341679 74.3120292 0.970329679 −0.043453095 6.14504777 0.890642379 Rv0917 betP glycine betaine transport MT0943 5.81001171 4.97691826 5.09216466 4.76159011 0.915641515 −0.127145219 2.41437446 0.819552181 MT0944 40.3889524 27.3278057 33.0081388 27.5547755 0.905004651 −0.144002888 5.01048166 0.624685486 Rv0918 Rv0918 conserved hypothetical protein MT0945 30.2682868 24.1606759 30.0073989 27.9450698 1.069886223 0.097457381 4.82117154 0.766178094 Rv0919 Rv0919 conserved hypothetical protein MT0946 13.8690602 11.4921567 13.5487953 17.3290656 1.218898995 0.285578581 3.83274301 0.384917628 MT0947 86.9627559 120.984358 77.2008535 103.037688 0.868961015 −0.202636641 6.60329897 0.296307581 Rv0920c Rv0920c probable transposase, related to IS1081 MT0948 47.6983219 39.1819201 39.8280022 34.814249 0.86111105 −0.215728794 5.34146499 0.335715426 Rv0921 Rv0921 resolvase MT0949 1089.28349 861.278326 948.870325 834.683328 0.918773842 −0.122218312 9.86680749 0.637012172 Rv0922 Rv0922 transposase MT0950 46.1052542 70.5817498 55.1954276 70.643263 1.090502334 0.124992858 5.92649756 0.647677438 Rv0923c Rv0923c hypothetical protein MT0951 50.2284833 102.705495 58.4689621 90.0799177 1.003161212 0.004553472 6.23962622 0.989612622 Rv0924c nramp transmembrane protein belonging to Nramp family MT0952 133.630259 246.583677 134.033048 227.463501 0.960763889 −0.057746167 7.53622602 0.839018102 Rv0925c Rv0925c hypothetical protein MT0953 112.35813 113.021289 104.934965 98.0419209 0.899943328 −0.152093942 6.74495283 0.476182576 Rv0926c Rv0926c conserved hypothetical protein MT0954 63.1604499 78.0923719 66.3800036 68.9259683 0.961529039 −0.056597666 6.11512963 0.864827105 Rv0927c Rv0927c short-chain alcohol dehydrogenase family MT0955 505.752148 328.838563 515.49074 356.104493 1.050410682 0.070953493 8.73710666 0.789993914 MT0956 157.151446 100.171791 162.858338 112.092515 1.076070584 0.105772713 7.05778769 0.661033931 Rv0929 pstC2 membrane-bound component of phosphate transport MT0957 160.431291 115.464504 157.038721 132.778111 1.060255696 0.084412234 7.14565389 0.762482462 Rv0930 pstA1 PstA component of phosphate uptake MT0958 2474.40902 1500.13365 2126.79713 1494.43676 0.925269844 −0.112053923 10.8911008 0.706925211 Rv0931c pknD serine-threonine protein kinase MT0959 2507.95715 1523.20845 2145.98368 1556.18132 0.934906009 −0.097106765 10.916992 0.757678733 Rv0932c pstS PstS component of phosphate uptake MT0960 128.851066 207.311268 128.668089 199.674549 0.980246741 −0.028783155 7.3778037 0.920168489 Rv0933 pstB ABC transport component or phosphate uptake MT0961 142.626417 276.626166 151.855625 257.750337 0.994246245 −0.008324886 7.69634756 0.977523735 Rv0934 phoS1 PstS component of phosphate uptake MT0962 131.568652 188.398978 121.757294 197.56696 0.986609351 −0.019449134 7.32207656 0.949144778 Rv0935 pstC PstC component of phosphate uptake MT0963 53.5083336 82.3453748 52.1946878 89.0651526 1.030051557 0.04271655 6.11843152 0.894346121 Rv0936 pstA2 PstA component of phosphate uptake MT0964 83.9640402 89.4035498 87.1123883 79.229737 0.958397896 −0.061303354 6.41107272 0.832160187 Rv0937c Rv0937c conserved hypothetical protein MT0965 333.888254 251.832064 305.711743 252.208158 0.957422072 −0.062773029 8.16025236 0.81765154 Rv0938 Rv0938 conserved hypothetical protein MT0966 422.631497 303.320545 375.456212 287.022407 0.916723644 −0.125441211 8.43990934 0.559675434 Rv0939 Rv0939 probable dehydrase MT0967 91.5545393 92.8421478 88.3854294 86.176975 0.946488262 −0.07934348 6.49045369 0.766178094 Rv0940c Rv0940c probable monooxygenase MT0968 45.4492851 64.0665114 47.9209067 57.2171401 0.967449378 −0.047741921 5.75076008 0.89069148 MT0968.1 29.0500585 30.1329778 28.0978371 33.0969542 1.032795109 0.046554073 4.92013445 0.895506652 MT0969 5.81001171 5.06740768 4.6375071 3.51264844 0.746386278 −0.422005631 2.29816118 0.306839725 Rv0943e Rv0943c probable monooxygenase MT0970 24.6456948 27.2373163 22.0963574 17.7974188 0.764821405 −0.386805194 4.5301913 0.086583543 Rv0944 Rv0944 possible formamidopyrimidine-DNA glycosylase MT0971 98.2079398 92.1182324 91.2043063 87.7381521 0.940540146 −0.08843857 6.53120722 0.738873933 Rv0945 Rv0945 ketoacyl reductase MT0972 131.381233 120.169954 114.391842 119.273929 0.929893394 −0.104862764 6.92454754 0.661238202 Rv0946c pgi glucose-6-phosphate isomerase MT0973 4.68549331 3.71006634 4.72843861 5.69829636 1.248635458 0.32035234 2.2900752 0.513096782 MT0974 16.118097 19.2742471 22.4600834 26.5400104 1.384448575 0.469311466 4.41223315 0.008998862 MT0975 203.44412 277.983507 240.377575 333.545484 1.192000916 0.253385345 8.04525955 0.126661694 Rv0948c Rv0948c hypothetical protein MT0976 209.441551 189.213383 193.229463 176.647187 0.928077618 −0.107682627 7.58723089 0.64618144 Rv0949 uvrD DNA-dependent ATPase I and helicase II MT0977 208.035903 447.560685 191.228969 382.098091 0.885123808 −0.176048826 8.2641027 0.380784281 Rv0950c Rv0950c conserved hypothetical protein MT0978 482.605811 560.039038 397.552569 549.06598 0.899048786 −0.153528691 8.95854907 0.500027581 Rv0951 sucC succinyl-CoA synthase [beta] chain MT0979 360.408146 422.947562 317.350976 434.319465 0.951377774 −0.071909773 8.58474313 0.795353177 Rv0952 sucD succinyl-CoA synthase [alpha] chain MT0980 14.8061559 25.6989961 14.3671789 22.4028912 0.912939052 −0.131409546 4.28595617 0.689343879 Rv0953c Rv0953c similar to alkanal monooxygenase beta chains MT0981 474.265633 694.777788 508.85274 697.61198 1.037737829 0.053442012 9.21448161 0.855875347 Rv0954 Rv0954 cell envelope antigen MT0982 307.462071 362.13867 319.078675 383.893445 1.048940308 0.068932581 8.42344355 0.789228518 Rv0955 Rv0955 possible membrane protein MT0983 42.9191138 51.3979922 42.5559475 54.5631391 1.027212174 0.038734206 5.58631315 0.904814009 Rv0956 purN phosphoribosylglycinamide formyltransferase I MT0984 238.772739 263.957646 221.3273 254.315747 0.945161749 −0.081366851 7.93529484 0.746089419 Rv0957 purH phosphoribosylaminoimidazole- carboxamide MT0985 179.641814 213.28357 173.588256 193.820135 0.93681099 −0.094170095 7.57183878 0.714079818 Rv0958 Rv0958 similar to magnesium-chelatase subunit MT0986 211.128329 232.557817 200.503983 204.514198 0.913669122 −0.130256296 7.73029817 0.544705077 Rv0959 Rv0959 hypothetical protein MT0987 15.2747032 11.3111779 14.0943843 11.3965927 0.962278931 −0.055472954 3.72088445 0.894736554 MT0988 66.9088445 46.0591162 70.5628531 53.2361386 1.102742698 0.141096207 5.89139279 0.579962096 Rv0960 Rv0960 conserved hypothetical protein MT0989 105.704729 69.5863662 106.298937 81.8837381 1.086128441 0.11919472 6.50835183 0.634017067 Rv0961 Rv0961 hypothetical protein MT0990 4.96662291 3.07664038 5.36495919 3.51264844 1.106244198 0.145669888 2.13626193 0.813012054 Rv0962c Rv0962c hypothetical protein MT0991 2.71758612 2.26223557 1.63676721 1.56117708 0.646111441 −0.630145073 1.14396507 0.283192189 MT0992 11.7137333 15.835649 12.8213432 11.786887 0.894760712 −0.160426185 3.72369988 0.69018019 Rv0963c Rv0963c conserved hypothetical protein MT0992.1 12.4634122 10.7682413 13.8215898 11.8649458 1.105366636 0.144524973 3.63263146 0.697208218 Rv0964c Rv0964c hypothetical protein MT0993 46.1052542 36.376748 45.9204134 44.2593703 1.100070635 0.137596161 5.43767619 0.634681239 Rv0965c Rv0965c conserved hypothetical protein MT0994 147.40562 128.766449 107.935705 117.088281 0.816372422 −0.292700647 6.97117757 0.087903845 Rv0966c Rv0966c conserved hypothetical protein MT0995 82.652102 91.3943171 74.5638396 97.4955089 0.932746355 −0.025108987 6.43814046 0.933484698 Rv0967 Rv0967 conserved hypothetical protein MT0996 89.3992124 145.416503 109.663403 131.763346 1.050721748 0.071380666 6.89780828 0.81765154 Rv0968 Rv0968 conserved hypothetical protein MT0997 341.666172 314.360255 365.09002 322.461127 1.04695007 0.066192641 8.39260526 0.801831984 Rv0969 ctpV cation transport ATPase MT0998 88.274694 76.3730729 77.291785 82.0398558 0.970185592 −0.04366734 6.34287476 0.893197075 Rv0970 Rv0970 hypothetical protein MT0999.1 75.6238621 51.1265239 88.658224 59.3247292 1.166492764 0.222177358 6.10535453 0.276480178 Rv0971c echA7 enoyl-CoA hydratase/isomerase superfamily MT1000 189.762479 123.246594 222.054752 165.094477 1.250949953 0.323024072 7.45293966 0.046433685 Rv0972c fadE12 acyl-CoA dehydrogenase MT1001 277.943453 184.598423 368.818212 220.828499 1.260634317 0.334149842 8.04007634 0.028052908 MT1002 135.035917 136.36756 182.499544 157.835003 1.250551116 0.322564029 7.25845829 0.048182941 Rv0974c accD2 acetyl/proplonyl-CoA carboxylase, [beta] subunit MT1003 82.3709725 75.1062209 121.302637 90.3140943 1.33159089 0.413150906 6.53058378 0.008820716 Rv0975c fadE13 acyl-CoA dehydrogenase MT1003.1 180.297733 172.925287 241.514095 180.940424 1.184197528 0.243909747 7.6005931 0.22614993 Rv0976c Rv0976c hypothetical protein MT1006.1 4.31065335 6.15328075 4.91030164 3.59070729 0.80723441 −0.308940422 2.29481819 0.564998538 MT1007 76.6546706 102.072069 103.752855 112.092515 1.216770157 0.283056675 6.62688333 0.123157185 MT1008 6.18485117 10.4062836 7.27452094 8.97676823 0.986276552 −0.01993586 3.06943339 0.973097519 Rv0980c PE_PGRS PE_PGRS-family protein MT1009 212.627637 195.728622 214.234642 170.636655 0.937386973 −0.093283349 7.63279616 0.720596123 Rv0981 Rv0981 two-component response regulator MT1010 829.800856 560.220017 801.19755 545.397214 0.969515051 −0.0446648 9.41851257 0.881775651 Rv0982 Rv0982 sensor histidine kinase MT1011 882.090971 798.207199 991.789999 828.126384 1.080065255 0.111118479 9.77351061 0.673121198 MT1012 327.328553 301.148799 350.540978 314.655241 1.057801624 0.081069096 8.33803185 0.757505397 Rv0984 moaB2 molybdenum cofactor biosynthesis, protein B MT1013 29.3311831 33.6620653 26.6429329 30.521012 0.907516148 −0.14000478 4.91726588 0.61875146 Rv0985c mscL highly similar to large-conductance mechanosensitive MT1014 47.6983219 54.9270797 60.9241129 63.696025 1.215816692 0.281925731 5.83280673 0.140711849 Rv0986 Rv0986 Probable ABC transporter MT1015 109.453124 154.012998 129.94113 176.881364 1.167222556 0.223079668 7.15751328 0.225429598 Rv0987 Rv0987 potential integral membrane protein MT1017 30.5494154 59.5420402 40.1917282 63.9302016 1.179747224 0.238477777 5.60745166 0.322355421 Rv0988 Rv0988 conserved hypothetical protein MT1018 55.1014014 67.6860883 45.1929613 68.0673209 0.911752448 −0.133285926 5.88748667 0.630293904 Rv0989c grcC2 heptaprenyl diphosphate synthase II MT1019 43.3876631 101.800601 53.5586604 89.1432115 1.029566136 0.042036507 6.17331625 0.904814009 Rv0990c Rv0990c hypothetical protein MT1020 131.662352 344.94568 142.489679 276.094167 0.926933503 −0.10946225 7.80732511 0.706672425 MT1021 57.1630184 46.9640104 58.105236 41.6053693 0.950178393 −0.073729695 5.67586926 0.818068286 Rv0992c Rv0992c conserved hypothetical protein MT1022 113.763778 115.102546 128.486226 130.514404 1.131655247 0.178434516 6.93248222 0.351103217 Rv0993 galU UTP-glucose-1-phosphate uridylytransferase MT1023 283.003736 320.965983 284.5247 302.556119 0.973348379 −0.038971831 8.21887868 0.893197075 Rv0994 moeA molybdopterin biosynthesis MT1024 65.5340051 86.6888671 69.3807435 85.6305631 1.014064891 0.020149975 6.27133858 0.948443219 Rv0995 riml acetylation of 30S S5 subunit MT1025 628.605733 546.918072 636.338719 617.21136 1.06883416 0.096038022 9.24660837 0.719637416 Rv0996 Rv0996 hypothetical protein MT1025.1 12.5571221 10.2253048 13.7306583 11.240475 1.096174266 0.132477171 3.59811937 0.733038419 MT1025.2 59.7868947 108.406329 56.8321949 87.8942698 0.874178337 −0.194000468 6.29310178 0.374521053 MT1026 70.9383698 106.59654 64.9250994 95.7782141 0.906469699 −0.1416693 6.40507915 0.521875569 MT1027 164.273396 132.205047 143.944583 115.761281 0.875946041 −0.191086093 7.12110351 0.328864961 Rv0998 Rv0998 hypothetical protein MT1028 97.1771313 97.8190661 99.8427999 107.487042 1.062861343 0.087953401 6.65480676 0.741445842 Rv0999 Rv0999 hypothetical protein MT1029 193.792003 66.8716835 148.491159 69.5504391 0.886475261 −0.173847724 6.90467677 0.477357404 MT1030 315.802249 169.034242 277.704837 154.088178 0.895013234 −0.16001908 7.84113218 0.420522227 Rv1001 arcA arginine deiminase MT1031 117.887012 158.808937 105.025896 146.516469 0.907003284 −0.14082032 7.04705953 0.519306729 MT1032 12.9319615 18.6408211 15.458357 20.9978318 1.156518675 0.209788562 4.10431526 0.461612363 Rv1003 Rv1003 conserved hypothetical protein MT1033 98.4890694 103.248431 161.767159 127.626227 1.424691674 0.510649731 6.94208332 0.00068608 Rv1004c Rv1004c possible exported protein MT1034 76.4672509 82.9788007 81.2927715 75.2487354 0.981233893 −0.027331028 6.30688421 0.929988815 Rv1005c pabB p-aminobenzoate synthase MT1035 610.94853 783.638402 692.807188 868.795047 1.103355617 0.141897854 9.53961583 0.543161321 Rv1006 Rv1006 hypothetical protein MT1036 171.489055 156.81817 165.131625 155.727414 0.977884194 −0.032264471 7.3439744 0.905823466 Rv1007c metS methionyl-tRNA synthase MT1037 12.4634122 15.1117336 10.2752608 16.5484771 0.964664752 −0.051900443 3.785442 0.90313325 Rv1008 Rv1008 conserved hypothetical protein MT1038 262.012786 293.819156 249.970726 292.096232 0.974013797 −0.037985887 8.10147791 0.894346121 Rv1009 Rv1009 conserved hypothetical protein MT1039 152.184823 163.695366 141.489432 171.261126 0.986856909 −0.019087181 7.29773777 0.94941324 Rv1010 ksgA 16S rRNA dimethyltransferase MT1040 119.10524 111.482969 116.210472 108.735984 0.975529662 −0.035742354 6.83359597 0.897921476 Rv1011 Rv1011 conserved hypothetical protein MT1040.1 6.84082024 9.77285767 7.7291785 8.19617969 0.960478055 −0.058175444 3.05536435 0.905590819 MT1041 675.367006 748.438016 603.603375 668.96438 0.893779363 −0.162009361 9.39717916 0.462931351 Rv1013 pks16 polyketide synthase MT1042 38.9833044 53.4792489 43.9199202 56.3584927 1.088006569 0.121687267 5.59616677 0.667813113 Rv1014c pth peptidyl-tRNA hydrolase MT1043 261.450527 272.282673 276.431796 267.429635 1.018941698 0.027071506 8.07453879 0.923772833 Rv1015c rplY 50S ribosomal protein L25 MT1044 86.4942056 125.870787 87.6579773 118.103046 0.973987157 −0.038025346 6.71036814 0.897921476 Rv1016c lpqT similar to M. kansasii Q49597 MT1045 362.282343 506.921747 366.453992 457.190709 0.954754384 −0.066798455 8.72586154 0.803210576 Rv1017c prsA ribose-phosphate pyrophosphokinase MT1046 331.545507 395.438778 315.441414 382.87868 0.959852344 −0.059115604 8.47778923 0.819552181 MT1047 229.401753 170.120115 186.136805 137.929995 0.811103771 −0.302041593 7.50027511 0.054644378 Rv1019 Rv1019 transcriptional regulator (TetR/AcrR family) MT1048 403.795814 317.436895 356.451526 310.752299 0.92949811 −0.105476163 8.43993711 0.648617706 Rv1020 mfd transcription-repair coupling factor MT1049 107.766346 97.5475978 89.5675391 102.88157 0.937039277 −0.093818574 6.63832647 0.746856645 Rv1021 Rv1021 conserved hypothetical protein MT1050 61.7548019 72.3915383 60.5603868 66.1158495 0.94568024 −0.080575643 6.030847 0.786093466 Rv1022 lpqU lipoprotein MT1051 204.006379 232.829285 186.227736 201.079608 0.887716893 −0.171828443 7.68797239 0.384917628 Rv1023 eno enolase MT1052 66.4402952 84.8790786 62.2880856 72.7508521 0.895313434 −0.159535261 6.16526173 0.490797064 Rv1024 Rv1024 hypothetical protein MT1053 69.4390109 70.5817498 64.4704418 74.6242646 0.991776969 −0.011912371 6.1284377 0.973097519 Rv1025 Rv1025 hypothetical protein MT1054 50.2284833 49.226246 47.4662491 50.8163141 0.988251674 −0.017049601 5.63260346 0.963845706 MT1054.1 316.083379 117.274292 208.778751 110.765514 0.786825922 −0.345883607 7.557385 0.083100703 MT1055 3.09242559 2.35272499 2.45515082 2.26370677 0.871951898 −0.197679546 1.43874042 0.798636571 MT1056 23.3337557 33.0286393 18.4590969 20.0611255 0.688148147 −0.539208908 4.57822167 0.004369491 Rv1027c kdpE two-component response regulator MT1057 116.387654 119.898485 98.0241697 86.176975 0.777885124 −0.362370977 6.71815513 0.022371345 Rv1028c kdpD sensor histidine kinase MT1057.1 9.83953596 42.2585605 8.63849362 14.0505938 0.515019215 −0.957301837 4.23774146 0.004008503 MT1058 91.5545393 467.377869 73.0180039 158.537533 0.516122254 −0.954215258 7.62786486 0.000316564 Rv1029 kdpA potassium-transporting ATPase A chain MT1059 113.388938 444.755513 87.8398404 179.301188 0.555188361 −0.848950772 7.68997961 7.96E−06 Rv1030 kdpB potassium-transporting ATPase B chain MT1060 49.0102631 101.619622 40.1917282 51.0504906 0.636393842 −0.652008219 5.92214963 0.001317745 Rv1031 kdpC potassium-transporting ATPase C chain MT1061 48.6354206 55.1985479 46.375071 53.7825505 0.96416186 −0.052652733 5.67744551 0.877734451 Rv1032c Rv1032c sensor histidine kinase MT1062 24.4582751 26.6038903 24.7333712 27.867011 1.029866356 0.042457134 4.70579238 0.90313325 Rv1033c Rv1033c two-component response regulator MT1063 4.68549331 3.80055576 4.09191803 5.69829636 1.157019056 0.210412626 2.24965232 0.727244526 Rv1034c Rv1034c hypothetical protein MT1065 37.0153972 34.5669595 39.1914816 38.014662 1.079166091 0.109916922 5.22396633 0.712080008 Rv1035c Rv1035c hypothetical protein MT1066 420.7573 436.520976 573.777839 496.532372 1.245372274 0.316577066 8.91311726 0.056339552 Rv1037c Rv1037c conserved hypothetical protein MT1067 209.254131 212.469165 304.893359 265.400104 1.348954753 0.431841958 7.95527868 0.001950676 Rv1038c Rv1038c conserved hypothetical protein MT1068 9.46469649 13.7543923 76.928059 58.8563761 5.824066211 2.542026757 5.32065862 8.24E−37 Rv1039c PPE PPE-family protein MT1069 7.40307944 15.0212442 96.2055394 84.5377391 8.3237569 3.057234831 5.67295552 2.77E−38 Rv1040c PE PE-family protein MT1070 4.12323412 3.1671298 4.09191803 3.27847188 1.012318046 0.017662621 1.93923779 0.979541419 MT1070.1 24.8331146 20.6315884 25.4608233 19.4366547 0.98405479 −0.023189451 4.5082053 0.94941324 MT1071 2.90500535 2.35272499 4.27378105 1.8734125 1.13094404 0.177527546 1.59118146 0.81765154 MT1073 108.516025 101.98158 130.577651 116.854105 1.174194285 0.23167114 6.84121577 0.171245612 Rv1043c Rv1043c hypothetical protein MT1074 31.6739348 22.8033346 28.9162207 21.7003615 0.931301431 −0.1026799 4.7244184 0.750079277 Rv1044 Rv1044 conserved hypothetical protein MT1075 35.9845836 24.8845913 30.2801934 24.5885391 0.909421556 −0.136978894 4.8628293 0.641653568 Rv1045 Rv1045 hypothetical protein MT1075.1 759.705836 656.772231 715.267272 673.1015 0.982294428 −0.025772579 9.4540593 0.930747689 Rv1046c Rv1046c hypothetical protein MT1077 19.1168127 19.7266942 15.7311515 22.8712443 0.985934619 −0.020436115 4.28895253 0.966222682 MT1078 36.453138 36.8291951 34.7358375 40.7467219 1.028659847 0.040765997 5.22392552 0.90313325 Rv1048c Rv1048c hypothetical protein MT1079 35.4223295 35.6528326 30.4620564 35.360661 0.92525517 −0.112076803 5.10441316 0.723313141 Rv1049 Rv1049 transcriptional regulator (MarR family) MT1080 7.12194984 10.5872625 9.00221966 10.694063 1.116098522 0.158464384 3.25365156 0.716280866 Rv1050 Rv1050 probable oxidoreductaseoxidoreducatse MT1082 17.8985845 21.2650144 17.4588503 18.5780073 0.920636802 −0.11929598 4.24610253 0.725019493 MT1083 61.3799624 53.5697383 52.1037562 53.7044917 0.922836321 −0.115853308 5.79082242 0.689343879 Rv1052 Rv1052 hypothetical protein MT1083.1 159.775322 166.772006 139.216145 146.672587 0.875430308 −0.191935763 7.26004063 0.322355421 MT1083.2 122.572505 152.565167 104.480307 117.400517 0.809204109 −0.30542445 6.95916119 0.045929327 MT1084 73.0936957 77.0064988 66.1981406 75.7170886 0.944353461 −0.08260115 6.19341641 0.764687847 Rv1054 Rv1054 integrase-a MT1085 81.0590343 99.1764074 73.0180039 89.6896235 0.902629536 −0.147794108 6.42484534 0.497727102 Rv1056 Rv1056 conserved hypothetical protein MT1086 4.87291305 1.71929903 3.91005501 1.79535365 0.881072007 −0.182668164 1.69049696 0.801831984 MT1087 320.206613 229.209703 332.354676 245.96345 1.055252589 0.077588369 8.1400566 0.764687847 Rv1057 Rv1057 conserved hypothetical protein MT1088 77.1232199 92.5706796 72.2905519 71.2677339 0.848306029 −0.237343279 6.29432045 0.241788414 MT1089 71.8754674 130.576237 71.5630998 111.233867 0.917720992 −0.123872486 6.59248467 0.619926139 Rv1059 Rv1059 conserved hypothetical protein MT1090 83.6829106 97.9095555 88.840087 111.468044 1.100227947 0.137802454 6.57989121 0.532508534 Rv1060 Rv1060 hypothetical protein MT1091 73.7496648 81.0785229 75.1094287 86.723387 1.044208148 0.062409321 6.31012043 0.822457187 MT1092 28.2066698 22.3508874 27.4613166 25.2910688 1.048530928 0.068369417 4.70046601 0.850613454 Rv1062 Rv1062 conserved hypothetical protein MT1093 143.094956 94.8329151 130.122993 88.9870938 0.923420488 −0.114940353 6.83816174 0.609343079 Rv1063c Rv1063c conserved hypothetical protein MT1094 24.1771455 26.7848692 23.096604 22.8712443 0.901764421 −0.149177505 4.60910725 0.607268227 Rv1064c lpqV lipoprotein MT1095 1088.15897 672.969838 690.5339 397.241509 0.612137646 −0.708071999 9.47647421 5.78E−08 Rv1065 Rv1065 conserved hypothetical protein MT1096 168.677759 144.964055 143.1262 97.1832735 0.754974831 −0.405499546 7.11521685 0.012386351 MT1096.1 9.74582609 9.13943171 14.6399734 14.2067115 1.527704064 0.611365102 3.59944444 0.003877189 Rv1067c PE_PGRS PE_PGRS-family protein MT1097 9.65211623 8.95845286 11.366439 10.5379453 1.176750797 0.23480883 3.3655497 0.496009459 Rv1068c PE_PGRS PE_PGRS-family protein MT1099 97.6456807 136.729518 87.5670458 149.014353 0.991781561 −0.011905691 6.88183995 0.973097519 Rv1069c Rv1069c conserved hypothetical protein MT1100 70.5635293 121.165337 74.4729081 123.411049 1.035897113 0.050880719 6.60880961 0.854827105 MT1101 83.3080711 102.615006 84.4753744 110.297161 1.044793418 0.063217713 6.57533468 0.817077148 Rv1071c echA9 enoyl-CoA hydratase/isomerase superfamily MT1102 2538.22544 2562.56997 3007.92348 2815.66093 1.141085711 0.190407162 11.4153576 0.442344612 Rv1072 Rv1072 probable transmembrane protein MT1103 811.527442 635.054769 973.876491 744.60341 1.186215992 0.246366727 9.62832957 0.192924304 Rv1073 Rv1073 conserved hypothetical protein MT1104 791.473531 759.749194 727.361163 682.078268 0.908317134 −0.138732 9.53203451 0.55335105 Rv1074c fadA3 acetyl-CoA C-acetyltransferase MT1105 68.4082024 93.4755738 123.939651 123.411049 1.54284481 0.625592953 6.67950343 5.96E−05 Rv1075c Rv1075c conserved hypothetical protein MT1106 83.7766204 86.7793565 159.584803 138.554466 1.743378678 0.80188597 6.87485067 8.35E−11 Rv1076 lipU probable esterase MT1107 2.99871572 2.35272499 1.81863024 2.02953021 0.726287955 −0.461386441 1.30402402 0.473118615 MT1108 218.156559 187.584574 211.14297 198.737843 1.012586731 0.018045485 7.67297948 0.950509824 Rv1077 cysM2 cystathionine [beta]-synthase MT1109 320.487743 706.179456 346.630923 598.399176 0.956112341 −0.064747953 8.94579312 0.831756973 Rv1078 pra MLPRAG (64.8% ld) proline rich Ag MT1110 270.352954 435.706571 239.331739 356.885081 0.851097821 −0.232603137 8.34763874 0.188114611 Rv1079 metB cystathionine [gamma]-synthase MT1111 900.176975 690.524786 1109.91003 901.501707 1.26869627 0.343346725 9.81490818 0.03929855 Rv1080c greA transcription elongation factor G MT1112 56.6944691 66.2382575 62.2880856 66.4280849 1.048704994 0.068608898 5.97940457 0.819552181 Rv1081c Rv1081c hypothetical protein MT1113 294.717529 254.456257 241.150369 208.573258 0.818968045 −0.288120934 7.96513204 0.056339552 Rv1082 Rv1082 similar to S. lincolnensis lmbE MT1114 71.1257835 59.0895931 64.9250994 56.5146104 0.934226026 −0.098156458 5.97913834 0.731548564 Rv1083 Rv1083 conserved hypothetical protein MT1115 277.474914 171.205988 248.606753 151.980589 0.891895895 −0.165052771 7.73111471 0.400849834 Rv1084 Rv1084 conserved hypothetical protein MT1116 6.9345301 3.52908749 5.81961675 4.99576667 1.061535271 0.086152307 2.45653219 0.894346121 MT1117 124.071853 147.678738 112.755075 128.250697 0.888088487 −0.171224664 7.00411432 0.393053826 Rv1085c Rv1085c possible hemolysin MT1118 286.189932 180.34542 242.332479 169.387714 0.891267586 −0.166069456 7.77952473 0.414134607 Rv1086 Rv1086 conserved hypothetical protein MT1118.2 1.31193813 2.44321442 1.90956175 1.95147136 1.028337929 0.040314436 1.05861312 0.970173849 MT1119 3.09242559 4.16251345 4.00098652 5.15188438 1.260987048 0.334553457 2.10144031 0.497727102 Rv1088 PE PE-family protein MT1121 3.93581438 5.97230191 4.18284954 4.99576667 0.927958822 −0.107867308 2.30791268 0.864827105 MT1122 22.7714975 15.4736913 20.0958641 17.4851833 0.994035302 −0.008631007 4.25737341 0.983253476 MT1123 72.7188562 70.6722392 92.8410735 79.0736193 1.19517229 0.257218605 6.30383825 0.162546584 Rv1091 PE_PGRS PE_PGRS-family protein MT1124 94.8343847 70.400771 80.7471824 66.2719672 0.894671676 −0.160569751 6.28958794 0.476182576 Rv1092c coaA pantothenate kinase MT1125 888.275822 718.576507 768.916863 652.415903 0.886509479 −0.173792037 9.56455028 0.430882277 Rv1093 glyA serine hydroxymethyltransferase MT1126 9890.98257 5112.92386 9453.33089 5165.93497 0.992670566 −0.025220252 12.8544674 0.946497216 Rv1094 desA2 acyl-[ACP] desaturase MT1127 1899.31157 1231.923 2028.77296 1287.42468 1.056560105 0.079374841 10.6546515 0.795819277 Rv1095 phoH2 PhoH-like protein MT1128 308.49288 339.697293 308.075962 336.043367 0.993914117 −0.0088069 8.33653456 0.976466231 Rv1096 Rv1096 carbohydrate degrading enzyme MT1129 198.758626 225.680621 203.32286 246.275685 1.05687446 0.079804018 7.77277316 0.753646659 Rv1097c Rv1097c probable membrane spanning protein MT1130 234.836925 284.679724 233.96678 314.343006 1.049373151 0.069527783 8.06148122 0.801337286 Rv1098c fum fumarase MT1131 182.921659 222.69447 200.503983 252.442335 1.114907017 0.156923395 7.74704897 0.436145896 Rv1099c Rv1099c conserved hypothetical protein MT1132 158.557094 112.025906 145.126693 101.594569 0.91098008 −0.134508587 7.01652656 0.530737399 Rv1100 Rv1100 conserved hypothetical protein MT1133 340.635354 260.971495 418.103091 326.207952 1.238589243 0.308697822 8.39511614 0.038344363 Rv1101c Rv1101c putative membrane protein MT1134 216.376031 145.054545 239.058944 206.075375 1.251752218 0.323949012 7.65690144 0.062232861 Rv1102c Rv1102c conserved hypothetical protein MT1135 228.652074 159.080405 222.964067 141.364585 0.93143941 −0.102466169 7.5559066 0.681433434 MT1137 203.818959 147.497759 238.331492 184.531131 1.209148994 0.273992028 7.5978012 0.091229323 Rv1106c Rv1106c probable cholesterol dehydrogenase MT1138 191.730336 145.326013 177.316448 186.404544 1.088924101 0.122903401 7.45427792 0.673946788 Rv1107c xseB exonuclease VII small subunit MT1139 265.105212 186.227232 244.332972 207.246258 1.012220542 0.017523658 7.81951193 0.953339877 Rv1108c xseA exonuclease VII large subunit MT1140 224.43513 234.729563 250.24352 259.311514 1.109818967 0.150324364 7.92101384 0.468223919 Rv1109c Rv1109c hypothetical protein MT1141 266.41715 195.547643 228.510889 185.233661 0.901110535 −0.15022401 7.7753793 0.476182576 Rv1110 lytB* very similar to LytB MT1142 273.16426 341.688061 288.889413 366.174085 1.064645514 0.090373149 8.31136896 0.723313141 Rv1111c Rv1111c hypothetical protein MT1143 27.4569908 38.4580047 25.1860288 36.2973672 0.931536607 −0.102315631 5.00164587 0.741632985 Rv1112 Rv1112 conserved hypothetical protein MT1143.1 11.8074432 13.2114557 8.72942513 13.3480641 0.877002929 −0.189346434 3.57983915 0.616132609 Rv1113 Rv1113 hypothetical protein MT1144 10.5892149 17.1929903 11.0936444 16.2362417 0.987106651 −0.018722127 3.80396503 0.968483965 Rv1114 Rv1114 conserved hypothetical protein MT1145 7.7779189 10.0443259 10.9117814 15.9240063 1.501150175 0.586068311 3.50680002 0.00977681 MT1147 3.46726505 8.50600575 4.54657559 7.96200313 1.05903229 0.082746578 2.65906307 0.886067917 Rv1116 Rv1116 hypothetical protein MT1148 31.2053855 48.9547778 36.8272623 48.0061953 1.069853658 0.097413468 5.37287589 0.760272935 MT1149 379.150119 311.283615 339.629196 325.973775 0.968475585 −0.046212415 8.40590937 0.878360152 Rv1117 Rv1117 conserved hypothetical protein MT1150 48.7291305 77.0969882 45.6476189 66.5061438 0.896935299 −0.156924176 5.89920169 0.520848866 Rv1118c Rv1118c hypothetical protein MT1151 3.84210452 3.52908749 2.72794535 1.95147136 0.630938313 −0.664429135 1.66541895 0.143692242 Rv1119c Rv1119c hypothetical protein MT1152 5.81001171 3.9815346 3.81912349 3.20041302 0.72305342 −0.467825855 2.12567066 0.280503699 Rv1120c Rv1120c conserved hypothetical protein MT1153 438.374754 301.601246 369.091006 310.362004 0.93046262 −0.103979902 8.47176147 0.683113264 Rv1121 zwf glucose-6-phosphate 1-dehydrogenase MT1154 222.467223 179.983462 177.498311 154.712649 0.828065412 −0.272183359 7.52221318 0.102961206 Rv1122 gnd2 6-phosphogluconate dehydrogenase (Gram +) MT1155 105.23618 95.1043834 98.0241697 96.0123907 0.969813344 −0.04422099 6.62596163 0.880856541 Rv1123c bpoB probable non-heme bromoperoxidase MT1156 49.4788094 54.2031643 49.1939479 50.0357255 0.957440194 −0.062745722 5.6696852 0.849425114 Rv1124 ephC probable epoxide hydrolase MT1157.1 11.9948629 11.8541144 11.2755075 12.2552401 0.9875217 −0.018115644 3.58765573 0.971893294 MT1158 84.05775 76.4635623 76.0187438 63.8521427 0.86917167 −0.202286943 6.23386393 0.322355421 MT1159 216.469731 202.786797 188.501024 167.280125 0.847546463 −0.238635635 7.59935386 0.168341051 Rv1127c ppdK similar to pyruvate, phosphate dikinase MT1160 151.060304 129.128406 105.662417 116.697987 0.795491252 −0.330082029 6.97505372 0.056753569 Rv1128c Rv1128c REP-family protein MT1161 97.0834215 111.573458 66.1072091 131.997522 0.902082512 −0.148668695 6.67080845 0.692019534 Rv1129c Rv1129c transcriptional regulator (PbsX/Xre family) MT1162 661.591656 1055.83059 570.777099 1140.59598 0.965913813 −0.05003363 9.74382316 0.881775651 Rv1130 Rv1130 conserved hypothetical protein MT1163 422.912626 735.498029 393.642514 847.328862 1.036470172 0.051678599 9.22894386 0.873642922 Rv1131 gltA1 citrate synthase 3 MT1164 200.445404 391.819201 208.233162 370.857616 0.990677572 −0.013512503 8.19493699 0.967251048 Rv1132 Rv1132 possible transporter MT1165 3771.54099 2349.73884 3546.32896 2524.73558 1.005105666 0.007347179 11.5737636 0.983253476 Rv1133c metE 5-methyltetrahy- dropteroyltriglutamate-homocysteine MT1167 4.49807358 3.34810864 5.18309617 4.44935469 1.232340914 0.301401418 2.18446075 0.540148468 MT1168 36.2657182 33.390597 46.4660025 32.3163656 1.115970086 0.158298356 5.22023402 0.595841111 Rv1135c PPE PPE-family protein MT1169.1 7.2156597 7.1486644 6.00147978 8.82065052 1.029224222 0.041557316 2.90365238 0.938478232 Rv1136 Rv1136 probable carnitine racemase MT1171 43.1065385 52.7553335 36.0088787 41.215075 0.806949345 −0.309449982 5.44110907 0.111712781 Rv1138c Rv1138c conserved hypothetical protein MT1172 32.6110335 37.4626211 26.5520014 26.1497162 0.75244322 −0.410345375 4.94767446 0.027353454 MT1172.1 4.21694338 7.1486644 4.00098652 4.13711927 0.720380339 −0.473169288 2.33529279 0.259268419 MT1173 469.48643 370.735165 369.363801 352.669903 0.865041327 −0.209159037 8.61002923 0.286460873 Rv1140 Rv1140 conserved hypothetical protein MT1174 69.4390109 72.12007 71.3812367 72.5947344 1.017095224 0.024454756 6.16109962 0.934442416 Rv1141c echA11 enoyl-CoA hydratase/isomerase superfamily MT1175 203.2567 158.627958 202.68634 187.029015 1.08402758 0.116401463 7.55515573 0.637012172 Rv1142c echA10 enoyl-CoA hydratase/isomerase superfamily MT1176 63.5352893 59.1800825 65.2888254 63.6179662 1.051113864 0.07191896 5.97914902 0.808331268 Rv1143 mcr [alpha]-methyl acyl-CoA racemase MT1177 51.165587 41.6251345 45.1020298 45.5863709 0.982433769 −0.025567944 5.52492118 0.944598499 Rv1144 Rv1144 short-chain alcohol dehydrogenase MT1178 1632.80071 1369.55741 1542.83496 1270.64203 0.936303095 −0.094952468 10.5059346 0.741445842 MT1180 9.55840636 13.482924 8.27476757 16.2362417 1.046657077 0.06578884 3.59535755 0.889814146 Rv1147 Rv1147 similar to phosphatidylethanolamine N-methyltransferase MT1181 3.09242559 5.24838652 3.36446594 3.66876615 0.846733234 −0.240020579 2.00701657 0.692019534 MT1182 76.7483805 168.491305 71.5630998 119.273929 0.807458145 −0.308540616 6.77090858 0.093229406 MT1183 231.838209 180.526399 226.055738 153.619825 0.911442374 −0.13377665 7.6305863 0.54870503 MT1185 58.3812467 65.1523844 60.5603868 68.6917917 1.045961271 0.064829434 5.98592547 0.830576393 Rv1151c Rv1151c putative transcriptional regulator MT1186 59.5994749 51.6694604 67.5621132 63.5399073 1.180555974 0.239466446 5.92531992 0.239812435 Rv1152 Rv1152 transcriptional regulator (GntR family) MT1187 31.0179657 37.5531105 36.9181938 38.1707797 1.097274446 0.133924412 5.1737847 0.640147081 Rv1153c omt PKS o-methyltransferase MT1188 29.6123177 25.6085067 27.006659 25.6033042 0.954850437 −0.066653321 4.7617634 0.849425114 Rv1154c Rv1154c hypothetical protein MT1189 170.833086 159.9853 172.224283 163.143005 1.013931326 0.019959942 7.3812862 0.946240485 Rv1155 Rv1155 hypothetical protein MT1190 45.6367049 50.6740768 45.1929613 53.1580797 1.019982292 0.028544105 5.61022144 0.930747689 MT1191 355.254103 261.695411 330.081388 265.165928 0.970102519 −0.043790878 8.24419319 0.880578033 Rv1156 Rv1156 hypothetical protein MT1192 107.485217 68.7719613 93.4775941 70.7993808 0.944468768 −0.082425005 6.41438292 0.767555172 MT1193 95.3966439 172.563329 161.130639 237.06474 1.519204478 0.603316063 7.38152034 1.33E−05 Rv1157c Rv1157c conserved hypothetical protein MT1194 143.469805 260.428559 257.608973 335.418897 1.517281695 0.601488958 7.96252136 8.74E−05 Rv1158c Rv1158c conserved hypothetical protein MT1195 80.0282258 73.1154536 80.0197304 76.8099125 1.024950997 0.035554936 6.27924639 0.90313325 Rv1159 Rv1159 probable membrane protein MT1196 103.047476 98.9049391 98.0241697 85.8014459 0.892329547 −0.164351484 6.61635191 0.438793963 MT1197 43.2002484 52.9363124 47.2843861 55.3437276 1.068949367 0.096193519 5.64026816 0.752487878 Rv1160 mutT2 MutT homologue MT1198 4743.40601 2331.279 5177.18562 2282.12866 1.033711695 0.04783387 11.8272019 0.894157772 Rv1161 narG nitrate reductase [alpha] subunit MT1199 1275.39128 561.667848 1384.43227 632.90119 1.10585455 0.145161645 9.91250925 0.546009693 Rv1162 narH nitrate reductase [beta] chain MT1200 270.727834 110.759054 302.347277 130.592463 1.146430482 0.197148875 7.67068365 0.294305462 Rv1163 narJ nitrate reductase [delta] chain MT1201 179.454394 84.4266315 188.228229 100.773981 1.1164784 0.15895534 7.11243241 0.476182576 Rv1164 narl nitrate reductase [gamma] chain MT1202 330.514698 186.408211 321.988483 190.853899 0.998344571 −0.002390258 8.00856575 0.99525661 Rv1165 Rv1165 conserved hypothetical protein MT1203 415.696967 335.53478 385.458678 334.326073 0.961138644 −0.05718354 8.52325569 0.828791613 Rv1166 lpqW lipoprotein MT1204 144.406904 138.267838 144.035515 138.866702 1.000883217 0.00127365 7.14535567 0.997032163 MT1205 253.110349 254.275278 223.964314 210.446671 0.855704194 −0.224815933 7.88030066 0.197908376 Rv1168c PPE PPE-family protein MT1206 67.0962642 89.4035498 57.4687154 67.2867323 0.80139721 −0.319410608 6.13930568 0.067667963 Rv1169c PE PE-family protein MT1207 180.860042 138.358328 252.880534 177.505834 1.339842071 0.422062958 7.55131118 0.002834959 Rv1170 Rv1170 similar to S. lincolnensis lmbE MT1208 203.631539 227.942856 242.696205 223.248323 1.080034735 0.111077712 7.81093367 0.654586496 Rv1171 Rv1171 hypothetical protein MT1209 391.988371 363.496012 468.479149 389.79506 1.131371787 0.1780731 8.65636861 0.374316021 Rv1172c PE PE-family protein MT1210 719.691773 543.298495 644.431624 572.95199 0.971655528 −0.041483156 9.27673296 0.894346121 Rv1173 Rv1173 conserved hypothetical protein MT1211 1871.29232 1801.7349 2121.70496 1879.34497 1.087498945 0.121014002 10.9059083 0.658063367 MT1212 301.0898 328.929052 285.70681 315.670006 0.954311876 −0.067467269 8.26691111 0.801831984 Rv1175c fadH 2,4-Dienoyl-CoA Reductase MT1213 72.6251454 71.6676229 65.4706885 69.9407334 0.938386942 −0.091745157 6.1313688 0.745116768 Rv1176c Rv1176c conserved hypothetical protein MT1214 994.167971 597.954106 858.120676 586.456172 0.919902996 −0.120446358 9.56858473 0.637012172 Rv1177 fdxC ferredoxin 4Fe-45 MT1215 1332.43353 681.837801 1213.93568 659.128965 0.94191589 −0.086329857 9.92107197 0.764687847 Rv1178 Rv1178 possible aminotransferase MT1216 33.4544223 54.1126749 10.6389869 21.6223026 0.362381577 −1.464418482 4.91246015 1.12E−21 MT1217 219.655927 248.212487 70.3809901 106.862571 0.372531336 −1.424566308 7.33475038 4.89E−26 Rv1179c Rv1179c hypothetical protein MT1218 1595.50418 2561.75556 315.077688 690.11833 0.230842913 −2.115016651 10.334003 1.39E−44 Rv1180 pks3 polyketide synthase MT1219 509.219413 1031.66991 90.2040597 290.535055 0.224387679 −2.155934636 8.90856975 1.10E−41 Rv1182 papA3 PKS-associated protein, unknown function MT1220 582.406819 908.875763 100.297458 333.15519 0.252195014 −1.98738834 8.9109085 4.40E−20 Rv1183 mmpL10 conserved large membrane protein MT1221 865.504325 892.13522 72.3814834 169.699949 0.126632779 −2.981277199 8.96594302 2.18E−37 Rv1184c Rv1184c conserved hypothetical protein MT1222 964.743073 1135.55177 272.612672 478.032423 0.345229335 −1.534373035 9.47752699 4.68E−23 Rv1185c fadD21 acyl-CoA synthase MT1223 28.9563437 33.7525547 36.5520014 29.1940115 0.889595838 −0.168778057 4.89671467 0.521875569 Rv1186c Rv1186c hypothetical protein MT1224 200.539114 171.025009 165.677214 112.560868 0.738030336 −0.438247977 7.34521491 0.004515496 Rv1187 rocA pyrroline-5-carboxylate dehydrogenase MT1225 58.3812467 50.4930979 47.2843861 38.1707797 0.782784305 −0.353313265 5.60709818 0.054673353 Rv1188 Rv1188 probable dehydrogenase MT1226 33.5481321 31.3998297 26.1882754 25.8374807 0.801751132 −0.31877361 4.8782498 0.112616436 MT1227 16.3992256 20.9935461 13.3669322 15.0653589 0.761439392 −0.39319794 4.0555119 0.068053722 Rv1190 Rv1190 conserved hypothetical protein MT1228 56.6007592 77.1874777 63.2883322 71.1116162 1.012314045 0.017656919 6.07101077 0.959550862 MT1229 1345.39255 668.445366 1269.04018 748.428294 1.02738314 0.038974304 9.97725134 0.90313325 Rv1192 Rv1192 hypothetical protein MT1230 498.349069 291.64741 518.309617 322.92948 1.072839614 0.101434414 8.67231015 0.667685559 Rv1193 fadD36 acyl-CoA synthase MT1231 851.541555 716.585739 768.644069 711.428397 0.946640144 −0.079111992 9.57406243 0.784361075 Rv1194c Rv1194c conserved hypothetical protein MT1232 88.8369532 69.4053873 86.0212101 64.1643781 0.946514267 −0.079303842 6.2718333 0.772198487 MT1233 842.920247 593.882082 1036.16458 691.133095 1.196137964 0.258383801 9.62788195 0.162234186 Rv1195 PE PE-family protein MT1234 1833.1524 1383.13083 2133.25327 1342.45617 1.062863112 0.087955801 10.7083587 0.7818709 Rv1196 PPE PPE-family protein MT1235 182.17198 160.075789 207.778504 165.484771 1.086050203 0.119090794 7.48420381 0.61875146 MT1236 200.351694 130.12379 247.060917 172.275891 1.277105195 0.352877365 7.55168472 0.018102412 MT1237 35.9845886 27.8707422 42.283153 26.4619516 1.060752144 0.085087595 5.05797135 0.802810858 MT1238 243.177103 254.275278 241.241301 225.824265 0.938500695 −0.091570281 7.91469042 0.720596123 Rv1200 Rv1200 probable sugar transporter MT1239 490.945939 509.093493 476.39019 511.129377 0.987070447 −0.018775042 8.95729754 0.949144778 Rv1201c Rv1201c conserved hypothetical protein MT1240 185.920375 178.264163 183.499791 161.894064 0.946742851 −0.078955473 7.47219551 0.76492809 Rv1202 dapE succinyl-diaminopimelate desuccinylase MT1241 15.8369674 11.0397096 14.0943843 13.1138875 1.02338458 0.0333484 3.7753471 0.938478232 Rv1203c Rv1203c hypothetical protein MT1242 129.319615 119.988975 114.209979 119.19587 0.936932009 −0.093983736 6.91710357 0.71209906 Rv1204c Rv1204c conserved hypothetical protein MT1243 124.540412 131.481131 129.577404 110.921632 0.93664883 −0.094419844 6.9576725 0.727349312 MT1244 153.403051 199.438638 180.044393 198.893961 1.080936424 0.112281672 7.5167136 0.653011426 Rv1206 fadD6 acyl-CoA synthase MT1245 126.13348 120.80338 129.850199 129.733816 1.051550924 0.072518718 6.98649501 0.7818709 Rv1207 folP2 dihydropteroate synthase MT1246 138.971732 127.04715 149.673268 143.628292 1.103455811 0.142028856 7.12935906 0.518774989 Rv1208 Rv1208 conserved hypothetical protein MT1247 120.042339 79.7211815 99.0244163 79.3077959 0.904548525 −0.144730196 6.56507052 0.540584159 Rv1209 Rv1209 conserved hypothetical protein MT1248 124.071863 110.216117 120.847979 109.594631 0.984125243 −0.023086165 6.86237304 0.932510447 Rv1210 tagA DNA-3-methyladenine glycosidase I MT1249 523.369603 414.984493 531.312823 373.745794 0.956375597 −0.064350776 8.84866835 0.814508736 MT1250 60.0680243 68.5909825 52.7402768 62.9154365 0.897947012 −0.155297781 5.93679647 0.518774989 Rv1212c Rv1212c possible involved in LPS synthesis MT1251 119.854919 120.260443 107.753841 105.769747 0.889165431 −0.169476235 6.82757126 0.385709947 Rv1213 glgc glucose-1-phosphate adenylytransferase MT1252 51.821556 47.0544999 66.2890721 46.054724 1.120737539 0.164448459 5.72717739 0.55857838 MT1253 159.025643 177.268779 176.316201 171.573362 1.03550389 0.050332973 7.41973171 0.869506445 Rv1215c Rv1215c conserved hypothetical protein MT1254 84.4325895 58.3656777 101.66143 59.9492 1.114817659 0.156807761 6.25290329 0.508865765 Rv1216c Rv1216c conserved hypothetical protein MT1255 203.16299 113.021289 247.333712 102.491276 1.054393823 0.076413824 7.38067541 0.808221041 Rv1217c Rv1217c probable integral membrane protein MT1256 96.6148721 59.4515508 103.389129 54.6411979 0.994874209 −0.007413971 6.29787151 0.981344332 Rv1218c Rv1218c probable ABC transmembrane transport proteinportein MT1257 69.2515912 44.7922643 81.1109085 45.3521943 1.092343418 0.127426491 5.91371471 0.635974597 Rv1219c Rv1219c putative transcriptional regulator MT1258 126.883159 214.82189 161.312502 270.161694 1.264259455 0.338292568 7.5961955 0.022000188 Rv1220c Rv1220c probable methyltransferase MT1259 1216.54148 1362.40875 1331.32826 1245.74125 1.000273224 0.000394125 10.3322368 0.999355608 Rv1221 sigE ECF subfamily sigma subunit MT1260 539.76883 434.892166 679.531187 523.774912 1.23140599 0.300306491 9.0892241 0.056753569 Rv1222 Rv1222 hypothetical protein MT1261 1006.53757 898.2885 1153.19343 985.10274 1.120911228 0.164672027 9.98150181 0.480991077 Rv1223 htrA serine protease MT1262 215.064143 174.192139 249.334205 201.547962 1.158192219 0.211874709 7.71566665 0.227121508 Rv1224 Rv1224 conserved hypothetical protein MT1263 53.227204 36.5577268 48.4664958 27.0864224 0.825455351 −0.276737914 5.37451188 0.22614993 Rv1225c Rv1225c conserved hypothetical protein MT1264 115.544255 62.1662335 104.116581 55.4998453 0.897140452 −0.15659423 6.40054251 0.473568514 Rv1226c Rv1226c possible membrane protein MT1264.1 2.99871572 2.89566153 4.09191803 2.41982448 1.084548004 0.11709391 1.70860051 0.880856541 MT1265 25.8639231 27.7802528 27.9159741 23.1054208 0.946778506 −0.078901141 4.71892689 0.830576393 MT1266 7.2156597 9.86334709 7.45638396 6.79112032 0.833915941 −0.262026128 3.00030368 0.518774989 MT1267 526.930578 365.577268 451.656819 372.65297 0.934483558 −0.097758814 8.74607102 0.712116442 Rv1229c mrp similar to MRP/NBP35 ATP-binding proteins MT1268 184.327307 258.70926 218.872149 229.727208 1.025633522 0.036515321 7.80147748 0.905696211 Rv1230c Rv1230c possible membrane protein MT1269 84.05775 73.9298585 72.3814834 72.282499 0.917712366 −0.123886047 6.2447771 0.620935457 Rv1231c Rv1231c hypothetical protein MT1270 213.283656 145.416503 188.86475 152.839237 0.964057663 −0.052808654 7.4533959 0.865029216 Rv1232c Rv1232c hypothetical protein MT1271 250.955022 168.400816 259.154809 205.841199 1.122732932 0.16701479 7.78957803 0.430911272 Rv1233c Rv1233c hypothetical protein MT1272 111.88958 103.42941 105.389622 104.052453 0.973542415 −0.038684259 6.73286442 0.894736554 MT1273 105.32939 100.805217 108.935951 93.7486839 0.980750282 −0.02804225 6.67771861 0.923772833 Rv1235 lpqY possible role in sugar transport MT1274 53.5083336 51.3979922 52.3765508 53.548374 1.010133459 0.014545914 5.72476589 0.969605889 Rv1236 sugA membrane protein probably involved in sugar MT1275 45.6367049 50.6740768 51.5581672 60.495612 1.162090459 0.216722375 5.7081448 0.335730191 MT1276 181.89085 220.341745 150.036994 205.997316 0.878926326 −0.186185855 7.56794698 0.365758936 Rv1238 sugC ABC transporter component of sugar uptake system MT1277 70.750949 141.434368 69.5626065 107.018689 0.857814856 −0.221261793 6.6055321 0.318869615 MT1278 268.385057 282.688957 289.071276 303.18059 1.074768138 0.104025458 8.15993074 0.658345643 Rv1240 mdh malate dehydrogenase MT1279 59.3183453 56.6463787 59.2873457 67.5989677 1.093262083 0.128639294 5.92826846 0.636019999 Rv1241 Rv1241 conserved hypothetical protein MT1280 68.9704616 72.2105594 73.2907935 93.670625 1.176192569 0.234124281 6.27101758 0.255022855 MT1280.1 23.0526271 19.9981624 20.9142477 17.4851833 0.890950441 −0.166582911 4.35953457 0.55335105 Rv1243c PE_PGRS PE_PGRS-family protein MT1281 182.17198 119.536528 182.954202 160.80124 1.161027504 0.215402149 7.33573942 0.346010758 Rv1244 lpqZ lipoprotein MT1283 74.6867634 125.689808 80.0197304 124.894167 1.030122475 0.042815875 6.66557891 0.886067917 Rv1245c Rv1245c putative dehydrogenase MT1284 67.0025544 89.4035498 67.0165242 96.0904495 1.03823922 0.054138892 6.32317479 0.856419101 MT1286 787.444006 883.719703 909.406049 969.334851 1.125467084 0.170523863 9.79386179 0.457229549 Rv1248c sucA 2-oxoglutarate dehydrogenase MT1287 153.96531 153.108103 160.221324 179.691482 1.105540885 0.14475238 7.33922479 0.518774989 Rv1249c Rv1249c possible membrane protein MT1288 2.43645652 2.89566153 1.81863024 1.8734125 0.692404079 −0.530313872 1.27822555 0.380784281 MT1289 57.0693016 58.0942095 56.1047428 58.1538464 0.992141174 −0.011382676 5.84629715 0.973114765 Rv1250 Rv1250 probable drug efflux protein MT1290 116.200234 266.943797 137.12472 272.269283 1.094246147 0.129937304 7.63183514 0.571424955 Rv1251c Rv1251c hypothetical protein MT1291 46.0115443 126.685192 66.5618666 123.33299 1.174251181 0.231741044 6.50547601 0.375125762 Rv1252c lprE lipoprotein MT1292 121.729116 161.52362 121.757294 145.81394 0.949394246 −0.074920789 7.10734636 0.787869534 Rv1253 deaD ATP-dependent DNA/RNA helicase MT1293 87.0564658 115.735972 80.5653194 105.457512 0.918088925 −0.123294196 6.60565268 0.597362575 Rv1254 Rv1254 acyltransferase MT1294 19.5853621 14.6592865 20.1867956 18.8902427 1.149535019 0.201050416 4.20997275 0.497727102 Rv1255c Rv1255c transcriptional regulator (TetR/AcrR family) MT1295 57.6315678 54.6556114 57.2868524 72.0483224 1.146885983 0.197721974 5.92109669 0.450685116 Rv1256c Rv1256c Probable cytochrome P-450 MT1296 299.403023 322.95675 268.702617 345.254312 0.979996688 −0.029151222 8.27268947 0.922469947 Rv1257c Rv1257c similar to many dehydrogenases MT1297 95.8651932 152.746146 69.653538 170.090243 0.90576788 −0.142786715 6.93419633 0.637012172 Rv1258c Rv1258c probable multidrug resistance pump MT1297.1 20.2413311 24.1606759 20.0958641 19.7488901 0.897623442 −0.155817742 4.40833689 0.607448979 MT1298 119.854919 144.511608 98.1151012 122.63046 0.833790006 −0.262244015 6.92427772 0.099282733 Rv1260 Rv1260 probable oxidoreductase MT1299 129.881875 151.569783 123.30313 120.913165 0.869617404 −0.201547281 7.03988485 0.326266799 Rv1261c Rv1261c conserved hypothetical protein MT1300 96.8022919 105.782135 94.8415668 81.6495615 0.86920535 −0.20223104 6.56887996 0.364078181 Rv1262c Rv1262c conserved hypothetical protein MT1301 46.4800937 44.7922643 38.1912349 37.7804854 0.832641659 −0.264232353 5.39161081 0.209209933 Rv1263 amiB2 putative amidase AMI2_MYCTU Q11056 MT1302 532.74059 241.42578 515.763535 289.051937 1.075327771 0.104776475 8.62533693 0.692332363 Rv1264 Rv1264 similar to adenylate cyclases MT1303 215.438983 234.096137 237.694972 231.678679 1.044703343 0.063093328 7.84488938 0.813012054 Rv1265 Rv1265 hypothetical protein MT1304 138.690602 156.275233 136.760994 136.524936 0.927719744 −0.108239049 7.15214957 0.661583768 MT1305 31.2053855 45.3352008 31.7350976 37.8585443 0.916938791 −0.125102663 5.19815431 0.683091419 Rv1267c embR regulator of embAB genes (AfsR/Dndl/RedD family) MT1305.1 4.49807358 5.06740768 4.6375071 4.05906042 0.905548028 −0.143136935 2.24378887 0.810799794 MT1306 10.3080853 11.6731355 12.5485486 11.1624162 1.075452418 0.104943695 3.53588694 0.806148616 Rv1268c Rv1268c hypothetical protein MT1307 27.6444106 46.5115633 32.5534812 42.9323698 1.034326431 0.048691568 5.23262835 0.894346121 Rv1269c Rv1269c conserved hypothetical protein MT1308 88.4621138 122.975126 98.4788272 117.712752 1.030414186 0.043224361 6.7427062 0.836066809 Rv1270c lprA lipoprotein MT1309 31.5802249 30.8568932 37.6456459 33.4091896 1.135852158 0.183775067 5.06821053 0.473118615 Rv1271c Rv1271c conserved hypothetical protein MT1310 101.581495 100.895706 105.753348 108.735984 1.059354935 0.083186043 6.70625853 0.752487878 Rv1272c Rv1272c probable ABC transporter MT1311 41.4197609 49.859672 49.9214 57.841611 1.181747499 0.240921811 5.64237306 0.271793205 Rv1273c Rv1273c ABC transporter MT1312 125.571221 167.314943 128.213432 164.235829 1.000751858 0.001084294 7.19494932 0.997789429 MT1312.1 158.650824 225.318663 156.584063 220.75044 0.983277094 −0.02433006 7.57375709 0.930747689 Rv1275 lprC lipoprotein MT1313 12.7445418 17.6454375 11.730165 14.2067115 0.855350808 −0.225411856 3.83385743 0.450620436 Rv1276c Rv1276c hypothetical protein MT1314 184.983276 245.950251 207.596641 241.670213 1.049324274 0.069460584 7.78289633 0.799343299 Rv1277 Rv1277 hypothetical protein MT1315 328.265652 406.478487 347.903964 410.979867 1.035008992 0.049643302 8.54531543 0.859858221 Rv1278 Rv1278 hypothetical protein MT1316 209.722631 372.725933 211.779491 373.745794 1.006197869 0.008914039 8.1907703 0.976143948 Rv1279 Rv1279 probable choline dehydrogenase MT1317 230.526271 382.136833 210.597381 346.269077 0.909777935 −0.13641365 8.19265468 0.52349722 Rv1280c oppA probable oligopeptide transport protein MT1318 66.8151347 144.421119 68.1986338 129.577698 0.953308257 −0.068985302 6.67879486 0.808221041 Rv1281c oppD probable peptide transport protein MT1319 47.9794515 101.257664 47.1934546 101.866805 0.995719424 −0.006188821 6.22455366 0.983783004 Rv1282c oppC oligopeptide transport system permease MT1320 69.1578813 135.372177 70.9265792 129.343521 0.987935568 −0.017511141 6.66389015 0.952996744 Rv1283c oppB oligopeptide transport protein MT1322 100.269557 194.280791 91.4771008 113.965927 0.728341806 −0.457312439 6.96777169 0.01811476 Rv1284 Rv1284 conserved hypothetical protein MT1323 253.110349 88.4986555 200.32212 68.0673209 0.780862419 −0.356859714 7.25389544 0.017058269 MT1324 591.309256 309.745294 460.74997 234.801033 0.768688386 −0.379529223 8.6413055 0.006058136 Rv1286 cysN ATP:sulphurylase subunit 1 MT1325 121.541697 98.9954286 97.6604436 73.0630875 0.770484442 −0.376162269 6.61429119 0.011888969 Rv1287 Rv1287 conserved hypothetical protein MT1326 92.9601873 90.308444 82.5658127 68.1453797 0.81877953 −0.288453061 6.38642621 0.100578109 Rv1288 Rv1288 conserved hypothetical protein MT1327 99.6135878 61.0803604 78.9285522 66.3500261 0.925322333 −0.111972083 6.26032586 0.721200634 Rv1289 Rv1289 hypothetical protein MT1328 61.8485117 49.5882037 61.469702 50.6601964 1.007467486 0.01073328 5.80889559 0.974671036 Rv1290c Rv1290c hypothetical protein MT1329 3.65468478 3.52908749 3.00073989 3.04429531 0.842735851 −0.246847595 1.79858338 0.692019534 MT1330.1 21.0847199 25.8799749 19.004686 21.8564792 0.870823338 −0.199548023 4.46811132 0.448874833 MT1331 268.666187 253.370384 252.244014 238.547858 0.940190034 −0.088975707 7.98514853 0.719637416 Rv1292 argS arginyl-tRNA synthase MT1332 461.895911 347.750852 377.547637 332.218483 0.883524842 −0.178657396 8.56992241 0.380784281 Rv1293 lysA diaminopimelate decarboxylase MT1333 415.603257 370.282718 357.26991 327.222717 0.871594909 −0.198270325 8.52262627 0.266655454 Rv1294 thrA homoserine dehydrogenase MT1334 365.468478 304.496908 307.166647 296.701705 0.904944285 −0.144099123 8.31572708 0.523152821 Rv1295 thrC homoserine synthase MT1335 134.567368 121.346316 112.48228 113.887868 0.885898365 −0.1747869 6.91577825 0.384917628 Rv1296 thrB homoserine kinase MT1336 5089.28913 3399.14468 6953.71457 4990.53673 1.416326795 0.502154183 12.3186397 0.003877189 Rv1297 rho transcription termination factor rho MT1337 1642.64025 1145.95805 1891.19358 1405.76191 1.188375118 0.248990304 10.5713317 0.220525182 Rv1298 rpmE 50S ribosomal protein L31 MT1338 744.899727 459.233821 890.765089 591.99835 1.241390709 0.311957254 9.39208102 0.058076676 MT1339 603.397829 501.492381 607.604362 491.146311 0.993095403 −0.009995776 9.10611078 0.974110692 Rv1300 hemK protoporphysinogen oxidase MT1340 328.546791 253.098916 331.990949 244.246155 0.987611896 −0.01798388 8.17808804 0.950509814 Rv1301 Rv1301 conserved hypothetical protein MT1341 331.732927 309.745294 176.316201 183.516366 0.56128475 −0.833195232 7.96856484 1.29E−12 Rv1302 rfe hypothetical protein MT1342 211.784298 116.550377 211.779491 111.155808 0.977181628 −0.033301355 7.34844661 0.904814009 MT1343 400.141129 246.402698 410.101118 268.912753 1.057296604 0.080380154 8.37308055 0.756319422 MT1344 516.528783 416.522813 574.141565 413.165515 1.050205685 0.070671911 8.9076566 0.798636571 MT1345 399.67258 322.95675 455.294079 336.980074 1.090410896 0.124871883 8.5656478 0.572054672 Rv1305 atpE ATP synthase c chain MT1346 803.187254 674.598647 907.951145 725.400932 1.102551408 0.140847234 9.60354264 0.548110991 Rv1306 atpF ATP synthase b chain MT1347 1753.49902 1196.63213 1862.91388 1342.45617 1.091691864 0.126565705 10.5878149 0.629689153 Rv1307 atpH ATP synthase [delta] chain MT1348 1876.91491 1499.04778 2064.9637 1593.64957 1.081499681 0.11303324 10.7803854 0.687203723 Rv1308 atpA ATP synthase [alpha] chain MT1349 924.166701 674.236689 971.966929 760.761593 1.089291625 0.123390244 9.70208764 0.624685486 Rv1309 atpG ATP synthase [gamma]hain MT1350 1648.45026 1100.71334 1728.88083 1253.78132 1.092938847 0.12821268 10.4849447 0.621541633 Rv1310 atpD ATP synthase [beta] chain MT1351 299.965232 207.401757 301.437962 230.663914 1.056791954 0.079691387 8.02255142 0.76159676 Rv1311 atpC ATP synthase [epsilon] chain MT1352 134.005109 93.747042 151.764693 99.6811568 1.098083226 0.134987403 6.90643875 0.52349722 Rv1312 Rv1312 conserved hypothetical protein MT1353 157.994835 117.726739 137.397514 124.972226 0.960318441 −0.058415213 7.07351307 0.849425114 Rv1313c Rv1313c transposase MT1354 51.6341353 49.1357566 54.2861125 52.9239031 1.064210887 0.089784068 5.705197 0.764687847 Rv1314c Rv1314c conserved hypothetical protein MT1355 289.750927 262.147858 272.248946 292.876821 1.024728335 0.035241488 8.12636484 0.90313325 Rv1315 murA UDP-N-ace- tylglucosamine-1-carboxyvinyltransferase MT1356 5.99743114 10.0443259 4.72843861 8.3522974 0.814534193 −0.295952833 2.90042738 0.427783411 MT1357 65.2220659 105.510667 73.0180039 92.2655657 0.985381222 −0.021246116 6.39556897 0.94941324 Rv1316c ogt methylated-DNA-protein-cysteine methyltransferase MT1358 181.703431 168.491305 179.22601 138.944761 0.902129861 −0.148592972 7.38590652 0.520848866 MT1359 52.4775251 77.4589459 65.6525515 76.4976771 1.107518706 0.147344093 6.09188064 0.584969964 Rv1318c Rv1318c similar at C-term to adenylate cyclases MT1360 109.453124 153.198593 121.939157 180.394012 1.146130476 0.196771291 7.14407449 0.311717327 MT1361 107.391537 143.335246 121.848226 139.64729 1.049960851 0.070335536 7.00269621 0.801831984 Rv1319c Rv1319c similar at C-term to adenylate cyclases MT1362 165.679044 179.531015 179.771599 191.712546 1.076356348 0.106155788 7.48667168 0.657287407 Rv1320c Rv1320c similar at C-term to adenylate cyclases MT1363 197.915238 173.015776 193.68412 176.803305 1.000002128 3.07E−06 7.53547939 0.999975832 MT1363.1 79.6533863 97.1856401 77.9283056 93.0461542 0.967572775 −0.047557919 6.4451781 0.875390859 Rv1322 Rv1322 hypothetical protein MT1364 1937.35778 1095.82691 1676.77708 1106.64038 0.934778082 −0.097304188 10.5061144 0.745116768 MT1365 882.74634 693.872894 930.774954 741.715233 1.061643889 0.086299919 9.6661278 0.760272935 Rv1323 fadA4 acetyl-CoA C-acetyltransferase (aka thiL) MT1366 1199.86113 602.388088 1144.55494 735.236348 1.078612313 0.109176408 9.84653658 0.723313141 Rv1324 Rv1324 hypothetical protein MT1367 101.768915 79.2687344 117.665376 85.0841511 1.114648639 0.156589013 6.58667636 0.468223919 MT1368 520.558307 345.126659 418.284954 280.621581 0.808273829 −0.30708396 8.61213318 0.040657205 Rv1326c glgB 1,4-[alpha]-glucan branching enzyme MT1369 700.38754 400.234717 621.516883 408.716161 0.951570189 −0.07161802 9.05763348 0.801337286 Rv1327c Rv1327c probable glycosyl hydrolase, [alpha]-amylase family MT1370 373.808657 407.926318 325.443881 386.313269 0.908200769 −0.138916837 8.54516147 0.517396887 Rv1328 glgP probable glycogen phosphorylase MT1371 97.4582609 122.613168 95.2962243 101.554569 0.898759578 −0.153992855 6.70605899 0.50431495 Rv1329c dinG probable ATP-dependent helicase MT1372 75.4364423 79.8116709 69.9263325 72.2044401 0.915617756 −0.127182654 6.21952775 0.593366813 Rv1330c Rv1330c conserved hypothetical protein MT1373 120.604538 97.1856401 95.3871558 97.4955089 0.890751558 −0.166904993 6.68423266 0.487999758 Rv1331 Rv1331 conserved hypothetical protein MT1374 674.898457 629.172957 642.885788 600.272589 0.953317088 −0.068971938 9.31510063 0.802899283 Rv1332 Rv1332 putative transcriptional regulator MT1375 227.714975 164.419281 212.052285 157.210532 0.943494628 −0.083913792 7.57372906 0.746089419 Rv1333 Rv1333 probable hydrolase MT1376 128.195097 144.421119 121.575431 139.022819 0.955559084 −0.065583014 7.06050904 0.808331268 MT1376.1 64.7535176 68.2290248 61.1969074 70.8774396 0.991691894 −0.012036132 6.0540809 0.973097519 Rv1335 Rv1335 conserved hypothetical protein MT1377 226.590457 196.271558 211.870422 202.016315 0.981012666 −0.027656332 7.70933757 0.92245505 Rv1336 cysM cysteine synthase B MT1378 278.880552 235.453478 271.976152 238.860094 0.994624247 −0.007776493 8.00260379 0.977735627 Rv1337 Rv1337 conserved hypothetical protein MT1379 162.211779 109.582691 151.491899 125.206402 1.031936499 0.045354196 7.10108682 0.886066809 Rv1338 murl glutamate racemase MT1380 446.340033 308.116485 421.376626 327.144658 1.000908234 0.00130971 8.55423874 0.997032163 Rv1339 Rv1339 conserved hypothetical protein MT1381 264.355533 187.675063 257.063384 222.467734 1.073111801 0.101800389 7.86456324 0.704237224 Rv1340 rphA ribonuclease PH MT1382 114.794536 72.9344748 120.30239 88.2845641 1.124514172 0.169301843 6.63292336 0.442630387 Rv1341 Rv1341 conserved hypothetical protein MT1383 125.758641 84.6980998 120.029596 75.1706766 0.921223131 −0.118377458 6.66632953 0.619926139 Rv1342c pks14 polyketidc synthase (chalcone synthase- like) MT1384 73.2811154 60.8088921 81.5655661 57.7635521 1.029504643 0.041950336 6.09844348 0.897921476 Rv1343c Rv1343c conserved hypothetical protein MT1385 86.9627559 75.1062209 83.7479223 77.8246776 0.998877656 −0.00162011 6.34131873 0.997032163 MT1387 187.700852 155.370339 189.683134 165.640889 1.037868845 0.053624143 7.44931302 0.852815959 Rv1345 fadD33 acyl-CoA synthase MT1388 127.445418 122.703657 125.758281 117.634693 0.972588989 −0.040097836 6.94904178 0.886067917 Rv1346 fadE14 acyl-CoA dehydrogenase MT1389 106.266938 47.8689047 113.391595 55.655963 1.110769301 0.15155921 6.33890204 0.50431495 Rv1347c Rv1347c possible aminoglycoside 6′-N-acetyltransferase MT1390 326.672534 139.082243 344.357635 160.80124 1.102641343 0.140963601 7.92408077 0.515488915 Rv1348 Rv1348 heavy metal tolerance protein MT1392 132.599451 49.5882037 149.218611 63.0715542 1.191350376 0.252597772 6.62595093 0.169809985 Rv1349 Rv1349 probable membrane protein MT1393 33.8292617 24.3416547 27.4613166 22.48095 0.864181283 −0.210594111 4.76502457 0.412841331 Rv1350 fabG2 3-oxoacyl-[ACP] reductase MT1394 39.6392734 63.342596 36.9181938 45.508312 0.813264281 −0.298203843 5.54006934 0.191125613 Rv1351 Rv1351 hypothetical protein MT1395 212.252847 194.190301 192.411079 180.706248 0.918475013 −0.122687622 7.60777329 0.581303031 MT1396 16.4929355 15.3832019 13.4578637 12.1771813 0.803784289 −0.315119717 3.86226122 0.206882418 Rv1353c Rv1353c transcriptional regulator (TetR/AcrR family) MT1397 42.1694338 35.1098961 34.0083854 34.3458958 0.888351688 −0.170797159 5.1929228 0.52349722 Rv1354c Rv1354c conserved hypothetical protein MT1398 46.948643 36.0147903 37.4637828 31.3796594 0.83320294 −0.263260165 5.25223157 0.216905457 Rv1355c moeY weak similarity to E. coli MoeB MT1399 4.12323412 5.79132306 4.91030164 3.82488386 0.876474792 −0.190215496 2.27239888 0.760272935 Rv1356c Rv1356c hypothetical protein MT1402 41.7008935 32.9381449 41.4647694 26.8522458 0.90342929 −0.146516407 5.16579564 0.616132609 Rv1358 Rv1358 transcriptional regulator (LuxR/UhpA family) MT1403 16.9614858 16.9215221 16.1858091 16.4704182 0.964030935 −0.052848653 4.07122441 0.89125591 Rv1359 Rv1359 putative transcriptional regulator MT1404 19.3979423 22.4413769 17.9135078 24.0421271 0.999820594 −0.000258851 4.40151223 0.999749229 MT1405 294.24838 275.811761 330.899771 329.798659 1.159640063 0.213677081 8.26617919 0.242716038 Rv1360 Rv1360 coenzyme F420-dependent MT1406 1704.20753 1601.48181 1551.92811 1112.72897 0.795483281 −0.330096486 10.5437507 0.108283998 MT1407 45.4492851 72.4820277 45.0110983 63.5399073 0.928703751 −0.106709633 5.8280001 0.714079818 Rv1362c Rv1362c conserved hypothetical protein MT1408 40.0141129 73.9298585 46.1022765 61.9787302 0.975336087 −0.036028658 5.79944078 0.922310673 MT1409 58.0064072 94.6519363 66.4709351 98.1980386 1.087661459 0.121229579 6.31336426 0.619926139 MT1410 273.44539 236.448862 277.068316 258.296749 1.052052662 0.073206923 8.03060566 0.781643628 Rv1364c rsbU SigB regulation protein MT1411 79.4659656 85.1505469 91.9317584 87.1136813 1.087333006 0.120793847 6.42782475 0.619926139 Rv1365c Rv1365c conserved hypothetical protein MT1412 30.0808671 27.5087845 25.8245493 24.2763037 0.87051086 −0.200065799 4.75973762 0.431856887 Rv1366 Rv1366 hypothetical protein MT1413 29.7997375 29.1375942 26.824796 29.6623646 0.958652524 −0.060920108 4.8596272 0.865317142 MT1414 81.1527412 90.2179546 70.3809901 69.0040271 0.813855241 −0.297155887 6.28276076 0.083664833 Rv1367c Rv1367c probable penicillin binding protein MT1414.1 57.3504332 46.4210739 54.2861125 44.0251938 0.947476749 −0.077837555 5.66352748 0.803054534 MT1415 161.36839 124.784914 156.765925 109.828808 0.925211155 −0.112145435 7.1121488 0.641879751 Rv1368 lprF lipoprotein MT1416 60.4428637 51.9409287 55.1044961 42.854311 0.867825349 −0.204523367 5.72103885 0.380784281 Rv1371 Rv1371 hypothetical protein MT1417 68.4082024 48.6833095 56.1956743 45.4302531 0.874494734 −0.193478398 5.77718059 0.415865749 Rv1372 pks18 polyketide synthase MT1418 110.296513 106.234582 91.9317584 89.4554469 0.837802779 −0.255317426 6.63876233 0.135022698 Rv1373 Rv1373 slight similarity to sulfotransferases MT1418.1 4.96662291 7.1486644 4.72843861 6.32276719 0.912907842 −0.131458868 2.57361661 0.803788741 MT1419 132.693171 258.799749 165.950009 199.908726 0.980104992 −0.028991791 7.56622172 0.942887721 Rv1375 Rv1375 conserved hypothetical protein MT1420 79.6533853 122.25121 79.8378673 84.6938568 0.830556063 −0.26785054 6.52014696 0.250978723 Rv1376 Rv1376 conserved hypothetical protein MT1421 100.925526 86.3269094 88.5672925 79.6980901 0.900034644 −0.15194756 6.47649041 0.490245331 Rv1377c Rv1377c some similarity to methyltransferases MT1422 499.005038 215.636295 391.823884 204.5826433 0.862401045 −0.213569169 8.35740475 0.285039845 Rv1378c Rv1378c conserved hypothetical protein MT1423 185.358116 146.683354 178.953215 160.254828 1.026782046 0.038129975 7.39217528 0.897921476 Rv1379 pyrR regulatory protein pyrimidine biosynthesis MT1424 130.350424 46.3305845 110.936444 45.3521943 0.907602808 −0.139867022 6.38164276 0.556524389 Rv1380 pyrB aspartate carbamoyltransferase MT1425 294.4354 103.338921 230.147656 96.2465672 0.850468869 −0.233669667 7.50126899 0.231692783 Rv1381 pyrC dihydroorotase MT1426 115.544255 48.8642883 89.02195 42.2298401 0.812753442 −0.299110334 6.2105345 0.08792534 MT1427 226.403037 103.791368 179.589736 87.3478578 0.816182636 −0.293036076 7.22327308 0.068053722 Rv1383 carA carbamoyl-phosphate synthase subunit MT1428 723.159038 333.363034 536.314056 323.866186 0.847986738 −0.237886393 8.90485321 0.257330868 Rv1384 carB carbamoyl-phosphate synthase subunit MT1429 104.486501 58.0942095 93.113868 60.7297886 0.962368728 −0.055338331 6.30856167 0.85855125 Rv1385 pyrF orotidine 5′-phosphate decarboxylase MT1430 31.2053855 50.6740768 38.1912349 82.5082089 1.425379899 0.511346484 5.66859036 0.005520797 Rv1386 PE PE-family protein MT1431 504.25279 517.870967 492.848794 661.158495 1.11744337 0.16020172 9.0880541 0.518774989 Rv1387 PPE PPE-family protein MT1433 555.418377 820.648576 415.102351 701.202687 0.799472532 −0.322879628 9.28373368 0.048861987 MT1434 640.132096 1058.00233 530.585371 988.303153 0.880220821 −0.184062597 9.65185783 0.412841331 MT1435 1563.3617 955.387326 1509.82682 1077.83666 1.043684294 0.061685374 10.318277 0.854187645 Rv1390 Rv1390 hypothetical protein MT1436 1532.71857 940.185103 1606.21422 1048.48653 1.080986943 0.112349097 10.3242496 0.689949133 MT1437 1689.49518 1240.88146 1585.39091 1162.45246 0.937589521 −0.092971649 10.4713863 0.745116768 Rv1392 metK S-adenosylmethionine synthase MT1438 82.4646823 99.1764074 78.6557577 83.6010328 0.895684429 −0.158937569 6.42876702 0.476182576 Rv1393c Rv1393c FAD-containing monooxygenase MT1439 78.8099975 99.2668968 71.0175107 83.6790917 0.87082315 −0.199548334 6.38146595 0.311717327 Rv1394c Rv1394c possible cytochrome p450 MT1440 22.0218186 26.6038903 20.8233162 21.8564792 0.878665882 −0.186613418 4.52358221 0.494261547 Rv1395 Rv1395 transcriptional regulator (AraC/XylS family) MT1441 1540.77762 696.225619 1515.00992 806.035728 1.066635005 0.09306658 10.1543915 0.760272935 Rv1397c Rv1397c conserved hypothetical protein MT1442 7449.37211 2644.91534 6375.29922 3072.70874 0.996995639 −0.004340901 12.2543542 0.992966231 Rv1398c Rv1398c conserved hypothetical protein MT1443 75.8112818 78.9067767 79.1104152 70.9554985 0.968327701 −0.046432729 6.25488675 0.881775651 Rv1399c lipH probable lipase MT1444 112.077 99.085918 95.2962243 91.8752714 0.887973384 −0.171411661 6.64028345 0.414134607 Rv1400c lipI probable lipase MT1445 65.0346472 64.5189585 80.0197304 66.2719672 1.124213898 0.168916555 6.11134835 0.49136425 Rv1401 Rv1401 possible membrane protein MT1446 97.3645511 77.9113931 111.754828 87.0356224 1.132517214 0.179532979 6.54977659 0.380784281 MT1447 41.6071806 55.1985479 60.1057293 51.2066084 1.15451283 0.207284206 5.70617205 0.517063573 MT1448 379.993508 293.004751 419.194269 347.986372 1.144482926 0.19469594 8.4927224 0.286557916 Rv1404 Rv1404 transcriptional regulator (MarR family) MT1449 210.19123 192.018555 278.977878 141.286526 0.989598441 −0.015084867 7.68491525 0.974588872 Rv1405c Rv1405c similar to phosphatidylethanolamine N-methyltransferase MT1450 99.7072977 62.9806383 107.026389 63.5399073 1.041807247 0.059088378 6.38320461 0.834327498 Rv1406 fmt methionyl-tRNA formyltransferase MT1451 111.421031 75.1967104 114.846499 82.6643266 1.063708141 0.08910236 6.58791055 0.733038419 Rv1407 fmu similar to Fmu protein MT1452 243.739352 185.05087 201.231436 186.01425 0.910737185 −0.134893305 7.67367023 0.569416225 Rv1408 rpe ribulose-phosphate 3-epimerase MT1453 264.730372 192.018555 244.696698 193.117605 0.963888927 −0.053061187 7.8060977 0.848674008 Rv1409 ribG riboflavin biosynthesis MT1454 1130.89057 1008.23315 1071.62787 1019.05834 0.978658936 −0.031121919 10.0466117 0.921400122 Rv1410c Rv1410c probable drug efflux protein MT1455 588.59167 535.063957 554.864085 508.787612 0.946786787 −0.078888522 9.09538853 0.764687847 Rv1411c lprG lipoprotein MT1456 42.1694398 46.2400951 43.0106051 46.9133714 1.017183823 0.024580423 5.48423802 0.941944031 Rv1412 ribc riboflavin synthase [alpha] chain MT1457 39.5455636 61.8042758 39.0096185 51.9871969 0.907215091 −0.140483456 5.59306552 0.619926139 Rv1414 Rv1414 hypothetical protein MT1458 596.088459 435.79706 567.503565 484.121014 1.028240889 0.040178288 9.02526739 0.894346121 Rv1415 ribA2 probable GTP cyclohydrolase II MT1459 205.693156 147.678738 198.594422 162.440476 1.030038857 0.042698762 7.4819537 0.887540971 Rv1416 ribH riboflavin synthase [beta] chain MT1460 72.5314356 50.8550556 73.6545245 57.4513167 1.069851461 0.097410506 5.995267 0.738873933 Rv1417 Rv1417 hypothetical protein MT1461 128.101337 111.844927 129.122747 121.693754 1.047218827 0.066562939 6.94093086 0.801831984 Rv1418 lprH lipoprotein MT1462 277.193784 216.903147 264.337905 205.841199 0.951322695 −0.071993298 7.91428353 0.781643628 Rv1419 Rv1419 hypothetical protein MT1463 296.872856 227.490409 249.061411 221.296852 0.903190587 −0.146897645 7.95911001 0.500206296 Rv1420 uvrC excinuclease ABC subunit C MT1464 145.625132 117.274292 123.666856 121.693754 0.938609757 −0.091402638 6.99136111 0.739414086 Rv1421 Rv1421 conserved hypothetical protein MT1465 157.807415 124.241978 136.760994 112.014456 0.883816459 −0.178181297 7.05386336 0.37638467 Rv1422 Rv1422 conserved hypothetical protein MT1466 108.797155 93.6565526 101.752362 86.0989162 0.927290189 −0.108907204 6.61091901 0.650984211 Rv1423 Rv1423 putative transcriptional regulator MT1467 15.6495477 18.7313105 13.6397268 15.9240063 0.860121074 −0.217388342 4.01455339 0.438953559 MT1468 172.988413 169.486689 182.044887 161.347652 1.00085972 0.001239781 7.42323065 0.997032163 Rv1425 Rv1425 conserved hypothetical protein MT1469 80.1219357 115.283525 85.2028265 155.33712 1.201994734 0.265430575 6.7707323 0.160382194 Rv1426c lipO probable esterase MT1470 132.693171 179.350036 140.489186 219.579557 1.140163494 0.189240715 7.39425863 0.364078181 Rv1427c fadD12 acyl-CoA synthase MT1471 149.935736 146.683354 157.493378 187.809603 1.160435383 0.214666191 7.32793641 0.293416398 Rv1428c Rv1428c conserved hypothetical protein MT1472 3691.23153 2296.35008 3769.38396 2429.97213 1.039503024 0.055893355 11.5731229 0.872232971 Rv1429 Rv1429 conserved hypothetical protein MT1474 368.654614 232.10537 545.407208 329.330306 1.449122114 0.535179172 8.52764229 1.82E−05 Rv1430 PE PE-family protein MT1475 132.693171 102.795984 168.587023 110.687455 1.170958526 0.227689978 7.00962515 0.228822124 Rv1431 Rv1431 possible transporter MT1476 47.6983219 32.6666816 51.1035036 33.2530719 1.045532706 0.064238193 5.36952519 0.839820353 Rv1432 Rv1432 putative dehydrogenase MT1477 69.2515912 123.246594 78.2920316 122.474342 1.056822585 0.079733203 6.62222626 0.774559491 Rv1433 Rv1433 possible membrane protein MT1478 15.2747032 28.1422105 13.3669322 24.5885391 0.874362394 −0.193696743 4.36001572 0.478563233 MT1479 577.065356 403.311358 873.39717 587.23676 1.484597909 0.570072242 9.25367199 1.12E−05 Rv1435c Rv1435c conserved hypothetical protein MT1480 468.268202 393.267032 444.109503 396.538979 0.977875479 −0.032277328 8.73374602 0.904814009 Rv1436 gap glyceraldehyde 3-phosphate dehydrogenase MT1481 349.912641 307.030612 340.993169 332.374601 1.027117649 0.038601441 8.37830534 0.894346121 MT1482 261.450527 231.200475 235.239821 257.438101 1.001137075 0.001639521 7.94550091 0.997032163 Rv1438 tpi triosephosphate isomerase MT1484 22.9589172 21.8079509 21.9144943 20.2953021 0.942447143 −0.085516388 4.45385995 0.801831984 Rv1439c Rv1439c hypothetical protein MT1485 221.248994 262.690795 243.969246 275.001343 1.074191519 0.103251236 7.97103263 0.652596324 MT1487 314.209182 315.989065 281.705823 284.680641 0.898744066 −0.154017754 8.22553578 0.459370243 Rv1442 bisC biotin sulfoxide reductase MT1488 17.8985845 13.5734134 15.094631 11.0843573 0.830732385 −0.267544297 3.86514339 0.318923756 MT1489 101.956335 76.192094 88.3854294 67.6770266 0.877341034 −0.188790348 6.38738405 0.347270937 Rv1443c Rv1443c hypothetical protein MT1491 81.3401639 84.969568 79.7469358 91.4069183 1.027714915 0.039440121 6.40168737 0.894346121 Rv1444c Rv1444c hypothetical protein MT1492 103.549402 104.062836 99.9337314 111.858338 1.019070753 0.02725422 6.71467316 0.926614192 Rv1445c devB glucoses-6-phosphate 1-dehydrogenase MT1493 213.845915 218.531956 200.958641 219.033145 0.970688155 −0.042920208 7.7365361 0.880578033 Rv1446c opcA unknown function, may aid G6PDH MT1494 314.771441 318.613258 284.615632 306.771297 0.933160463 −0.099802911 8.25912336 0.68274425 Rv1447c zwf2 glucose-6-phosphate 1-dehydrogenase MT1495 290.500585 289.385174 274.431303 278.592051 0.953677607 −0.068426452 8.14670375 0.800525302 Rv1448c tal transaldolase MT1496 866.254004 799.836008 819.656647 748.818588 0.941198862 −0.087428518 9.65965876 0.754149065 Rv1449c tkt transketolase MT1497.1 25.6765034 22.893824 26.6429329 21.6223026 0.990626673 −0.013586628 4.60746631 0.973097519 Rv1450c PE_PGRS PE_PGRS-family protein MT1497.2 3.09242559 3.80055576 2.00049326 2.02953021 0.584588158 −0.774507491 1.53401515 0.085938213 MT1498 388.802235 291.285452 362.816732 281.948581 0.950322147 −0.073511444 8.37232815 0.778848241 Rv1451 ctaB cytochrome c oxidase assembly factor MT1499 8.80872743 9.41089997 12.9122747 10.2257099 1.261134228 0.334721836 3.39452042 0.293615483 MT1500 53.6957534 66.2382575 55.2863592 61.042024 0.972715749 −0.039909819 5.88861793 0.90313325 MT1501 86.0256572 91.7562747 91.2952378 91.2508006 1.026992356 0.038425443 6.4960011 0.897840055 Rv1454c qor Probable quinone oxidoreductase MT1502 8.43388796 9.32041055 9.91153478 7.96200313 1.000394716 0.000569343 3.18231964 0.999355608 Rv1455 Rv1455 conserved hypothetical protein MT1503 62.2233512 70.6722392 66.6527981 69.7065568 1.027155118 0.03865407 6.07666114 0.90313325 Rv1456c Rv1456c probable membrane protein MT1504 71.500628 76.192094 76.7461959 87.9723287 1.113920089 0.15564574 6.29071066 0.486636212 Rv1457c Rv1457c probable membrane protein MT1505 130.631554 154.193977 135.215158 151.121942 1.006869665 0.009876945 7.15958239 0.974588872 MT1506 206.723955 195.276175 227.146916 238.703976 1.159113123 0.213021372 7.76251636 0.240010573 Rv1459c Rv1459c conserved hypothetical protein MT1507 127.351738 83.1597796 136.488199 88.8309761 1.070006132 0.097619065 6.76975615 0.687906803 Rv1460 Rv1460 putative transcriptional regulator MT1508 677.709753 482.308624 683.532174 451.960766 0.972312427 −0.040508134 9.16499954 0.89125591 Rv1461 Rv1461 conserved hypothetical protein MT1509 330.514638 185.593806 301.34703 169.778008 0.913243738 −0.130928139 7.94812683 0.536471852 MT1510 181.047452 137.543923 174.861297 134.339288 0.971204788 −0.042152561 7.2956505 0.884772098 Rv1463 Rv1463 ABC-type transporter MT1511 224.809959 132.657494 206.414532 126.611462 0.935778854 −0.095760467 7.43277048 0.706925111 Rv1464 Rv1464 NifS-like protein MT1512 67.6585234 41.5346451 62.1062225 48.8648427 1.035736269 0.050656694 5.78675732 0.886712512 Rv1465 Rv1465 conserved hypothetical protein MT1513 87.3375954 52.0314181 80.9290455 72.0483224 1.129212177 0.175316591 6.19491699 0.549225529 Rv1466 Rv1466 conserved hypothetical protein MT1514 136.066726 309.202358 153.492392 210.836965 0.874015949 −0.194268489 7.66237333 0.525764889 Rv1467c fadE15 acyl-CoA dehydrogenase MT1514.1 132.130911 167.405432 149.7642 154.868767 1.022931944 0.032710165 7.24051988 0.914775343 Rv1468c PE_PGRS PE_PGRS-family protein MT1515 61.0988328 152.565167 83.6569908 146.984822 1.139453332 0.188341838 6.79804451 0.462914078 Rv1469 ctpD probable cadmium-transporting ATPase MT1516 54.632852 79.4497132 52.3765508 73.6094995 0.941740968 −0.086597803 6.02688279 0.764687847 Rv1470 trxA thioredoxin MT1517 115.356845 245.769272 143.308063 199.59649 1.000735974 0.001061396 7.46104921 0.998970234 Rv1471 trxB thioredoxin reductase MT1518 274.195069 350.827492 269.793795 343.224782 0.981111073 −0.02751162 8.27470298 0.92245505 Rv1472 echA12 enoyl-CoA hydratase/isomerase superfamily MT1519 355.628943 388.109135 334.809826 381.005267 0.961461893 −0.056698416 8.51201821 0.828791613 Rv1473 Rv1473 ABC transporter, possible in EF-3 subfamily MT1520 35.04749 44.2493278 37.4637828 45.4302531 1.046646699 0.065774535 5.34811944 0.833892451 MT1521 70.6572392 63.1616171 84.748169 64.6327313 1.10861327 0.148756182 6.14913634 0.543161321 Rv1474c Rv1474c transcriptional regulator (TetR/AcrR family) MT1522 897.646809 631.978129 954.508079 731.333405 1.109195977 0.149514289 9.65111296 0.52349722 Rv1475c sen aconitate hydratase MT1523 158.088544 213.012101 151.764693 185.858132 0.914583876 −0.12881261 7.47054951 0.577977324 Rv1476 Rv1476 hypothetical protein MT1524 235.867733 245.226336 407.645967 410.667632 1.701147107 0.766507904 8.34450746 8.24E−11 Rv1477 Rv1477 putative exported p60 protein homologue MT1525 162.305488 181.702761 302.892866 315.279712 1.799029323 0.847218702 7.91135974 2.95E−13 MT1526 971.490134 890.868368 1121.27647 1010.00351 1.143908699 0.193971908 9.96374269 0.375125762 Rv1479 moxR transcriptional regulator, MoxR homologue MT1527 427.22328 343.02232 487.756629 408.247807 1.157226328 0.210671052 8.70731055 0.233546465 Rv1430 Rv1480 conserved hypothetical protein MT1528 370.060232 277.350081 404.099638 334.248014 1.14695509 0.197808903 8.43717551 0.2845248 Rv1481 Rv1481 possible membrane protein MT1529 7.12194934 9.22992113 8.18383606 8.66453282 1.030455469 0.04328216 3.08404025 0.93031752 Rv1482c Rv1482c conserved hypothetical protein MT1530 301.55835 297.348243 301.437962 282.807229 0.975014263 −0.036504772 8.20926075 0.898649898 Rv1483 fabG1 3-oxoacyl-[ACP] reductase (aka MabA) MT1531 524.868961 376.616978 468.842875 403.017864 0.97746984 −0.032875906 8.79280173 0.909012405 Rv1484 inhA enoyl-[ACP] reductase MT1532 115.637975 94.1089997 115.573951 103.740217 1.049369988 0.069523435 6.74735443 0.801281341 Rv1485 hemZ ferrochelatase MT1533 280.848459 234.639073 228.783684 217.784203 0.869513251 −0.201720081 7.91097892 0.287526242 MT1533.1 118.636691 126.685192 123.212198 118.103046 0.983617227 −0.023831093 6.92876732 0.932278083 MT1533.2 471.360627 492.624418 456.112463 433.3047 0.922503342 −0.116373957 8.8564935 0.619926139 Rv1488 Rv1488 conserved hypothetical protein MT1534 145.531422 146.049928 111.30017 107.018689 0.74853562 −0.417857124 6.99592437 0.002006393 MT1535 123.041054 107.229966 103.570992 91.2508006 0.846361327 −0.240654388 6.73386671 0.175761343 MT1536 20.8035903 18.6408211 20.2777271 27.3986578 1.203278564 0.266970671 4.45756193 0.377003647 Rv1490 Rv1490 unknown putative membrane protein MT1537 14.8061589 18.4598423 18.0953708 16.8607125 1.050813833 0.071507098 4.10704755 0.865216734 MT1538 1652.01123 786.715042 1643.49614 892.837174 1.062354213 0.087264873 10.2806741 0.775693751 Rv1491c Rv1491c probable membrane protein MT1539 370.153972 158.085022 344.266704 154.166237 0.951779706 −0.071300401 8.00456395 0.783679782 Rv1492 mutA methylmalonyl-CoA mutase, [beta] subunit MT1540 350.943449 178.173674 293.708783 165.875065 0.881852756 −0.181390308 7.95025521 0.357935504 Rv1493 mutB methylmalonyl-COA mutase, [alpha] subunit MT1541 71.2194934 52.3933758 71.1084422 59.4808469 1.063614756 0.088975698 5.99367928 0.764687347 Rv1494 Rv1494 hypothetical protein MT1542 73.1874056 63.7950431 62.8336746 60.3394943 0.901164538 −0.150137552 6.02698447 0.539269301 Rv1495 Rv1495 conserved hypothetical protein MT1543 120.698308 84.4266315 114.664636 89.5335058 1.00289107 0.004164915 6.67941967 0.988617034 MT1545 368.279774 302.325162 690.806696 549.144039 1.845390631 0.884317076 8.9003428 4.33E−14 Rv1497 lipL esterase MT1546 150.966595 175.368501 156.856858 162.050181 0.979364116 −0.030082759 7.33527909 0.917486193 Rv1498c Rv1498c methyltransferase MT1547 32.7047433 44.2493278 30.0073989 35.5948375 0.856354596 −0.223719789 5.1625436 0.350424024 MT1548 7.68420903 6.06279133 8.27476757 9.44512136 1.296042315 0.374112822 3.00948822 0.280920151 Rv1499 Rv1499 hypothetical protein MT1549 104.205371 156.546702 136.670062 164.079712 1.170020027 0.226533224 7.13510004 0.272968529 Rv1500 Rv1500 similarity to B. subtilis glycosyltransferase MT1550 82.0898429 121.889253 101.479567 129.733816 1.144583254 0.194822404 6.76804637 0.327313667 Rv1501 Rv1501 conserved hypothetical protein MT1551 77.0295101 79.5402027 88.5672925 89.6896235 1.138508201 0.187144684 6.39038931 0.351739042 Rv1502 Rv1502 hypothetical protein MT1553 37.4839455 29.7710201 39.4642761 39.9661334 1.188133412 0.248696841 5.20366576 0.306839725 Rv1505c Rv1505c conserved hypothetical protein MT1554 77.3106397 74.6537738 84.8391005 94.6853901 1.180566737 0.239479599 6.37603991 0.21126188 Rv1506c Rv1506c hypothetical protein MT1555 78.9974173 113.111779 85.7484156 130.670522 1.121034279 0.164830393 6.6770669 0.438953559 Rv1507c Rv1507c hypothetical protein MT1555.1 4.40436371 4.43398172 6.63800036 6.01053177 1.427270143 0.513258423 2.47370267 0.141086868 MT1556 215.813822 250.112765 227.783437 287.334642 1.101574087 0.139566527 7.93928209 0.513606961 Rv1508c Rv1508c probable membrane protein MT1557 55.9447902 43.7968807 64.5613734 57.9977287 1.235248534 0.304801344 5.80097902 0.110283133 Rv1509 Rv1509 hypothetical protein MT1558 31.7676447 28.3231893 34.3721114 33.721425 1.135097073 0.182815681 5.01010158 0.476182576 MT1560 13.1193813 10.6777519 16.0039461 15.3775943 1.323727645 0.40460632 3.804989 0.081619749 Rv1510 Rv1510 probable membrane proteinvery similar to MT1560.1 15.3684131 14.7497759 15.9130146 15.6117708 1.047028256 0.066300377 3.9622851 0.867153389 MT1561 254.047447 256.356535 249.152342 267.273517 1.01131308 0.016229692 8.0049836 0.954279935 Rv1511 gmdA GDP-mannose 4,6 dehydratase MT1562 188.91909 172.653819 176.86179 170.012184 0.960162711 −0.058649186 7.46991723 0.831756973 Rv1512 epiA nucleotide sugar epimerase MT1563 138.596892 143.878182 143.217131 145.11141 1.020799866 0.029700045 7.15864045 0.917388404 Rv1513 Rv1513 conserved hypothetical protein MT1564 19.7727818 42.9824758 16.9132612 41.9956636 0.924389572 −0.11342711 4.93641467 0.725019493 Rv1514c Rv1514c involved in polysaccharide synthesis MT1565 29.1437634 64.1570008 30.916714 58.9344349 0.980047973 −0.029075725 5.52315795 0.932510447 Rv1515c Rv1515c conserved hypothetical protein MT1566 64.3786731 104.062836 62.4699486 87.0356224 0.897951246 −0.155290978 6.31599484 0.500550049 Rv1516c Rv1516c probable glucosyltransferase MT1567 10.495505 8.05355863 30.6439195 22.6370677 2.865856841 1.518966544 4.18209787 2.33E−21 Rv1517 Rv1517 conserved hypothetical protein MT1568 30.1745769 15.7451596 35.0995635 27.7108932 1.414793291 0.500591283 4.77384524 0.02607446 Rv1518 Rv1518 involved in exopolysaccharide synthesis MT1569 54.1643027 15.835649 43.4652626 17.0948891 0.910103888 −0.135896857 5.03460926 0.68274425 Rv1519 Rv1519 conserved hypothetical protein MT1570 168.771459 106.053604 149.673268 100.461745 0.915958254 −0.126646248 7.0377826 0.580025191 Rv1520 Rv1520 glycosyltransferase MT1571 9.65211623 5.24838652 8.00197304 5.77635521 0.93945386 −0.090105787 2.87404955 0.870054573 MT1572 562.634037 393.267032 622.608061 500.591432 1.186589317 0.246820699 9.02221971 0.178041056 Rv1521 fadD25 acyl-CoA synthase MT1573 367.248356 265.043519 597.420032 401.92504 1.570929779 0.651618693 8.67272453 7.21E−08 Rv1522c mmpL12 conserved large membrane protein MT1574 86.7753362 104.515283 132.396281 133.636758 1.395090002 0.480358198 6.83946058 0.000459515 Rv1523 Rv1523 possible methyl-sterol transferase MT1575 68.1270728 73.2964325 88.0217034 91.9533302 1.272847495 0.348059574 6.33156683 0.02272273 Rv1524 Rv1524 possible rhamnosyl/glycosyl transferase MT1576 67.1899741 69.133919 78.7466892 85.5525042 1.204694179 0.268666953 6.23537108 0.129154339 Rv1525 wbbI2 dTDP-rhamnosyl transferase MT1577 55.9447902 44.9732431 71.1084422 48.9429016 1.178037852 0.236385896 5.7920837 0.279643406 Rv1526c Rv1526c possible rhamnnosyl/glycosyl transferase MT1578.1 4.12323412 3.07664038 3.63726047 1.71729479 0.727239124 −0.459498279 1.7194147 0.399360959 MT1579 9.46469649 12.0350932 6.72893187 11.7088281 0.849511789 −0.235294127 3.34631619 0.52349722 Rv1528c papA4 PKS-associated protein, unknown function MT1580 102.424834 126.594703 105.84428 135.354053 1.051537769 0.07250067 6.87948115 0.778577179 Rv1529 fadD24 acyl-CoA synthase MT1581 19.3979423 24.9750807 20.7323847 25.2910688 1.038336213 0.054273663 4.50994485 0.880856541 Rv1530 adh alcohol dehydrogenase (Zn) MT1582 61.3799624 92.2992113 50.1941945 69.7846157 0.784953434 −0.349321023 6.10000144 0.037991116 Rv1531 Rv1531 conserved hypothetical protein MT1583 52.1963955 35.4718538 51.1035096 38.4049563 1.027947278 0.039766273 5.4743989 0.903824113 Rv1532c Rv1532c conserved hypothetical protein MT1585 204.756058 151.569783 240.331986 173.290656 1.158560001 0.2123327762 7.58987626 0.245451994 Rv1534 Rv1534 transcriptional regulator (TetR/AcrR family) MT1585.1 1520.06774 2735.31427 730.270971 1934.53258 0.583199596 −0.777938375 10.7567498 1.01E−05 MT1586 628.980622 1585.37469 282.615139 815.558909 0.48114939 −1.055443195 9.6940307 5.54E−16 Rv1535 Rv1535 hypothetical protein MT1587 818.087133 1064.87953 618.788938 769.191949 0.739114736 −0.436129757 9.6757968 0.003677928 Rv1536 ileS isoleucyl-tRNA synthase MT1589 74.8741831 41.2631768 62.197154 41.2931339 0.908203216 −0.13891295 5.78297835 0.61875146 Rv1537 dinX probable DNA-damage-inducible protein MT1590 63.5352893 63.9760219 69.835401 72.7508521 1.118181825 0.161154801 6.08120347 0.490245331 Rv1538c ansA L-asparaginase MT1591 259.951169 150.755378 214.598368 146.048116 0.893289858 −0.162799713 7.59240592 0.464084488 Rv1539 lspA lipoprotein signal peptidase MT1592 331.451797 170.663051 289.34407 183.516366 0.967441104 −0.047754259 7.93013435 0.878588917 Rv1540 Rv1540 conserved hypothetical protein MT1593 42.6379892 58.637146 48.3755643 41.8395459 0.897072201 −0.15670399 5.58623511 0.664400777 Rv1541c lprI lipoprotein MT1594 64.1912584 42.6205182 73.563593 21.0758906 0.763129224 −0.39000072 5.65816409 0.335715426 Rv1542c glbN hemoglobin-like, oxygen carrier MT1595 296.123177 311.826551 288.252892 339.087663 1.029117474 0.041407676 8.27148651 0.888210196 MT1596 249.268244 216.450699 241.605027 223.170264 0.999651641 −0.000502664 7.86291905 0.999355608 Rv1544 Rv1544 probable ketoacyl reductase MT1596.1 74.2182141 83.1597795 78.2920316 82.6643266 1.023518818 0.033537628 6.31764257 0.905590819 MT1597 85.3696882 79.9926498 86.2940047 92.4216834 1.08119073 0.112621048 6.42961306 0.648504395 Rv1546 Rv1546 conserved hypothetical protein MT1598 651.283571 1142.51945 674.439023 1165.57481 1.027799228 0.039558473 9.82758449 0.898938436 Rv1547 dnaE1 DNA polymerase III, [alpha] subunit MT1599 80.590435 72.9344748 84.6572375 76.6537948 1.050721098 0.071379773 6.30163433 0.798636571 Rv1548c PPE PPE-family protein MT1600 56.8818838 66.3287469 64.5613734 67.6770266 1.075058612 0.104415317 6.00097429 0.716971772 Rv1550 fadD11 acyl-CoA synthase, N-term MT1601 22.2092333 21.7174615 22.7328779 25.0568922 1.088393051 0.112199651 4.53048577 0.698416576 Rv1551 plsB1 glycerol-3-phosphate acyltransferase MT1602 1.96790719 1.9907673 0.90931512 2.02953021 0.74266417 −0.429218119 0.92974608 0.580968556 MT1603 18.2734239 12.6685192 19.8230696 18.6560662 1.257797805 0.330900023 4.13209586 0.204723294 Rv1552 frdA fumarate reductase flavoprotein subunit MT1604 4.59178345 8.14404805 8.27476757 6.94723802 1.207512486 0.272038107 2.84173119 0.601304701 Rv1553 frdB fumarate reductase iron sulphur protein MT1606 1.59306773 4.07202403 4.54657559 4.44935469 1.62661283 0.701870898 1.94685055 0.143692242 MT1607 39.920403 51.1265239 49.0120848 60.3394943 1.202821304 0.266422326 5.65222159 0.203829462 Rv1556 Rv1556 putative transcriptional regulator MT1608 73.6559549 76.1016046 73.38173 71.9702636 0.970429639 −0.043304481 6.20850984 0.886590154 Rv1557 mmpL6 conserved large membrane protein MT1609 128.288807 138.448817 116.937924 130.12411 0.925757146 −0.111294314 7.0070451 0.628146178 Rv1558 Rv1558 conserved hypothetical protein MT1610 708.259169 643.922733 621.516883 571.156636 0.882251038 −0.180738872 9.31374748 0.380337403 Rv1559 ilvA threonine deaminase MT1611 53.7894632 42.7110076 49.1030164 41.2931339 0.93910565 −0.090640623 5.55122211 0.76492809 Rv1560 Rv1560 conserved hypothetical protein MT1612 30.4557065 23.3462711 28.1887686 25.4471865 1.003012612 0.004339746 4.75649031 0.991365542 MT1613 76.373541 73.839369 76.3824699 71.3457927 0.982963167 −0.024790737 6.22222425 0.932785035 Rv1562c glgZ maltooligosyltrehalose trehalohydrolase MT1614 96.0526129 82.9788007 92.8410735 84.8499745 0.994099254 −0.008538193 6.48142861 0.977279079 Rv1563c glgY putative [alpha]-amylase MT1615 191.542967 172.925287 195.229956 179.379247 1.028242784 0.040180948 7.53093301 0.89125591 Rv1564c glgX probable glycogen debranching enzyme MT1616 400.234839 356.980773 481.20956 474.441716 1.264098756 0.338109176 8.74281378 0.023070853 Rv1565c Rv1565c Unknown membrane protein MT1617 252.829219 357.52371 411.010433 537.122976 1.562211254 0.643589559 8.60668679 9.33E−08 Rv1566c Rv1566c putative exported p60 protein homologue MT1618 49.5725193 69.4958767 51.2853726 66.6622615 0.994614149 −0.00779114 5.89336377 0.981245688 Rv1567c Rv1567c hypothetical protein MT1619 57.3504332 84.8790786 63.2883322 77.5905011 1.001147938 0.001655175 6.14897068 0.997032163 Rv1568 bioA adenosylmethionine-8-amino-7- oxononanoate MT1620 111.514741 105.872625 95.9327449 101.944864 0.910500912 −0.135267633 6.70029831 0.555180056 Rv1569 bioF 8-amino-7-oxononanoate synthase MT1621 80.2156455 65.061895 68.9260859 65.6474964 0.930894038 −0.103311137 6.13201052 0.719637416 Rv1570 bioD dethiobiotin synthase MT1622 16.6803552 17.9169057 14.9127679 19.5147136 0.99282949 −0.010382127 4.1243285 0.978929348 Rv1571 Rv1571 conserved hypothetical protein MT1622.1 11.5263136 10.7682413 10.6389869 9.52318021 0.903559095 −0.146309135 3.4307201 0.71643291 Rv1587c Rv1587c REP-family protein MT1623 116.200234 71.3056652 102.388882 71.9702636 0.941413172 −0.087100056 6.50183256 0.752487878 MT1624 177.486437 253.460873 174.042914 246.197626 0.975878597 −0.035226413 7.73461022 0.898649898 Rv1589 bioB biotin synthase MT1625 70.750949 92.9326372 68.8351544 97.2613323 1.010394779 0.01491909 6.36866728 0.963845706 Rv1590 Rv1590 conserved hypothetical protein MT1626 41.1386313 62.9806383 38.736824 62.4470834 0.967827604 −0.047178007 5.68700708 0.889094771 Rv1591 Rv1591 conserved hypothetical protein MT1627 43.3876681 31.7617874 48.1027697 41.0589573 1.195148824 0.257190279 5.36640052 0.236423847 MT1628 422.444077 370.554187 439.653859 429.87011 1.098792156 0.135918517 8.69977318 0.530737399 Rv1592c Rv1592c conserved hypothetical protein MT1629 318.519835 162.247535 296.982317 157.288591 0.950351592 −0.073466744 7.8698013 0.780655736 Rv1593c Rv1593c conserved hypothetical protein MT1630 1967.43864 1276.17233 2037.04773 1391.78937 1.062596478 0.087593836 10.7041401 0.76492809 Rv1594 nadA quinolinate synthase MT1631 2094.22809 1152.20182 2018.2249 1227.00713 1.012962294 0.01858043 10.6645098 0.955286813 Rv1595 nadB l-aspartate oxidase MT1632 1184.49271 643.379796 1119.73064 702.919982 1.016036881 0.022952771 9.83413384 0.944598499 Rv1596 nadC nicotinate-nucleotide pyrophosphatase MT1633 271.571192 205.682458 303.438455 223.716676 1.102508221 0.140789414 7.97309074 0.498859273 Rv1597 Rv1597 hypothetical protein MT1634 83.7766204 100.895706 89.3856761 96.0904495 1.007052328 0.01013865 6.53475721 0.974588872 Rv1598c Rv1598c conserved hypothetical protein MT1635 845.637833 337.706526 777.464426 341.897781 0.964258583 −0.052508012 9.1694708 0.859858221 Rv1599 hisD histidinol dehydrogenase MT1636 658.78036 251.832064 529.130467 239.328447 0.872554385 −0.196683039 8.71392634 0.323615741 Rv1600 hisC histidinol-phosphate aminotransferase MT1637 268.572477 149.488527 230.329519 141.520703 0.900240519 −0.151617595 7.62665733 0.476182576 Rv1601 hisB imidazole glycerol-phosphate dehydratase MT1638 195.103942 106.777519 186.409599 105.457512 0.970973356 −0.042496387 7.21518799 0.88463114 Rv1602 hisH amidotransferase MT1639 197.446688 99.085918 190.319654 102.413217 0.997071566 −0.004231036 7.20425091 0.988617034 Rv1603 hisA phosphoribosylformimino-5- aminoimidazole MT1640 359.658467 162.338025 347.540238 186.560662 1.052148502 0.073338343 8.04535213 0.798636571 Rv1604 impA impA, inositol monophosphatasemonophosphtase MT1641 335.762451 143.063778 316.168866 145.735881 0.978357306 −0.031566646 7.87852503 0.906626924 Rv1605 hisF imidazole glycerol-phosphate synthase MT1641.1 89.2117927 42.801497 82.2020866 49.6454313 1.028236671 0.040172371 6.04701218 0.903351005 Rv1606 hisI2 probable phosphoribosyl-AMP 1,6 cyclohydrolase MT1642 168.49034 104.786752 146.399734 112.716986 0.965338195 −0.050893633 7.05810309 0.873880503 Rv1607 chaA putative calcium/proton antiporter MT1643 119.10524 140.711053 114.573705 143.706351 0.991695955 −0.012030224 7.01912351 0.971262002 Rv1608c bcpB probable bacterioferritin comigratory protein MT1644 291.062845 249.479339 272.248946 249.554157 0.967258627 −0.048026404 8.05396182 0.870054573 Rv1609 trpE anthranilate synthase component I MT1645 107.110377 87.0508248 112.48228 90.3140943 1.043856007 0.061922716 6.63529055 0.819552181 Rv1610 Rv1610 possible membrane protein MT1646 1288.41695 892.587667 1191.11187 1007.42757 1.021381554 0.03052191 10.0967854 0.927656812 Rv1611 trpC indole-3-glycerol phosphate synthase MT1647 704.698194 613.880244 711.266285 692.694272 1.067194839 0.093823595 9.41110979 0.733387277 Rv1612 trpB tryptophan synthase [beta] chain MT1648 209.535251 160.347257 205.505217 193.117605 1.086499039 0.119686899 7.58722018 0.637012172 Rv1613 trpA tryptophan synthase [alpha] chain MT1649 533.958818 487.737989 542.588331 558.120808 1.078375891 0.108860148 9.05197039 0.656145138 Rv1614 lgt prolipoprotein diacylglyceryl transferase MT1650 7.87162877 9.04894228 8.36569908 8.11812084 0.9726706 −0.039976783 3.09188739 0.933484698 MT1651 248.518565 252.646469 256.699658 232.30315 0.974458874 −0.037326795 7.95252948 0.896668126 MT1652 92.5853479 83.7932055 102.025156 94.6073313 1.11541013 0.157574279 6.54580206 0.466422624 Rv1616 Rv1616 conserved hypothetical protein MT1653 415.322127 451.723199 395.552076 423.469284 0.944872759 −0.081808032 8.72004888 0.745116768 Rv1617 pykA pyruvate kinase MT1654 311.772725 390.642838 282.978865 345.098194 0.895356887 −0.159465244 8.37852201 0.430002617 Rv1618 tesB1 thioesterase II MT1655 69.8138504 63.7045537 62.4699486 59.6369646 0.915309623 −0.127668246 6.00172525 0.619926139 Rv1619 Rv1619 conserved hypothetical protein MT1656 397.423543 397.067587 403.099392 275.157461 0.838614753 −0.253919885 8.52491567 0.267751697 Rv1620c cydC ABC transporter MT1657 495.444063 390.009412 494.212766 284.7587 0.854001054 −0.227690244 8.70133693 0.304341874 Rv1621c cydD ABC transporter MT1658 230.432561 242.059206 240.877575 173.993186 0.867014372 −0.205872186 7.79442987 0.412841331 Rv1622c cydB cytochrome d ubiquinol oxidase subunit II MT1659 911.04732 768.888626 839.752511 519.09138 0.789057168 −0.341798267 9.56956577 0.088442852 Rv1623c appC cytochrome bd-II oxidase subunit I MT1660 93.0538972 91.8467642 109.208746 95.9343318 1.107061767 0.146735718 6.61008111 0.518774989 Rv1624c Rv1624c possible membrane protein MT1661 442.12349 341.235614 393.36972 326.442128 0.922489851 −0.116395056 8.55442452 0.609214338 Rv1625c Rv1625c C-term similar eukaryotic adenylate/guanylate cyclases MT1662 547.171909 561.486869 537.587098 580.367581 1.007779374 0.011179835 9.12109796 0.973097519 Rv1626 Rv1626 two-component response regulator MT1663 356.847171 310.016763 355.45128 309.425298 0.9970886 −0.004206389 8.37983343 0.988617034 Rv1627c Rv1627c lipid carrier protein MT1664 178.798425 149.217058 165.313488 125.440579 0.881903913 −0.181306618 7.27476292 0.37638467 Rv1628c Rv1628c conserved hypothetical protein MT1665 279.349111 249.660318 239.877328 235.971916 0.900944851 −0.150489297 7.97375391 0.473546612 Rv1629 polA DNA polymerase I MT1666 2418.08939 2218.07673 2311.1153 2545.96759 1.047418974 0.066838645 11.2127951 0.844643034 Rv1630 rpsA 30S ribosomal protein S1 MT1667 490.945989 395.16731 496.122328 487.399486 1.116357505 0.158799113 8.86908801 0.48870294 Rv1631 Rv1631 conserved hypothetical protein MT1668 125.196331 243.778505 155.947543 270.317812 1.173249402 0.230509725 7.63672772 0.198891918 Rv1632c Rv1632c hypothetical protein MT1669 653.626317 452.537604 607.331567 424.484049 0.933563678 −0.099179664 9.06246115 0.689793351 Rv1633 uvrB excinuclease ABC subunit B MT1670 208.785582 117.726739 186.136805 114.200104 0.929098194 −0.106097015 7.29338515 0.661033931 Rv1634 Rv1634 probable drug efflux protein MT1671 228.183524 148.764611 247.060917 173.759009 1.124018953 0.168666362 7.64101778 0.401746068 Rv1635c Rv1635c unknown membrane protein MT1672 238.30419 188.851425 291.526427 262.511927 1.303754441 0.382672167 7.93945277 0.007113683 Rv1636 Rv1636 conserved hypothetical protein MT1673 97.8331004 114.197652 101.479567 106.472277 0.982709785 −0.025162674 6.71662507 0.930747689 Rv1637c Rv1637c conserved hypothetical protein MT1675 682.770036 501.401892 636.884308 494.190606 0.958777562 −0.060731948 9.17735741 0.826956414 Rv1638 uvrA excinuclease ABC subunit A MT1676 208.317033 355.261474 75.7459493 110.765514 0.336028627 −1.573343949 7.5520732 3.35E−38 MT1677 1156.56717 1458.32754 362.998595 479.5936 0.321310343 −1.637960672 9.7557478 2.22E−39 Rv1639c Rv1639c conserved hypothetical protein MT1678 125.94606 215.817273 116.937924 179.769541 0.878108856 −0.187528299 7.32016916 0.358887222 MT1679 908.142314 980.814854 1041.98419 1035.76294 1.100714539 0.138440367 9.95398605 0.578518157 Rv1641 infC Initiation factor IF-3 MT1680 359.283627 305.220823 404.736159 323.397833 1.09259845 0.127763282 8.44431062 0.548791269 MT1681 842.076858 547.370519 912.861447 612.527829 1.101351356 0.139274795 9.50952102 0.549830576 Rv1643 rplT 50S ribosomal protein L20 MT1682 795.221925 452.899561 849.482183 545.084979 1.133557538 0.180857623 9.36814169 0.405114511 Rv1644 tsnR putative 23S rRNA methyltransferase MT1683 92.491638 100.262281 93.7503886 113.263397 1.070996299 0.098953494 6.64568792 0.705777107 Rv1645c Rv1645c conserved hypothetical protein MT1684 301.37093 319.246684 383.458185 316.684771 1.123366743 0.167828998 8.36791375 0.476182576 Rv1646 PE PE-family protein MT1685 221.155234 195.185685 206.3236 167.514301 0.894919388 −0.160170361 7.62723465 0.435013023 Rv1647 Rv1647 conserved hypothetical protein MT1686 209.066712 215.364826 193.956915 200.923491 0.930349059 −0.104155991 7.67949581 0.65210155 Rv1648 Rv1648 possible membrane protein MT1687 118.636691 146.592865 107.481047 128.328756 0.890270858 −0.167683763 6.97083238 0.389888324 Rv1649 pheS phenylalanyl-tRNA synthase [alpha] subunit MT1688 296.404307 302.234672 275.613412 296.467528 0.955142892 −0.066211515 8.19404916 0.803788741 Rv1650 pheT phenylalanyl-tRNA synthase [beta] subunit MT1689 118.261851 130.304769 167.313982 161.894064 1.325222073 0.406234138 7.17621575 0.005525981 Rv1651c PE_PGRS PE_PGRS-family protein MT1690 211.971718 193.285407 195.320887 151.590295 0.850317629 −0.233926247 7.55615095 0.218180025 Rv1652 argC N-acetyl-[gamma]-glutamyl-phosphate reductase MT1691 472.016596 336.620653 428.105557 269.06887 0.851800337 −0.231412794 8.55691401 0.197032317 MT1692 390.863852 225.680621 318.078428 188.512133 0.824339159 −0.278690065 8.13407978 0.078033157 Rv1654 argB acetylglutamate kinase MT1693 393.206599 253.098916 343.539251 185.467838 0.800918656 −0.320272369 8.19955059 0.050375148 Rv1655 argD acetylornithine aminotransferase MT1694 272.133452 200.072114 223.327793 160.489004 0.811444048 −0.301436476 7.74255453 0.041540952 Rv1656 argF ornithine carbamoyltransferase MT1695 103.361933 77.9113931 87.1123883 59.1686115 0.800939517 −0.320234794 6.35831071 0.048182941 Rv1657 argR arginine repressor MT1696 730.562117 525.110121 585.598936 434.241406 0.81412995 −0.296669002 9.15237197 0.062084717 Rv1658 argG arginosuccinate synthase MT1697 342.884401 226.495025 298.34629 207.636552 0.892918382 −0.163399784 8.07144885 0.428699683 Rv1659 argH arginosuccinate lyase MT1698 182.827949 190.570725 195.048093 199.59649 1.057003979 0.079980808 7.58638656 0.760272935 Rv1660 pks10 polyketide synthase (chalcone synthase- like) MT1701 208.691872 176.363885 206.596395 213.022613 1.093532238 0.128995753 7.65354233 0.593366813 Rv1661 pks7 polyketide synthase MT1702 76.5609607 89.7655074 81.383703 94.9976256 1.060577033 0.084849412 6.42393157 0.746512526 Rv1662 pks8 polyketide synthase MT1703 57.7252776 56.284421 45.5566874 52.1433146 0.856188853 −0.223999042 5.73067024 0.330235793 Rv1663 pks17 polyketide synthase MT1704 110.390223 88.4081661 113.300664 105.145277 1.1044662 0.143349268 6.70716769 0.533790532 Rv1664 pks9 polyketide synthase MT1705 87.0564658 64.5189585 108.208499 77.9027365 1.225410902 0.293265592 6.40244153 0.069533486 Rv1665 pks11 polyketide synthase (chalcone synthase- like) MT1706 64.0975435 83.883695 57.6505785 71.6580282 0.875831653 −0.191274505 6.1189769 0.380784281 Rv1666c Rv1666c Probable cytochrome p450 MT1707 93.3350258 99.719344 89.9312651 94.0609193 0.953222791 −0.069114649 6.56128698 0.801337286 Rv1668c Rv1668c probable ABC transporter MT1708 19.8664917 34.1145124 23.0056725 27.9450698 0.962369814 −0.055306722 4.72335661 0.894346121 Rv1670 Rv1670 conserved hypothetical protein MT1709 11.0577642 18.0073951 10.9117814 16.6265359 0.949691651 −0.074468925 3.84194556 0.852607709 Rv1671 Rv1671 similar to many mercuric transport proteins MT1710 145.344003 208.849588 136.579131 151.590295 0.824545463 −0.278329053 7.3288077 0.150034395 Rv1672c Rv1672c probable ABC transporter MT1711 14.4313194 17.2834798 14.2762474 13.4261229 0.872667131 −0.196496636 3.90930596 0.533790532 Rv1673c Rv1673c conserved hypothetical protein MT1712 2.90500585 3.52908749 4.18284954 4.68353125 1.376190258 0.460679936 2.00456675 0.311717327 Rv1674c Rv1674c putative transcriptional regulator MT1714 13.1193813 13.5734134 12.2757541 12.4894167 0.927680551 −0.1083 3.70469655 0.780655736 Rv1675c Rv1675c putative transcriptional regulator MT1715 340.260524 331.734224 304.165907 294.828292 0.89133008 −0.165968301 8.31250787 0.412841331 Rv1676 Rv1676 possible cytochrome P450 MT1716 256.109065 236.901309 223.054998 228.478266 0.916607648 −0.125623772 7.88452652 0.572054672 Rv1677 dsbF highly similar to C-term Mpt53 MT1717 36.8279774 26.1514432 31.9169606 27.6328344 0.954660834 −0.066939822 4.94481679 0.853090888 MT1718 324.236137 282.326999 294.254372 255.720806 0.906650152 −0.141382127 8.17642783 0.508095243 Rv1678 Rv1678 probably integral membrane protein MT1719 190.980707 163.604877 171.951489 167.59236 0.960371209 −0.058335941 7.44048981 0.839018102 Rv1679 fadE16 acyl-CoA dehydrogenase MT1720 121.354277 112.297374 110.936444 113.965927 0.963423414 −0.053758109 6.84314165 0.847103215 Rv1680 Rv1680 hypothetical protein MT1721 109.265704 91.7562747 100.661184 99.9153334 1.001565391 0.002256616 6.65210788 0.996375463 Rv1681 moeX weak similarity to E. coli MoaA MT1722 206.630255 123.156105 259.791329 144.018586 1.213409337 0.279066318 7.52009662 0.09134139 Rv1682 Rv1682 conserved hypothetical protein MT1723 702.542867 631.616171 631.246555 531.736915 0.869748612 −0.201329624 9.286442 0.305758294 Rv1683 Rv1683 possible a cyl-CoA synthase MT1724 47.9794515 51.0360345 39.8280022 37.8585443 0.784203887 −0.350699302 5.47058691 0.060813062 Rv1684 Rv1684 conserved hypothetical protein MT1725 24.3645652 18.6408211 22.0963574 16.8607125 0.90580318 −0.14273049 4.36829738 0.618146178 Rv1685c Rv1685c conserved hypothetical protein MT1726 33.5481321 25.8799749 28.3706317 22.48095 0.856817196 −0.222940661 4.79345538 0.363381298 Rv1686c Rv1686c probable transmembrane protein MT1727 42.731699 23.6177394 25.7336178 22.0906557 0.745394014 −0.423924862 4.84291004 0.084604125 Rv1687c Rv1687c probable ABC transporter MT1727.1 13.5879306 17.9169057 15.094631 16.080124 0.991617153 −0.012144868 3.98632159 0.97711178 Rv1688 Rv1688 probable 3-methylpurine DNA glycosylase MT1728 81.0590343 116.459887 76.8371274 113.419515 0.961300309 −0.056940898 6.60188911 0.839820353 Rv1689 tyrS tyrosyl-tRNA synthase MT1729 48.2605811 70.8532181 59.2873457 64.5546724 1.053633628 0.075373297 5.92888385 0.825902812 Rv1690 lprJ lipoprotein MT1730 58.3812457 67.870671 60.6513183 75.0926177 1.073024963 0.101683639 6.03748023 0.719637416 MT1731 91.1796999 83.6122267 84.2025799 88.9870938 0.991790157 −0.011893188 6.44578933 0.973097519 Rv1692 Rv1692 probable hydrolase MT1732 74.2182141 68.5004931 60.9241129 80.5567375 0.984707097 −0.022233439 6.15447976 0.952654537 Rv1693 Rv1693 hypothetical protein MT1733 111.702161 105.963114 105.116828 107.018689 0.975081985 −0.036404569 6.74987001 0.898649898 Rv1694 tlyA cytotoxin/hemolysin homologue MT1734 141.033349 141.525457 148.673022 147.375117 1.047697842 0.067222701 7.17820555 0.803210576 Rv1695 Rv1695 conserved hypothetical protein MT1735 163.148877 141.1635 156.493132 159.318121 1.040544636 0.057338854 7.27805359 0.846298701 Rv1696 recN recombination and DNA repair MT1736 408.668727 628.63002 578.415346 861.145279 1.392280345 0.477449737 9.2747745 0.000438697 MT1737 204.287509 284.589235 277.704837 380.224679 1.347510958 0.430297005 8.16441412 0.001425923 Rv1698 Rv1698 conserved hypothetical protein MT1738 1275.11015 1049.22486 1118.4576 1215.22024 1.007943951 0.011415417 10.1857176 0.975577295 Rv1699 pyrG CTP synthase MT1739 171.301636 176.182906 158.948283 203.499433 1.036170435 0.051261325 7.4730442 0.873642922 Rv1700 Rv1700 conserved hypothetical protein MT1740 212.627637 235.18201 184.500037 241.201859 0.944106964 −0.082977773 7.77189041 0.758228843 Rv1701 Rv1701 integrase/recombinase MT1741 46.0115443 34.1145124 43.5561941 46.054724 1.12946819 0.17564364 5.41324458 0.571424955 Rv1702c Rv1702c REP-family protein MT1742 4.49807358 3.43859807 3.18260291 3.51264844 0.851285768 −0.232284583 1.93729055 0.708369659 MT1743 468.080732 523.66219 449.2926 500.74755 0.958044565 −0.061835328 8.923696 0.817895779 Rv1703c Rv1703c putative methyltransferase MT1744 201.944762 268.844075 215.053025 252.598452 0.999617489 −0.000551953 7.87524459 0.999355608 Rv1704c cycA transport of D-alanine, D-serine and glycine MT1745 55.1951112 60.0849768 80.3834564 46.4450182 1.062893088 0.087996489 5.92337374 0.857846065 Rv1705c PPE PPE-family protein MT1746 63.7227091 60.1754662 85.9302786 49.3331959 1.054337622 0.076336923 6.02128471 0.860113777 Rv1706c PPE PPE-family protein MT1746.1 13.6816405 13.6639029 16.7313982 14.3628291 1.133348011 0.18059093 3.88609361 0.567031306 MT1748 321.799681 350.465535 363.998842 401.690864 1.138651808 0.187326648 8.49054294 0.306768873 MT1749 167.553241 203.239244 201.50423 301.385236 1.337111808 0.419120107 7.77230412 0.00461349 Rv1708 Rv1708 possible role in chromosome partitioning MT1750 176.643098 157.270617 211.415765 274.376873 1.445780792 0.531848829 7.68036116 0.001760349 Rv1709 Rv1709 conserved hypothetical protein MT1751 149.560947 147.497759 173.951982 185.623955 1.210065567 0.275085222 7.36057175 0.096644572 Rv1710 Rv1710 conserved hypothetical protein MT1751.1 110.202803 87.6552296 126.30387 131.138875 1.307531412 0.386845606 6.83368593 0.017705235 Rv1711 Rv1711 conserved hypothetical protein MT1752 78.4351531 74.8347527 89.1128815 78.683325 1.092926126 0.128195889 6.32986143 0.584969964 Rv1712 cmk cytidylate kinase MT1753 226.309327 165.414665 264.337905 221.374911 1.249741731 0.321629981 7.7783035 0.036950653 Rv1713 Rv1713 conserved hypothetical protein MT1753.1 21.5532692 12.4875404 24.1877821 16.8607125 1.221003006 0.288066752 4.24332793 0.250978723 MT1754 14.0564799 8.50600575 16.8223297 12.8797109 1.332740056 0.414395418 3.72677145 0.094091612 Rv1715 fadB3 3-hydroxyacyl-CoA dehydrogenase MT1755 32.6110335 15.1117336 33.2809333 21.5442438 1.18919195 0.249981602 4.68922865 0.381485881 Rv1716 Rv1716 conserved hypothetical protein MT1756 7.02823997 3.43859807 10.1843293 6.79112032 1.64794809 0.720670799 2.81447857 0.008668617 Rv1717 Rv1717 conserved hypothetical protein MT1757 4.31065385 2.98615095 1.63676721 2.65400104 0.597791692 −0.742285249 1.61606028 0.139650854 MT1758 8.80872743 8.14404805 11.912028 9.21094479 1.238930504 0.309095264 3.2770137 0.350297356 MT1759 2.53016639 2.35272499 1.5458357 2.57594219 0.846230976 −0.240876599 1.28167083 0.764687847 MT1760 1.87419733 2.62419326 1.36397268 2.02953021 0.755623092 −0.404261303 1.10456524 0.564270992 MT1761 12.1822826 11.4921567 11.4573705 11.3185339 0.962836256 −0.054637627 3.5590365 0.900323347 Rv1720c Rv1720c conserved hypothetical protein MT1762 6.37227091 7.69160094 6.36520582 8.19617969 1.035091764 0.049758672 2.87593651 0.923058103 Rv1721c Rv1721c hypothetical protein MT1763 54.9139816 64.8809162 48.4664958 51.4407849 0.835527984 −0.259239947 5.78391931 0.204723294 Rv1722 Rv1722 possible biotin carboxylase MT1764 20.8035903 21.8984403 18.1863024 21.5442438 0.929984467 −0.104721475 4.37757772 0.754876855 Rv1723 Rv1723 6-aminohexanoate-dimer hydrolase MT1765 43.9499273 52.3028864 40.9191803 51.5969026 0.959370689 −0.059839733 5.5660493 0.859651322 Rv1724c Rv1724c hypothetical protein MT1766 29.9871572 32.2142345 32.1897552 27.320599 0.953333325 −0.068947367 4.93535289 0.852001416 Rv1725c Rv1725c conserved hypothetical protein MT1767 2.43645652 3.07664038 3.81912349 2.41982448 1.111460454 0.152456618 1.63603251 0.849425114 Rv1726 Rv1726 6-hydroxy-d-nicotine oxidase MT1768 2.81129599 5.97230191 3.36446594 4.21517813 0.874638851 −0.193240661 2.09471562 0.762482462 Rv1727 Rv1727 conserved hypothetical protein MT1769 118.82411 113.111779 121.4845 130.982757 1.08849392 0.122333349 6.92221854 0.593384983 Rv1728c Rv1728c conserved hypothetical protein MT1770 84.05775 93.2041055 80.1106619 86.6453282 0.941081257 −0.087608798 6.42929953 0.739414086 Rv1729c Rv1729c conserved hypothetical protein MT1771 141.408188 148.221675 125.212692 130.748581 0.883786588 −0.178230057 7.09350205 0.380268704 Rv1730c Rv1730c probable penicillin binding protein MT1771.1 5.71630184 2.98615095 4.09191803 2.41982448 0.754043303 0.407280718 1.98493602 0.409241084 MT1772 409.324696 551.080585 423.649913 488.258133 0.957243694 −0.063041844 8.87116219 0.822804121 Rv1731 gabD1 succinate-semialdehyde dehydrogenase MT1773 235.961443 293.276219 239.513602 241.045742 0.912843665 −0.131560292 7.98084354 0.583058152 Rv1732c Rv1732c conserved hypothetical protein MT1774 282.066698 636.5026 219.781464 409.184514 0.706619392 −0.500994752 8.59644414 0.000281241 Rv1733c Rv1733c possible membrane protein MT1775 630.6674 545.741709 351.450293 363.676202 0.609456689 −0.714404396 8.88581946 2.96E−08 MT1776 38.3273353 83.4312478 32.1897552 66.0377906 0.812946203 −0.298768211 5.78633201 0.114545514 Rv1735c Rv1735c hypothetical protein MT1777 109.078234 257.804366 77.9283056 169.699949 0.684367404 −0.547157049 7.26505696 3.56E−05 MT1778 1381.84559 2428.55513 981.605669 1455.56345 0.652378662 −0.6162185 10.6092398 5.35E−05 Rv1736c narX fused nitrate reductase MT1779 864.192337 1101.79921 565.048414 775.905011 0.678649247 −0.55926197 9.69158272 7.08E−05 Rv1737c narK2 nitrite extrusion protein MT1780 755.582652 1714.95554 438.653613 991.971919 0.579482671 −0.787162576 9.92995693 2.23E−09 Rv1738 Rv1738 conserved hypothetical protein MT1781 39.3581438 59.7230191 39.0096185 56.2804339 0.965054396 −0.051317831 5.60825712 0.880856541 Rv1739c Rv1739c possible sulphate transporter MT1782 14.5250293 10.7682413 14.9127679 13.9725349 1.150506894 0.202269629 3.77830081 0.533790532 Rv1740 Rv1740 conserved hypothetical protein MT1783 30.1745759 24.8845913 32.7353442 34.814249 1.232029501 0.301036802 4.94654159 0.197768014 MT1784 26.3324724 22.9843134 29.6436728 26.3838927 1.136626739 0.18475856 4.72855376 0.483174937 Rv1742 Rv1742 hypothetical protein MT1785 281.972938 244.683399 274.704097 238.547858 0.974573397 −0.037157253 8.02317847 0.894346121 Rv1743 pknE serine-threonine protein kinase MT1786 2.71758612 5.88181248 4.09191803 6.55694375 1.248741243 0.320474561 2.32459818 0.498825774 Rv1744c Rv1744c hypothetical protein MT1787 5.90372158 7.60111152 7.27452094 14.2847703 1.568591281 0.649469486 3.16650257 0.015496852 Rv1745c Rv1745c conserved hypothetical protein MT1788 129.881875 153.922508 138.124966 161.269593 1.055459746 0.077871557 7.18966401 0.76492809 Rv1746 pknF serine-threonine protein kinase MT1789 834.861199 721.924615 748.911931 711.272279 0.940110794 −0.089097304 9.55921018 0.750567759 MT1790 13.7753503 5.97230191 9.09315118 6.94723802 0.85032617 −0.233911756 3.18650472 0.606853401 MT1791 32.8921631 38.2770259 30.734851 29.2720703 0.843517646 −0.245509846 5.04279647 0.30379452 Rv1748 Rv1748 hypothetical protein MT1792 185.264406 217.717551 150.855378 188.434074 0.839808105 −0.251868383 7.53717863 0.144154503 Rv1749c Rv1749c possible integral membrane protein MT1793 85.7445276 113.926183 84.2025799 101.320393 0.933394127 −0.099441705 6.59214716 0.704237224 Rv1750c fadD1 acyl-CoA synthase MT1794 353.098776 442.312299 312.713469 445.716057 0.945167549 −0.081357997 8.60231555 0.756319422 Rv1751 Rv1751 possible hydroxylasehyroxylase MT1795 35.2349097 43.6159018 32.8262757 52.3774912 1.06466903 0.090405015 5.36486696 0.791300223 Rv1752 Rv1752 hypothetical protein MT1796 41.5134708 33.2096182 59.6510717 50.9724318 1.484217382 0.569702408 5.53975813 0.000255851 Rv1753c PPE PPE-family protein MT1797 36.5468478 92.7516584 69.9263325 145.033351 1.715511825 0.77863907 6.4311443 1.22E−08 MT1798 24.0834356 27.9612317 20.4595902 26.6961281 0.903763282 −0.14598315 4.6427601 0.620486305 MT1799 17.2426154 49.0452672 22.0963574 59.0124938 1.234492505 0.303918078 5.21215805 0.140711849 Rv1755c plcD partial CDS for phospholipase C MT1800 2.62387626 1.53370384 2.45515082 3.04429531 1.068754146 0.095930016 1.5086836 0.90313325 MT1801 47.0423529 42.2585605 48.4664958 30.1307177 0.860195944 −0.217261767 5.39681758 0.462931351 MT1802 332.951155 361.233776 305.075222 351.49902 0.944378646 −0.082562674 8.40031739 0.745116768 MT1803 9.74582609 11.4016673 8.27476757 8.89870938 0.812066485 −0.300330248 3.2857331 0.357876722 MT1804 7.59049917 8.95845286 9.45687722 9.44512136 1.140776653 0.190016361 3.17689535 0.626914187 MT1805 1.1245134 2.35272499 0.81838361 2.10758906 0.839873581 −0.251755908 0.83861091 0.786545243 Rv1758 Rv1758 partial cutinase MT1808 2.43645652 3.80055576 1.81863024 2.7320599 0.730759898 −0.45253063 1.52326219 0.431688147 MT1809 108.328605 127.137639 93.0229365 105.067218 0.842133477 −0.247879179 6.76239148 0.138030276 Rv1760 Rv1760 conserved hypothetical protein MT1810 15.2747032 22.260398 18.5500284 17.5632422 0.969604267 −0.044532047 4.21627096 0.921052928 Rv1761c Rv1761c hypothetical protein MT1811 57.6315678 74.5632844 61.5606335 69.9407334 0.999237533 −0.001100427 6.04669906 0.998009016 Rv1762c Rv1762c hypothetical protein MT1812 24.3645652 29.1375942 24.5515082 30.0526589 1.020098982 0.028709146 4.76608974 0.933447653 MT1813 40.670082 58.0942095 37.9184404 46.8353125 0.864203017 −0.210557828 5.52539752 0.386355369 MT1814 158.463384 135.191198 151.58283 143.08188 1.006135364 0.008824417 7.20214845 0.97711178 Rv1765c Rv1765c conserved hypothetical protein MT1816 117.699592 88.8606132 129.395541 106.081983 1.145056431 0.195418699 6.79026704 0.297099247 Rv1766 Rv1766 conserved hypothetical protein MT1817 63.3478696 42.801497 72.8361409 46.6791948 1.120870318 0.164619372 5.82219305 0.49400037 MT1820 158.182254 142.430352 138.94335 144.564998 0.944412772 −0.082510543 7.19183959 0.764687847 Rv1769 Rv1769 hypothetical protein MT1820.1 241.115486 231.833901 213.598121 225.199794 0.927799099 −0.108115649 7.83359175 0.637790353 Rv1770 Rv1770 conserved hypothetical protein MT1821 173.550672 204.777564 159.493872 196.86443 0.940194953 −0.088968159 7.52240783 0.733038419 Rv1771 Rv1771 oxidoreductase, possible MT1821.1 56.8818838 17.0563374 44.7383038 23.8079505 0.827794261 −0.272655849 5.25801457 0.203989651 MT1822 15.9306773 9.59187882 9.09315118 6.94723802 0.637328838 −0.649890154 3.39806209 0.005373441 MT1823 109.078284 69.2244085 78.7466892 44.5716057 0.683358131 −0.549286238 6.23934064 8.86E−05 Rv1773c Rv1773c transcriptional regulator (IclR family) MT1824 86.213077 82.0739065 91.7498954 85.6305631 1.05369214 0.075453413 6.43615995 0.783679782 Rv1774 Rv1774 putative oxidoreductase with FAD- binding site MT1825 136.347855 116.731355 131.577898 124.738049 1.015430915 0.022092089 6.99460239 0.938478232 Rv1775 Rv1775 conserved hypothetical protein MT1826 7.96533853 6.96768556 9.91153478 7.64976771 1.171108214 0.227874392 3.05244579 0.548909973 Rv1776c Rv1776c putative transcriptional regulator MT1827 11.901153 11.2206884 13.5487953 12.5674755 1.129019819 0.175070812 3.64231269 0.612425659 Rv1777 Rv1777 probable cytochrome p450 MT1828 92.3979231 122.3417 74.2001136 93.1242131 0.781259728 −0.356125846 6.58031332 0.016049672 Rv1778c Rv1778c hypothetical protein MT1829 355.722652 315.446128 303.438455 266.258752 0.84854169 −0.236942552 8.27789662 0.169999787 Rv1779c Rv1779c possible integral membrane protein MT1830 110.952432 184.869891 141.94409 202.640786 1.18194223 0.241159522 7.32462089 0.197828952 Rv1780 Rv1780 conserved hypothetical protein MT1831 50.4159031 70.2197921 44.3745777 55.8901396 0.835272805 −0.259680627 5.79189966 0.202085662 Rv1781c Rv1781c probable 4-[alpha]- glucanotransferase MT1832 653.532607 588.00027 616.788444 582.553229 0.966974532 −0.048450202 9.25358789 0.870656307 MT1833 1399.46314 1692.06172 1405.16465 1548.29737 0.958477695 −0.061183236 10.5616935 0.847981531 Rv1783 Rv1783 conserved hypothetical protein MT1834 37.0153972 42.4395393 38.0093719 40.2003099 0.985149452 −0.02158549 5.30721126 0.94941324 Rv1785c Rv1785c Probable member of the cytochrome P450 MT1835 57.7252776 48.2308624 55.9228797 57.6074344 1.075756603 0.105351696 5.78265637 0.736124871 Rv1786 Rv1786 Probable ferredoxin MT1836 115.544265 78.2733507 116.483267 71.3457927 0.959932044 −0.058995818 6.57845792 0.83350394 Rv1787 PPE PPE-family protein MT1837 24.6456948 15.835649 33.7355909 16.7045948 1.216380141 0.282594168 4.5165551 0.258866356 Rv1788 PE PE-family protein MT1838 512.124419 384.670536 555.955263 401.300569 1.064276006 0.089872343 8.85697888 0.724333443 Rv1789 PPE PPE-family protein MT1838.1 12.2092333 16.7405432 25.5517548 17.7193599 1.106002524 0.145354678 4.37304705 0.624685486 MT1839 94.6469649 121.074848 79.4741413 70.7213219 0.699353308 −0.515906617 6.51791966 0.003263149 Rv1790 PPE PPE-family protein MT1840 214.408174 290.742516 231.60256 209.197729 0.880895478 −0.182957248 7.88665857 0.50431495 Rv1791 PE PE-family protein MT1842 164.648235 212.740633 203.32286 196.161901 1.066077983 0.092312974 7.60286203 0.760272935 Rv2346c Rv2346c conserved hypothetical protein MT1843 877.499138 795.944963 968.511532 750.613942 1.020272034 0.028953867 9.72844744 0.928669788 MT1844 646.879207 603.021514 733.362642 683.873622 1.133883487 0.181272403 9.38145982 0.384917628 Rv1795 Rv1795 probable membrane protein MT1845 1028.6532 828.521155 1116.91176 921.640891 1.099004025 0.13619667 9.92792987 0.578518157 Rv1796 Rv1796 conserved hypothetical protein MT1846 581.46972 461.586546 606.785978 499.966961 1.0631221 0.08807301 9.0704481 0.73439713 Rv1797 Rv1797 conserved hypothetical protein MT1847 486.073076 372.002017 516.854713 441.42282 1.123138967 0.167536445 8.82737619 0.415865749 Rv1798 Rv1798 conserved hypothetical protein MT1848 34.0166815 34.4764701 42.1012899 43.7910172 1.254003209 0.32654104 5.27730315 0.079262095 Rv1799 lppT probable lipoprotein MT1849 156.682896 110.306606 138.852419 108.735984 0.934046792 −0.09843327 7.00906745 0.694453898 Rv1800 PPE PPE-famlly protein MT1850 31.4865151 45.8781374 27.8250426 49.9576667 0.988922574 −0.016070523 5.28477716 0.969101493 Rv1801 PPE PPE-family protein MT1851 18.3671338 24.7941019 19.004686 21.2320083 0.935537355 −0.096132835 4.39425019 0.783679782 Rv1802 PPE PPE-family protein MT1853 42.731699 39.9963249 52.1946878 38.2488386 1.08212472 0.113866786 5.44166233 0.727244526 Rv1803c PE_PGRS PE_PGRS-family protein MT1854 11.901153 11.4921567 11.184576 8.89870938 0.854061068 −0.227588865 3.46386114 0.513096782 Rv1804c Rv1804c conserved hypothetical protein MT1855 7.02823997 27.0563374 6.27427431 23.2615386 0.869821898 −0.201208066 4.01039581 0.518774989 Rv1806 PE PE-family protein MT1856 20.0539114 86.7793565 21.6416998 67.989262 0.897210461 −0.156481653 5.62425 0.622324844 Rv1807 PPE PPE-family protein MT1856.1 15.0872835 53.931696 16.0039461 35.7509552 0.810774324 −0.302627693 4.92545192 0.308884338 Rv1808 PPE PPE-family protein MT1857 76.9358002 304.315929 75.2003602 207.09014 0.808259387 −0.307109737 7.37578837 0.15022018 Rv1809 PPE PPE-family protein MT1858 335.012772 624.286528 330.990703 576.698815 0.954955833 −0.066494085 8.86710108 0.803788741 MT1859 85.2759783 79.3592238 88.2035664 86.6453282 1.062783517 0.087847758 6.41020225 0.739473063 Rv1811 mgtC probable magnesium transport ATPase protein C MT1860 206.817675 482.127645 216.053272 393.182449 0.921006111 −0.118717366 8.34314334 0.65049304 Rv1812c Rv1812c probable dehydrogenase MT1861 366.311867 1327.38934 387.459172 863.721222 0.828192956 −0.271961162 9.52437657 0.335308461 Rv1813c Rv1813c conserved hypothetical protein MT1862 64.7535176 97.6380872 64.3795103 82.43015 0.913448803 −0.130604224 6.27580664 0.603659007 Rv1814 Rv1814 possible C-5 sterol desaturase MT1863 163.336297 137.815391 205.596148 242.372742 1.488109894 0.573481071 7.55055993 0.00036775 Rv1815 Rv1815 conserved hypothetical protein MT1864 78.0603186 65.061895 108.663157 125.830873 1.641004654 0.71457933 6.56380544 2.84E−06 Rv1816 Rv1816 putative transcriptional regulator MT1865 39.4518537 42.6205182 49.0120848 49.4112547 1.199373722 0.262281269 5.50166368 0.219917194 Rv1817 Rv1817 flavoprotein MT1866 130.725263 124.784914 157.220584 123.879402 1.092915418 0.128181754 7.06956828 0.609343079 Rv1818c PE_PGRS PE_PGRS-family protein MT1867 56.1322099 109.854159 54.5589071 105.535571 0.965909617 −0.050039896 6.35260678 0.870054573 Rv1819c Rv1819c probable multidrug resistance pump MT1868 193.417164 150.393421 182.86327 133.324523 0.915762366 −0.126954818 7.36772456 0.578518157 Rv1820 ilvG acetolactate synthase II MT1869 1154.13071 1121.34493 1074.71954 1093.91678 0.95312051 −0.069269458 10.1179051 0.816959095 Rv1821 secA2 SecA, preprotein translocase subunit MT1870 84.1514599 79.5402027 81.5655661 91.4069183 1.056212166 0.078899665 6.39826518 0.784361075 Rv1822 pgsA2 CDP-diacylglycerol-glycerol-3-phosphate MT1871 67.0962642 71.2151758 63.2883322 72.5947344 0.981254605 −0.027300576 6.10283406 0.93032752 Rv1823 Rv1823 conserved hypothetical protein MT1872 18.2734239 19.907673 18.8228229 24.8227156 1.139481513 0.188377518 4.3678094 0.512021531 Rv1824 Rv1824 small basic protein similar SBP_BACSU MT1873 76.373541 98.0905343 72.3814834 99.2908625 0.980477306 −0.028443857 6.43830878 0.923557668 Rv1825 Rv1825 hypothetical protein MT1874 128.944776 152.746146 128.668089 152.058648 0.9966594 −0.004827535 7.13736593 0.936668385 Rv1826 gcvH glycine cleavage system H protein MT1875 679.115401 709.527564 640.521569 742.651939 0.993677069 −0.009151022 9.43699155 0.97711178 Rv1827 Rv1827 conserved hypothetical protein MT1876 372.590428 399.963249 383.367254 401.300569 1.016011892 0.022917288 8.60541867 0.932785035 Rv1828 Rv1828 conserved hypothetical protein MT1877 439.499273 367.115588 445.655339 414.258339 1.069635333 0.097119028 8.70323331 0.695240735 Rv1829 Rv1829 conserved hypothetical protein MT1879 606.583954 648.628183 767.643822 837.649564 1.278418433 0.354360115 9.48243435 0.024418139 Rv1830 Rv1830 conserved hypothetical protein MT1880 1917.86612 880.190616 1818.44837 809.236141 0.933717266 −0.098942334 10.4057564 0.726511707 Rv1832 gcvB glycine decarboxylase MT1881 56.788179 59.0895931 58.8326881 52.7677854 0.961424054 −0.056755196 5.83392357 0.865029216 Rv1833c Rv1833c similar to 1,3,4,6-tetrachloro-1,4- cyclohexadien MT1882 33.1732927 45.2447114 30.3711249 31.5357771 0.795161515 −0.330680162 5.13963522 0.140110706 Rv1834 Rv1834 conserved hypothetical protein MT1884 687.361859 475.431428 742.910451 628.061541 1.19465461 0.256593577 9.30746162 0.190889592 Rv1836c Rv1836c conserved hypothetical protein MT1885 1615.18326 935.298674 1658.22705 1207.80465 1.151222248 0.203166378 10.4033245 0.406290183 Rv1837c glcB malate synthase MT1886 39.920403 31.671298 42.646879 36.9998969 1.116357581 0.158799212 5.24727896 0.538270037 Rv1838c Rv1838c conserved hypothetical protein MT1887 29.8934473 25.6085067 28.1887686 27.1644813 1.000066267 9.56E−05 4.80152744 0.999874639 Rv1839c Rv1839c conserved hypothetical protein MT1888 56.2259198 38.4580047 82.9295387 46.8353125 1.345268504 0.427894151 5.81447015 0.012795563 Rv1840c PE_PGRS PE_PGRS-family protein MT1889 144.594324 120.441422 131.032308 115.370987 0.931600049 −0.102217379 7.00030774 0.664133224 Rv1841c Rv1841c possible membrane protein MT1890 191.449257 185.141359 163.767653 160.80124 0.861974426 −0.214283028 7.45499107 0.245722863 Rv1842c Rv1842c possible membrane protein MT1891 489.165502 456.428649 443.29112 397.397627 0.888266583 −0.170935377 8.80328499 0.38833378 Rv1843c guaB1 inosine-5′-monophosphate dehydrogenase MT1892 382.804804 338.068484 368.272623 319.416831 0.953404374 −0.06883985 8.46069763 0.787869534 MT1893 503.315692 285.946576 484.392163 278.904286 0.9687984 −0.045731612 8.60100017 0.871130682 Rv1845c Rv1845c hypothetical protein MT1894 560.010161 395.891225 486.483588 360.631906 0.889485724 −0.168956644 8.81670635 0.398713975 Rv1846c Rv1846c putative transcriptional regulator MT1895 247.300337 115.645482 303.893112 121.303459 1.138106571 0.186635656 7.62338628 0.364078181 Rv1847 Rv1847 conserved hypothetical protein MT1896 61.5673821 34.6574489 75.3822233 41.761487 1.215154278 0.281139493 5.74150722 0.155996345 MT1897 29.7060276 24.2511653 35.8270156 20.9197729 1.026755983 0.038093354 4.79886571 0.923772833 Rv1849 ureB urease [beta] subunit MT1898 156.870316 126.323234 175.952475 124.738049 1.053033527 0.074551371 7.19116889 0.790412569 Rv1850 ureC urease [alpha] subunit MT1899 51.6341353 43.2539441 59.4692087 40.668663 1.042652202 0.060257997 5.6123776 0.869500615 Rv1851 ureF urease accessory protein MT1900 39.920403 43.7968807 42.9196736 39.2636037 0.98071119 −0.028099755 5.38018071 0.934979861 Rv1852 ureG urease accessory protein MT1901 56.6944691 63.4330854 64.1067158 55.9681985 0.997922335 −0.003000555 5.91224036 0.99525661 MT1902 930.538972 663.10649 929.32005 723.293343 1.043632987 0.06161445 9.6648574 0.837506926 Rv1854c ndh probable NADH dehydrogenase MT1903 254.047447 237.172777 257.699904 251.973981 1.038146743 0.054010384 7.96808654 0.839820353 Rv1855c Rv1855c probable monooxygenase MT1904 256.483904 379.512639 391.096432 572.405578 1.516424631 0.600673795 8.64415441 7.34E−07 Rv1856c Rv1856c short-chain dehydrogenase/reductase family MT1905 204.100089 172.834798 216.235135 262.902221 1.2698755 0.34468706 7.74287183 0.074449473 Rv1857 modA molybdate binding protein MT1906 13.4005109 12.4875404 14.9127679 16.1581828 1.20194635 0.265372501 3.85036205 0.337196914 Rv1858 modB transport system permease, molybdate uptake MT1907 183.390208 116.550377 154.219844 126.455344 0.953972263 −0.067980775 7.18306336 0.82501449 Rv1859 modC molybdate uptake ABC-transporter MT1908 91.3671196 229.028729 110.481787 223.638617 1.081930349 0.113607627 7.35609966 0.664557787 Rv1860 modD precursor of Apa (45/47 kD secreted protein) MT1909 6.37227091 6.15328075 4.81937012 6.32276719 0.891262579 −0.166077561 2.60769545 0.748713356 MT1910 9.74582609 27.2373163 13.0032062 23.573774 1.035940868 0.050941655 4.21638148 0.905696211 Rv1861 Rv1861 hypothetical protein MT1911 120.979437 171.748925 116.756061 136.056583 0.872923762 −0.196072436 7.09342144 0.365758936 Rv1862 adhA alcohol dehydrogenase (Zn) MT1912 445.496704 441.316915 438.108024 443.842645 0.994525618 −0.007919561 8.78909916 0.977735627 Rv1863c Rv1863c probable membrane protein MT1913 35.04749 58.4561671 40.5554542 50.9724318 0.997791648 −0.003189501 5.53741002 0.99525661 Rv1864c Rv1864c conserved hypothetical protein MT1914 23.3337557 32.1237451 23.46033 30.6771297 0.978048751 −0.032021716 4.78575624 0.927656812 Rv1865c Rv1865c Short-chain alcohol dehydrogenase MT1915 68.5956221 95.6473199 73.199867 91.016624 1.005847994 0.008412298 6.36281963 0.977735627 Rv1866 Rv1866 conserved hypothetical protein MT1916 10.8703445 10.4062836 9.36594571 7.80588542 0.804416416 −0.313985571 3.28928404 0.326266799 MT1917 111.608451 101.348154 124.48524 108.501807 1.09278483 0.128009362 6.80296442 0.55335105 Rv1868 Rv1868 conserved hypothetical protein MT1918 493.476156 288.661259 465.478409 300.44853 0.990434985 −0.01386582 8.59683442 0.965915186 Rv1869c Rv1869c probable reductase (like rhodocoxin reductase) MT1919 462.27077 285.494129 483.210054 376.477854 1.173371982 0.230660449 8.65116655 0.245451994 Rv1870c Rv1870c hypothetical protein MT1920 1176.05832 1076.00973 1295.04659 1247.69273 1.129989996 0.17631 10.2274714 0.45709859 Rv1871c Rv1871c hypothetical protein MT1921 2761.62976 2529.81279 2959.72978 2540.8157 1.037496555 0.053106546 11.3977642 0.879216791 Rv1872c lidD2 L-lactate dehydrogenase MT1922 36.1720084 18.7313105 28.0069056 17.7193599 0.848570375 −0.236893782 4.6615884 0.16701592 Rv1873 Rv1873 hypothetical protein MT1923 20.2413311 28.1422105 19.550275 24.2763037 0.908805258 −0.137956913 4.53812834 0.641653568 MT1924 55.1014014 100.986196 52.6493453 82.43015 0.879174701 −0.185778222 6.18942696 0.41035137 Rv1875 Rv1875 conserved hypothetical protein MT1924.1 814.338738 160.075789 862.030732 192.727311 1.126723577 0.172133617 8.98703377 0.423662019 MT1925 262.106496 291.375942 289.34407 314.889418 1.092183354 0.127215074 8.17797523 0.563048544 Rv1876 bfrA bacterioferritin MT1926 268.759896 256.628003 277.432042 272.113166 1.046231196 0.065201694 8.07097741 0.806860351 MT1927 48.9165502 47.2354787 47.5571807 45.9766651 0.972790343 −0.039799188 5.57273331 0.90313325 Rv1878 glnA3 probable glutamine synthase MT1928 19.1168127 25.7894855 22.6419464 23.4957151 1.031969219 0.04539994 4.51985135 0.90313325 Rv1879 Rv1879 conserved hypothetical protein MT1929 293.967851 306.306696 285.070289 308.566651 0.988452829 −0.016755975 8.22234042 0.952996744 Rv1880c Rv1880c Similar to 6-deoxyerythronolide beta hydroxylase MT1930 156.964026 126.323234 167.495845 158.693651 1.157553333 0.211078666 7.25310713 0.290294572 MT1931 153.309341 83.9741844 163.767653 119.586165 1.230100978 0.29877675 7.02598815 0.122792761 Rv1882c Rv1882c probable dehydrogenase MT1931.1 379.899798 220.884681 448.292353 394.899743 1.451152822 0.537199459 8.49655088 0.0022042 Rv1883c Rv1883c conserved hypothetical protein MT1932 680.427339 412.722258 801.743139 761.854417 1.474240504 0.559971901 9.37584426 0.003702573 MT1933 129.788165 214.550422 136.488199 213.25679 1.021652969 0.030905231 7.44057937 0.914315517 Rv1885c Rv1885c hypothetical protein MT1934 499.473587 826.801856 529.585125 830.155914 1.031611102 0.044899205 9.39167067 0.880977785 Rv1886c fbpB antigen 85B, mycolyltransferase MT1935 698.794473 678.308714 655.343405 723.605578 1.000301766 0.00043529 9.4287611 0.999355608 Rv1887 Rv1887 hypothetical protein MT1936 124.634122 125.780298 121.757294 107.799278 0.914882001 −0.128342415 6.90883145 0.564270992 Rv1888c Rv1888c hypothetical protein MT1937 22.5840778 28.0517211 20.0958641 25.1349511 0.893172293 −0.162989596 4.5937335 0.548909973 Rv1889c Rv1889c conserved hypothetical protein MT1940 9.46469649 15.835649 7.09265792 9.3670625 0.655223948 −0.609940008 3.4076393 0.010436215 MT1941 340.166815 379.241171 363.453253 362.739495 1.010738177 0.015409328 8.49815878 0.958106946 Rv1891 Rv1891 hypothetical protein MT1942 58.9435059 77.1874777 66.9255927 76.9660302 1.062130899 0.086961577 6.13319204 0.754687847 MT1943 70.9383638 97.1856401 67.9258393 70.4090865 0.830654145 −0.26768018 6.26278828 0.20900061 MT1944 154.52757 125.056382 155.856611 121.147342 0.988623584 −0.016505772 7.12218277 0.955286813 Rv1894c Rv1894c some similarity to dioxygenases MT1945 12.5571221 8.86796344 13.0032062 10.6160042 1.108931705 0.149170518 3.51498684 0.706925211 MT1946 37.0153972 61.3518287 35.4632896 54.2509037 0.917917591 −0.123563458 5.56099158 0.660006357 Rv1895 Rv1895 similar to sorbitol and alcohol dehydrogenases MT1947 55.1014014 71.486644 57.2868524 69.7065568 1.00582564 0.008380235 5.99048548 0.978929348 Rv1896c Rv1896c conserved hypothetical protein MT1948 44.3247657 40.2677932 36.1907417 35.7509552 0.851676426 −0.231622677 5.29653993 0.293416398 Rv1897c Rv1897c conserved hypothetical protein MT1949 98.11423 61.2613393 78.9285522 59.0124938 0.878349603 −0.187132815 6.2189202 0.409365522 Rv1898 Rv1898 hypothetical protein MT1950 1162.00234 836.031778 918.590132 732.113993 0.83197081 −0.265395183 9.83343296 0.167597174 Rv1899c lppD lipoprotein MT1951 396.392734 260.519048 350.177252 249.163863 0.918926801 −0.121978149 8.29563856 0.594850468 Rv1900c lipJ probable esterase MT1952 204.006379 197.53841 180.408119 187.965721 0.917454034 −0.124292217 7.58986111 0.584969964 Rv1901 cinA competence damage protein MT1953 42.6379892 44.7922643 45.1020298 42.854311 1.005408155 0.007781296 5.46013153 0.98219487 MT1954 65.2220669 60.2659556 62.4699486 59.1686115 0.969760098 −0.044300201 5.95312283 0.890352778 Rv1903 Rv1903 unknown membrane protein MT1955 540.049959 491.448055 614.424225 505.977493 1.08232766 0.114137321 9.07185487 0.633618212 Rv1904 Rv1904 conserved hypothetical protein MT1956 312.990953 235.001031 344.812293 260.014043 1.104033285 0.142783668 8.17178897 0.50431495 Rv1905c aao D-amino acid oxidase MT1957 297.060276 243.597526 312.076948 254.940218 1.048559571 0.068408826 8.11420047 0.800312889 Rv1906c Rv1906c conserved hypothetical protein MT1958 43.0128286 43.0729653 51.5581672 44.2593703 1.109603592 0.150044363 5.51255795 0.584969964 Rv1907c Rv1907c hypothetical protein MT1959 823.428595 862.997616 1116.00244 861.223338 1.162975035 0.217820127 9.83933895 0.390012328 Rv1908c katG catalase-peroxidase MT1960 110.015383 91.5752959 123.30313 86.9575636 1.032608028 0.046292719 6.68828537 0.880856541 MT1961 52.0089758 90.4894228 51.3763041 68.535674 0.860172206 −0.217302579 6.03967976 0.377003647 Rv1910c Rv1910c probable secreted protein MT1962 211.596878 265.767435 178.316695 202.796903 0.801501385 −0.319223082 7.74679852 0.0330897 Rv1911c lppC lipoprotein MT1963 55.7573704 91.4848065 50.1941945 70.1749099 0.827885346 −0.272497113 6.06790973 0.169999787 Rv1912c fadB5 3-hydroxyacyl-CoA dehydrogenase MT1964 31.2053855 34.9289172 24.9152342 32.1602479 0.860325163 −0.217046061 4.95330859 0.380784281 Rv1913 Rv1913 hypothetical protein MT1965 53.0397813 51.6694604 48.1027697 49.4112547 0.931555179 −0.102286867 5.66475276 0.73439713 Rv1914c Rv1914c hypothetical protein MT1966 1017.12639 1119.08269 927.137694 949.820138 0.879547606 −0.185166428 9.97077292 0.411109847 Rv1915 aceAa isocitrate lyase, [alpha] module MT1968 30.1745769 30.6759143 31.5532346 36.0631906 1.110431615 0.151120548 5.01348947 0.581433109 Rv1917c PPE PPE-family protein MT1969 100.175817 146.954823 123.30313 158.693651 1.151150982 0.203077066 7.04956282 0.305491905 Rv1918c PPE PPE-family protein MT1970 144.032064 199.438688 141.125706 194.912959 0.978540819 −0.031296062 7.40994122 0.909950839 Rv1919c Rv1919c weak similarity to pollen antigens MT1971 72.0628872 88.4936555 84.2935114 82.1959735 1.040614314 0.057435458 6.35650572 0.859814922 Rv1920 Rv1920 probableproable membrane protein MT1972 19.0231019 22.9843134 13.5487953 18.8121839 0.768180011 −0.380483672 4.23025493 0.075344841 Rv1921c lppF lipoprotein MT1973 136.066726 176.363885 104.480307 116.073516 0.710097601 −0.493910762 7.05976623 0.000419332 Rv1922 Rv1922 probable penicillin binding protein MT1974 215.438933 189.575341 176.679927 172.822303 0.864696991 −0.209733426 7.56069581 0.273603377 Rv1923 lipD probable esterase MT1975 108.703445 115.554993 101.843293 105.379453 0.924208851 −0.113709189 6.75548252 0.619926139 MT1976 3610.26631 2698.66606 3063.11891 2557.20806 0.896633235 −0.157410119 11.5422954 0.555180056 Rv1925 fadD31 acyl-CoA synthase MT1977 87.618725 114.37863 90.1131282 98.9005683 0.941487343 −0.086986395 6.61369306 0.759681853 Rv1926c Rv1926c hypothetical protein MT1979 90.4300209 59.5420402 87.3851828 61.2762005 0.996346988 −0.005279832 6.22534208 0.985701566 Rv1927 Rv1927 hypothetical protein MT1980.2 6.46598077 11.2206884 7.91104152 9.05482709 0.969404481 −0.044829344 3.14479848 0.910747689 Rv1930c Rv1930c conserved hypothetical protein MT1981 19.3979423 20.541099 17.4588503 17.7193599 0.880606702 −0.18343027 4.24423795 0.518774989 MT1982 234.368376 283.593851 233.148396 255.720806 0.946763179 −0.078924496 7.97662553 0.760272935 Rv1932 tpx thiol peroxidase MT1983 2.34374656 2.98615095 3.27353442 3.66876615 1.30076811 0.379363793 1.70192987 0.503252495 Rv1933c fadE18 acyl-CoA dehydrogenase MT1984 6.27856104 8.95845286 7.82011001 7.02529688 0.974598813 −0.037119629 2.94392322 0.948443219 Rv1934c fadE17 acyl-CoA dehydrogenase MT1985 18.7419733 23.7082288 20.5505217 25.6033042 1.087542454 0.12107172 4.48143307 0.697208218 Rv1935c echA13 enoyl-CoA hydratase/isomerase superfamily MT1986 43.7625075 59.7230191 49.1030164 55.7340219 1.020235663 0.028902437 5.70772186 0.932510447 Rv1936 Rv1936 similar alkanal monooxygenase alpha chain MT1987 42.5442793 56.1939316 44.8292353 43.7910172 0.9032814 −0.146752593 5.55498518 0.633618212 Rv1937 Rv1937 similar to ring-hydroxylating dioxygenases MT1988 13.9627701 28.0517211 15.2176494 21.3881261 0.894840827 −0.160297014 4.31143931 0.646182127 Rv1938 ephB probable epoxide hydrolase MT1989 5.99743144 8.86796344 6.81986338 8.43035625 1.027924018 0.039733628 2.94735636 0.937911005 Rv1939 Rv1939 similar nitrilotrlacetate monooxygenase component MT1990 16.6803562 24.1606759 15.0036994 20.4514198 0.869881752 −0.201108794 4.26724272 0.471498466 Rv1940 ribA GTP cyclohydrolase II MT1991 38.8895945 53.4792489 33.5537278 50.6601964 0.906559159 −0.141526927 5.47029392 0.606853401 Rv1941 Rv1941 short-chain alcohol dehydrogenase family MT1992 114.888236 74.472795 108.208499 75.6390297 0.977162831 −0.033329107 6.5463125 0.905696211 Rv1942c Rv1942c conserved hypothetical protein MT1993 84.9011338 71.2151758 73.9273191 69.5504391 0.922056144 −0.117073496 6.23012228 0.641653568 Rv1943c Rv1943c conserved hypothetical protein MT1994 18.929393 27.6897634 16.8223297 22.0906557 0.837723988 −0.25545311 4.43046901 0.285491558 MT1995 35.7971639 33.8430441 33.6446594 29.0378938 0.898095334 −0.155059498 5.05519122 0.558074612 Rv1148c Rv1148c REP-family protein MT1997 6.55969054 6.42474902 5.09216466 5.46411979 0.814425994 −0.296144487 2.5984438 0.476182576 Rv1946c lppG lipoprotein MT1998 75.5301522 98.7239603 66.9255927 99.3689214 0.946555875 −0.079240425 6.41490072 0.775934881 Rv1947 Rv1947 hypothetical protein MT1998.1 9.27727676 11.4016673 10.0933978 11.240475 1.031925765 0.04533919 3.41741701 0.920483794 Rv1948c Rv1948c hypothetical protein MT1999 12.0885728 16.9215221 12.6394801 14.3628292 0.9336963 −0.098974729 3.8260218 0.801831984 Rv1949c Rv1949c conserved hypothetical protein MT2000 6.46598077 13.1209663 5.36495919 10.3037688 0.801943586 −0.318427343 3.17032802 0.327313667 Rv1950c Rv1950c conserved hypothetical protein MT2001 16.6803552 22.4413769 17.8225763 20.6855964 0.987157717 −0.018547494 4.29198138 0.965915186 Rv1951c Rv1951c conserved hypothetical protein MT2002 72.3440158 75.4681786 67.1074557 57.0610224 0.837261763 −0.256249354 6.09035637 0.224811663 Rv1952 Rv1952 conserved hypothetical protein MT2003 36.8279774 33.0286393 39.6461391 34.4239547 1.059319777 0.083138162 5.17609282 0.796116941 MT2004 73.4685352 61.8042758 77.7464426 56.6707281 0.986040053 −0.020281845 6.07866942 0.950509824 Rv1955 Rv1955 hypothetical protein MT2005 23.6148863 33.390597 23.6421931 29.9746 0.944419971 −0.082499545 4.79901717 0.806148616 Rv1956 Rv1956 putative transcriptional regulator MT2006 52.7586547 75.7396469 53.4677289 66.4280849 0.940254001 −0.088877555 5.96072173 0.764687847 Rv1957 Rv1957 hypothetical protein MT2007 42.5442793 54.6556114 49.0120848 50.5821375 1.029850346 0.042434705 5.62579654 0.90313325 MT2008 43.6687977 34.2050018 41.9194269 31.1454828 0.935604158 −0.096029822 5.24402586 0.752437878 Rv1959c Rv1959c conserved hypothetical protein MT2009 20.4287509 18.188374 18.1863024 14.2847703 0.83733034 −0.256131194 4.16466212 0.322355421 Rv1960c Rv1960c hypothetical protein MT2010 13.0256714 12.5780298 10.7299184 12.333299 0.901982029 −0.148829405 3.62555434 0.694085957 Rv1961 Rv1961 hypothetical protein MT2011 2.81129599 5.51985479 2.90980838 4.37129584 0.879109383 −0.185885411 2.0311042 0.764687847 MT2012 33.2670025 37.4626211 34.7358375 40.3564276 1.061120685 0.085588748 5.19530571 0.786996698 Rv1962c Rv1962c conserved hypothetical protein MT2013 28.6752191 37.3721316 35.008632 44.0251938 1.198059551 0.260699621 5.18831819 0.222687869 MT2014 59.1309256 63.6140642 58.5598936 67.2086735 1.023542249 0.033570654 5.96138924 0.914775343 Rv1963c Rv1963c putative transcriptional regulator MT2015 17.8048746 19.1837576 14.5490419 21.0758906 0.956748217 −0.053788787 4.19683288 0.879970853 MT2015.1 18.1797141 16.0166278 22.7328779 18.1096542 1.190192754 0.25119524 4.24286748 0.326266799 MT2016 49.1039699 56.8273575 57.3777839 46.6791948 0.978777521 −0.030947126 5.71882478 0.93458603 Rv1964 Rv1964 part of mce3 operon MT2017 18.5545535 24.2511653 22.0054259 23.9640682 1.076936008 0.106932527 4.48391374 0.750845053 MT2018 22.3029432 31.1283615 27.370385 31.613836 1.110384026 0.151058718 4.82222143 0.613920518 Rv1966 mce3 cell Invasion protein MT2019 15.5558378 23.8892076 16.9132612 20.4514198 0.954935737 −0.066524446 4.27685576 0.870054573 Rv1967 Rv1967 part of mce3 operon MT2020 18.0860042 36.9196845 23.1875355 31.613836 1.030544901 0.043407364 4.78877591 0.917694685 Rv1968 Rv1968 part of mce3 operon MT2021 20.5224607 45.0637326 23.7331246 34.7361901 0.928255511 −0.10740612 4.9635764 0.785509211 Rv1969 Rv1969 part of mce3 operon MT2022 24.551985 36.8291951 23.6421931 36.9998969 0.985497293 −0.021076187 4.94004522 0.952431559 Rv1970 lprM part of mce3 operon MT2023 20.0539114 38.815346 21.0961107 41.3711927 1.044584943 0.062929814 4.94421946 0.857846065 Rv1971 Rv1971 part of mce3 operon MT2024 7.7779189 13.5734134 7.54731548 16.9387714 1.129536241 0.17573056 3.54420369 0.641869092 Rv1972 Rv1972 conserved hypothetical protein MT2024.1 4.40436371 11.0397096 4.72843861 9.67929792 0.942173767 −0.085934932 2.93721268 0.872354136 MT2025 6.9345301 10.6777519 5.18309617 10.2257099 0.867343698 −0.205324298 3.0782461 0.618762751 MT2026 11.8074432 25.9704644 11.912028 18.4999484 0.826069975 −0.275664099 4.10709895 0.356794349 Rv1975 Rv1975 hypothetical protein MT2027 2.15532692 3.25761922 3.00073989 2.7320599 1.056065251 0.078698977 1.56724588 0.921400122 MT2028 22.7714975 24.7941019 20.4595902 18.4218896 0.815733878 −0.293829525 4.4448201 0.208217539 Rv1976c Rv1976c hypothetical protein MT2029 87.9935644 87.955719 88.9310185 82.1959735 0.971674236 −0.041455379 6.44196909 0.89125591 Rv1977 Rv1977 probable zinc metallopeptidase MT2030 69.9075602 92.3897007 71.3812367 81.6495615 0.948153533 −0.076807403 6.30399705 0.790412569 Rv1978 Rv1978 similar to methyltransferases MT2031 372.121879 318.34179 413.647447 343.146723 1.094655303 0.13047665 8.4997904 0.531483649 Rv1979c Rv1979c unknown permease MT2032 974.957449 993.845331 1256.85536 1189.61694 1.242185043 0.312880102 10.1085251 0.08076305 Rv1980c mpt64 secreted immunogenic protein Mpb64/Mpt64 MT2033 1070.72893 598.859 1553.11022 1042.63212 1.58876378 0.667904638 10.0586756 6.00E−06 Rv1981c nrdF ribonucleotide reductase small subunit MT2034 397.517253 219.708319 667.437296 405.984101 1.760498628 0.815984103 8.72394941 4.61E−12 Rv1982c Rv1982c conserved hypothetical protein MT2035 301.37093 135.100708 435.289147 242.841095 1.608141856 0.685394674 8.1231675 3.47E−07 MT2036 54.4454323 50.9455451 58.7417566 56.0462573 1.089483051 0.123643753 5.78715964 0.637012172 Rv1983 PE_PGRS PE_PGRS-family protein MT2037 87.1501756 94.8329151 95.1143613 92.5778011 1.031652572 0.044957199 6.53286904 0.880856541 Rv1984c Rv1984c probable secreted protein MT2038 59.7868947 50.7645662 50.6488521 45.7424886 0.873610132 −0.194938506 5.69771999 0.409241084 MT2039 39.920403 29.951999 36.4635362 29.8184823 0.952615161 −0.070019441 5.09610178 0.832160187 Rv1985c Rv1985c transcriptional regulator (LysR family) MT2040 226.121907 99.085918 190.137791 71.8141459 0.783201999 −0.352543647 7.19893605 0.02607446 Rv1986 Rv1986 membrane protein, LYSE/YGGA family MT2041 367.717515 341.054635 535.222878 519.715851 1.489295754 0.574630282 8.78501599 3.62E−06 Rv1987 Rv1987 probable secreted protein MT2042 259.2952 325.490454 284.706563 305.756532 1.015115585 0.021644008 8.19963431 0.942710539 Rv1988 Rv1988 possible rRNAmethyltransferase MT2042.1 76.9358002 67.8670671 114.119047 113.887868 1.577615238 0.657745392 6.54525666 4.66E−07 MT2043 123.041054 103.157942 120.575185 99.2908625 0.971259267 −0.042071636 6.80327111 0.880856541 Rv1989c Rv1989c hypothetical protein MT2044 76.373541 63.4330854 77.5645795 67.9112032 1.042540007 0.060102748 6.1597117 0.839018102 Rv1990c Rv1990c putative transcriptional regulator MT2045 36.3594231 27.7802528 33.6446594 28.4134229 0.971802578 −0.041264835 4.98717743 0.90313325 MT2045.1 20.0539114 11.8541144 18.6409599 12.1771813 0.972216044 −0.040651152 3.98553909 0.917293811 MT2046 31.6739348 29.6805307 34.9177005 33.0969542 1.108732814 0.148911742 5.02323303 0.578518157 Rv1991c Rv1991c conserved hypothetical protein MT2047 36.8279774 32.1237451 37.5547144 29.428188 0.967315813 −0.047941111 5.09381128 0.892238469 MT2048 292.281073 134.914217 338.265224 165.328653 0.992558633 −0.010775767 7.95331596 0.975447043 Rv1992c ctpG probable cation transport ATPase MT2049 40.1078228 37.7340893 45.1020298 30.7551886 0.959607289 −0.059483979 5.27006474 0.879854448 Rv1993c Rv1993c conserved hypothetical protein MT2050 46.1052512 41.3536662 46.6478655 37.0779557 0.953015752 −0.069428035 5.4250069 0.831756973 Rv1994c Rv1994c transcriptional regulator (MerR family) MT2051 14.0564799 10.1348154 19.9140011 10.9282396 1.251854769 0.324067201 3.79925231 0.240609573 MT2052 1002.22702 937.873029 1054.80554 625.641716 0.816583168 −0.292328265 9.84202131 0.308438093 Rv1996 Rv1996 conserved hypothetical protein MT2053 401.453057 1144.14826 333.265224 741.012703 0.737725561 −0.438843872 9.35845472 0.00852784 Rv1997 ctpF probable cation transport ATPase MT2054 41.326051 55.3795268 42.0103584 46.3669594 0.919693119 −0.120775548 5.53755638 0.692332363 MT2055 6.37227091 3.25761922 9.45687722 4.37129584 1.426026048 0.512000334 2.59120656 0.127414551 MT2056 64.1912584 90.308444 65.8344145 85.0841511 0.981477475 −0.026972937 6.25814167 0.929337887 Rv2000 Rv2000 hypothetical protein MT2057 27.363281 40.2677932 25.9154809 38.2488386 0.948606054 −0.076119019 5.05037261 0.812642214 Rv2001 Rv2001 conserved hypothetical protein MT2058 53.1334942 79.2687344 53.7405235 77.0440891 0.990550634 −0.013697372 6.04409095 0.969989124 Rv2002 fabG3 3-oxoacyl-[ACP] reductase MT2059 146.187391 722.286573 128.940884 381.863915 0.678899496 −0.558730081 8.43050488 0.00461349 Rv2003c Rv2003c conserved hypothetical protein MT2060 440.811211 1053.38737 394.824624 721.810225 0.782576699 −0.35369594 9.35071045 0.052180271 Rv2004c Rv2004c hypothetical protein MT2061 292.093653 874.127825 254.244507 725.244814 0.849399723 −0.235484457 9.06779327 0.190551971 Rv2005c Rv2005c conserved hypothetical protein MT2062 167.92808 610.170178 144.672035 454.38059 0.79878625 −0.324118596 8.42832897 0.034830279 Rv2006 otsB trehalose-6-phosphate phosphatase MT2063 1504.79303 2745.26811 1105.36346 1983.47549 0.728496049 −0.457006947 10.8414927 0.003877189 Rv2007c fdxA ferredoxin MT2064 8.15275837 12.7590086 8.27476757 11.786887 0.961754744 −0.056259054 3.38268237 0.90313325 Rv2008c Rv2008c conserved hypothetical protein MT2064.1 78.5288679 37.4626211 74.5638396 54.0167271 1.162147171 0.216792779 5.93797429 0.465200545 MT2065 209.535261 107.591924 238.695218 149.248529 1.25457273 0.327196109 7.46295346 0.053172126 Rv2010 Rv2010 conserved hypothetical protein MT2066 6.74711037 15.2927125 9.36594571 17.5632422 1.235521591 0.305120222 3.63785255 0.299390389 Rv2011c Rv2011c hypothetical protein MT2067 5.71630184 13.2114557 6.72893187 12.2552401 1.016228314 0.023224566 3.27422274 0.967101325 Rv2012 Rv2012 hypothetical protein MT2068 2.81129599 7.96306921 3.36446594 6.55694375 0.937230295 −0.093524506 2.42431682 0.880856541 MT2071 158.275954 131.7526 155.674748 145.891999 1.043489682 0.061416335 7.21015914 0.828256087 MT2072 15.4621279 25.6085067 14.3671789 21.4661849 0.876737859 −0.189782548 4.27885238 0.505322279 Rv2016 Rv2016 hypothetical protein MT2073 18.6482634 22.4413769 15.8220331 20.2172432 0.876288734 −0.190521784 4.28255369 0.495769938 Rv2017 Rv2017 putative transcriptional regulator (PbsX/Xre MT2074 51.4467166 72.753496 53.1949344 61.042024 0.928365502 −0.107235182 5.90180308 0.725019493 Rv2018 Rv2018 conserved hypothetical protein MT2075 17.4300351 21.8079509 16.7313982 21.0758906 0.963440258 −0.053732886 4.28125458 0.886067917 MT2076 64.472388 55.8319739 66.1072091 52.7677854 0.984809015 −0.022084126 5.90597631 0.946497216 Rv2020c Rv2020c hypothetical protein MT2077 88.0872743 99.9003228 82.2020866 83.8352094 0.88432413 −0.17735284 6.47051916 0.406339213 MT2078 60.53656736 54.1126749 61.9243595 53.8606094 1.009090092 0.013054985 5.85248253 0.972119393 Rv2022c Rv2022c conserved hypothetical protein MT2079 47.9794515 46.1496056 51.9218932 58.2319052 1.169633528 0.226056572 5.67964121 0.328864961 Rv2023c Rv2023c hypothetical protein MT2080 79.3722557 83.883695 116.392335 97.1052146 1.302452975 0.381231285 6.56022438 0.021281542 MT2080.1 4.12323412 4.88642883 5.09216466 4.52741354 1.063336197 0.088597809 2.27288656 0.89069148 MT2081 53.6020435 97.0046613 57.8324415 124.113578 1.18146588 0.240577966 6.38111151 0.222687869 MT2082 253.485188 329.381499 250.789109 343.302841 1.015738463 0.022528978 8.20177157 0.936063793 Rv2024c Rv2024c conserved hypothetical protein MT2083 6.46598077 6.51523844 3.54632896 5.30800209 0.682681334 −0.550715788 2.49357393 0.117616165 MT2084 36.8279774 35.3813643 24.6424397 27.2425401 0.719012205 −0.475911835 4.96299843 0.005509103 Rv2025c Rv2025c possible membrane protein MT2085 30.830546 31.1283615 33.6446594 30.8332474 1.039214396 0.055493321 4.99021486 0.877295001 Rv2026c Rv2026c conserved hypothetical protein MT2086 208.879292 225.409152 187.68264 215.98885 0.928124344 −0.107609994 7.71196152 0.637012172 Rv2027c Rv2027c sensor histidine kinase MT2087 558.323333 719.209933 450.656572 599.726177 0.820473741 −0.285470933 9.18526585 0.079731215 Rv2028c Rv2028c conserved hypothetical protein MT2088 780.415756 1176.90543 549.862852 837.727623 0.708201162 −0.497768885 9.70805834 0.000515386 MT2089 4387.68336 5717.93614 3215.70198 4060.15324 0.721388536 −0.471151599 12.0853195 0.006509103 Rv2030c Rv2030c conserved hypothetical protein MT2090 3096.26769 11000.3467 2495.16068 5870.72837 0.655681934 −0.60893195 12.4552786 0.003877189 MT2091 598.243736 997.012461 384.549363 603.546827 0.62626372 −0.675157791 9.338206 1.26E−07 Rv2032 Rv2032 conserved hypothetical protein MT2092 5.71630134 24.5226336 7.7291785 18.9683016 0.950126371 −0.073808684 3.85174047 0.885389982 MT2093 61.1925427 177.359269 61.3787704 147.531234 0.906868379 −0.141034918 6.80824036 0.545350748 MT2094 65.6906153 57.2798047 71.3812367 55.3437276 1.025251746 0.0359782 5.96789609 0.906626924 MT2095 104.017952 87.8552296 115.937678 73.7656172 0.969166943 −0.045182898 6.57828309 0.894157772 Rv2035 Rv2035 hypothetical protein MT2096 121.354277 117.183803 144.94483 103.193805 1.026254095 0.037387979 6.92878679 0.905590819 Rv2036 Rv2036 similar to lincomycin production genes MT2097 81.0590343 127.04715 64.1067158 88.9870938 0.742544604 −0.429450404 6.49947958 0.003505566 Rv2037c Rv2037c probableprob transmembrane protein MT2098 21.740689 31.5808086 20.3686586 28.3353641 0.91514343 −0.127930221 4.68319831 0.673053573 Rv2038c Rv2038c probable ABC sugar transporter MT2099 16.9614858 26.2419326 16.1858091 21.6223026 0.880092703 −0.1842726 4.35298572 0.518774989 MT2100 31.4865151 44.0683489 23.1887686 33.4049563 0.882547463 −0.160254227 5.15865137 0.476182576 Rv2040c Rv2040c probable sugar transporter MT2101 61.1925427 82.5263536 56.9231264 68.0673209 0.874299516 −0.193800495 6.0737247 0.389888324 Rv2041c Rv2041c probable sugar transporter MT2102 65.2220659 78.9067767 66.3800036 73.7656172 0.974480627 −0.03729459 6.15477816 0.90313325 Rv2042c Rv2042c conserved hypothetical protein MT2103 174.95632 166.952985 146.76346 150.965824 0.871080208 −0.199122529 7.32265416 0.299631174 Rv2043c pncA pyrazinamide resistance/sensitivity MT2104 6.37227091 7.87257979 4.72843861 4.6054724 0.65436624 −0.611829776 2.59915185 0.017331548 Rv2044c Rv2044c hypothetical protein MT2105 159.119353 175.730459 151.491899 160.567063 0.932537852 −0.100765809 7.3389841 0.683091419 MT2106 61.4736723 93.8375315 67.8349078 84.4596802 0.993126603 −0.009950452 6.26840624 0.976466231 Rv2046 lppI probable lipoprotein MT2107 97.7393905 121.255827 94.5687722 118.493341 0.972493707 −0.04023918 6.75752609 0.887726461 MT2108 1039.055 985.972751 1091.26907 1024.13217 1.044459284 0.062756253 10.0158077 0.83350394 Rv2048c pks12 polyketido synthase (erythronolide synthase-like) MT2109 144.500614 135.824624 157.766173 161.425711 1.139264121 0.188102253 7.22939682 0.347270937 Rv2049c Rv2049c hypothetical protein MT2110 157.057736 203.239244 168.950749 178.130305 0.970063652 −0.04384868 7.46778876 0.890225316 MT2111 440.436371 321.689898 502.760329 384.049563 1.167270147 0.22313849 8.68791379 0.203668834 Rv2051c Rv2051c probable membrane protein MT2112 343.35295 249.117381 470.115916 308.722768 1.303048664 0.381890964 8.4220473 0.005438023 Rv2052c Rv2052c hypothetical protein MT2114 67.3773938 71.9390911 70.3809901 69.1601448 1.001652152 0.002381585 6.12701639 0.996101793 Rv2054 Rv2054 hypothetical protein MT2115 16.5866453 15.4736913 14.7309049 20.5294787 1.094275162 0.129975558 4.08904719 0.746856645 MT2116 11.9948629 17.4644586 16.7313982 25.2130099 1.421696279 0.507613291 4.17430673 0.007375796 Rv2055c rpsR2 30S ribosomal protein S18 MT2117 18.929393 27.2373163 24.4605767 35.2826021 1.293787046 0.371600173 4.73752054 0.054952605 Rv2056c rpsN2 30S ribosomal protein S14 MT2117.1 30.1745759 37.3721316 28.5524947 38.561074 0.990462452 −0.013825811 5.08113654 0.973097519 MT2118 13.306801 23.9796971 12.7304117 19.2024781 0.864141541 −0.210660458 4.17850084 0.472451693 Rv2058c rpmB2 50S ribosomal protein L28 MT2119 65.0346472 79.7211815 59.6510717 77.3563245 0.944248462 −0.082761566 6.14208598 0.766212238 Rv2059 Rv2059 conserved hypothetical protein MT2120 79.2785459 85.9649517 93.2957311 84.3035625 1.073614337 0.102475843 6.42435718 0.707679183 MT2121 312.897244 325.218986 279.796262 331.672072 0.955255005 −0.066042184 8.28806207 0.812642214 Rv2062c cobN cobalt Insertion MT2122 1.96790719 2.08125673 2.36421931 0.78058854 0.735204521 −0.443782456 0.96746884 0.584815826 MT2123 24.7394047 17.1929903 22.5510149 14.3628292 0.875509988 −0.191804458 4.31235827 0.49400037 MT2124 93.8035761 82.5263536 101.570499 78.2930308 1.014065164 0.020150363 6.47922306 0.948443219 Rv2064 cobG percorrin reductase MT2125 78.4351531 79.0877556 82.9295387 68.9259683 0.959882792 −0.059069841 6.27637187 0.851813893 Rv2065 cobH precorrin isomerase MT2126 112.920339 103.700879 116.66513 105.223335 1.023880117 0.034046804 6.77873464 0.90313325 Rv2066 cobI CobI-CobI fusion protein MT2127 146.655911 166.048091 173.22453 204.436139 1.206159987 0.270421281 7.43279704 0.099289484 Rv2067c Rv2067c conserved hypothetical protein MT2128 180.297733 151.750762 183.137298 164.704182 1.064148479 0.089699462 7.42117913 0.72747096 Rv2068c blaC class A [beta]-lactamase MT2129 268.291347 377.250404 309.894592 338.931545 1.017905295 0.025603341 8.33884031 0.934082845 Rv2069 sigC ICF subfamily sigma subunit MT2130 29.0500535 34.3859807 27.8250426 36.3754261 1.009181293 0.013185368 5.00426223 0.973097519 Rv2070c cobK precorrin reductase MT2131 13.2130911 18.4598423 10.5480554 17.4071245 0.877601669 −0.188361826 3.91592298 0.544489057 MT2132 28.3003796 32.304724 25.9154809 29.428188 0.913272813 −0.130882208 4.86613427 0.643016594 Rv2072c cobL probable methyltransferase MT2133 22.7714975 25.8799749 22.6419464 25.681363 0.993274969 −0.009734939 4.61021939 0.977998987 Rv2073c Rv2073c probable oxidoreductase MT2134 322.736779 334.448907 331.718155 402.861747 1.113065165 0.154538059 8.44347406 0.474786144 Rv2074 Rv2074 hypothetical protein MT2135 74.1245042 134.376793 112.936938 172.275891 1.392901683 0.47809343 6.94994276 0.000497845 Rv2075c Rv2075c hypothetical protein MT2136 9.65211613 21.3555038 9.63874025 18.3438307 0.911070817 −0.134364897 3.90132983 0.711450931 MT2137 20.335041 40.0868143 22.0963574 34.267837 0.951639565 −0.071512841 4.87712774 0.846087251 Rv2077c Rv2077c conserved hypothetical protein MT2138 5.71630134 8.41551632 4.45564408 5.30800209 0.69215513 −0.530832675 2.61945163 0.099009742 MT2138.2 1.49935786 2.35272499 2.63701384 2.7320599 1.39050488 0.475608808 1.3162862 0.459370243 MT2139 9.93324582 14.11635 7.82011001 12.5674755 0.844860068 −0.243215683 3.49748588 0.467943625 MT2140 54.632852 111.121011 51.2853726 69.7065568 0.761521543 −0.393043244 6.16721316 0.063072789 Rv2079 Rv2079 hypothetical protein MT2141 45.542995 94.9234045 48.2846327 80.9470318 0.944230507 −0.082789 6.07933579 0.797206045 MT2142 63.2541597 42.0775816 55.6500852 48.9429016 1.009224725 0.013247456 5.71834819 0.973114765 MT2143 229.964012 175.006544 221.600094 182.033248 1.00094023 0.001355828 7.66048141 0.997032163 Rv2081c Rv2081c hypothetical protein MT2144 105.32939 157.089638 99.2972108 143.003821 0.92589007 −0.111087181 6.98147656 0.627668106 Rv2082 Rv2082 conserved hypothetical protein MT2145 89.680312 112.206384 101.479567 127.782344 1.135255444 0.183016955 6.75458122 0.344769268 MT2146 93.3350268 104.605773 106.298937 121.771813 1.151613536 0.203656652 6.73727136 0.272521354 Rv2084 Rv2084 hypothetical protein MT2147 29.7997375 29.7710201 31.9169606 38.4830151 1.179529194 0.238211127 5.03035939 0.322355421 Rv2085 Rv2085 putative transposase MT2149 52.1963955 56.4653998 55.7410167 58.3880229 1.050542703 0.071134807 5.80418986 0.813012054 Rv2088 pknJ serine-threonine protein kinase MT2150 23.4274656 42.168071 18.1863024 31.6918948 0.762342628 −0.391488545 4.86063742 0.03641775 Rv2089c pepE cytoplasmic peptidase MT2151 17.7111647 30.5854249 16.0948776 22.5590089 0.809210519 −0.305413022 4.45409248 0.195110476 MT2152 659.998538 678.218224 682.71379 624.548892 0.975956139 −0.035111783 9.36968864 0.904814009 Rv2091c Rv2091c potential transmembrane region MT2153 532.55317 379.331661 527.675563 418.785753 1.045707669 0.064479598 8.8603214 0.813012054 Rv2092c helY probable helicase, Ski2 subfamily MT2154 299.777862 319.88011 318.987743 330.891483 1.049093015 0.069142596 8.31090084 0.798636571 Rv2093c Rv2093c membrane protein MT2155 452.056335 522.03348 476.026464 526.819207 1.03078773 0.043747269 8.94957856 0.880856541 Rv2094c Rv2094c conserved hypothetical protein MT2156 120.229758 112.84031 121.211705 123.567166 1.050906136 0.071633817 6.90255445 0.783679782 Rv2095c Rv2095c conserved hypothetical protein MT2157 314.584021 243.597526 298.619085 254.706041 0.996103366 −0.005632636 8.11917382 0.984096717 Rv2096c Rv2096c conserved hypothetical protein MT2158 842.076858 766.62639 749.730314 791.048428 0.958527467 −0.061108322 9.62121893 0.841534546 Rv2097c Rv2097c conserved hypothetical protein MT2159 32.6110335 18.8218 37.1000568 20.8417141 1.123718103 0.168280165 4.78145662 0.533790532 Rv2098c PE_PGRS PE_PGRS-family protein MT2160 28.7689289 28.2326999 28.3706317 28.0231287 0.989410182 −0.015359349 4.83408662 0.969605889 Rv2100 Rv2100 conserved hypothetical protein MT2160.1 34.4852308 77.4589459 33.0990703 75.0926177 0.965152335 −0.051171426 5.78759503 0.879138773 MT2161 466.206535 994.388267 510.489507 996.733509 1.047277075 0.066643182 9.53558227 0.818068286 Rv2101 helZ probable helicase, Snf2/Rad54 family MT2162 131.193813 297.076775 143.76272 301.073001 1.052358201 0.073625852 7.77137523 0.778848241 Rv2102 Rv2102 conserved hypothetical protein MT2163 75.5301522 53.29827 80.2925249 54.9534334 1.047360854 0.066758589 6.04835435 0.821548578 Rv2103c Rv2103c conserved hypothetical protein MT2164 33.2670025 23.6177394 35.2814266 26.774187 1.094994923 0.130924181 4.90220729 0.647569832 Rv2104c Rv2104c conserved hypothetical protein MT2165 19.5853621 6.06279133 22.0054259 10.3037688 1.322811352 0.403607331 3.87214588 0.140682899 MT2166 10.0269557 13.2114557 9.18408269 10.6160042 0.853143113 −0.229140334 3.4509876 0.50431495 Rv2107 PE PE-family protein MT2167 26.1450527 66.1477681 22.0054259 36.1412495 0.665884928 −0.586655209 5.23988564 0.004561921 Rv2108 PPE PPE-family protein MT2168 13.4005109 20.541099 14.0943843 20.9197729 1.032796196 0.046555592 4.12351849 0.90313325 MT2169 428.628928 279.793295 388.368487 274.220755 0.942083305 −0.086073457 8.42169368 0.730503677 Rv2109c prcA proteasome [alpha]-type subunit 1 MT2170 491.039599 352.81826 496.031397 351.811256 1.003666172 0.005279496 8.72481172 0.985115965 Rv2110c prcB proteasome [beta]-type subunit 2 MT2171 187.044893 123.699041 170.132859 146.126175 1.035502746 0.050331379 7.29387597 0.879854448 Rv2111c Rv2111c conserved hypothetical protein MT2172 330.233569 278.073996 268.161961 287.959113 0.950600462 −0.073088992 8.21081392 0.798636571 MT2173 43.9499273 71.0341969 48.1937012 60.7297886 0.96311092 −0.054226135 5.81150533 0.880429144 Rv2113 Rv2113 possible integral membrane protein MT2174 83.8703303 171.748925 102.025156 174.617657 1.108166548 0.148174723 7.05817245 0.52349722 Rv2114 Rv2114 hypothetical protein MT2175 1267.80078 1356.43645 1444.81079 1316.07228 1.051497601 0.072445559 10.39495 0.819552181 Rv2115c Rv2115c ATPase of AAA-family MT2176 65.5031965 91.5752959 70.2900586 93.8267427 1.047638162 0.067140518 6.33070008 0.808331268 Rv2116 lppK lipoprotein MT2177 5.43517224 7.96306921 7.54731548 6.94723802 1.082769599 0.114726286 2.83820716 0.812160187 Rv2117 Rv2117 conserved hypothetical protein MT2178 63.5352893 45.3352008 59.6510717 55.3437276 1.068935577 0.096174907 5.81093402 0.764687847 Rv2118c Rv2118c conserved hypothetical protein MT2179 30.2682858 63.6140642 37.2819198 75.0926177 1.203252453 0.266939364 5.69416372 0.20290041 Rv2119 Rv2119 conserved hypothetical protein MT2180 103.080853 120.80338 116.66513 124.972226 1.081348018 0.112830911 6.86495848 0.620935457 Rv2120c Rv2120c hypothetical protein MT2181 45.7304147 42.5300287 35.008632 36.3754261 0.809753173 −0.304445878 5.32479525 0.116473773 Rv2121c hisG ATP phosphoribosyltransferase MT2182 53.5083336 22.8033346 44.1017832 22.7931854 0.899105531 −0.153437636 5.16783192 0.593366813 Rv2122c hisI phosphoribosyl-AMP cyclohydrolase MT2182.1 43.2939582 7.69160094 46.738797 9.05482709 1.110486789 0.15119223 4.7452954 0.629959346 MT2183 1560.26927 1496.06163 985.697587 1060.35148 0.669173969 −0.579546769 10.3171375 0.000115169 MT2184 351.880548 230.024113 300.255852 223.170264 0.909447369 −0.136937946 8.11109321 0.543817303 Rv2125 Rv2125 conserved hypothetical protein MT2186 452.243815 346.574489 436.834983 432.446052 1.097705253 0.134490726 8.70459959 0.593384983 Rv2127 ansP L-asparagine permease MT2187 121.260557 120.260443 127.758774 113.887868 0.998770674 −0.001774634 6.91843263 0.997032163 MT2188 216.844631 167.76739 205.505217 159.552298 0.94936026 −0.074972434 7.55137112 0.778848241 Rv2130c cysS2 cysteinyl-tRNA synthase MT2189 363.406851 207.220778 335.62821 205.841199 0.957373743 −0.062845856 8.11986697 0.814508736 Rv2131c cysQ homologue of M. leprae cysQ MT2190 124.165573 160.528236 125.12176 166.733713 1.023360173 0.033313993 7.17317829 0.904814009 Rv2132 Rv2132 conserved hypothetical protein MT2191 144.688034 109.582691 141.034775 102.569334 0.955449845 −0.065747952 6.96151599 0.801831984 Rv2133c Rv2133c conserved hypothetical protein MT2192 405.107752 288.027833 356.724321 279.29458 0.923839897 −0.114285243 8.37699653 0.622290708 Rv2134c Rv2134c conserved hypothetical protein MT2193 143.469805 137.634412 107.844773 121.459577 0.81500537 −0.295118529 6.99744168 0.073080305 Rv2135c Rv2135c conserved hypothetical protein MT2194 261.825356 258.890239 169.04168 231.444503 0.760568877 −0.39484919 7.84846507 0.023431441 Rv2136c Rv2136c putative bactracin resistance protein MT2195 1508.54143 1639.93981 834.660346 1002.90016 0.581730248 −0.781577774 10.283865 2.07E−03 Rv2137c Rv2137c conserved hypothetical protein MT2196 477.732838 420.956795 455.475942 491.614664 1.055286785 0.07763512 8.85057483 0.788018169 Rv2138 lppI lipoprotein MT2197 226.028197 252.46549 225.692012 250.881157 0.996099303 −0.00563852 7.90054346 0.983783004 Rv2139 pyrD dihydroorotate dehydrogenase MT2198 37.9524958 78.0923719 31.4623031 61.8226125 0.80838954 −0.30687744 5.71490852 0.111712781 Rv2140c Rv2140c conserved hypothetical protein MT2199 98.0205201 139.715669 82.3839497 117.790811 0.84183471 −0.248391099 6.77689672 0.110623245 Rv2141c dapE2 ArgE/DapE/Acy1/Cpg2/yscS family MT2200 44.9807358 37.8245787 53.1949344 39.9661334 1.118897837 0.162078314 5.464702 0.533790532 Rv2142c Rv2142c hypothetical protein MT2201 119.573789 94.0185103 96.478334 92.0313891 0.888448691 −0.170639633 6.65382122 0.461612363 MT2202 92.3979231 80.897544 80.6562509 69.4723802 0.865864325 −0.207787112 6.34022231 0.281405936 Rv2143 Rv2143 conserved hypothetical protein MT2203 330.889538 391.957243 415.64794 509.334024 1.278553571 0.35451261 8.68658991 0.012386351 Rv2144c Rv2144c probable transmembrane protein MT2204 1041.49145 960.273755 1360.33542 1315.29169 1.337545714 0.4195882 10.1917163 0.008456157 Rv2145c wag31 antigen 84 (aka wag31) MT2205 201.382503 215.545805 221.145437 245.651214 1.118840824 0.1620048 7.78865424 0.412841331 MT2206 755.863731 988.325476 892.765582 1198.90594 1.197025884 0.259454349 9.90562715 0.170769284 Rv2147c Rv2147c hypothetical protein MT2207 119.667499 105.420178 140.76198 136.056583 1.232091086 0.301108916 6.97335708 0.051883229 Rv2148c Rv2148c conserved hypothetical protein MT2208 358.533948 266.400861 385.094952 353.60661 1.193696112 0.255435606 8.41399118 0.161870571 Rv2149c yfiH YFIH_STRGR P45496 MT2209 703.667336 669.621729 873.669965 936.472074 1.317767531 0.398095885 9.63670766 0.011888969 Rv2150c ftsZ cicumferential ring, GTPase MT2210 182.3594 152.746146 229.965793 212.398142 1.324051194 0.404958905 7.60399202 0.004018981 Rv2151c ftsQ ingrowth of wall at septum MT2211 284.784234 217.808041 342.720868 275.157461 1.232856849 0.302005293 8.13078378 0.048868744 Rv2152c murC UDP-N-acetyl-muramate-alanine ligase MT2212 245.894639 169.667668 339.720128 213.100672 1.317968944 0.398316376 7.9204296 0.004109043 Rv2153c murG transferase in peptidoglycan synthesis MT2213 702.449158 600.39732 924.955338 802.288903 1.326462865 0.407584287 9.56548763 0.006584455 Rv2154c ftsW membrane protein (shape determination) MT2214 415.228417 335.625269 456.748984 350.562314 1.071976255 0.10027295 8.60615414 0.667654864 Rv2155c murD UDP-N-acetytmuramoylalanine-D- glutamate ligase MT2215 315.23999 246.312209 304.802427 222.701911 0.935162788 −0.096710572 8.0897191 0.699467496 Rv2156c murX phospho-N-acetylmuramoyl-pentapeptide transferase MT2216 387.302877 254.908704 404.82709 232.771503 0.977585734 −0.032704863 8.32241197 0.907426106 Rv2157c murF D-alanine:D-alanine-adding enzyme MT2217 1290.57228 926.430711 1427.89753 868.170576 1.018391395 0.026292134 10.1400959 0.935036846 Rv2158c murE meso-diaminoplmelate-adding enzyme MT2218 844.981854 725.634682 935.958051 580.269522 0.941392143 −0.087132282 9.59222172 0.798636571 Rv2159c Rv2159c hypothetical protein MT2218.1 417.946004 413.89862 455.839668 348.688902 0.958643011 −0.060934424 8.67687078 0.843777525 Rv2160c Rv2160c hypothetical protein MT2219 1501.70051 1087.95433 1672.13957 1091.88725 1.057198753 0.080246629 10.3864895 0.798287058 Rv2161c Rv2161c similar to alkanal monooxygenase beta chain MT2220 1184.68013 1006.15189 1339.5121 977.218796 1.04800163 0.067640961 10.1383442 0.830576393 Rv2162c PE_PGRS PE_PGRS-family protein MT2221 699.450442 602.840535 673.984365 628.295717 1.00212785 0.003066577 9.3472112 0.993327109 Rv2163c pbpB penicillin-binding protein 2 MT2222 702.636577 456.881096 774.009028 503.791845 1.102112494 0.140284579 9.25146192 0.52349722 Rv2164c Rv2164c hypothetical protein MT2223 402.109036 309.835784 389.005007 305.132061 0.976042602 −0.034983975 8.45814145 0.897921476 Rv2165c Rv2165c conserved hypothetical protein MT2224 927.915096 796.39741 995.245396 974.955089 1.145872345 0.196446331 9.85144741 0.382897645 MT2225 269.322156 366.482163 289.253139 322.695303 0.971821439 −0.041236836 8.28594897 0.894346121 Rv2169c Rv2169c hypothetical protein MT2226 17.523745 24.0701865 19.4593435 20.6075375 0.967778592 −0.047251069 4.36412439 0.90313325 Rv2170 Rv2170 hypothetical protein MT2227 89.680342 86.3269094 85.3846895 97.2613323 1.036564766 0.051810161 6.48935439 0.870122152 Rv2171 lppM probable lipoprotein MT2228 897.08455 722.015105 1015.52312 784.335367 1.108960036 0.149207375 9.73962642 0.52349722 Rv2172c Rv2172c hypothetical protein MT2229 108.797155 142.158883 115.210225 151.278059 1.061596424 0.086235416 7.01736392 0.735519493 Rv2173 idsA2 geranylgeranyl pyrophosphate synthase MT2230 108.422315 139.625179 122.666609 155.024884 1.120566405 0.164228146 7.04028241 0.430882277 Rv2174 Rv2174 probable membrane protein MT2231 71.7817576 73.5679008 70.5628531 65.9597318 0.938523175 −0.091535725 6.14240465 0.745116768 Rv2175c Rv2175c putative transcriptional regulator MT2232 100.550687 92.027743 96.7511285 74.7803823 0.884692143 −0.176752584 6.51081155 0.429062414 Rv2176 pknL serine-threonine protein kinase, truncated MT2233 18.2734239 19.907673 20.2777271 21.7784203 1.10143019 0.139378058 4.33922131 0.641879751 Rv2177c Rv2177c hypothetical protein MT2234 350.756029 359.423987 428.469283 470.929067 1.265236596 0.33940719 8.65314104 0.019194735 Rv2178c aroG DAHP synthase MT2234.1 14.8061589 27.2373163 14.4581104 22.0906557 0.878765885 −0.186449232 4.30997312 0.52349722 Rv2179c Rv2179c hypothetical protein MT2235 25.6765034 35.3813643 22.0054259 29.9746 0.851767428 −0.231468534 4.82987717 0.326697091 Rv2180c Rv2180c probable Integral membrane protein MT2236 400.328519 306.487675 349.540731 308.800827 0.937780706 −0.092677497 8.41555725 0.719637416 Rv2181 Rv2181 probable Integral membranemem protein MT2237 343.35295 404.125762 339.901991 392.557978 0.980568146 −0.028310199 8.53202605 0.917923192 Rv2182c Rv2182c conserved hypothetical protein MT2238 86.213077 106.958498 89.3856761 116.073516 1.061332399 0.085876565 6.64162942 0.745116768 MT2239 171.676475 230.024113 170.132859 214.193496 0.960192822 −0.058603944 7.61978144 0.828256087 MT2240 167.740661 275.087845 148.309296 257.203925 0.909859069 −0.136284996 7.72981219 0.519336263 Rv2185c Rv2185c conserved hypothetical protein MT2241 41.8883102 38.6389836 37.6456459 32.0821891 0.864002727 −0.210892229 5.23760399 0.372415583 MT2242 213.471075 286.85147 278.341358 390.840683 1.333192239 0.414884824 8.19267242 0.00245183 Rv2187 fadD15 acyl-CoA synthase MT2243 181.89085 125.327851 136.215405 106.316159 0.796510188 −0.328235279 7.10427603 0.040109659 Rv2188c Rv2188c conserved hypothetical protein MT2244 116.856203 143.244756 113.755321 140.740114 0.978066164 −0.031996032 7.0093497 0.905590819 Rv2189c Rv2189c hypothetical protein MT2245 842.732827 3352.00247 788.649002 1266.66103 0.936352918 −0.0948757 10.053521 0.740445414 Rv2190c Rv2190c putative p60 homologue MT2246 6.37227091 11.4921567 7.27452094 14.6750646 1.221911454 0.289139744 3.34474566 0.380784281 MT2247 46.3863838 44.520796 44.8292353 49.8796078 1.041610613 0.058816054 5.54177057 0.867153389 Rv2191 Rv2191 similar to both PolC and UvrC proteins MT2248 171.770185 113.383247 155.674748 101.710687 0.901757095 −0.149189226 7.08523856 0.491535092 Rv2192c trpD anthranilate phosphoribosyltransferase MT2249 1269.8624 825.173047 1072.62811 829.687561 0.921454577 −0.118015045 9.96506 0.669164449 Rv2193 ctaE cytochrome c oxidase polypeptide III MT2250 1147.75844 761.287514 1017.15989 699.64151 0.902434663 −0.148105611 9.82435184 0.530550672 Rv2194 qcrC cytochrome b/c component of ublQ-cytB reductase MT2251 1275.11015 1037.82319 1213.20823 1012.57946 0.963482247 −0.053670011 10.1482818 0.869657136 Rv2195 qcrA Rieske Iron-sulphur component of ubiQ- cytB MT2252 2555.37434 1870.05441 2301.38563 1830.1679 0.938808745 −0.091096815 11.0629961 0.764687847 Rv2196 qcrB cytochrome b component of ubiQ-cytB reductase MT2253 262.762455 199.981624 283.615385 238.703976 1.134788762 0.182423768 7.94508201 0.350424024 Rv2197c Rv2197c hypothetical protein MT2254 316.739348 310.921657 351.904951 333.311307 1.091314099 0.126066394 8.35929392 0.567031306 MT2255 343.821499 337.887505 348.085827 344.239547 1.015601526 0.022334468 8.42494001 0.933447653 MT2256 878.342577 889.963474 891.219747 969.256793 1.05125645 0.072114652 9.82555642 0.806148616 Rv2200c ctaC cytochrome c oxidase chain II MT2257 144.032054 200.253093 131.305103 195.381312 0.94379237 −0.083458586 7.39172816 0.751431314 Rv2201 asnB asparagine synthase B MT2258 610.800908 571.983642 627.97302 59.8866528 1.034062027 0.048322726 9.23262598 0.870656307 Rv2202c cbhK carbohydrate kinase MT2259 53.976833 93.9280209 56.5594003 83.9132683 0.963537676 −0.053587015 6.17561264 0.869845509 Rv2203 Rv2203 hypothetical protein MT2260 873.188534 927.426095 951.780134 882.377288 1.018320335 0.026191464 9.82792558 0.933447653 Rv2204c Rv2204c conserved hypothetical protein MT2261 82.8395218 79.7211815 73.199867 70.4090865 0.883427705 −0.178816018 6.26138096 0.395131067 MT2262 145.625132 145.235524 159.948529 174.617657 1.149462284 0.200959129 7.29039288 0.297857769 Rv2206 Rv2206 hypothetical protein MT2263 145.999972 127.499597 151.491899 135.041818 1.048304383 0.068058363 7.13114644 0.802800925 Rv2207 cobT nicotinate-nucleotide- dimethylbenzimidazole MT2264 91.5545393 66.781194 95.4780873 70.7213219 1.05072525 0.071385474 6.34517032 0.798512961 Rv2208 cobS cobalamin (5′-phosphate) synthase MT2265 208.973002 134.286304 188.501024 135.119877 0.952003321 −0.070961489 7.38266489 0.800312889 Rv2209 Rv2209 probable drug efflux protein MT2266 203.53783 158.175511 216.780724 183.204131 1.110429066 0.151117137 7.57437747 0.484421074 Rv2210c ilvE branched-chain-amino-acid transaminase MT2267 257.139873 309.383337 232.78467 290.691173 0.922425635 −0.116495487 8.09106887 0.616132609 Rv2211c gcvT T protein or glycine cleavage system MT2268 216.844631 240.430396 221.600094 231.522562 0.991825193 −0.011843223 7.83147777 0.97089977 Rv2212 Rv2212 conserved hypothetical protein MT2269 193.792003 298.615095 178.953215 282.651111 0.93513877 −0.096747625 7.89901509 0.687906803 Rv2213 pepB aminopeptidase A/I MT2270 545.391422 456.24767 477.299505 451.492413 0.930587006 −0.103787053 8.91521384 0.67738269 Rv2214c ephD probable epoxide hydrolase MT2272 972.614702 809.970824 818.474537 734.689936 0.87366233 −0.194852309 9.70408157 0.369948383 Rv2215 sucB dihydrolipoamide succinyltransferase MT2273 286.564771 191.837576 231.60256 174.227363 0.856303505 −0.223805864 7.78931064 0.209209933 Rv2216 Rv2216 conserved hypothetical protein MT2274 379.712378 341.688061 312.8044 264.697575 0.798887803 −0.323935192 8.34379483 0.030405592 Rv2217 lipB lipoate biosynthesis protein B MT2275 371.17849 385.484941 347.358375 327.534952 0.89151001 −0.165677098 8.4841542 0.407497409 Rv2218 lipA lipoate biosynthesis protein A MT2276 379.712378 406.478487 348.631416 376.868148 0.9226577 −0.116132579 8.5626168 0.602452485 Rv2219 Rv2219 hypothetical protein MT2277 18.1797141 18.2788634 18.1863024 17.4071245 0.975616495 −0.035613944 4.18480762 0.923772833 MT2278 847.88687 850.691064 926.592105 699.407334 0.947921868 −0.077159944 9.69924163 0.814508736 Rv2220 glnA1 glutamine synthase class I MT2279 541.736737 488.371415 530.49444 458.595768 0.958939246 −0.060488679 8.98004863 0.823630484 Rv2221c glnE glutamate-ammonia-ligase adenyltransferase MT2280 963.712265 610.894094 975.786053 658.192259 1.04437733 0.062643047 9.64801013 0.831756973 Rv2222c glnA2 glutamine synthase class II MT2281 208.973002 224.1423 236.603794 260.638514 1.147504719 0.198500087 7.86278641 0.284385973 Rv2223c Rv2223c probable exported protease MT2282 422.818917 370.825655 371.000568 324.334539 0.876040319 −0.190930825 8.54074942 0.300046275 Rv2234c Rv2224c probable exported protease MT2284 179.360684 249.931786 172.951735 208.417141 0.895867719 −0.158642371 7.66423304 0.465535793 Rv2225 panB 3-methyl-2-oxobutanoate hydroxymethyltransferase MT2285 120.604598 194.823727 113.118801 173.915127 0.914376648 −0.129139536 7.23653496 0.564998538 Rv2226 Rv2226 hypothetical protein MT2285.2 9.55840636 12.4875404 8.00197304 11.7088281 0.892256089 −0.164470254 3.4091065 0.669164449 MT2286 28.3940895 42.5300287 28.9162207 37.7804854 0.946926904 −0.07867503 5.1112698 0.813012054 MT2287 80.6841949 99.8098334 72.8361409 88.6748584 0.895377962 −0.159431285 6.42089329 0.457813846 Rv2228c Rv2228c hypothetical protein MT2290 88.9306631 81.9834171 86.5667992 81.4934438 0.983688232 −0.023726952 6.40796621 0.933447653 Rv2231c cobC aminotransferase MT2292 63.2541597 51.4884816 57.1049894 48.708725 0.923944101 −0.114122524 5.78934829 0.674598293 Rv2232 Rv2232 hypothetical protein MT2293 57.2567283 38.4580047 47.9209067 35.9851318 0.883473614 −0.178741048 5.49392362 0.484044695 Rv2234 ptpA low molecular weight protein-tyrosine- phosphatase MT2294 125.85235 129.128406 112.755075 104.9111 0.852985573 −0.229406755 6.88666721 0.191980061 Rv2235 Rv2235 hypothetical protein MT2295 13.2130911 14.3878182 15.0036994 11.5527104 0.954655409 −0.066948021 3.7768511 0.881775651 Rv2236c cobD cobinamide synthase MT2296 58.3812457 62.7996594 60.4694553 81.1031495 1.159395653 0.213372981 6.04177224 0.366108488 Rv2237 Rv2237 conserved hypothetical protein MT2297 108.703445 86.9603353 98.6606903 86.4111516 0.949387078 −0.074931682 6.57518582 0.783679782 MT2298 116.575074 104.424794 101.752362 111.468044 0.965756262 −0.050268968 6.76462411 0.871130682 Rv2238c ahpE member of AhpC/TSA family MT2299 137.191244 159.261384 122.575678 133.090346 0.863765571 −0.211288282 7.11064999 0.267466322 Rv2239c Rv2239c hypothetical protein MT2300 104.299031 111.39248 94.6597037 107.955395 0.938284836 −0.091902145 6.71086919 0.7261232 Rv2240c Rv2240c conserved hypothetical protein MT2301 688.017838 684.823952 627.700226 638.287251 0.922147924 −0.116929899 9.36606031 0.626930912 Rv2241 aceE pyruvate dehydrogenase E1 component MT2302 149.092397 135.281687 129.759267 135.275994 0.933114672 −0.099873708 7.10355882 0.706925211 Rv2242 Rv2242 hypothetical protein MT2303 1305.0036 1425.84184 1362.97243 1640.87517 1.096378331 0.13274572 10.4856874 0.611538154 MT2304 1371.44339 1547.36913 1410.43868 1939.9967 1.135628373 0.1834908 10.6142536 0.472451693 Rv2244 acpM acyl carrier protein (meromycolate extension) MT2305 1801.10353 1718.03218 2011.13225 2221.96005 1.202015826 0.265455891 10.9207192 0.209383008 Rv2245 kasA [beta]-kectoacyl-ACP synthase (meromycolate MT2306 974.676319 849.424212 1039.71091 1006.8031 1.124436837 0.169202623 9.91861168 0.475355973 MT2307 1562.4246 1201.51856 1458.35959 1381.71978 1.036009493 0.051037223 10.4524246 0.880856541 Rv2247 accD6 acetyl/propionyl CoA carboxylase [beta] subunit MT2308 216.844631 174.463607 199.140011 217.940321 1.071139483 0.099146359 7.66018475 0.742812998 Rv2248 Rv2248 conserved hypothetical protein MT2309 27.9255402 24.4321442 14.0943843 17.9535365 0.612937003 −0.706189292 4.41037338 0.00026945 Rv2249c glpD1 glycerol-3-phosphate dehydrogenase MT2310 10.2143754 10.8587307 5.54682222 8.19617569 0.651191399 −0.618846451 3.14976598 0.017512436 Rv2250c Rv2250c putative transcriptional regulator MT2311 91.1796999 110.940032 56.4684688 82.1959735 0.679407497 −0.557650957 6.41564377 6.78E−05 Rv2251 Rv2251 conserved hypothetical protein MT2314 8.99614716 11.4921567 9.72967176 12.6455344 1.091751124 0.126644017 3.44671922 0.760272935 Rv2253 Rv2253 hypothetical protein MT2315 34.2041012 19.907673 38.736824 24.4324214 1.17526019 0.232980189 4.88181197 0.326531322 Rv2254c Rv2254c hypothetical protein MT2316 1.87419733 2.08125673 2.81887686 2.34176563 1.295742929 0.373779521 1.29684042 0.584969964 MT2317 997.260397 740.655926 1193.93075 880.738052 1.193168462 0.25479775 9.89681015 0.182678572 Rv2256c Rv2256c conserved hypothetical protein MT2318 70.09498 96.099767 71.5630998 109.126278 1.078881411 0.109536295 6.44154705 0.662188383 Rv2257c Rv2257c hypothetical protein MT2319 172.426254 247.66955 165.495351 272.113166 1.028240295 0.040177455 7.74565343 0.891170159 Rv2258c Rv2258c putative transcriptional regulator MT2320 298.934473 225.590131 272.521741 240.889624 0.986392156 −0.019766767 8.02043912 0.948443219 MT2321 132.693171 115.645482 124.303377 112.40475 0.954184555 −0.067659761 6.92399698 0.798636571 Rv2260 Rv2260 conserved hypothetical piotein MT2322 23.7085952 36.1052797 28.7343577 30.4429531 1.002812998 0.004052601 4.90342335 0.993735965 Rv2261c Rv2261c apollpoprotein N-acyltransferase-a MT2323 57.9126974 46.0591162 56.8321949 41.2931339 0.93884876 −0.091035324 5.66352895 0.765620289 Rv2263 Rv2263 possible oxidoreductase MT2324 116.762493 107.591924 124.030582 110.921632 1.046482454 0.065548123 6.84548757 0.802829663 Rv2264c Rv2264c conserved hypothetical protein MT2325 3.56097492 3.61957691 3.27353442 2.18564792 0.751405873 −0.412335703 1.73208332 0.462369842 MT2326 2.81129599 2.62419326 3.00073989 3.66876615 1.229453545 0.298017224 1.68299127 0.630293904 MT2327 12.2759925 16.7405432 12.8213432 19.3585958 1.105681482 0.144935843 3.95351556 0.658487479 Rv2265 Rv2265 putative integral membrane protein MT2328 156.495477 130.666727 139.125213 116.229634 0.88926567 −0.169313604 7.08527221 0.413826101 Rv2266 Rv2266 Probable cytochrome P-450 MT2329 25.8639231 87.4117825 23.7331246 63.5399073 0.803852773 −0.314996802 5.65356906 0.15276274 Rv2267c Rv2267c hypothetical protein MT2330 49.759939 113.021289 54.9226331 81.1031495 0.881985286 −0.181173507 6.226671 0.548110991 Rv2268c Rv2268c Probable cytochrome P-450 MT2330.1 36.5468478 19.0027788 27.6431796 24.3543625 0.975820088 −0.035312913 4.75764042 0.940814532 MT2331 14.4313194 14.3878182 9.63874025 13.9725349 0.815566354 −0.294125836 3.73183705 0.357935504 Rv2270 lppN possible lipoprotein MT2332 132.412041 179.983462 107.753841 168.685184 0.874781152 −0.193005958 7.20354794 0.351739042 MT2333 141.127059 145.326013 118.392828 141.05235 0.903030691 −0.147153074 7.09436305 0.519306729 Rv2272 Rv2272 conserved hypothetical protein MT2334 29.1437634 36.376748 26.7338645 33.8775427 0.924693137 −0.112953413 4.98707114 0.71023833 MT2334.1 11.245184 10.4967731 7.09265792 8.43035625 0.715985311 −0.481998106 3.24560079 0.079262095 MT2335 256.765034 269.65848 182.317681 255.408571 0.820992124 −0.284559713 7.9141832 0.139550854 Rv2275 Rv2275 hypothetical protein MT2336 157.057736 180.164441 115.73951 160.020651 0.809605224 −0.304709496 7.26099213 0.076710999 Rv2276 Rv2276 Probable cytochrome P-450 MT2337 27.7381204 16.6020528 25.0061657 40.7467219 0.886567048 −0.173698353 5.13801076 0.503200664 Rv2277c Rv2277c possible glycerolphosphodiesterase MT2338 231.27595 195.819111 193.502257 193.585958 0.909502568 −0.136850383 7.67041815 0.548791269 Rv2280 Rv2280 similar to D-lactate dehydrogenase MT2339 108.047476 130.485748 87.8398404 103.579866 0.822722078 −0.281522935 6.76704997 0.071839145 Rv2281 pitB phosphate permease MT2340 23.8960159 32.0332557 17.9135078 24.8227156 0.763347006 −0.389589061 4.63479431 0.040362138 Rv2282c Rv2282c transcriptional regulator (LysR family) MT2341 2.43645652 2.53370384 1.27304117 1.8734125 0.636935415 −0.650781003 1.13824957 0.267751697 MT2342 110.671352 138.629796 89.8403336 113.965927 0.81705739 −0.291490679 6.8259599 0.054673353 Rv2284 lipM probable esterase MT2343 104.580211 131.119174 96.660197 111.624162 0.886316177 −0.174106649 6.7966645 0.380329258 Rv2285 Rv2285 conserved hypothetical protein MT2344 33.9229716 51.578971 33.1900018 46.054724 0.931865111 −0.101806958 5.37060058 0.736124871 Rv2286c Rv2286c conserved hypothetical protein MT2345 39.6392734 47.9593941 36.3726047 45.8205474 0.937088418 −0.093742917 5.41378708 0.761658278 Rv2287 yjcE probable Na+/H+ exchanger MT2345.1 77.779159 139.987137 31.28044 45.3521943 0.358773601 −1.478854357 6.20461948 7.79E−29 Rv2288 Rv2288 hypothetical protein MT2346 208.223323 362.772096 120.019596 213.35679 0.582296279 −0.780174695 7.82174127 1.63E−11 Rv2289 cdh CDP-diacylglycerol phosphatidylhydrolase MT2347 363.219442 297.981669 234.421437 236.752505 0.716133316 −0.48169991 8.14595819 0.000924471 Rv2290 lppO probable lipoprotein MT2348 608.270742 420.594837 493.303451 388.498917 0.865328031 −0.208680958 8.90034309 0.27842955 Rv2291 sseB thiosulfate sulfurtransferase MT2349 8.24646823 6.06279133 9.54780873 6.94723802 1.15203715 0.20418724 2.97645896 0.61875146 Rv2292c Rv2292c hypothetical protein MT2350 32.0487743 37.1911528 47.3753176 53.4703151 1.457078864 0.543078965 5.41670375 0.000539955 Rv2293c Rv2293c hypothetical protein MT2351 55.0076915 75.7396469 55.7410167 76.7318537 1.013208756 0.01893145 6.04425575 0.953431559 Rv2294 Rv2294 aminotransferase MT2352 293.405591 190.570725 280.88744 218.955086 1.048032368 0.067683274 7.94321905 0.808331268 MT2353 172.707284 180.707377 186.500531 164.391947 0.990968127 −0.013089439 7.46146734 0.970173849 Rv2296 Rv2296 halokane dehalogenase MT2354 93.897286 83.6122267 88.0217034 78.2149719 0.936446663 −0.094731269 6.42802919 0.714079818 Rv2297 Rv2297 hypothetical protein MT2355 110.765062 151.298315 109.026883 140.583996 0.955698935 −0.065371884 7.00115753 0.806148616 Rv2298 Rv2298 conserved hypothetical protein MT2356 343.44686 476.517301 351.995882 446.808881 0.979977487 −0.029179488 8.66133951 0.917293811 Rv2299c htpG heat shook protein Hsp90 family MT2357 48.0731614 63.1616171 48.6483588 64.1643781 1.013997001 0.020053386 5.81246772 0.950509824 Rv2300c Rv2300c conserved hypothetical protein MT2358 64.0038337 97.9095555 82.2930181 89.7676823 1.081609537 0.113179778 6.38676735 0.719940528 MT2359 162.586618 205.682458 177.498311 197.410842 1.022944726 0.032728192 7.53897369 0.908782929 Rv2302 Rv2302 conserved hypothetical protein MT2360 15.5558378 22.9843134 16.8223297 18.1096542 0.913529179 −0.130477284 4.21298305 0.726511707 Rv2303c Rv2303c similar to S. griseus macrotetrolide resistance MT2361 11.4326037 13.2114557 9.54780873 11.3185339 0.846791115 −0.239921963 3.53022809 0.461831822 Rv2304c Rv2304c hypothetical protein MT2362 34.8600703 35.3813643 39.6461391 40.4344865 1.140053276 0.189101245 5.23885193 0.435262942 Rv2305 Rv2305 hypothetical protein MT2363 37.6713652 21.2650244 34.644906 24.2763037 1.017813447 0.025473157 4.88875376 0.946497216 Rv2306c Rv2306c hypothetical protein MT2364 34.9537801 40.1773037 40.2826597 39.8100156 1.066804911 0.093296372 5.28483269 0.764687847 Rv2307c Rv2307c conserved hypothetical protein MT2364.1 1.03080853 1.9907673 1.09117814 1.95147136 1.007524486 0.010814901 0.76753518 0.993154066 MT2365 2.53016639 1.80978846 2.45515082 2.49788333 1.150668146 0.202471818 1.32237586 0.801997347 MT2365.1 10.3080853 9.22992113 14.2762474 14.1286526 1.455832559 0.541844435 3.60557163 0.014710726 MT2365.2 52.6649448 19.8171836 65.379757 45.4302531 1.663427303 0.734158817 5.52340544 0.001831238 MT2366 16.3992256 13.0304769 20.0049326 19.3585958 1.344080127 0.426619147 4.11947443 0.046556493 Rv2308 Rv2308 putative transcriptional regulator MT2367 8.9024373 8.59649517 12.0029596 12.6455344 1.409364387 0.495044664 3.42290743 0.044555497 MT2367.1 48.1668713 30.0424884 45.1020298 32.3163656 1.000482734 0.00069627 5.28793723 0.999355608 MT2368 136.254146 90.5799123 126.758527 98.9005683 1.00655768 0.009429847 6.82384827 0.975577295 MT2370.2 7.96533853 7.87257979 8.18383606 9.13288594 1.094468647 0.130230626 3.08237818 0.775533909 MT2370.3 2.24903679 3.52908749 3.00073989 3.746825 1.168528587 0.224693029 1.73016763 0.739473063 MT2373 5.24775251 9.41089997 7.27452094 9.52318021 1.154991318 0.207882007 3.00985262 0.621557879 Rv2311 Rv2311 hypothetical protein MT2374 18.4608437 20.4506096 18.4590969 22.1687146 1.043360891 0.061238262 4.32684305 0.871130682 MT2375 28.2066698 15.9261384 24.5515082 19.5147136 1.022846155 0.032589167 4.47343003 0.93458603 MT2376 175.893419 155.822786 192.411079 169.543831 1.090975916 0.125619254 7.43955319 0.581433109 Rv2313c Rv2313c hypothetical protein MT2377 219.187377 195.366664 188.682887 177.037481 0.883225399 −0.179146434 7.60908009 0.362424956 Rv2314c Rv2314c conserved hypothetical protein MT2378 163.430007 154.465445 136.215405 142.535468 0.877197648 −0.189026151 7.22239091 0.347475973 MT2379 4.02952425 6.60572787 6.54706885 5.54217865 1.140000928 0.189034999 2.55061591 0.74942399 MT2380 4.49807358 5.88181248 4.27378105 6.86917917 1.070336387 0.09806428 2.47807408 0.870656307 MT2381 39.920403 24.9750807 32.0078921 24.3543625 0.880424945 −0.183728074 4.9294924 0.503948039 Rv2318 uspC sugar transport protein MT2382 71.8754674 32.9381499 65.379757 27.867011 0.880066972 −0.18431478 5.63392162 0.468785455 MT2383 60.255444 31.4903191 56.8321949 31.2235417 0.965402124 −0.050798094 5.49511948 0.881775651 Rv2320c rocE arginine/ornithine transporter MT2385 81.7150034 44.7017749 83.2023333 40.668663 0.965650154 −0.050427486 5.97087644 0.879854448 Rv2323c Rv2323c conserved hypothetical protein MT2386 41.5134708 39.3628989 46.1022765 31.4577182 0.944209812 −0.082820619 5.31366159 0.818068286 MT2387 348.975542 217.89853 306.802921 217.471968 0.936193762 −0.095120943 8.09246959 0.716971772 MT2388 1062.8573 606.460112 915.680323 585.753642 0.912018283 −0.132865349 9.63088825 0.593366813 Rv2326c Rv2326c ABC transporter MT2389 477.545479 293.819156 510.762302 390.528448 1.19163229 0.252939122 8.70850646 0.175737947 Rv2327 Rv2327 conserved hypothetical protein MT2390 116.481354 71.5771335 128.668089 92.5778011 1.193097581 0.254712043 6.67938448 0.169809985 Rv2328 PE PE-family protein MT2391 627.387555 704.822114 86.0212101 165.016418 0.179783783 −2.475665204 8.62915134 2.52E−47 Rv2329c narK1 probable nitrite extrusion protein MT2392 32.5173236 27.7802528 25.6426863 29.9746 0.92437935 −0.113443064 4.86566294 0.750079277 Rv2330c lppP lipoprotein MT2393 110.952482 143.968672 16.8223297 39.8100156 0.208578985 −2.261334285 6.28594525 1.91E−34 Rv2331 Rv2331 hypothetical protein MT2394 83.401781 120.169954 32.6444127 56.748787 0.432413656 −1.209516008 6.19775275 2.32E−20 Rv2332 mez probable malate oxidoreductase MT2395 53.3209139 76.4635623 54.4679755 63.2276719 0.916014726 −0.126557304 5.95534651 0.651061634 MT2397 355.628943 285.494129 440.563175 427.450286 1.36174625 0.445457894 8.56021238 0.0018083 MT2398 146.281101 109.76367 188.228229 179.457306 1.449577182 0.535632151 7.28649336 0.000267118 Rv2335 cysE serine acetyltransferase MT2399 50.5096179 44.1588383 67.4711817 62.8373776 1.378492313 0.463091222 5.81834338 0.00287005 Rv2336 Rv2336 hypothetical protein MT2400 34.2978111 33.7525547 53.0130714 45.4450182 1.458063761 0.54405381 5.39442916 0.000695532 Rv2337c Rv2337c hypothetical protein MT2401 36.3594231 49.5882037 56.2866058 60.4175531 1.368474371 0.452568416 5.66829849 0.013933488 Rv2338c moeW molybdopterin biosynthesis MT2401.2 2.34274656 3.89104518 3.63726047 3.27847188 1.109225855 0.14955315 1.79312835 0.819018102 MT2402 245.707259 233.711097 264.883494 277.733403 1.120065503 0.163583105 8.00528821 0.414134607 Rv2339 mmpL9 conserved large membrane protein MT2404 198.383737 133.109941 206.778258 123.098813 0.982771081 −0.02507269 7.37067791 0.910747689 Rv2340c PE PE-family protein MT2405 13.4942207 9.95383651 12.6394801 10.2257099 0.978786195 −0.030934341 3.55401014 0.945485848 MT2406 9.27727676 7.1486644 7.36545245 6.94723802 0.876735614 −0.189786241 2.97323746 0.651061634 Rv2341 lppQ lipoprotein MT2407 42.1694398 33.8430441 42.7378105 35.5167787 1.030994177 0.044036184 5.27560712 0.894736554 Rv2342 Rv2342 hypothetical protein MT2408 226.671586 231.924391 217.508176 215.676614 0.944175598 −0.082872897 7.80199007 0.741632985 Rv2343c dnaG DNA primase MT2409 140.18996 129.037917 133.032802 124.425814 0.95658297 −0.064037988 7.04267564 0.813012054 Rv2344c dgt probable deoxyguanosine triphosphate hydrolase MT2410 259.01407 248.031508 224.782697 213.647084 0.864599537 −0.209896031 7.88592274 0.232719377 Rv2345 Rv2345 precursor of probable membrane protein MT2411 656.625033 695.863662 850.118703 802.366962 1.221752579 0.28895215 9.55348528 0.107112345 Rv1793 RV1793 conserved hypothetical protein MT2412 1633.17555 1301.05692 1988.12657 1604.10945 1.225102333 0.292902263 10.6722403 0.116473773 MT2413 146.458521 166.681517 241.059438 231.288385 1.510454898 0.594983106 7.61885974 5.90E−06 Rv2348c Rv2348c hypothetical protein MT2414 77.8728939 176.816332 111.118307 237.689211 1.3828651 0.467660427 7.23929716 0.000547165 Rv2349c plcC phospholipase C precursor MT2415 117.512172 256.628003 173.588256 335.262779 1.386402024 0.471345666 7.7876632 0.000379677 Rv2350c plcB phospholipase C precursor MT2416 55.1951112 104.511608 78.5648262 202.406609 1.410969898 0.496687209 6.91164849 0.000109276 Rv2351c plcA phospholipase C precursor MT2417 6.65340051 7.96306921 6.81986338 8.19617969 1.027295897 0.038851788 2.92420894 0.938478232 MT2418 14.6187391 11.6731355 17.9135078 14.1286526 1.217968116 0.284476367 3.88332812 0.273603377 MT2419 28.5815092 32.4857028 46.193208 422.854311 1.457423926 0.54342058 5.23710268 0.00125921 Rv2352c PPE PPE-family protein MT2420 134.848498 151.569783 196.775791 201.079608 1.390853664 0.475970637 7.4200267 0.000439557 MT2421 95.6777735 133.019452 142.035021 160.09871 1.334302965 0.41608628 7.05420083 0.006989149 MT2422 48.0731614 54.2031643 68.7442229 69.082086 1.348691662 0.431560557 5.91200877 0.007169388 MT2423 189.38754 238.168161 198.685353 252.364276 1.054398419 0.076420112 7.78030075 0.764687847 Rv2353c PPE PPE-family protein MT2423.1 27.5507007 22.1699086 24.0059191 24.9788333 0.990813648 −0.013314354 4.6352364 0.974110692 MT2424 36.7342676 36.7387057 33.2809333 36.6096026 0.951139138 −0.072271693 5.17063061 0.822804121 MT2425 173.175833 216.993636 177.771106 227.931854 1.038563054 0.054588809 7.63774796 0.839018102 MT2426 82.8395218 140.258605 87.2033198 130.592463 0.987570746 −0.018043993 6.78679009 0.950820746 Rv2357c glyS glycyl-tRNA synthase MT2427 109.359414 99.8098334 106.026143 84.9280334 0.908551251 −0.138360196 6.64667687 0.548110991 Rv2358 Rv2358 transcriptional regulator (ArsR family) MT2428 93.0538972 92.1182324 78.9285522 81.1031495 0.864322469 −0.210358428 6.43415983 0.277268978 MT2429 65.5969064 47.7784153 59.9238663 56.1243162 1.034602538 0.049076636 5.84619091 0.890225316 Rv2360c Rv2360c hypothetical protein MT2430 170.364537 140.892031 150.127926 148.467941 0.963601076 −0.053492091 7.25394504 0.863840149 Rv2361c Rv2361c conserved hypothetical protein MT2431 204.943478 169.3962 195.775545 182.345483 1.013943923 0.019977865 7.55679276 0.948402527 Rv2362v Rv2362c conserved hypothetical protein MT2432 138.503132 164.509771 131.396035 168.138772 0.985251918 −0.021435442 7.23669626 0.94164517 Rv2363 amlA2 putative amidase MT2433 287.40816 141.796926 267.611439 165.016418 1.038967973 0.055151183 7.75230422 0.857846636 Rv2364c bex GTP-binding protein of Era/ThdF family MT2434 58.3812457 31.8522768 62.4699486 39.4977802 1.147466145 0.198451589 5.59130175 0.431434762 MT2435 388.521106 201.791413 372.455472 225.199794 1.033346773 0.047324479 8.21503362 0.878360152 Rv2366c Rv2366c conserved hypothetical protein MT2436 200.632824 138.448817 190.501517 143.316056 0.990942855 −0.013126232 7.39564544 0.969101493 Rv2367c Rv2367c conserved hypothetical protein MT2437 521.016856 354.899516 466.387724 362.115025 0.955426999 −0.065782449 8.73562292 0.808331268 Rv2368c phoH ATP-binding pho reguion component MT2438 7.40307914 6.96768556 7.54731548 7.88394427 1.075377574 0.104843291 2.93152894 0.830576393 MT2439 40.2015316 47.2354787 43.0106051 44.8838412 1.006814508 0.00979791 5.4598021 0.977523735 Rv2370c Rv2370c conserved hypothetical protein MT2440 8.9024373 9.5013894 8.63849362 7.10335573 0.850951701 −0.232850846 3.12149726 0.543161321 MT2441 226.684157 173.649202 216.689793 165.875065 0.955575595 −0.655558086 7.61388555 0.802899283 MT2442 538.738021 397.610524 507.397836 372.809088 0.939732233 −0.08967836 8.82750176 0.725019493 Rv2373c dnaJ2 DnaJ homologue MT2443 543.517224 375.802573 436.834983 335.965308 0.847473356 −0.238760083 8.72515561 0.167622083 MT2444 71.3132032 66.9621729 87.5670458 73.2972641 1.159495023 0.213496628 6.22804433 0.293416398 Rv2375 Rv2375 hypothetical protein MT2445 324.610977 440.412021 124.212445 233.317915 0.451359652 −1.147650637 8.1334107 1.46E−16 MT2445.1 15.9306773 11.3111779 17.5497818 17.4071245 1.29651715 0.37464129 3.97557991 0.142836826 MT2446 66.2528755 47.6879258 72.8361409 57.5293755 1.150489074 0.202247282 5.93656788 0.364078181 Rv2378c mbtG mycobactin/exochelin synthesis (lysine hydroxylase) MT2447 263.137305 183.42206 279.70533 209.353847 1.101144812 0.139004211 7.87080462 0.519336263 Rv2379c mbtF mycobactin/exochelin synthesis (lysine ligation) MT2448 354.129585 257.713876 367.181445 292.876821 1.085276376 0.118062486 8.31353605 0.616042531 Rv2380c mbtE mycobactin/exochelin synthesis (lysine ligation) MT2449 178.517295 88.6796344 203.959381 110.687455 1.192495838 0.253984231 7.18603926 0.146461776 Rv2381c mbtD mycobactin/exochelin synthesis (polyketide MT2450 135.223337 56.1034422 156.311269 66.1158495 1.166415738 0.222082091 6.69468708 0.233546465 Rv2382c mbtC mycobactin/exochelin synthesis MT2451 660.279718 199.348199 769.826179 251.115334 1.210855913 0.2760272 8.87737974 0.091229323 Rv2383c mbtB mycobactin/exochelin synthesis (serine/ threonine MT2452 68.2207826 25.6989961 82.8386072 32.8627776 1.242571794 0.313329211 5.71569134 0.105227729 Rv2384 mbtA mycobactin/exochelin synthesis (salicylate- AMP MT2453 27.2695711 20.6315884 28.5524947 22.5590089 1.069136385 0.096445903 4.63934214 0.764687847 MT2454 661.497946 83.0692902 654.888748 119.039753 1.181706861 0.240872199 8.56888165 0.304341874 MT2455 162.211779 122.3417 191.774558 116.854105 1.064141034 0.089689369 7.21389196 0.752487878 MT2456 214.876723 156.81817 254.608233 171.65142 1.139327488 0.188182494 7.64135703 0.326266799 Rv2387 Rv2387 conserved hypothetical protein MT2457 178.423585 161.161662 154.128912 136.91523 0.856679313 −0.223172844 7.30216245 0.217679742 Rv2388c hemN oxygen-independent coproporphyrinogen III oxidase MT2458 56.0385 71.7581123 39.1005501 43.6348995 0.650090019 −0.62128859 5.72241053 4.88E−05 Rv2389c Rv2389c conserved hypothetical protein MT2459 65.5969054 61.4423181 27.8250426 37.0779557 0.508247391 −0.976397191 5.58924949 5.83E−09 Rv2390c Rv2390c conserved hypothetical protein MT2460 261.637947 164.238302 116.210472 119.117812 0.567384874 −0.817600405 7.37026002 4.65E−06 MT2461 1351.95224 1008.50462 657.071104 721.810225 0.589823089 −0.761645796 9.86880601 8.47E−06 Rv2391 nirA probable nitrite reductase/sulphite reductase MT2462 262.200206 215.726734 141.125706 156.820238 0.625783351 −0.676264818 7.60085748 4.11E−06 Rv2392 cysH 3′-phosphoadenylylsulfate (PAPS) reductase MT2463 155.277248 108.496818 82.2020866 79.776149 0.623601345 −0.681304055 6.73595096 1.09E−05 Rv2393 Rv2393 conserved hypothetical protein MT2464 441.74831 364.672374 299.710263 313.484358 0.763766869 −0.388795756 8.47195404 0.011888969 Rv2394 ggtB [gamma] -glutamyltranspeptidase precursor MT2465 165.023075 177.721226 123.757788 155.024884 0.809531852 −0.304840248 7.28129684 0.064959061 Rv2395 Rv2395 probable membrane protein MT2466 4373.8143 3300.42072 1080.17543 1181.3427 0.297335237 −1.749837649 11.2784899 5.97E−27 Rv2395a aprA conserved hypothetical protein MT2467 768.608323 994.207289 220.963574 314.264947 0.301574806 −1.729412187 9.16655077 6.97E−48 Rv2395b aprB conserved hypothetical protein MT2467.1 1060.32714 887.701238 317.350976 385.376563 0.360595047 −1.471548515 9.37249515 8.21E−23 Rv2396 aprC PE_PGRS-family protein MT2468 128.944776 160.437747 161.949022 167.280125 1.143280925 0.193179943 7.27459829 0.365758936 Rv2397c cysA sulphate transport ATP-binding protein MT2469 66.4402952 70.9437075 80.2015934 93.3583896 1.261267334 0.334874097 6.28403461 0.036617087 Rv2398c cysW sulphate transport system permease protein MT2470 46.1052542 56.1034422 57.1049894 59.8711412 1.147713529 0.198762588 5.78083076 0.406031587 Rv2399c cysT sulphate transport system permease protein MT2471 153.684131 170.391583 190.228723 194.210429 1.187444738 0.247860374 7.47014842 0.157889306 Rv2400c subI sulphate binding precursor MT2472 7.68420903 12.3065615 10.0933978 13.3480641 1.178488541 0.236937731 3.46598244 0.49146328 Rv2401 Rv2401 hypothetical protein MT2473 11.901153 15.0212442 18.0953708 17.8754776 1.336681103 0.418655317 3.9918444 0.066640892 MT2474 188.544251 195.366664 215.053025 203.265256 1.089196275 0.123263953 7.64914524 0.584969964 Rv2402 Rv2402 conserved hypothetical protein MT2475 96.0526129 111.030522 94.4778407 115.292928 1.011144886 0.015989734 6.70593756 0.958106946 Rv2403c lppR lipoprotein MT2476 189.856189 240.882844 185.318421 223.4825 0.951335173 −0.071974376 7.71470155 0.7818709 Rv2404c lepA GTP-binding protein LepA MT2477 108.984575 155.551318 108.84502 116.307693 0.862240144 −0.213838362 6.93777674 0.326531322 MT2478 26.2387626 38.4580047 24.2787136 32.2383068 0.877523898 −0.188489679 4.93004288 0.469324523 MT2479 9.18356689 9.22992113 8.63849362 8.97676823 0.957098647 −0.053260465 3.1988923 0.894346121 Rv2407 Rv2407 conserved hypothetical protein MT2480 8.0590485 8.77747401 7.00172641 8.89870938 0.944429489 −0.082485006 3.06433947 0.870656307 MT2481 1.49935736 2.89566153 1.36397268 3.04429531 0.999784014 −0.000311636 1.25863269 0.999874639 Rv2408 PE PE-family protein MT2482 114.326037 140.801542 118.756554 160.254828 1.08825692 0.122019194 7.06312748 0.609343079 Rv2409c Rv2409c conserved hypothetical protein MT2483 141.876738 155.27985 148.127433 158.147239 1.031068216 0.044139786 7.23876223 0.880578033 Rv2410c Rv2410c conserved hypothetical protein MT2484 243.270813 270.744353 277.159248 281.167993 1.087509058 0.121027417 8.06751843 0.602930136 MT2485 646.879207 874.580272 715.630998 900.408883 1.067095993 0.093689963 9.61574448 0.734837124 MT2486 68.5956221 34.6574489 62.8336746 39.8100156 1.020015136 0.02859056 5.69015567 0.934442416 Rv2413c Rv2413c conserved hypothetical protein MT2487 163.992256 162.338025 155.583817 155.259061 0.952571776 −0.070100292 7.31711381 0.79743892 MT2488 8.24646823 16.469075 10.1843293 12.4113578 0.937647487 −0.092882458 3.58623338 0.855750561 Rv2415c Rv2415c conserved hypothetical protein MT2488.1 12.7445418 18.5503317 7.63824699 13.8164172 0.680024459 −0.556341457 3.74060053 0.010586731 MT2489 68.8767517 135.643645 51.2853726 116.073516 0.802084631 −0.318173626 6.54172696 0.056753569 Rv2416c Rv2416c conserved hypothetical protein MT2490 164.648235 162.157046 160.766913 174.149304 1.024293752 0.034629518 7.37164076 0.90313325 Rv2417c Rv2417c conserved hypothetical protein MT2491 62.1296413 82.4358642 57.5596469 84.7719157 0.978124963 −0.031909302 6.16819064 0.917080606 Rv2418c Rv2418c hypothetical protein MT2492 71.3132032 75.7396469 76.3824699 89.9238 1.128691388 0.174651072 6.29509678 0.420522227 MT2493 45.0744457 45.0637326 43.5561941 42.4640167 0.954125282 −0.067749383 5.46639263 0.831938786 Rv2420c Rv2420c conserved hypothetical protein MT2494 133.723979 161.614109 133.032802 161.269593 0.996371363 −0.005244538 7.20548279 0.985131579 Rv2421c Rv2421c conserved hypothetical protein MT2495 1.31193813 1.53832019 2.18235628 1.95147136 1.440530439 0.526600146 0.94628366 0.456226727 Rv2422 Rv2422 hypothetical protein MT2496 22.1155284 37.5531105 28.2797002 35.4387198 1.087305635 0.12075753 4.95585414 0.728777959 Rv2423 Rv2423 hypothetical protein MT2497 20.235041 18.9122894 24.3696452 23.1054208 1.20994593 0.274942578 4.45026985 0.226533034 MT2498 102.337454 119.627017 113.391595 128.250697 1.090121885 0.12448945 6.85373701 0.564270992 Rv2425c Rv2425c conserved hypothetical protein MT2499 178.048746 181.521782 192.592942 184.531131 1.048517181 0.068350501 7.52630237 0.802800925 Rv2426c Rv2426c conserved hypothetical protein MT2500 407.075659 317.798953 407.282241 343.615076 1.039979586 0.056555209 8.52791641 0.83350394 Rv2427c proA [gamma]-glutamyl phosphate reductase MT2501 6.18485117 5.33887595 5.36495919 4.29323698 0.836490626 −0.257578722 2.44900903 0.578518157 MT2502 8.43388796 6.24377018 7.09265792 5.46411979 0.857018222 −0.22602215 2.8014808 0.595039324 MT2503 200.445404 268.934565 186.773325 200.923491 0.83353907 −0.262678272 7.74444569 0.148160607 Rv2428 ahpC alkyl hydroperoxide reductase MT2504 113.763778 174.825565 111.936691 147.297058 0.908869439 −0.137855031 7.09949665 0.585180526 Rv2429 ahpD member of AhpC/TSA family MT2505 1259.27318 889.420537 1004.24762 865.750752 0.880980108 −0.182818651 9.97274395 0.459370243 Rv2430c PPE PPE-family protein MT2506 299.684152 223.870832 262.701138 239.328447 0.967772361 −0.047260357 8.00318 0.878360152 MT2507 9.18356689 9.95383651 6.09241129 9.60123907 0.815815938 −0.293684402 3.15195421 0.428699683 Rv2433c Rv2433c hypothetical protein MT2508 29.9871572 38.0055576 32.9172073 40.668663 1.083091911 0.115155675 5.15306044 0.697208218 Rv2434c Rv2434c probable membrane protein MT2509 75.7175719 105.420178 75.8368808 107.096748 1.008967461 0.012879649 6.51107728 0.969802669 Rv2435c Rv2435c hypothetical protein MT2511 87.5250151 66.781194 71.0175107 61.588436 0.864504528 −0.210054574 6.16775374 0.315008839 Rv2436 rbsK ribokinase MT2512 19.2105226 11.4016673 13.7306583 12.5674755 0.879331519 −0.185520913 3.84719332 0.624685486 Rv2437 Rv2437 conserved hypothetical protein MT2513 379.899798 324.223602 349.267937 320.743832 0.95365316 −0.068463436 8.42502092 0.795267516 Rv2438c Rv2438c conserved hypothetical protein MT2515 91.2734097 97.0046613 85.111895 99.9153334 0.980798621 −0.027971145 6.54700002 0.923928243 Rv2439c proB glutamate 5-kinase MT2516 341.759832 402.587442 349.722594 416.287869 1.028680942 0.040795582 8.56137595 0.884772098 Rv2440c obg Obg GTP-binding protein MT2517 185.076936 250.474722 184.954695 201.00155 0.894594753 −0.160593799 7.68336734 0.484283855 MT2518 306.899812 351.008471 300.528646 380.224679 1.030260018 0.043008492 8.38737529 0.880856541 Rv2442c rplU 50S ribosomal protein L21 MT2518.1 36.9216873 21.8984403 31.4623031 26.227775 1.003856579 0.005553166 4.8724953 0.988617034 MT2519 108.516025 126.866171 101.388636 125.36252 0.961390334 −0.056805796 6.85443754 0.831756973 Rv2443 dctA C4-dicarboxylate transport protein MT2520 1856.861 996.560014 2001.31164 1185.47982 1.132185131 0.179109882 10.560534 0.453805878 Rv2444c rne similar at C-term to ribonuclease E MT2520.1 41.4197609 32.5761922 42.5559475 29.7404235 0.970267451 −0.043545618 5.19909661 0.89957148 MT2521 104.673921 118.088697 98.2969642 123.33299 0.991330249 −0.012562342 6.79807269 0.969605889 Rv2445c ndkA nucleoside diphosphate kinase MT2522 48.0731614 37.1006634 48.7392903 42.6201344 1.078253019 0.108695755 5.46940941 0.723355375 MT2523 403.795814 251.560595 338.810813 249.944451 0.912532765 −0.132051735 8.28163525 0.578518157 MT2524 663.278433 482.85156 565.503072 457.659062 0.898836543 −0.153869315 9.08343998 0.48135099 Rv2448c valS valyl-tRNA synthase MT2525 302.308029 185.774785 250.24352 166.811771 0.861692152 −0.214755551 7.82297452 0.227886379 Rv2449c Rv2449c conserved hypothetical protein MT2526 86.1193671 157.270617 66.2890721 148.155705 0.856154937 −0.224056192 6.84118313 0.248581216 Rv2450c Rv2450c conserved hypothetical protein MT2527 2.24903679 3.71006634 1.63676721 2.49788333 0.695390968 −0.524103767 1.43304516 0.357876722 Rv2451 Rv2451 hypothetical protein MT2527.1 7.40307944 11.4016673 6.72893187 13.1138875 1.044625052 0.062985207 3.3015801 0.897840055 Rv2452c Rv2452c hypothetical protein MT2528 138.315753 183.603039 120.938911 155.805473 0.861151827 −0.215660478 7.22733284 0.239799128 Rv2453c Rv2453c hypothetical protein MT2529 623.92029 738.122222 576.687648 635.63325 0.892085311 −0.164746412 9.33039322 0.452994957 Rv2454c Rv2454c oxidoreductase, beta subunit MT2530 1055.54793 1280.24435 1044.34841 1090.63831 0.917997344 −0.123438115 10.1265362 0.647058444 Rv2455c Rv2455c probable oxidoreductase alpha subunit MT2531 299.309313 315.08417 367.545171 364.534849 1.191828732 0.253176933 8.39575117 0.121489885 Rv2456c Rv2456c probable transmembrane transport protein MT2532 1786.76602 2161.79231 2194.08645 2488.59433 1.188921449 0.249653401 11.0754771 0.236664882 Rv2457c clpX ATP-dependent Clp protease ATP-binding subunit ClpX MT2533 37.2028159 36.9196845 33.9174539 33.0969542 0.903977616 −0.145641045 5.14793785 0.589953244 Rv2458 Rv2458 conserved hypothetical protein MT2534 157.245156 180.34542 172.224283 184.296955 1.0576364 0.080843735 7.44052808 0.762893473 Rv2459 Rv2459 probable drug efflux protein MT2535 365.374769 430.729653 372.91013 425.186579 1.003655535 0.005264206 8.63927363 0.985115966 Rv2460c clpP2 ATP-dependent Clp protease proteolytic subunit MT2536 234.836925 307.483059 263.701384 314.343006 1.070985217 0.098938565 8.13070937 0.690804185 Rv2461c clpP ATP-dependent Clp protease proteolytic subunit MT2537 565.539043 548.365902 516.309124 530.01962 0.939400459 −0.090187797 9.07743563 0.727349312 Rv2462c tig chaperone protein, similar to trigger factor MT2538 396.954994 426.657629 482.664464 493.800312 1.186204676 0.246352964 8.81443074 0.140711849 Rv2463 lipP probable esterase MT2539 67.6585234 88.5891449 75.3822233 89.2993292 1.058280291 0.081721783 6.32943657 0.764687847 Rv2464c Rv2464c probable DNA glycosylase, endonuclease VIII MT2540 127.070579 159.261384 128.940884 156.66412 0.998833707 −0.001683587 7.16156275 0.997032163 Rv2465c rpi phosphopentose isomerase MT2542 400.141129 425.481266 372.091746 410.979867 0.947803123 −0.07734068 8.65230962 0.763576794 Rv2467 pepD probable aminopeptidase MT2543 364.906219 282.960425 356.0878 319.651008 1.049767901 0.07007039 8.37100572 0.801831984 Rv2468c Rv2468c hypothetical protein MT2544 146.093632 130.938195 126.485733 126.06505 0.913104904 −0.131147478 7.05057624 0.565529532 MT2545 62.8793203 63.2521066 60.9241129 50.347961 0.87821541 −0.187353245 5.89521596 0.450620436 Rv2469c Rv2469c conserved hypothetical protein MT2546 111.98329 74.7442633 103.934718 76.7318537 0.97509642 −0.036383211 6.52372556 0.90313325 Rv2470 glbO hemoglobin-like, oxygen carrier MT2547 277.662334 152.655656 273.249193 166.265359 1.034374476 0.048758581 7.76562938 0.865910551 Rv2471 Rv2471 probable maltase [alpha]- glucosidase MT2547.1 165.116734 168.762774 171.769626 153.463707 0.972482036 −0.040256494 7.36588081 0.894346121 Rv2472 Rv2472 hypothetical protein MT2548 61.4736723 64.9714036 64.0157843 62.8373776 1.003160424 0.004552338 5.98868949 0.988617034 Rv2473 Rv2473 probable membrane protein MT2549 83.8703303 74.2918161 69.1988805 82.8985032 0.960715997 −0.057818084 6.28065382 0.870054573 Rv2474c Rv2474c hypothetical protein MT2550 131.943492 118.450655 111.936691 123.254931 0.940045711 −0.089197184 6.92566526 0.745116768 Rv2475c Rv2475c conserved hypothetical protein MT2551 1423.26545 1521.03671 1224.21094 1476.63935 0.913856697 −0.129960142 10.462979 0.62049128 Rv2476c Rv2476c hypothetical protein MT2552 475.296442 587.638312 432.015612 562.960456 0.933273456 −0.099628231 9.00747765 0.69018019 Rv2477c Rv2477c ABC-transporter ATP binding protein MT2554.1 9.83953596 14.9307548 18.8228229 24.8227156 1.768663984 0.822659987 4.11360918 1.91E−06 MT2554.2 3.27984532 6.96768556 6.72893187 7.72782657 1.437147161 0.523207798 2.67114561 0.164010305 MT2555 398.079512 492.986376 390.914569 457.581003 0.954574398 −0.067070451 8.76510614 0.801831984 Rv2482c plsB2 glycerol-3-phosphate acyltransferase MT2556 224.997389 274.454419 232.14815 242.216625 0.953760567 −0.068300959 7.92855252 0.803788741 Rv2483c Rv2483c possible transferase MT2557 374.745755 367.749014 375.547144 335.809191 0.956582529 −0.064038653 8.50633964 0.806148616 Rv2484c Rv2484c conserved hypothetical protein MT2558 1.59306773 7.96306921 2.18235628 8.97676823 1.180264507 0.239110216 2.43216593 0.641653568 MT2559 52.1963955 138.177349 75.1094287 163.611358 1.296276591 0.374373584 6.74806071 0.017771935 Rv2485c lipQ probable carboxlyesterase MT2560 123.603314 103.248431 112.573212 97.5735677 0.927660978 −0.108330439 6.7736881 0.636783872 Rv2436 echA14 enoyl-CoA hydratase/isomerase superfamily MT2561 14.8061589 14.9307548 13.6397268 16.1581828 1.002272925 0.003275416 3.91307085 0.995412459 Rv2487c PE_PGRS PE_PGRS-family protein MT2563 84.3388796 103.972347 83.8388538 92.1875068 0.937809458 −0.092633266 6.5119447 0.733038419 Rv2488c Rv2488c transcriptional regulator (LuxR/UhpA family) MT2563.1 12.0885728 7.42013267 11.184576 8.97676823 1.047305053 0.066681723 3.33414887 0.89125591 MT2564 42.2631497 31.037872 39.4642761 29.7404235 0.945534051 −0.080798681 5.1614557 0.801831984 Rv2490c PE_PGRS PE_PGRS-family protein MT2566 3.93581438 5.79132306 4.72843861 4.99576667 1.000432884 0.000624385 2.33398764 0.999355608 Rv2491 Rv2491 hypothetical protein MT2567 7.30936957 11.130199 11.8210965 11.8649458 1.291812631 0.369396832 3.42192485 0.253930311 Rv2492 Rv2492 hypothetical protein MT2568 215.813822 120.441422 207.596641 130.514404 1.019766702 0.028239136 7.39872973 0.923622644 Rv2493 Rv2493 conserved hypothetical protein MT2569 362.844602 232.10537 403.463118 287.334642 1.172773267 0.229924123 8.32913861 0.208877516 MT2570 757.831689 713.690078 644.158829 540.323389 0.802213853 −0.317941216 9.37539294 0.055667778 Rv2495c pdhC dihydrolipoamide acetyltransferase MT2571 526.649448 498.59672 453.293586 367.735262 0.796792889 −0.327723323 8.85090407 0.038660649 Rv2496c pdhB pyruvate dehydrogenose E1 component [beta] subunit MT2572 744.056338 672.51739 631.519349 493.410017 0.789173805 −0.341585025 9.31182704 0.035875425 Rv2497c pdhA pyruvate dehydrogenase E1 component [alpha] subunit MT2573 165.679044 144.421119 147.763707 107.64316 0.815813404 −0.293688893 7.14501444 0.090433444 Rv2498c citE citratelyase [beta] chain MT2574 104.486501 99.1764074 98.3878957 72.1263813 0.828169485 −0.272002049 6.55003948 0.17403775 Rv2499c Rv2499c putative aldehyde dehydrogenase MT2575 370.153972 440.231042 306.984784 267.976046 0.710329338 −0.493440023 8.4366999 0.001573521 Rv2500c fadE19 acyl-CoA dehydrogenase (aka mmgC) MT2576 320.675162 260.881006 306.802921 202.484668 0.862229188 −0.213856694 8.09205709 0.296307581 MT2577 155.464658 133.924346 176.498064 110.687455 0.969924031 −0.044056342 7.1729605 0.897921476 Rv2502c accD1 acetyl/propionyl-CoA carboxylase, [beta] subunit MT2578 94.4595452 69.767345 95.5690189 58.4660318 0.9229974 −0.115601511 6.31690022 0.657330385 Rv2503c scoB 3-oxo acid:CoA transferase, [beta] subunit MT2579 73.6559549 72.9344748 85.7484156 56.9829636 0.955044622 −0.066359954 6.17976132 0.864761178 Rv2504c scoA 3-oxo acid:CoA transferase, [alpha] subunit MT2580 21.5532692 33.5715759 23.9149876 35.1264844 1.074500808 0.103666567 4.84472563 0.745116768 Rv2505c fadD35 acyl-CoA synthase MT2581 44.9807358 31.3998297 36.2816732 29.6623646 0.871087242 −0.199110879 5.15958622 0.435583523 Rv2506 Rv2506 transcriptional regulator (TetR/AcrR family) MT2582 303.057708 330.286393 269.430069 260.95075 0.837947249 −0.25506867 8.18537085 0.139650854 Rv2507 Rv2507 probable membrane spanning protein MT2583 24.4582761 36.0147903 25.4608233 33.721425 0.983373638 −0.024188414 4.91169352 0.946497216 Rv2508c Rv2508c possible membrane protein MT2584 177.205357 164.147813 165.58653 156.586062 0.94699035 −0.07857837 7.37766595 0.764687847 Rv2509 Rv2509 putative oxidoreductase MT2585 62.3170611 92.8421478 74.1091821 92.6558599 1.086174653 0.119256102 6.3339541 0.639625191 Rv2510c Rv2510c conserved hypothetical protein MT2586 66.4402952 67.0526623 59.2873457 62.8373776 0.914760581 −0.128533896 6.00177142 0.618762751 Rv2511 Rv2511 conserved hypothetical protein MT2586.1 42.4505694 53.3887595 46.2841395 48.2403719 0.990248874 −0.014136939 5.57800856 0.973097519 MT2587 38.7958846 26.0609538 37.1909883 29.6623646 1.041367823 0.058479735 5.04851635 0.871130682 MT2588 48.9165502 54.3841431 47.5571807 56.5926693 1.006710209 0.00964845 5.70168378 0.977279079 MT2589 69.7201405 88.8606132 81.2927715 91.8752714 1.096401561 0.132776287 6.3771581 0.57479471 MT2589.1 54.3517224 60.4469345 53.6495919 64.6327313 1.028377639 0.040370146 5.86922319 0.900042957 MT2590 4.87291305 5.06740768 4.45564408 4.29323698 0.879289937 −0.185589137 2.27618298 0.741445842 MT2591 30.2682868 22.4413769 24.6424397 19.826949 0.847018126 −0.239535251 4.61212423 0.322018463 Rv2515c Rv2515c hypothetical protein MT2593 112.545549 80.3546075 111.663896 78.2149719 0.982922445 −0.024850506 6.58279903 0.93054576 Rv2516c Rv2516c hypothetical protein MT2593.1 68.0333629 48.5928201 67.0165242 54.7973156 1.052626687 0.073993877 5.90155128 0.809132929 Rv2517c Rv2517c hypothetical protein MT2593.2 12.8382517 12.7590086 12.0029596 11.3185339 0.910362358 −0.135487189 3.63234948 0.723313141 MT2594 427.31699 432.539441 377.547637 362.817554 0.860845722 −0.216173389 8.64466475 0.222785143 Rv2518c lppS lipoprotein MT2595 404.358073 359.695456 389.095939 377.258442 1.004622568 0.00665359 8.58035558 0.981739573 Rv2519 PE PE-family protein MT2596 9.65211623 17.1025009 8.72942513 10.2257099 0.71931268 −0.475309058 3.53605815 0.087358903 Rv2520c Rv2520c conserved hypothetical protein MT2597 140.00254 113.745205 130.850445 114.746515 0.970819509 −0.042724995 6.96584035 0.880856541 Rv2521 bcp bacterioferritin comigratory protein MT2598 105.4236 111.482969 106.298937 106.628395 0.981806027 −0.026490072 6.74998999 0.924310616 Rv2522c Rv2522c conserved hypothetical protein MT2599 114.794586 87.5937613 136.124473 107.487042 1.205999123 0.270228858 6.80312995 0.088442852 Rv2523c acpS CoA:apo-[ACP] pantethtienephosphotransferase MT2600 13836.4432 5408.46231 14717.1743 5963.69646 1.082971572 0.114995373 13.2850533 0.730503677 Rv2524c fas fatty acid synthase MT2601 149.373527 214.82189 240.422917 290.378938 1.473305532 0.559056645 7.80702284 2.41E−05 Rv2525c Rv2525c hypothetical protein MT2601.1 23.6148853 19.8171836 18.1863024 20.8417141 0.902034007 −0.14874627 4.37778039 0.657183257 MT2601.2 44.3247657 33.6620653 36.0088787 34.3458958 0.909534769 −0.136799306 5.21931564 0.641879751 Rv2526 Rv2526 conserved hypothetical protein MT2602 49.1039699 64.7904267 54.9226331 65.0230255 1.057567421 0.08074964 5.87393835 0.792169102 Rv2527 Rv2527 conserved hypothetical protein MT2603 7.7779189 15.202223 7.27452094 12.5674755 0.86845873 −0.203470802 3.44556365 0.572054672 Rv2518c mrr restriction system protein M12604 23.9897258 42.5300287 28.4615632 39.8880745 1.045170481 0.063738284 5.08357673 0.865818984 Rv2529 Rv2529 hypothetical protein MT2605 49.1039699 37.1911528 52.6493453 46.4450182 1.155856284 0.208962028 5.53984072 0.392693044 Rv2530c Rv2530c conserved hypothetical protein MT2606 23.802306 17.554948 25.5517548 20.0611255 1.106057689 0.145426634 4.4536521 0.619926139 MT2607 423.568596 342.321487 423.649913 363.988437 1.031195921 0.044318462 8.6019644 0.877756142 Rv2531c adi ornithine/arginine decarboxylase MT2608 313.365793 260.519048 295.163687 281.089934 1.008050028 0.011581551 8.16845823 0.973097519 Rv2533c nusB N-utilisation substance protein B MT2609 321.237422 304.758376 309.621798 287.881054 0.954160824 −0.067695642 8.25761553 0.801337286 Rv2534c efp elongation factor P MT2610 246.644358 237.082238 236.421931 218.408674 0.939690246 −0.089741822 7.87534905 0.719637416 MT2611 139.815121 163.966834 149.855131 165.484771 1.039716851 0.056190688 7.2757704 0.839820353 Rv2536 Rv2536 potential membrane protein MT2612 136.441555 71.7581123 131.214172 82.976562 1.051544203 0.072509497 6.72458258 0.803210576 Rv2537c aroD 3-dehydroquinate dehydratase MT2613 302.308029 157.813553 298.619085 178.988953 1.057212693 0.080265651 7.87398675 0.762893473 Rv2538c aroB 3-dehydroquinate synthase MT2614 218.718828 112.84031 224.509903 116.619928 1.029880563 0.042477036 7.39509298 0.884423914 Rv2539c aroK shikimate kinase I MT2615 822.116657 407.926318 783.102179 392.714095 0.957572381 −0.062546554 9.23269013 0.819552181 Rv2540c aroF chorismate synthase MT2615.1 31.1116756 55.650995 36.2816732 52.3774912 1.040164199 0.056811288 5.46099089 0.878360152 MT2616 29.9871572 47.1449893 29.1890153 47.7720188 0.994864315 −0.007428319 5.27490031 0.982651332 Rv2542 Rv2542 conserved hypothetical protein MT2617 318.613545 138.991754 368.272623 168.529066 1.183085684 0.242554563 7.95856394 0.143692242 MT2618 7.87162877 9.5013894 9.72967176 8.89870938 1.069654383 0.097144721 3.19801623 0.839018102 Rv2543 lppA lipoprotein MT2619 5.99743144 5.97230191 5.81961675 6.55694375 1.035321624 0.050079013 2.64759998 0.926747303 MT2620 6.18485117 7.96306921 7.18358943 9.28900365 1.16402243 0.219118858 2.97160992 0.581076946 Rv2544 lppB lipoprotein MT2621 5.99743144 4.3434923 6.36520582 5.38606094 1.141966844 0.191520764 2.51003461 0.709140127 Rv2545 Rv2545 conserved hypothetical protein MT2622 4.40436371 2.26223557 7.27452094 4.29323698 1.744751426 0.803021511 2.24219247 0.015151628 Rv2546 Rv2546 conserved hypothetical protein MT2623 28.1129599 22.893824 25.5517548 24.0421271 0.976413007 −0.034436581 4.66229226 0.923772833 Rv2547 Rv2547 conserved hypothetical protein MT2624 22.4903679 16.7405432 22.914741 20.5294787 1.115006503 0.157052124 4.38146261 0.605395375 Rv2548 Rv2548 conserved hypothetical protein MT2625 214.783014 229.843134 223.691519 215.676614 0.988374077 −0.016870922 7.78903236 0.952654537 MT2626 19.0231029 33.6620653 21.2779738 24.9007745 0.897310949 −0.15632008 4.63783123 0.660281759 MT2627 9.74582639 11.4016673 10.7299184 10.3818276 0.997085127 −0.004211413 3.42500328 0.994942526 MT2627.1 20.1476213 6.42474902 21.7326313 10.0695922 1.249573264 0.321435491 3.88223582 0.277296766 MT2628 28.7689239 16.3785855 32.6444127 21.2320083 1.205901266 0.27011179 4.63925337 0.245451994 MT2629 296.123177 126.594703 296.618591 142.457409 1.059951568 0.083998346 7.75218939 0.746089419 Rv2552c aroE shikimate 5-dehydrogenase MT2630 553.91922 312.912424 539.223865 342.67837 1.03203466 0.045491423 8.77261413 0.878901047 Rv2553c Rv2553c hypothetical protein MT2631 201.382503 106.777519 209.233409 120.210636 1.080418677 0.111590485 7.31792524 0.640147081 MT2632 1835.40144 1304.85748 1827.63246 1322.47311 1.004585927 0.00660097 10.6190767 0.983783004 Rv2555c alaS alanyl-tRNA synthase MT2633 621.577543 338.158973 567.958222 395.602273 1.033200815 0.047120687 8.90984426 0.884292189 Rv2556c Rv2556c conserved hypothetical protein MT2634 371.840749 410.279043 356.178732 325.037069 0.870972066 −0.199301645 8.5157092 0.311717327 Rv2557 Rv2557 conserved hypothetical protein MT2635 764.391379 663.19698 667.710091 475.690657 0.791669969 −0.33702897 9.32845845 0.049406522 Rv2558 Rv2558 conserved hypothetical protein MT2636 42.8254039 52.212397 42.0103584 53.2361386 1.000810036 0.001168162 5.57760058 0.998009016 Rv2559c Rv2559c conserved hypothetical protein MT2637 47.6046121 118.360165 68.5623599 164.15777 1.411031728 0.496750428 6.64234485 0.000267118 Rv2560 Rv2560 probableproable membrane protein MT2637.1 7.87162877 12.6685192 9.00221966 12.4894167 1.050615217 0.071234386 3.41917332 0.880429144 MT2638 97.1771313 124.241978 103.661923 142.847703 1.10853684 0.148656716 6.87251248 0.476182576 Rv2562 Rv2562 hypothetical protein MT2639 109.827953 180.978846 106.4808 186.404544 1.000314707 0.000453955 7.19101223 0.999355608 Rv2563 Rv2563 possible membrane protein MT2640 35.6097452 94.6519363 44.4655093 93.1242131 1.09697293 0.133527925 6.06974953 0.636019999 Rv2564 glnQ probable ATP-binding transport protein MT2641 180.485202 212.197697 179.22601 209.978318 0.991262741 −0.01266059 7.61215651 0.969101493 Rv2565 Rv2565 conserved hypothetical protein MT2642 123.509604 133.833856 120.666116 135.666289 0.995381242 −0.006678895 7.00673364 0.981739573 Rv2566 Rv2566 hypothetical protein MT2643 226.590457 261.423943 261.791822 319.885185 1.189248937 0.250050736 8.06400472 0.140682899 Rv2567 Rv2567 conserved hypothetical protein MT2644 33.2670025 44.4303066 31.4623031 38.4830151 0.903058285 −0.14710899 5.21298518 0.584815826 Rv2568c Rv2568c conserved hypothetical protein MT2645 47.5109022 54.3841431 50.1941945 50.0357255 0.984731566 −0.02219759 5.66412098 0.94941324 Rv2569c Rv2569c conserved hypothetical protein MT2646 23.2400468 18.9122894 22.0963574 17.2510058 0.931921916 −0.101719016 4.36033849 0.760272935 MT2647 67.8459432 85.3315257 66.2890721 81.1812084 0.963751939 −0.053266237 6.23542567 0.860243051 Rv2571c Rv2571c conserved hypothetical protein MT2648 139.346571 181.069335 138.761487 171.02695 0.969419275 −0.044807327 7.30135068 0.879854448 Rv2572c aspS aspartyl-tRNA synthase MT2649 15.0872835 13.7543923 14.2762474 11.786887 0.901166985 −0.150133635 3.79625148 0.657330385 Rv2573 Rv2573 hypothetical protein MT2650 67.283684 75.3776892 67.5621132 71.1116162 0.972793729 −0.039794166 6.1397742 0.897921476 MT2651 89.1180828 93.4755738 87.9307719 99.4469802 1.025082918 0.035740627 6.5340895 0.90313325 Rv2575 Rv2575 conserved hypothetical protein MT2652 552.325952 304.949355 466.478655 309.26918 0.924859018 −0.112694632 8.67387571 0.645405187 Rv2576c Rv2576c hypothetical protein MT2654 52.571235 46.6020528 47.9209067 36.3754261 0.844342129 −0.244100394 5.52445127 0.284385973 Rv2577 Rv2577 hypothetical protein MT2655 49.1039699 18.6408211 33.0081388 18.3438307 0.799181015 −0.323405784 4.90291037 0.217482131 Rv2578c Rv2578c hypothetical protein MT2656 68.7830418 85.9649517 65.925346 83.6790917 0.966135534 −0.049702503 6.25307478 0.870656307 Rv2579 linB 1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase MT2657 319.550644 184.779401 283.524454 179.223129 0.927101195 −0.109201275 7.91840741 0.617037691 MT2658 119.761209 78.7257979 116.483267 72.4386167 0.94675476 −0.078937325 6.60003689 0.767489209 Rv2581c Rv2581c putative glyoxylase II MT2659 173.925512 238.25865 153.492392 206.387611 0.874208852 −0.193950108 7.59393612 0.306768873 Rv2582 ppiB peptidyl-prolyl cis-trans isomerase MT2660 1114.58515 1214.18708 941.777667 942.17037 0.809701813 −0.304537387 10.0407667 0.091229323 Rv2583c relA (p)ppGpp synthase I MT2661 263.512144 440.412021 145.672282 203.577492 0.504820039 −0.986158916 8.04141857 1.75E−15 Rv2584c apt adenine phosphoribosyltransferases MT2662 219.468507 275.449803 204.50497 237.923388 0.896815562 −0.157116782 7.87353348 0.445118181 Rv2585c Rv2585c conserved hypothetical protein MT2663 524.775251 440.050063 450.747504 442.281468 0.929130181 −0.106047348 9.85995136 0.673053573 Rv2586c secF protein-export membrane protein MT2664 765.797027 645.823011 671.983872 607.844298 0.908773821 −0.138006819 9.39452554 0.549830576 Rv2587c secD protein-export membrane protein MT2665 319.363224 286.670492 265.610946 238.157564 0.831236328 −0.266669389 8.11694222 0.097064113 Rv2588c Rv2538c conserved hypothetical protein MT2666 278.037173 192.92345 245.878808 195.303253 0.94572422 −0.08050855 7.83414723 0.760272935 Rv2589 gabT 4-aminobutyrate aminotransferase MT2667 4692.89639 2835.39558 2403.04706 1694.81384 0.553218153 −0.854079597 11.5051553 1.14E−08 Rv2590 fadD9 acyl-CoA synthase MT2668.1 363.781701 166.048091 226.874122 155.727414 0.76311747 −0.390022941 7.83449891 0.046862744 Rv2591 PE_PGRS PE_PGRS-family protein MT2669 161.649519 143.244756 183.590722 182.501601 1.202939262 0.266563801 7.39169967 0.119148308 Rv2592c ruvB Holliday junction binding protein MT2670 83.7766204 70.400771 99.2062793 102.491276 1.312917048 0.392775768 6.47823315 0.015153827 Rv2593c ruvA Holliday junction binding protein, DNA helicase MT2671 237.367091 197.719389 252.880534 295.452763 1.261941527 0.335645064 7.9427696 0.078033157 Rv2594c ruvC Holliday junction resolvase, endodeoxyribonuclease MT2672 67.6585234 57.2798047 79.7469358 62.3690245 1.133349806 0.180593215 6.06468121 0.427783411 Rv2596 Rv2596 conserved hypothetical protein MT2673 83.4954928 104.424794 94.3869092 99.6811568 1.037294753 0.052825902 6.58010687 0.864827105 Rv2597 RV2597 hypothetical protein MT2673.1 16.4929355 24.9750807 16.8223297 24.4324214 0.996503271 −0.005053554 4.38336565 0.988617034 MT2674 6.18485117 11.5826461 7.36545245 12.0210636 1.096506517 0.132914387 3.245538 0.761658278 Rv2599 Rv2599 conserved hypothetical protein MT2674.1 34.5789407 38.6389836 35.7360841 46.9133714 1.123589549 0.168115111 5.29118172 0.519336263 Rv2600 Rv2600 conserved hypothetical protein MT2675 23.0526271 35.2908749 26.3701384 37.9366031 1.105905807 0.145228513 4.94748911 0.603157539 Rv2601 speE spermidine synthase MT2676 49.9473587 37.1911528 49.6486054 36.9998969 0.994428127 −0.008060992 5.4466196 0.981344332 MT2677 75.5301522 51.2170133 75.7459493 54.7192568 1.034219005 0.048541721 6.01048127 0.880856541 Rv2602 Rv2602 conserved hypothetical protein MT2678 409.137276 481.31324 400.00772 452.116854 0.958238416 −0.061543442 8.76759796 0.816959095 Rv2603c Rv2603c conserved hypothetical protein MT2679 46.8549331 58.1846989 44.7383038 54.7192568 0.947367766 −0.07800351 5.6810491 0.802601312 Rv2604c Rv2604c conserved hypothetical protein MT2680 177.299067 201.067498 158.857351 197.410842 0.938383783 −0.091750013 7.52230522 0.717244526 Rv2605c tesB2 thioesterase II MT2681 226.684167 253.460873 202.959134 222.858029 0.887209569 −0.172653169 7.82442039 0.372493132 Rv2606c Rv2606c conserved hypothetical protein MT2682 26.5198922 43.1634547 24.0968506 33.2530719 0.831158342 −0.266804748 4.99728223 0.242082344 Rv2607 pdxH pyridoxamine 5′-phosphate oxidase MT2683 90.0551815 96.5522142 104.116581 109.594631 1.145426474 0.195884854 6.64764005 0.311717327 Rv2608 PPE PPE-family protein MT2684 170.364537 170.572562 163.131132 177.505834 0.998474576 −0.002202402 7.41423557 0.996101743 Rv2609c Rv2609c conserved hypothetical protein MT2685 166.428723 169.758157 145.399487 179.223129 0.961160284 −0.057151059 7.36967049 0.852228223 Rv2610c Rv2610c glycosyltransferase MT2686 87.5250151 96.8236824 85.4756211 104.052453 1.025352062 0.036119354 6.54925266 0.90313325 Rv2611c Rv2611c conserved hypothetical protein MT2687 80.2156455 73.2964325 71.0175107 82.2740323 0.997941644 −0.002972641 6.26454468 0.994942526 Rv2612c pgsA CDP-diacylglycerol-glycerol-3- phosphate MT2688 126.50832 130.214279 111.84576 124.503872 0.91980712 −0.120596729 6.94771432 0.588744411 Rv2613c Rv2613c conserved hypothetical protein MT2689 326.766304 351.008471 289.435002 339.399898 0.925658184 −0.11448545 8.35239955 0.633618212 MT2690 145.812552 195.004706 164.767899 211.539495 1.106804774 0.146400772 7.48760715 0.501532816 Rv2615c PE_PGRS PE-family protein MT2691.1 36.1720084 39.0009412 35.3723581 32.5505422 0.902509636 −0.14798576 5.1676861 0.597495067 Rv2616 Rv2616 hypothetical protein MT2692 305.587874 114.559609 317.805634 132.700052 1.095510401 0.131603181 7.76690919 0.548791269 Rv2617c Rv2617c hypothetical protein MT2693 32.7984532 20.541099 44.3745777 29.438188 1.389520006 0.474586606 4.9979971 0.005202584 MT2694 14.8061589 13.482924 18.4590969 14.3628292 1.154243032 0.206947023 3.94954899 0.48870294 MT2695 432.658453 22.7128451 418.103091 25.8374807 1.029401596 0.041805924 7.81334745 0.894736554 MT2696 969.803406 57.9132306 941.595804 60.8078474 1.005606181 0.008065423 8.98764656 0.978929348 Rv2621c Rv2621c putative transcriptional regulator MT2697 383.741902 18.9122894 394.188104 20.2953021 1.043636152 0.061618826 7.67517007 0.839018102 MT2698 4312.34063 5498.77076 3530.32501 4058.59207 0.777317431 −0.363424227 12.0868586 0.062575211 Rv2623 Rv2623 conserved hypothetical protein MT2699 557.479994 830.692902 422.922461 539.933094 0.701936844 −0.510586863 9.19949817 0.00026945 Rv2624c Rv2624c conserved hypothetical protein MT2700 988.26425 1529.09027 795.741659 1013.12587 0.7302434 −0.453550681 10.0791232 0.006422352 Rv2625c Rv2625c conserved hypothetical protein MT2701 1383.34505 4454.25135 1016.06871 2760.55138 0.674508588 −0.568091283 11.2310689 0.000438697 Rv2626c Rv2626c conserved hypothetical protein MT2702 796.440153 1999.27331 522.492467 1351.58906 0.66603274 −0.586334998 10.18938 4.63E−05 Rv2627c Rv2627c conserved hypothetical protein MT2703 221.904953 325.490454 126.212938 208.963553 0.605084352 −0.724791818 7.78670213 1.96E−09 Rv2628 Rv2628 hypothetical protein MT2704 1135.0139 1692.15221 904.495747 1278.68209 0.775957195 −0.365951025 10.2908997 0.032203115 Rv2629 Rv2629 hypothetical protein MT2705 275.413297 377.612361 243.969246 280.777699 0.811040867 −0.302153483 8.20269832 0.072250354 Rv2630 Rv2630 hypothetical protein MT2707 260.044879 238.439629 230.784177 210.52473 0.885204223 −0.175917761 7.87722829 0.362195684 Rv2631 Rv2631 conserved hypothetical protein MT2708 108.047476 184.96038 99.0244163 119.8984 0.768173067 −0.380496712 7.00177318 0.019268685 Rv2632c Rv2632c conserved hypothetical protein MT2709 295.748338 408.831212 213.052532 287.566819 0.711749994 −0.490557519 8.23588953 0.000134624 Rv2633c Rv2633c hypothetical protein MT2710 5.06033278 7.87257979 6.63800036 7.88394427 1.126107367 0.171344385 2.81763096 0.721200634 MT2712 74.0307944 73.3869219 85.7484156 80.2445021 1.125218021 0.170204563 6.29518057 0.426477174 Rv2634c PE_PGRS PE_PGRS-family protein MT2714 32.1424841 39.7248566 37.6456459 36.2193083 1.030305406 0.043072049 5.19417153 0.903631866 Rv2636 Rv2636 hypothetical protein MT2715 35.04719 40.9012191 34.5539745 36.0631906 0.930887322 −0.103321545 5.20230052 0.738873933 Rv2637 dedA dedA family MT2716 74.8741831 66.781194 56.3775373 51.9871969 0.765650527 −0.385242056 5.9696494 0.017512436 Rv2638 Rv2638 conserved hypothetical protein MT2717 34.1103913 22.6223557 33.4627963 21.2320083 0.960914014 −0.057520755 4.8081227 0.873642922 Rv2639c Rv2639c conserved hypothetical protein MT2718 59.7868947 33.0286393 61.833428 34.6581313 1.041273786 0.058349452 5.56930003 0.864827105 MT2719 99.1450335 84.969568 106.571732 96.6368615 1.105559824 0.144777094 6.59999845 0.516663035 Rv2641 Rv2641 conserved hypothetical protein MT2720 56.2259198 38.729473 59.1054826 35.9070729 0.989693511 −0.014946275 5.57439531 0.969989124 Rv2643 arsC probable arsenical pump MT2721 48.6354206 29.7710201 41.8284954 28.6475995 0.907134461 −0.140611683 5.22410675 0.613920518 MT2722 15.0872885 9.04894228 16.0039461 10.8501807 1.120601315 0.164273091 3.69065635 0.637012172 MT2723 60.7779047 72.0295806 73.38173 60.7297886 0.875370001 −0.192035151 6.16780162 0.36632184 Rv2645 Rv2645 hypothetical protein MT2724 49.4788094 44.2493278 48.2846327 40.1222511 0.940912446 −0.087867612 5.51414986 0.779853341 Rv2646 Rv2646 phiRV2 integrase MT2725 30.0808671 18.0978846 31.5532346 22.0125969 1.123902481 0.163516861 4.67811769 0.553927263 MT2726 14.2438997 8.86796344 12.0029596 8.74259167 0.905461254 −0.143275187 3.4757314 0.716511707 MT2727 103.080853 64.7904267 107.390115 52.45555 0.922802196 −0.115906658 6.35892892 0.679317766 Rv2650c Rv2650c phiRV2 phage related protein MT2728 99.1450385 45.2447114 81.2927715 36.921838 0.818163904 −0.289538205 6.03983595 0.115557394 MT2729 7.96533853 7.69160094 7.36545245 8.89870938 1.040227832 0.056899544 3.02891969 0.905696211 Rv2652c Rv2652c phIRV2 phage related protein MT2730 3.56097492 4.16251345 1.45564408 3.82488386 1.066633462 0.093064494 2.06205673 0.891807837 Rv2653c Rv2653c phIRV2 phage related protein MT2732 14.8061589 13.3019452 14.4581104 11.4746516 0.91904767 −0.121788401 3.773592 0.745116768 Rv2655c Rv2655c phIRV2 phage related protein MT2733 13.4005109 10.1348154 11.8210965 8.27423854 0.850906445 −0.232927575 3.4682191 0.490434251 MT7734 98.5827793 83.6122267 94.2050462 72.1263813 0.908396718 −0.138605602 6.44781971 0.54870503 Rv2657c Rv2657c similar to gp36 of mycobacteriophage L5 MT2734.1 67.1899741 62.5281912 46.2841395 47.6159011 0.724653173 −0.464637425 5.80911959 0.003125161 MT2735 122.191376 111.030522 101.570499 81.9617969 0.783233232 −0.352486117 6.70561144 0.02272273 Rv2659c Rv2659c phIRV2 integrase MT2736.1 14.8998637 24.4321442 18.0044393 25.6033042 1.115827913 0.158114547 4.38739314 0.593366813 MT2737 22.1155234 19.7266942 24.0059191 23.027362 1.125659621 0.170770649 4.48520616 0.530550672 MT2738 21.8343938 29.4995518 28.0978371 21.7784203 0.97115794 −0.042222154 4.67083883 0.93032752 Rv2664 Rv2664 hypothetical protein MT2739 301.65206 137.99637 349.086074 199.830667 1.291871219 0.369462261 7.95012235 0.019607099 MT2740 7.30936957 4.79593941 8.45663059 6.63500261 1.255130183 0.327837009 2.80165776 0.380784281 MT2741 7.7779189 8.41551632 10.0933978 10.5379453 1.273331292 0.348607825 3.23132243 0.249583092 Rv2667 clpX′ similar to ClpC from M. leprae but shorter MT2742 53.5033336 58.7276354 56.3775373 53.6264328 0.980022248 −0.029113594 5.80048884 0.910326316 MT2743 21.9281087 23.0748028 19.7321381 19.5147136 0.871699591 −0.198097063 4.40826713 0.456184621 Rv2669 Rv2669 putative transcriptional regulator MT2744 16.4929365 26.2419326 18.1863024 28.0231237 1.082953102 0.114970767 4.48741589 0.720045953 Rv2670c Rv2670c conserved hypothetical protein MT2745 47.4171923 46.5115633 45.1020298 45.4302531 0.964022189 −0.052861742 5.53261846 0.878588917 Rv2671 ribD probable riboflavin deaminase MT2746 238.866449 331.100798 223.600587 234.134229 0.895852633 −0.158666665 8.07471246 0.457114027 Rv2672 Rv2672 putative exported protease MT2747 140.564799 192.109045 130.304856 175.632422 0.920477647 −0.119545407 7.32045656 0.604577867 Rv2673 Rv2673 potential membrane protein MT2748 116.387654 131.028684 110.118061 138.32029 1.000314001 0.000452936 6.95591305 0.999355608 MT2749 116.949913 87.4127825 97.023923 84.5377391 0.895153757 −0.159792586 6.59463589 0.481478708 Rv2675c Rv2675c putative methyltransferase MT2750 167.365821 143.787693 146.581597 122.942695 0.865407671 −0.208548186 7.18322107 0.266959219 Rv2676c Rv2676c conserved hypothetical protein MT2751 253.578898 167.133964 241.059438 143.784409 0.905011918 −0.143991304 7.6549412 0.505315094 Rv2677c hemY′ protoporphyrinogen oxidase MT2752 312.053855 202.696307 263.883247 176.647187 0.858323033 −0.220407381 7.90071338 0.207439757 Rv2678c hemE uroporphyrinogen decarboxylase MT2753 58.193827 72.3915383 62.1062225 70.7213219 1.019914968 0.028448877 6.045166 0.928752266 Rv2679 echA15 enoyl-CoA hydratase/isomerase superfamily MT2754 211.128329 266.219882 244.514835 314.108829 1.169065362 0.225355593 8.01783727 0.19487179 Rv2680 Rv2680 conserved hypothetical protein MT2755 151.903693 218.934403 176.407133 259.467631 1.173243374 0.230502313 7.65741282 0.183968871 Rv2681 Rv2681 conserved hypothetical protein MT2756 568.537759 473.983597 674.166228 595.43294 1.2204642 0.287429977 9.17544326 0.078398165 Rv2682c dxs 1-deoxy-D-xylulose 5-phosphate synthase MT2757 112.545549 147.226291 123.030335 167.202066 1.114653291 0.156595035 7.10531223 0.468836578 Rv2683 Rv2683 conserved hypothetical protein MT2758 132.786831 150.755378 133.396528 162.986888 1.042660332 0.060269247 7.18156185 0.828791613 Rv2684 arsA probable arsenical pump MT2759 122.666215 126.685192 137.12472 144.799175 1.130441104 0.17688583 7.055295 0.379503003 Rv2685 arsB probable arsenical pump MT2760 5.62259198 5.42936537 4.72843861 4.6054724 0.844995992 −0.242983596 2.39689026 0.617184719 Rv2686c Rv2686c possible membrane protein MT2761 3.09242559 2.53370384 2.72794535 2.81011875 0.989396409 −0.015379431 1.5685427 0.984096717 Rv2687c Rv2687c hypothetical protein MT2762 208.598152 128.223512 189.046613 132.543934 0.966943945 −0.048495838 7.36424107 0.873642922 Rv2688c Rv2688c similar to transport ATP-binding proteins MT2763 34.5789407 59.5420402 36.6453992 50.347961 0.940462705 −0.088557361 5.50668474 0.798287058 MT2764 74.5930536 120.169954 76.4734014 107.096748 0.953296968 −0.069002387 6.56637038 0.806836075 Rv2690c Rv2690c possible transport protein MT2765 102.518594 113.654715 91.2952378 104.833041 0.906572894 −0.141505069 6.6900321 0.521875569 Rv2691 trkA probable potassium uptake protein MT2766 111.514741 115.283525 102.116088 109.126278 0.931197134 −0.102841477 6.7772286 0.658063367 Rv2692 trkB probable potassium uptake protein MT2767 101.675205 104.243815 107.481047 107.721219 1.045069205 0.063598482 6.72052341 0.816959095 Rv2693c Rv2693c conserved hypothetical protein MT2768 246.550658 282.688957 269.248206 264.619516 1.010738597 0.015409928 8.05502916 0.961451501 MT2769 21.3658495 32.2142345 24.1877821 27.9450698 0.982951 −0.024808595 4.73391309 0.949768257 Rv2695 Rv2695 conserved hypothetical protein MT2770 331.170667 356.256858 307.166647 374.838618 0.988202637 −0.017121189 8.42013034 0.952431559 Rv2696c Rv2696c conserved hypothetical protein MT2771 172.332444 207.130289 147.490912 205.06061 0.921417692 −0.118072796 7.51718101 0.628146178 Rv2697c dut deOxyuridine triphosphatase MT2772 45.0744457 58.8181248 44.1927147 52.6897266 0.935686283 −0.095903191 5.65461475 0.756319422 Rv2698 Rv2698 conserved hypothetical protein MT2773 54.5391422 170.482073 57.74151 147.531234 0.949132136 −0.075319145 6.75195441 0.798636571 Rv2699c Rv2699c conserved hypothetical protein MT2774 150.872835 166.13858 140.580117 151.200001 0.92077451 −0.1190802 7.25146774 0.609343079 Rv2700 Rv2700 conserved hypothetical protein MT2775 31.3928052 26.7848692 25.0970972 23.7256583 0.927626242 −0.108384462 4.81638042 0.762826526 Rv2701c suhB putative extragenic suppressor protein MT2776 109.359414 108.22535 104.66217 112.170574 0.996303502 −0.0053428 6.76529634 0.985115966 Rv2702 ppgK polyphosphate glucokinase MT2777 2095.72745 2036.73593 2034.68351 2238.02541 1.032892648 0.046690318 11.0371847 0.89125591 Rv2703 sigA RNA polymerase sigma factor (aka MysA, RpoV) MT2777.1 189.38764 190.751703 197.412312 213.569025 1.080502959 0.111703023 7.62907538 0.626654945 Rv2704 Rv2704 concerved hypothetical protein MT2778 65.2220659 74.2918161 63.7429897 69.3162625 0.954496953 −0.067187502 6.09425333 0.819007221 Rv2705c Rv2705c hypothetical protein MT2779 509.500543 533.163679 561.956743 497.31296 1.014232864 0.020388927 9.03797522 0.948443219 MT2780 905.143598 1053.74933 1082.81244 1134.19515 1.134660294 0.182260433 10.0281242 0.431160055 Rv2707 Rv2707 conserved hypothetical protein MT2781 226.028137 269.296522 206.596395 214.505731 0.852870856 −0.229600794 7.84095939 0.197977006 Rv2708c Rv2708c conserved hypothetical protein MT2782 173.644382 126.775681 156.220337 119.8984 0.922182284 −0.116876145 7.17289349 0.619926139 Rv2709 Rv2709 conserved hypothetical protein MT2783 1897.06253 1150.20967 2367.03818 2104.07642 1.104939648 0.143967572 11.0564836 0.620935457 Rv2710 sigB RNA polymerse sigma factor (aka MysB) MT2784 598.618626 532.530253 610.877696 496.532372 0.975467847 −0.035804195 9.12878569 0.90313325 MT2785 94.0847057 80.5355863 95.3871558 73.1411464 0.960088624 −0.058760511 6.42546075 0.838597999 Rv2712c Rv2712c hypothetical protein MT2786 154.15273 122.070231 129.031815 102.491276 0.838324668 −0.254419013 6.98978546 0.116754925 Rv2713 Rv2713 probable dehydrogenase MT2787 237.835641 258.980728 264.428836 275.625814 1.08766347 0.121232246 8.01902661 0.584969964 Rv2714 Rv2714 conserved hypothetical protein MT2788 343.63408 388.74256 369.454732 409.262573 1.063852051 0.089297531 8.56207338 0.719637416 Rv2715 Rv2715 2-hydroxymuconic semialdehyde hydrolase MT2789 138.409473 136.36756 138.852419 129.733816 0.976861571 −0.033773959 7.08760466 0.904814009 Rv2716 Rv2716 conserved hypothetical protein MT2790 47.2297726 62.2567229 44.2836462 59.5589058 0.947513843 −0.077781074 5.74192816 0.801831984 Rv2717c Rv2717c conserved hypothetical protein MT2791 100.363267 138.267838 97.2967176 134.573465 0.97142147 −0.041830722 6.88034887 0.880856541 Rv2718c Rv2718c conserved hypothetical protein MT2792 63.7227091 79.0877556 67.5621132 92.5778011 1.115796723 0.15807422 6.24658845 0.490255942 Rv2719c Rv2719c conserved hypothetical protein MT2793 1007.66219 335.715759 714.176093 395.13392 0.912121896 −0.132701456 9.26048385 0.720596123 Rv2720 lexA LexA, 50S repressor protein MT2794 374.839465 463.667803 610.696033 708.149925 1.577205944 0.657371053 9.07558026 1.34E−07 Rv2721c Rv2721c conserved hypothetical protein MT2794.1 2.81129599 3.80055576 3.54632896 4.21517813 1.173193292 0.230440727 1.9177948 0.707679183 Rv2722 Rv2722 hypothetical protein MT2795 158.369674 217.808041 175.134092 201.391844 1.010109056 0.014511062 7.55733772 0.966783763 Rv2723 Rv2723 probable membrane protein, tellurium resistance MT2796 110.202803 255.904088 140.852912 267.819929 1.15281126 0.205156332 7.59918089 0.322355421 Rv2724c fadE20 acyl-CcA dehydrogenase MT2797 591.309256 683.5571 595.328608 738.046466 1.04272746 0.060362127 9.34927171 0.831756973 Rv2725c hfiX GTP-binding protein MT2798 187.607152 170.663051 192.229216 181.87713 1.044980089 0.063475454 7.51781794 0.814508736 Rv2726c dapF diaminopimelate epimerase MT2799 89.9614716 55.1080585 98.1151012 58.2319052 1.074197875 0.103259773 6.23864027 0.692332363 Rv2727c miaA tRNA [delta](2)- isopentenylpyrophosphate transferase MT2800 47.4171923 32.9381499 52.6493453 34.1897781 1.075055273 0.104410836 5.3909718 0.733038419 Rv2728c Rv2728c conserved hypothetical protein MT2801 245.894689 127.680576 243.332726 127.39205 0.993552639 −0.00933169 7.54090637 0.975497364 Rv2729c Rv2729c conserved hypothetical protein MT2801.1 3.27984532 3.52908749 3.91005501 3.66876615 1.110255618 0.150891871 1.91618902 0.81765154 Rv2730 Rv2730 hypothetical protein MT2802 162.774038 146.049928 183.681654 144.564998 1.057120059 0.080139235 7.31684217 0.76492809 Rv2731 Rv2731 hypothetical protein MT2802.1 101.206656 110.397096 92.8410735 102.959629 0.92506946 −0.112366398 6.67281766 0.636019999 Rv2732c Rv2732c conserved hypothetical protein MT2803 320.768872 342.050018 305.620811 330.188953 0.959055881 −0.060313216 8.34355941 0.819552181 Rv2733c Rv2733c conserved hypothetical protein MT2803.2 40.5763721 60.4469345 39.7370706 63.7698505 1.060338673 0.084525136 5.71647087 0.795267516 Rv2734 Rv2734 hypothetical protein MT2804 48.1668713 57.0083364 56.0138112 64.788849 1.149223828 0.200659811 5.82480107 0.365758936 Rv2735c Rv2735c hypothetical protein MT2805 89.8677618 77.3684565 107.117321 111.389985 1.310068623 0.389642384 6.59427757 0.014274156 Rv2736c recX regulatory protein for RecA MT2806 552.232242 413.355684 580.597703 551.251628 1.18392725 0.243580433 9.03490052 0.230822487 Rv2737c recA recombinase (contains intein) MT2807 34.2041012 34.2050018 28.3706317 34.5800724 0.918406919 −0.122794584 5.04519941 0.692019534 MT2808 10.4017952 7.69160094 7.00172641 9.75735677 0.931012217 −0.103127996 3.15264465 0.860243051 Rv2738c Rv2738c conserved hypothetical protein MT2808.1 81.5275837 103.972347 89.8403336 112.248632 1.090431292 0.124898869 6.60117981 0.591423487 Rv2739c Rv2739c glycosyltransferase MT2810 31.6739348 41.1441557 44.5564408 40.9028396 1.173865659 0.231267311 5.31559295 0.407201814 MT2812 177.767616 164.509771 197.230449 158.537533 1.034182313 0.048490537 7.44857702 0.875390859 Rv2741 PE_PGRS PE_PGRS-family protein MT2813 60.8177032 47.506947 57.923373 53.9386683 1.039179622 0.055445046 5.78710359 0.871382309 Rv2742c Rv2742c conserved hypothetical protein MT2814 169.802278 214.097974 219.599601 214.037378 1.136116021 0.184110171 7.67641825 0.420522227 Rv2743c Rv2743c conserved hypothetical protein MT2815 557.198855 602.659556 621.425951 637.506662 1.086112791 0.119173933 9.24049994 0.617543876 Rv2744c 35kd_ag 35-kd antigen MT2816 82.1835527 101.98158 97.9332382 110.531338 1.135388804 0.18318642 6.61975581 0.3766923 Rv2745c Rv2745c putative transcriptional regulator MT2817 50.4159081 30.8568932 59.6510717 46.8353125 1.334601386 0.416408907 5.55807284 0.030238778 Rv2746c pgsA3 CDP-diacylglycerol-glycerol-3- phosphate MT2818 20.0539114 17.2834798 20.8233162 22.7151266 1.169463064 0.225846297 4.3506222 0.420522227 Rv2747 Rv2747 conserved hypothetical protein MT2819 1416.04979 931.22665 1444.90172 1128.88715 1.112069975 0.15324757 10.2649512 0.555180056 Rv2748c ftsK chromosome partitioning MT2820 138.034633 102.976963 132.123487 112.951162 1.024027417 0.034254342 6.9270735 0.90313325 Rv2750 Rv2750 putative dehydrogenase MT2821 89.024373 89.5845286 74.5638396 85.6305631 0.895605262 −0.15906509 6.40729543 0.476182576 MT2822 402.390166 295.447966 382.912595 324.178422 1.02157994 0.030802101 8.45697275 0.911298733 Rv2752c Rv2752c conserved hypothetical protein MT2823 1175.30914 744.365992 949.77964 700.187922 0.871733548 −0.198040863 9.80181742 0.380784281 Rv2753c dapA dihydrodipicolinate synthase MT2824 47.8857417 71.486644 49.0120848 52.45555 0.862719295 −0.213036872 5.79142303 0.431856887 Rv2754c Rv2754c conserved hypothetical protein MT2825 8.15275837 7.51062209 8.18383606 7.41559115 0.995548841 −0.0006435999 2.99786747 0.989881476 MT2826 40.5763721 37.7340893 49.8304684 47.1475479 1.238681997 0.308805856 5.45953625 0.111098322 Rv2756c hsdM type I restriction/modification system DNA MT2827 21.3658495 18.5503317 23.6421931 23.8079505 1.191857554 0.253211821 4.4609133 0.298568475 Rv2757c Rv2757c conserved hypothetical protein MT2828 24.0834356 17.3739692 18.4590959 20.9978318 0.962126162 −0.05570201 4.35076952 0.90313325 MT2829 22.6777876 18.9122894 23.5512615 22.4028912 1.108581906 0.148715366 4.46351969 0.617184719 Rv2759c Rv2759c conserved hypothetical protein MT2830 17.523745 14.6592865 19.004685 16.0020651 1.087907802 0.121556296 4.08488124 0.721200634 Rv2760c Rv2760c conserved hypothetical protein MT2831 121.729116 109.401712 107.571978 123.879402 1.001085556 0.001522042 6.85580158 0.997032163 Rv2761c Rv2761c hypothetical protein MT2832 17.2426154 21.1745249 20.1867956 24.5885391 1.165558789 0.221021774 4.39141062 0.380784281 Rv2762c Rv2762c hypothetical protein MT2833 113.482648 144.330629 112.118554 141.598762 0.984448509 −0.022612346 7.00075425 0.934082845 Rv2763c dfrA dihydrofolate reductase MT2834 401.921616 445.750897 385.367747 419.800518 0.950229544 −0.073652032 8.69135036 0.776070416 Rv2764c thyA thymidylate synthase MT2835 15.8369674 40.2677932 18.9137545 33.2530719 0.970366911 −0.043397738 4.76891084 0.916845409 Rv2765 Rv2765 hypothetical protein MT2836 85.3696832 106.958438 65.379757 73.9217349 0.726670816 −0.460626128 6.37636839 0.001128435 Rv2766c fabG5 3-oxoacyl-[ACP] reductase MT2837 10.2143754 22.8033346 4.81937012 6.71306146 0.358446923 −1.480168586 3.49749824 7.73E−12 MT2838 92.3042183 156.094254 42.9196736 53.6264328 0.397690542 −1.330281844 6.43277182 1.63E−21 Rv2768c PPE PPE-family protein MT2839 32.4236137 88.6796344 18.7318914 26.6961281 0.409860945 −1.28679357 5.38514347 3.82E−09 Rv2769c PE PE-family protein MT2840 152.559662 161.252152 160.221324 173.368715 1.062696643 0.087729825 7.34012981 0.734697142 Rv2770c PPE PPE-family protein MT2841 65.0346472 78.8162873 59.5601402 74.5462058 0.931149942 −0.102914593 6.12248059 0.706501579 Rv2771c Rv2771c hypothetical protein MT2842 85.8382375 87.5032719 87.0214568 81.2740323 0.976085378 −0.03492075 6.42345132 0.90313325 Rv2772c Rv2772c hypothetical protein MT2843 139.346571 156.546702 139.125213 141.989056 0.951236493 −0.072124032 7.17419862 0.797346562 Rv2773c dapB dihydrodipicolinate reductate MT2844 16.4929365 17.6454375 15.0036994 16.7826537 0.931218826 −0.10280787 4.05814977 0.767312271 Rv2774c Rv2774c hypothetical protein MT2845 57.1630184 84.4266315 54.013318 90.1579766 1.007622402 0.010955102 6.16260183 0.974110692 Rv2775 Rv2775 hypothetical protein MT2846 145.344003 141.434968 128.940884 127.079815 0.89283678 −0.163531636 7.08609015 0.436488273 MT2847 381.118026 318.884726 321.897552 310.049769 0.906191488 −0.142112156 8.38005671 0.519306729 Rv2777c Rv2777c hypothetical protein MT2848 236.992252 267.848692 226.055738 237.455034 0.919376221 −0.121272743 7.92042939 0.587717543 Rv2778c Rv2778c conserved hypothetical protein MT2849 103.455692 64.3379796 70.4719216 51.5969026 0.737566799 −0.439154379 6.18223929 0.004515496 Rv2779c Rv2779c transcriptional regulator (Lrp/AsnC family) MT2850 2252.41035 1200.07073 2689.29946 1016.24822 1.00585948 0.008428772 10.8054619 0.982772325 Rv2780 aid L-alanine dehydrogenase MT2851 169.989697 169.848647 199.6856 178.988953 1.112512855 0.153822007 7.49028338 0.484283855 Rv2781c Rv2781c probable oxidoreductase MT2852 562.352907 286.670492 669.074054 468.118949 1.39260389 0.477784958 8.95629832 0.003968675 MT2853 1644.79557 1061.89338 1984.03466 1520.43036 1.314073901 0.394046412 10.6008057 0.025323008 Rv2783c gpsI pppGpp synthase and polyribonucleotide phosphoryfase MT2854 216.657211 215.455316 247.879301 234.722975 1.116366939 0.158811305 7.83830016 0.426056587 Rv2784c lppU lipoprotein MT2855 1830.34111 1430.18533 1703.51094 1632.75705 1.030770571 0.043723253 10.6877005 0.898938436 MT2856 208.035903 181.431293 208.869683 193.664017 1.03510473 0.049916114 7.63062086 0.859911201 Rv2786c ribF riboflavin kinase MT2857 32.9858729 65.2428739 33.0990703 51.1285495 0.878973165 −0.186103974 5.51733408 0.499431176 Rv2787 Rv2787 conserved hypothetical protein MT2858 88.274694 80.897544 87.9307719 75.8732063 0.966628081 −0.048967189 6.38220505 0.870656307 Rv2788 sirR iron-dependent transcriptional repressor MT2859 266.41715 242.149696 245.696945 242.372742 0.960816952 −0.057666489 7.96192422 0.830576393 Rv2789c radE21 acyl-CoA dehydrogenase MT2860 244.301621 211.202313 224.055245 218.486733 0.974051005 −0.037930776 7.8117539 0.694736554 Rv2790c ltp1 non-specific lipid transport protein MT2861 505.564729 572.436089 475.026217 564.833869 0.962953081 −0.054462589 9.04888417 0.847554093 Rv2791c Rv2791c transposase MT2862 152.747082 136.729518 149.400474 144.174704 1.015583384 0.022308696 7.18920304 0.938478232 Rv2792c Rv2792c resolvase MT2862.1 150.872835 91.5752959 135.215405 108.267631 1.031080004 0.044156279 6.92952642 0.89125591 Rv2793c truB tRNA pseudouridine 55 synthase MT2863 185.076936 118.179186 164.586036 136.446877 1.012013549 0.017228605 7.24067885 0.959550862 Rv2794c Rv2794c conserved hypothetical protein MT2864 308.58659 232.286348 288.70755 242.763037 0.988610655 −0.01652564 8.06745092 0.955286813 Rv2795c Rv2795c hypothetical protein MT2865 34.1103913 46.9640104 36.1907417 50.1918432 1.065053841 0.090926364 5.39420263 0.76492809 Rv2796c lppV lipoprotein MT2866 34.1103913 47.9593941 40.3735912 47.3036656 1.076309636 0.106093177 5.41354008 0.740445414 Rv2797c Rv2797c conserved hypothetical protein MT2867 35.3286196 36.376748 35.008632 34.7361901 0.972473516 −0.040269134 5.15125929 0.90313325 Rv2798c Rv2798c conserved hypothetical protein MT2867.1 115.263136 113.021289 104.207513 104.442747 0.914107894 −0.129563635 6.77354653 0.547623335 Rv2799 Rv2799 hypothetical protein MT2868 187.044893 192.742471 188.955681 176.959422 0.962917888 −0.054500333 7.5437901 0.852001416 Rv2800 Rv2800 conserved hypothetical protein MT2869 41.326051 36.0147903 35.7360841 36.1412495 0.931854847 −0.101822848 5.22792709 0.745126768 Rv2801c Rv2801c conserved hypothetical protein MT2870 108.047476 90.2179546 96.1146079 90.0018589 0.941911201 −0.086337039 6.5889442 0.745984651 Rv2802c Rv2802c hypothetical protein MT2871 27.1758612 39.815346 33.2809333 33.4872485 1.008452365 0.012142939 5.07118234 0.97711178 MT2873 6.09114131 8.3250269 7.00172641 6.40082604 0.928700413 −0.106714818 2.8334909 0.82411886 Rv2806 Rv2806 hypothetical protein MT2874 2.43645652 2.62419326 3.0916714 2.41982448 1.080924361 0.112265572 1.49369619 0.89125591 MT2875 38.514755 44.7017749 37.6456459 45.4302531 0.997355913 −0.003819663 5.38389968 0.99240563 Rv2808 Rv2808 hypothetical protein MT2876 103.643112 74.2918161 97.2967176 85.4744453 1.038151482 0.05401697 6.49739679 0.867153389 Rv2809 Rv2809 hypothetical protein MT2878 4.40436371 2.08125673 5.00123315 2.10758906 1.088205301 0.121950762 1.82991409 0.870054573 MT2879 3.84210452 2.26223557 4.72843861 2.02953021 1.08668065 0.119928029 1.75443318 0.877628603 Rv2812 Rv2812 low similarity to transposases MT2880 2.53016639 0.99538365 3.18260291 1.0147651 1.175435968 0.23319595 1.06206624 0.793710095 Rv2813 Rv2813 probable general secretion pathway protein MT2881 9.93324582 9.13943171 9.91153478 11.0843573 1.102994239 0.141425256 3.35029862 0.740705091 Rv0796 Rv0796 possible IS6110 transposase MT2882 9.08985703 8.59649517 8.36569908 9.13288594 0.991200823 −0.012750709 3.16568199 0.978929348 MT2883 7.68420903 7.96306921 5.81961675 7.49365 0.851562915 −0.231814972 2.89086675 0.572054672 MT2884 10.5892149 14.6592865 10.4571239 15.2214766 1.015792491 0.022605715 3.69162296 0.958935651 Rv2817c Rv2817c conserved hypothetical protein MT2885 37.858736 38.5484941 28.8252892 34.814249 0.831371609 −0.266434614 5.13693777 0.240570157 MT2886 37.9524958 40.9012191 29.6436728 48.708725 0.971843015 −0.041204806 5.30350638 0.920687641 Rv2819c Rv2819c hypothetical protein MT2887 16.0243871 21.0840355 14.7309049 17.7193599 0.875834342 −0.191270075 4.13486753 0.508237044 Rv2820c Rv2820c hypothetical protein MT2888 7.59049917 14.3878182 7.91104152 14.9092412 1.038557269 0.054580772 3.51070824 0.90313325 Rv2821c Rv2821c conserved hypothetical protein MT2889 5.99713144 11.2206884 5.27402768 10.4598865 0.911876079 −0.133090314 3.07580514 0.767312271 MT2890 41.7008905 51.6694604 37.5547144 49.801549 0.933033467 −0.099999265 5.50350776 0.745116768 Rv2823c Rv2823c conserved hypothetical protein MT2891 27.8318303 26.7848692 26.824796 23.4176563 0.917938401 −0.123530752 4.72155347 0.69018019 Rv2824c Rv2824c hypothetical protein MT2892 101.956335 70.6722392 92.2954844 60.8078474 0.883179699 −0.179221085 6.35030277 0.386355369 MT2893 106.548118 42.2585605 100.206526 49.4893136 1.042125567 0.05952912 6.22445352 0.857528568 Rv2826c Rv2826c hypothetical protein MT2894 206.536545 115.464504 201.595162 121.537636 1.012758163 0.018289714 7.33484492 0.950509824 Rv2827c Rv2827c hypothetical protein MT2895 5.24775251 5.33887595 4.81937012 4.13711927 0.843233362 −0.245996147 2.33733513 0.619926139 MT2895.1 82.2772626 62.6186806 63.0167708 52.7677854 0.834535523 −0.260954634 6.05700796 0.169999787 Rv2825c Rv2825c conserved hypothetical protein MT2896 163.804846 170.120115 166.677461 148.311823 0.94168813 −0.086678751 7.34339648 0.75056169 Rv2829c Rv2829c conserved hypothetical protein MT2897 50.3844574 61.8042758 58.7417566 56.4365516 1.024751093 0.035273529 5.83651694 0.917488009 Rv2831 echA16 enoyl-CoA hydratase/isomerate superfamily MT2898 19.7727818 25.6989961 17.9135078 20.4514198 0.845516557 −0.242095089 4.40153554 0.327313667 Rv2832c ugpC sn-glycerol-3-phosphate transport ATP- binding MT2899 16.4929365 19.0932682 14.2762474 18.3438307 0.915500555 −0.127367335 4.10704555 0.708533073 Rv2833c ugpB sn-glycerol-3-phosphate-binding periplasmic MT2900 13.9627701 16.6500538 13.1850692 16.0020651 0.953334392 −0.068945752 3.91941256 0.862316016 Rv2834c ugpE sn-glycerol-3-phosphate transport system protein MT2901 19.0231029 14.5687971 18.2772339 15.4556531 1.007942993 0.011414046 4.08748555 0.97711178 Rv2835c ugpA sn-glycerol-3-phosphate permease MT2902 137.284954 85.9649517 126.30387 99.3689214 1.029305968 0.041671896 6.81244082 0.894346121 Rv2836c dinF DNA-damage-inducible protein F MT2903 520.089758 335.396738 504.397096 344.161488 0.96670622 −0.004811291 8.73571165 0.986258409 Rv2837c Rv2837c conserved hypothetical protein MT2904 512.686678 337.435058 505.033616 340.570781 0.997033849 −0.00428561 8.72823055 0.988617034 Rv2838c rbfA ribosome-binding factor A MT2905 1849.73905 1338.97199 2014.67857 1461.02757 1.090160669 0.124540777 10.7024061 0.636705647 Rv2839c lnfB initiation factor IF-2 MT2906 806.841949 591.257889 845.753991 676.770266 1.095283464 0.131304294 9.51239462 0.591535558 MT2907 226.590457 202.515328 282.160481 256.969748 1.256990389 0.329973619 7.92028784 0.012272273 Rv2841c nusA transcription termination factor MT2908 202.413311 184.598423 283.706317 248.461333 1.373511807 0.457869312 7.84534495 0.000367056 Rv2842c Rv2842c conserved hypothetical protein MT2909 117.137333 98.3620026 111.391102 101.008157 0.988067434 −0.017318588 6.743425 0.952431559 Rv2843 Rv2843 hypothetical protein MT2910 130.069294 122.703657 129.213678 128.484874 1.020010282 0.028583695 6.99767203 0.918108429 Rv2844 Rv2844 hypothetical protein MT2911 173.456953 193.466386 198.594422 198.581725 1.083716019 0.115986757 7.57897137 0.626654945 Rv2845c proS prolyl-tRNA synthase MT2912 1054.14229 746.447249 1240.76048 1053.32618 1.288638174 0.365847238 9.99978195 0.038123605 Rv2846c efpA putative efflux protein MT2913 97.9268102 68.3195142 94.8415668 72.9069698 1.015663293 0.022422207 6.38652929 0.940001112 Rv2847c cysG2 multifunctional enzyme, siroheme synthase MT2914 118.636691 55.650995 114.482773 69.7065568 1.09396957 0.129572608 6.48825393 0.632483493 Rv2848c cobB cobyrinic acid a,c-diamide synthase MT2915 97.2708412 53.6602277 82.8386072 62.3690245 0.990935208 −0.013137364 6.2132621 0.973097519 Rv2849c cobA cob(l)alamin adenosyltransferase MT2916 408.293837 238.439629 364.362563 241.357977 0.949873791 −0.074192259 8.29126155 0.788284075 MT2917 195.103912 141.615947 181.681161 148.311823 0.987094864 −0.018739355 7.38235756 0.950509824 Rv2851c Rv2851c conserved hypothetical protein MT2918 455.33624 327.481221 404.19057 314.421065 0.923033879 −0.115544494 8.55274296 0.614602544 Rv2852c Rv2852c conserved hypothetical protein MT2919 44.5121855 48.3213518 56.0138112 51.0504906 1.152036778 0.204186774 5.64826047 0.414134607 Rv2853 PE_PGRS PE_PGRS-family protein MT2921 50.0410686 60.8088921 48.4664958 57.3732578 0.955562201 −0.065578309 5.76428983 0.833112946 Rv2854 Rv2854 hypothetical protein MT2922 74.8741831 90.6704017 68.3804968 80.0103255 0.897344089 −0.156266798 6.29758967 0.476182576 Rv2855 gorA glutathione reductase homologue MT2923 78.4351581 91.6657853 67.5621132 80.9470318 0.872436214 −0.196878438 6.31885469 0.322018463 Rv2856 nicT probable nickel transport protein MT2924 7.2156597 4.61496056 7.09265792 5.93247292 1.112451377 0.15374228 2.67474892 0.764687847 MT2925 117.512172 125.237361 108.026636 129.031286 0.973984529 −0.038029239 6.90848512 0.894346121 MT2926 125.85235 132.295536 118.392828 131.997522 0.969129761 −0.045238247 6.99223452 0.876498775 MT2927 68.1270728 62.70917 60.1966608 71.736087 1.00676371 0.009725119 6.04161752 0.977735627 Rv2859c Rv2859c conserved hypothetical protein MT2928 94.3658353 90.8513805 93.3866626 95.6220964 1.020784903 0.029678897 6.55049103 0.918339426 Rv2860c glnA4 proable glutamine synthase MT2929 409.043566 376.707467 417.830297 436.348995 1.087831979 0.121455743 8.68005044 0.600343889 Rv2861c map methionine aminopeptidase MT2930 39.6392734 33.4810864 37.6456459 34.1897781 0.984562678 −0.022445043 5.18625412 0.948920342 Rv2862c Rv2862c conserved hypothetical protein MT2933 105.23618 118.631633 122.393815 167.514301 1.28346571 0.360044752 7.00720955 0.022616024 MT2934 50.6033278 26.965848 50.7397836 31.1454828 1.070949382 0.098890293 5.32270654 0.749160651 MT2935 713.413212 485.747222 720.995957 490.443781 1.010150268 0.014569921 9.23556102 0.964244862 Rv2867c Rv2867c hypothetical protein MT2936 819.211651 800.650413 807.744619 711.272279 0.935907365 −0.095562355 9.61634409 0.733038419 Rv2868c gcpE essential gene of unknown function MT2937 230.151432 233.372222 231.147903 215.520496 0.962978083 −0.054425132 7.83111823 0.840411204 Rv2869c Rv2869c probable integral membrane protein MT2938 260.794558 191.747087 235.239821 173.680951 0.90388396 −0.145790522 7.75171635 0.479908014 Rv2870c Rv2870c conserved hypothetical protein MT2939 35.7034591 37.9150682 36.3726047 42.1517813 1.065521235 0.091559345 5.25621333 0.76492809 MT2940 40.1078228 118.903102 46.6478655 117.400517 1.062580409 0.087572019 6.33943825 0.761658278 Rv2873 mpt83 surface lipoprotein Mpt83 MT2941 11.245184 10.3157942 11.4573705 13.4261129 1.155874602 0.208922484 3.56018826 0.548791269 MT2942 41.9820201 49.226246 35.7360841 46.8353125 0.901929206 −0.148913896 5.44712151 0.580968556 MT2943 17.0551957 58.8181248 17.1860557 53.3141974 0.944997036 −0.081618291 5.20184466 0.806148616 Rv2875 mpt70 major secreted Immunogenic protein Mpt70 precursor MT2944 27.7381204 16.1976067 34.644906 20.8417141 1.265861448 0.340119506 4.64497453 0.09796298 MT2945 97.9268102 53.8412066 98.1151012 61.1981417 1.064381101 0.090014799 6.28407757 0.745155862 Rv2877c Rv2877c possible mercury resistance transport system MT2946 159.025643 119.988975 159.766666 121.225401 1.00744828 0.010705776 7.13099915 0.973097519 Rv2878c mpt53 secreted protein Mpt53 MT2947 444.465896 333.90597 406.554789 351.030667 0.980445281 −0.02849098 8.58555201 0.921052928 Rv2879c Rv2879c conserved hypothetical protein MT2948 320.206613 292.190346 314.895825 291.237585 0.990055943 −0.014418048 8.25174079 0.961758558 Rv2881c cdsA phosphatidate cytidylyltransferase MT2949 260.138539 221.246639 248.788616 207.402376 0.946879404 −0.078747401 7.87381743 0.757308533 Rv2882c frr ribosome recycling factor MT2950 275.975556 206.94931 239.240807 194.522665 0.90248586 −0.148023766 7.84131293 0.476182576 MT2951 544.360613 381.593896 489.120602 413.477751 0.986464848 −0.019660452 8.83701174 0.94941324 Rv2883c pyrH uridylate kinase MT2952 31.6739348 44.9732431 36.1907417 51.909138 1.148730261 0.200040071 5.37092284 0.389888324 MT2953 124.821542 97.4571084 130.122993 118.493341 1.125311149 0.170323963 6.88140313 0.412841331 Rv2885c Rv2885c transposase MT2954 14.5250293 10.5872625 14.6399734 9.99153334 0.977674739 −0.032573517 3.65515737 0.938478232 Rv2886c Rv2886c resolvase MT2955 99.3324582 84.3361421 105.571485 114.668457 1.202357005 0.265865326 6.6605129 0.183721813 Rv2887 Rv2887 transcriptional regulator (MarR family) MT2956 511.70958 391.638222 490.666437 439.627467 1.037308127 0.052844503 8.84106554 0.860113777 Rv2888c amiC putative amidase MT2957 438.937014 349.108193 449.2926 332.17615 1.058480638 0.081994879 8.66195262 0.74702628 Rv2889c tsf elongation factor EF-Ts MT2958 479.794515 507.736152 500.941698 532.907798 1.046827549 0.066023797 8.981638 0.806148616 Rv2890c rpsB 30S ribosomal protein S2 MT2958.1 4.02952425 2.53370384 4.81937012 3.27847188 1.237082886 0.306942166 1.93925981 0.572054672 MT2959 47.3234825 42.9824758 49.8304684 45.5863709 1.056755723 0.079641926 5.54240819 0.801831984 Rv2892c PPE PPE-family protein MT2960 10.9640544 4.3434923 12.0938911 7.72782657 1.34524703 0.427871122 3.16154912 0.202085662 MT2621 14.8061589 14.11635 15.276594 14.2847703 1.021691975 0.030960311 3.88704808 0.937048156 Rv2893 Rv2893 similar to alkanal monooxygenase alpha chain MT2962 286.564771 242.240185 396.916049 298.575117 1.306843413 0.386086287 8.25855889 0.007266187 Rv2894c xerC integrase/recombinase MT2963 237.92935 273.549525 219.508669 240.265153 0.900028516 −0.151957383 7.9247453 0.454084488 Rv2895c viuB similar to proteins involved in vibriobactin uptake MT2964 17.6174549 18.9122894 15.64022 15.4556531 0.850727617 −0.233230806 4.09396776 0.386187689 Rv2896c Rv2896c conserved hypothetical protein MT2965 9.55840636 6.87719613 10.0933978 4.52741354 0.860175198 −0.217297562 2.98462835 0.629689153 Rv2897c Rv2897c conserved hypothetical protein MT2966 30.0808671 21.5364826 23.278467 19.2024781 0.828736206 −0.271015143 4.56593519 0.245722863 Rv2898c Rv2898c conserved hypothetical protein MT2967 70.3761096 57.0988258 68.6532914 53.6264328 0.95744163 −0.062743559 5.96817431 0.836979867 Rv2899c fdhD affects formate dehydrogenase-N MT2968 666.089729 436.249507 653.888501 463.201241 1.020782377 0.029675328 9.11639312 0.917923192 Rv2900c fdhF molybdopterin-containing oxidoreductase MT2969 487.666144 341.416592 493.758109 419.878577 1.115550636 0.157756001 8.76769107 0.484283855 Rv2901c Rv2901c hypothetical protein MT2970 558.979352 370.554187 615.515403 477.486011 1.190824672 0.251961017 8.98243364 0.167258959 Rv2902c rnhB ribonuclease HII MT2971 1076.1641 933.488886 1253.2181 1091.49696 1.166889681 0.222668174 10.08848 0.282184031 Rv2903c lepB signal peptidase I MT2972 999.228304 861.278326 1052.35039 932.334954 1.067725902 0.094541338 9.90909901 0.738117508 Rv2904c rplS 50S ribosomal protein L19 MT2973 745.087147 740.293968 409.646461 554.373983 0.641917356 −0.639540526 9.2586067 3.47E−05 Rv2905 lppW Slight similarity to beta-lactamase MT2974 51.3530067 65.3333633 47.8299752 68.535674 0.990897461 −0.013192321 5.86916932 0.972119393 Rv2906c trmD tRNA (guanine-N1)-methyltransferase MT2975 49.8536489 52.1219076 43.3743311 58.1538464 0.988288137 −0.016996372 5.67414523 0.967251048 MT2976 36.8279774 50.8550556 40.4645227 51.8310792 1.056338892 0.079072751 5.49769015 0.803788741 Rv2908c Rv2908c conserved hypothetical protein MT2977 270.446674 344.402743 325.080155 412.384927 1.199673471 0.262641784 8.40203606 0.096693623 Rv2909c rpsP 30S ribosomal protein S16 MT2978 16.5866453 21.8079509 15.7311515 22.5590089 0.994658131 −0.007727345 4.27495096 0.983783004 MT2979 63.9101288 88.2271873 70.1081956 94.8415078 1.085484798 0.118339522 6.31220517 0.619926139 Rv2911 dacB penicillin binding protein MT2980 34.8600703 32.0332557 31.8260291 31.5357771 0.948332842 −0.076534536 5.0328325 0.812642214 Rv2912c Rv2912c transcriptional regulator (TetR/AcrR family) MT2981 94.2721255 91.6657853 75.6550178 78.136913 0.827330096 −0.273465031 6.4111173 0.100742188 Rv2913c Rv2913c probable D-amino acid aminohydrolase MT2982 122.291376 150.755378 129.94113 141.286526 0.99711008 −0.00417531 7.09009461 0.988617034 Rv2914c pknI serine-threonine protein kinase MT2983 7.30936957 9.5013894 6.00147978 10.2257099 0.958960093 −0.060457316 3.07883257 0.90313325 MT2984 393.394019 549.994712 418.194023 495.049253 0.977743366 −0.032472252 8.85903877 0.91003342 Rv2916c ffh signal recognition particle protein MT2985 46.7612233 101.438643 39.4642761 76.029324 0.791526737 −0.337290011 6.04687782 0.057144453 Rv2917 Rv2917 conserved hypothetical protein MT2986 317.863856 182.607655 395.279282 193.820135 1.150241017 0.20193619 8.09036057 0.313261553 Rv2918c glnD uridylyltransferase MT2987 226.590457 151.750762 268.157028 153.775943 1.09634004 0.132695333 7.64549323 0.562031833 Rv2919c glnB nitrogen regulatory protein MT2988 68.7830418 40.0868143 143.217131 64.3204959 1.839243145 0.879112214 6.30863918 3.07E−10 MT2989 294.24898 241.335291 264.337905 215.364379 0.89537715 −0.159432593 7.98860102 0.421550226 Rv2921c ftsY cell division protein FtsY MT2990 330.420988 457.514522 310.712976 437.754054 0.948625407 −0.076089586 8.58604226 0.764687847 Rv2922c smc member of Smc1/Cut3/Cut14 family MT2991 19.8664917 20.4506096 18.7318914 18.6560662 0.927095831 −0.109209622 4.29274121 0.745116768 MT2992 23.3337567 27.5087845 23.1875355 26.0716573 0.969414348 −0.04481466 4.65562153 0.900323347 Rv2923c Rv2923c conserved hypothetical protein MT2994 55.6636606 49.3167354 56.4684688 44.1813115 0.953910942 −0.068073514 5.68855236 0.832553638 Rv2924c fpg formamidopyrimidine-DNA glycosylase MT2995 368.560904 263.41471 355.633143 266.414869 0.987753144 −0.017777562 8.29309968 0.950934337 Rv2925c rnc RNAse III MT2996 415.884387 272.73512 387.095446 297.638411 1.007385816 0.010616323 8.42417483 0.973114765 MT2997 804.780332 751.967104 909.496981 853.963865 1.132874365 0.179987876 9.69736647 0.412841331 Rv2927c Rv2927c conserved hypothetical protein MT2998 68.9704616 121.074848 67.3802502 114.590398 0.96076385 −0.057746226 6.54223452 0.839018102 Rv2928 tesA thioesterase MT2998.1 60.6302835 97.0046613 64.4704418 110.219102 1.101124952 0.13897819 6.37992235 0.541162389 Rv2929 Rv2929 hypothetical protein MT2999 1593.53628 1400.14284 1724.60705 1440.81033 1.05531976 0.077680199 10.5886626 0.800608216 Rv2930 fadD26 acyl-CoA synthase MT3000 2807.92243 1774.40709 2965.82219 2021.80238 1.097005786 0.133571135 11.2243939 0.623595316 Rv2931 ppsA phenolpthiocerol synthesis (pksB) MT3002 856.414458 648.356715 823.112044 640.082604 0.974067685 −0.03790607 9.53557802 0.900501119 MT3003 1286.54275 1450.72643 1035.0734 1319.03852 0.855351303 −0.225411021 10.3140428 0.306839725 Rv2933 ppsC phenolpthiocerol synthesis (pksD) MT3004 1418.67357 1388.83166 1193.74889 1222.24554 0.860547229 −0.216673722 10.3509889 0.318868558 Rv2934 ppsD phenolpthiocerol synthesis (pksE) MT3005 2176.41154 1446.11147 2000.22046 1467.19422 0.965587664 −0.05052085 10.7916878 0.880578033 Rv2935 ppsE phenolpthiocerol synthesis (pksF) MT3006 408.481307 299.610479 403.463118 324.724833 1.034458724 0.48876081 8.48879264 0.864375748 Rv2936 drrA similer daunorubicin resistance ABC- transporter MT3007 189.949899 138.358328 200.231189 155.102943 1.086750912 0.120021306 7.41851381 0.607715214 Rv2937 drrB similar daunorubicin resistance transmembrane MT3008 241.490325 164.871728 223.964314 181.564895 1.009953981 0.014189557 7.66632131 0.966783763 Rv2938 drrC similar daunorubicin resistance transmembrane MT3009 326.391454 305.039844 305.166154 287.724937 0.939099739 −0.090649705 8.25857281 0.719637416 Rv2939 papA5 PKS-associated protein, unknown function MT3010 4391.99401 2218.52918 3900.77999 2279.55272 0.955230598 −0.066079045 11.642893 0.849425114 Rv2940c mas mycocerosic acid synthase MT3011 937.192373 840.918206 888.946459 822.428088 0.963153804 −0.054161897 9.76908059 0.862436015 Rv2941 fadD28 acyl-CoA synthase MT3012 1872.13571 1111.84354 1729.88108 1247.45855 1.018063117 0.025827007 10.5415713 0.938478232 Rv2942 mmpL7 conserved large membrane protein MT3014 3.46726505 4.79593941 3.0916714 3.04429531 0.741777571 −0.430941448 1.91443057 0.385970978 MT3015 31.1116756 46.3305845 38.1003034 45.0399589 1.084987899 0.117678952 5.33385759 0.707679183 Rv2943 Rv2943 hypothetical protein MT3016 41.8883102 55.3795268 39.7370706 44.5716057 0.871386155 −0.198615903 5.51001841 0.431434762 Rv2944 Rv2944 hypothetical protein MT3017 77.3106397 109.039755 63.8339213 99.1347448 0.868132165 −0.204013398 6.45147587 0.308884338 Rv2945c lppX lipoprotein MT3018 545.578841 521.309565 465.933066 448.994519 0.857647365 −0.221543511 8.9530971 0.219545748 Rv2946c pks1 polyketide synthase MT3021 587.279732 417.789665 521.128494 427.684462 0.952906595 −0.069593289 8.93261347 0.802899283 Rv2948c fadD22 acyl-CoA synthase MT3021.1 99.1450335 63.6140642 81.8383606 57.2171401 0.86061611 −0.216558248 6.24049655 0.27878362 Rv2947c pks15 polyketide synthase MT3022 450.182198 327.028774 410.010187 355.948375 0.99540007 −0.006651607 8.59230886 0.982495673 MT3023 2266.1857 1732.60098 2026.13595 1632.05452 0.917696961 −0.123910265 10.9026819 0.642667394 Rv2950c fadD39 acyl-CoA synthase MT3024 4.68549331 3.43859807 2.18235628 3.20041302 0.671035413 −0.575539191 1.82657024 0.245280902 MT3025 192.011516 239.163545 168.768886 234.566857 0.929182665 −0.105965856 7.70606554 0.655440987 Rv2951c Rv2951c putative oxidoreductase MT3026 268.759896 358.338114 247.151849 324.25648 0.912143829 −0.132666765 8.22790131 0.536497011 Rv2952 Rv2952 glycosyltransferase MT3027 202.132132 285.856087 198.776285 282.02664 0.985024323 −0.021768745 7.92116613 0.937243401 Rv2953 Rv2953 conserved hypothetical protein MT3028 274.382488 306.759143 341.902484 397.007332 1.270028151 0.344860476 8.36721213 0.017143152 Rv2954c Rv2954c hypothetical protein MT3029 61.3862525 90.6704017 71.2903052 87.4259167 1.055789134 0.078321723 6.28271806 0.795267516 Rv2955c Rv2955c conserved hypothetical protein MT3030 332.670025 344.402743 339.629196 395.680332 1.083276051 0.115400932 8.46466674 0.612706348 Rv2956 Rv2956 conserved hypothetical protein MT3031 200.820243 185.141359 218.599354 207.870729 1.105525909 0.144732837 7.66736006 0.491084358 Rv2957 Rv2957 similarity to glycosyltransferases MT3032 11.4326037 8.50600575 11.912028 7.88394427 0.987240947 −0.018525862 3.3357244 0.973097519 MT3033 22.396658 19.907673 18.0044393 17.3290656 0.836755238 −0.057122417 4.29108499 0.299508256 MT3034 161.555809 167.043475 159.039214 154.322355 0.953519625 −0.068665463 7.32789764 0.801831934 Rv2958c Rv2958c similar to variety of glycosyltransferases MT3035 154.996119 228.395303 187.591709 208.573258 1.049700067 0.069977163 7.60786588 0.819552181 Rv2959c Rv2959c some similarity to methyltransferases MT3036 83.4954908 86.9603353 83.5660593 90.470212 1.020660878 0.0295036 6.43132741 0.920168489 Rv2960c Rv2960c hypothetical protein MT3037 7.40307944 10.1348154 7.09265792 10.694063 1.012397555 0.017775929 3.1731609 0.973097519 MT3038 104.205371 165.595644 103.389129 144.330821 0.928183982 −0.107517295 7.01754902 0.658835922 Rv2962c Rv2962c similarity to variety of glycosyltransferases MT3039 65.0346472 117.455271 72.8361409 96.4807438 0.954152414 −0.067708358 6.4616882 0.839018102 Rv2963 Rv2963 integral membrane protein MT3041 70.6572392 101.619622 61.7424965 93.2022719 0.896213366 −0.158085852 6.35741524 0.471498466 Rv2964 purU formyltetrahydrofolate deformylase MT3041.1 11.8074432 16.2880961 11.6392335 14.8311823 0.943505359 −0.083897383 3.78911793 0.810576393 MT3042 11.4326037 26.0609538 10.5480554 14.440888 0.693461583 −0.528110054 3.98153801 0.043989046 MT3043 52.3838152 54.1126749 52.1946878 59.9492 1.051674259 0.07268792 5.77721842 0.814508736 Rv2965c kdtB lipopolysaccharide core biosynthesis protein MT3044 45.6367049 44.3398172 43.9199202 45.5863709 0.995093587 −0.007095879 5.49336329 0.983253476 MT3045 333.981953 441.678873 340.811306 437.597937 1.005379889 0.007740736 8.602526 0.977735627 Rv2967c pca pyruvate carboxylase MT3046 113.576358 112.659331 106.389869 121.693754 1.006633643 0.00953872 6.82934961 0.975396051 MT3047 399.953709 419.327985 424.832023 464.372124 1.084640172 0.11721651 8.73911714 0.606500069 MT3048 278.037173 284.046298 275.704344 282.434993 0.993078091 −0.010020926 8.1305551 0.973616553 Rv2970c lipN probable lipase/esterase MT3049 309.992238 358.428604 336.628457 392.792154 1.090913862 0.125537192 8.44974914 0.551370994 Rv2971 Rv2971 oxidoreductase of Aldo/keto reductase family MT3050 24.8331146 16.8310326 24.4605767 19.7488901 1.0705822 0.098395571 4.43542344 0.773887379 Rv2972c Rv2972c hypothetical protein MT3051 65.5031955 42.5300287 63.3792637 45.8986063 1.020094251 0.028702456 5.76793486 0.93032752 Rv2973c recG ATP-dependent DNA helicase MT3052 65.0346472 39.5438778 66.1072091 47.0694891 1.096861164 0.133380927 5.77090486 0.626654945 Rv2974c Rv2974c conserved hypothetical protein MT3052.1 20.4287509 17.3739692 19.2774805 16.7826537 0.954605042 −0.067024138 4.2199135 0.857846065 Rv2975c Rv2975c conserved hypothetical protein MT3052.2 336.980679 433.806293 402.190077 460.078887 1.124704217 0.169545641 8.67401649 0.407510497 MT3053 44.5121855 44.8827537 44.0108517 51.0504906 1.06188788 0.086631446 5.5328405 0.789940271 Rv2976c ung uracil-DNA glycosylase MT3055 117.887012 102.162558 123.575925 99.9933922 1.013132004 0.018822159 6.79536601 0.948443219 MT3056 281.129599 186.860658 278.432289 198.659784 1.025765465 0.036700905 7.88528738 0.896513559 Rv2978c Rv2978c transposase MT3057 81.8087133 59.4515508 74.0182506 56.4365516 0.926334921 −0.110394193 6.08938832 0.67738269 Rv2979c Rv2979c resolvase MT3058 33.1670025 31.3998297 35.9179471 35.0484255 1.097892812 0.13473721 5.09111353 0.629689153 Rv2980 Rv2980 hypothetical protein MT3058.1 2.15532692 6.60572787 2.90980838 5.22994323 0.953135471 −0.069246813 2.1430657 0.920168489 MT3058.2 8.80872743 25.0655701 15.276494 25.1349511 1.269243576 0.343968958 4.23074881 0.291510728 MT3059 224.997389 173.106266 228.783684 205.76314 1.099066961 0.136279285 7.7027686 0.546752598 Rv2981c ddlA D-alanine-D-alanine ligase A MT3060 80.590435 71.2151758 70.5628531 73.9217349 0.953711331 −0.068375437 6.21425779 0.818068286 Rv2982c gpdA2 glycerol-3-phosphate dehydrogenase MT3061 28.7689239 30.2234672 27.9159741 27.6328344 0.941345644 −0.087203545 4.84844423 0.791822733 Rv2983 Rv2983 conserved hypothetical protein MT3062 250.486473 276.626166 245.42415 255.642748 0.951420678 −0.071844714 8.00686277 0.785561673 Rv2984 ppk polyphosphate kinase MT3063 60.5365736 72.12007 59.1964142 71.8922047 0.987567156 −0.018049238 6.04699218 0.95527257 Rv2985 mutT1 MutT homologue MT3064 1228.44254 1147.49637 1469.27137 1533.31007 1.264208533 0.338234458 10.3931923 0.06221357 Rv2986c hupB DNA-binding protein II MT3065 123.884443 41.8966028 110.034528 32.0821891 0.945673852 −0.080585389 6.40264699 0.81765154 Rv2987c leuD 3-isopropylmalate dehydratase small subunit MT3066 827.458119 231.924391 970.602957 104.670316 1.020077109 0.028678212 9.12616459 0.930747689 Rv2988c leuC 3-isopropylmalate dehydratase large subunit MT3067 1590.06901 237.987182 1514.3734 199.518431 0.894874454 −0.1602428 9.79051141 0.507235719 Rv2989 Rv2989 transcriptional regulator (IcIR family) MT3068 1052.17438 691.882127 1023.79789 787.145486 1.051992425 0.073124316 9.79590164 0.808331268 Rv2990c Rv2990c hypothetical protein MT3069 76.5609607 41.6251345 70.6537846 44.5716057 0.990621019 −0.013594863 5.87058682 0.972119393 Rv2991 Rv2991 conserved hypothetical protein MT3070 203.53783 234.639073 194.229709 260.170161 1.029442195 0.041862823 7.80304448 0.885712512 Rv2992c gltS glutamyl-tRNA synthase MT3071 173.456963 213.645527 171.951489 210.993083 0.989428707 −0.015332337 7.59017627 0.95887131 Rv2993c Rv2993c conserved hypothetical protein MT3072 71.0320786 94.1089997 75.4731548 91.9533302 1.017662485 0.025259161 6.38070353 0.930747689 Rv2994 Rv2994 probable fluoroquinolone elflux protein MT3073 414.103899 314.812702 319.169606 260.95075 0.799207385 −0.323358181 8.35499033 0.031964051 Rv2995c leuB 3-isopropylmalate dehydrogenase MT3074 472.110306 381.593896 393.460651 311.610946 0.824990701 −0.277550237 8.60678907 0.07132719 Rv2996c serA D-3-phosphoglycerate dehydrogenase MT3075 35.9845836 31.3998297 28.9162207 28.8037172 0.858863491 −0.219499249 4.97475963 0.373393202 Rv2997 Rv2997 putative dehydrogenase MT3076 17.1489055 17.4544586 14.8218364 14.1286526 0.835702677 −0.258938338 4.00535229 0.323615741 MT3077 5.15404254 4.61496056 5.18309617 4.91770781 1.035190665 0.049896513 2.3623872 0.932785035 MT3078 27.7381204 36.9196845 22.0054259 27.320599 0.764568492 −0.387282348 4.84147554 0.039268685 Rv2999 lppY lipoprotein highly similar to MTCY19H5.18c MT3080 14.6187391 18.3693528 11.912028 15.2995354 0.824770097 −0.277936067 3.92859278 0.281405936 Rv3000 Rv3000 conserved hypothetical protein MT3080.1 90.3363111 81.1690123 96.660197 101.788746 1.158699069 0.212505926 6.53404045 0.29554559 MT3081 337.824058 303.501524 333.354922 318.402066 1.017464499 0.024978457 8.33737445 0.93032752 Rv3001c ilvC ketol-acid reductoisomerase MT3082 183.671338 147.31678 190.04686 173.915127 1.105003428 0.144050845 7.44221467 0.52349722 Rv3002c ilvN acetolactate synthase I small subunit MT3083 760.174435 584.923629 777.009768 622.909656 1.043289573 0.061139644 9.42295218 0.831756973 Rv3003c ilvB acetolactate synthase I large subunit MT3084 80.0282258 74.9252421 93.4775941 96.3246261 1.225694318 0.293599223 6.43250348 0.081568603 MT3085 363.125732 461.043609 481.20956 604.800002 1.318434747 0.39882617 8.90008364 0.003950399 Rv3005c Rv3005c conserved hypothetical protein MT3086 452.524944 579.494264 494.667424 531.658856 1.001145315 0.001651395 9.00777288 0.997032163 Rv3006 lppZ M. leprae lipoprotein MLCB637.17c MT3087 26.8010218 39.2724095 32.2806867 36.2973672 1.048562938 0.068413459 5.08092878 0.85689125 Rv3007c Rv3007c hypothetical protein MT3088 55.9447902 60.0849768 58.0143045 56.0462573 0.982889382 −0.024899035 5.85042764 0.937911005 Rv3008 Rv3008 hypothetical protein MT3089 235.680314 232.648306 220.599848 214.896026 0.929820072 −0.104976525 7.82099645 0.641879751 Rv3009c gatB glu-tRNA-gln amidotransferase, subunit A MT3090 187.607152 173.830181 151.128173 144.643057 0.818752493 −0.2885007 7.36166619 0.071155343 Rv3010c pfkA phosphofructokinase I MT3091 102.331174 128.947428 100.024663 129.499639 0.991105909 −0.012888863 6.8503249 0.967745454 Rv3011c gatA glu-tRNA-gln amidotransferase, subunit B MT3092 37.2028159 46.6020528 33.9174539 38.4830151 0.866011513 −0.20754189 5.29378107 0.377003647 Rv3012c gatC glu-tRNA-gln amidotransferase, subunit C MT3093 80.7779047 26.6038903 72.9270724 23.6518328 0.896833399 −0.157088089 5.67591983 0.548110991 Rv3013 Rv3013 conserved hypothetical protein MT3094 117.137333 129.128405 113.846253 118.961694 0.945964358 −0.080142268 6.90621873 0.75056169 Rv3014c ligA DNA ligase MT3095 45.6367049 47.7784153 40.5554542 44.2593703 0.907714112 −0.139690108 5.48325454 0.606853401 Rv3015c Rv3015c conserved hypothetical protein MT3096 99.9884273 114.46912 85.6574841 99.056686 0.851097418 −0.215751633 6.64340061 0.245280902 Rv3016 lpqA lipoprotein MT3097 6.18485117 9.68236824 6.81986338 8.3522974 0.959802249 −0.059190902 2.98953672 0.904814009 Rv3017c Rv3017c conserved hypothetical protein MT3101 18.8356831 24.0701865 18.4590969 18.187713 0.855853266 −0.224564624 4.32624298 0.436145896 Rv3018c PPE PPE-family protein MT3104 1.68677759 3.89104518 2.00049326 3.27847188 0.954055088 −0.067855523 1.53677094 0.930767792 Rv3019c Rv3019c similar to Esat6 MT3106 8.71501756 11.4016673 8.09290455 12.1771813 1.004624362 0.006656165 3.36253411 0.988617034 Rv3021c PPE PPE-family protein MT3106.1 1.59306773 4.61496056 2.09142477 3.51264844 0.920053534 −0.120210287 1.65111558 0.880856541 MT3107 25.3016639 18.0978846 31.3713716 20.2172432 1.180660767 0.239594502 4.5796942 0.326266799 Rv1047 Rv1047 possible IS1081 transposase MT3108 134.848498 127.952044 132.214418 124.738049 0.977665508 −0.032587139 7.02359716 0.904814009 Rv3024c Rv3024c conserved hypothetical protein MT3109 340.729074 303.411035 319.897058 269.06887 0.91250267 −0.132099315 8.26885767 0.548110991 Rv3025c Rv3025c NifS-like protein MT3110 12.7445418 14.6592865 14.1853158 17.9535365 1.171573068 0.228446934 3.91407874 0.425693826 Rv3026c Rv3026c some similarity to acyltransferase QS9601 MT3111 52.1963955 52.6648441 50.285126 57.3732578 1.025525733 0.036363693 5.73635546 0.91003342 Rv3027c Rv3027c hypothetical protein M13112 515.310555 568.002107 533.313317 676.848325 1.110763734 0.151551979 9.16379316 0.50431495 Rv3028c fixS electron transfer flavoprotein [alpha] subunit MT3113 843.669926 816.576552 825.476264 902.906766 1.04018853 0.056845035 9.72679204 0.85855125 Rv3029c fixA electron transfer flavoprotein [beta] subunit MT3114 93.2413169 111.39248 104.025649 145.423645 1.208958521 0.273764747 6.82929956 0.103072102 Rv3030 Rv3030 conserved hypothetical protein MT3115 103.080853 104.877241 119.393075 135.510171 1.224010482 0.291615913 6.8567757 0.062063165 Rv3031 Rv3031 conserved hypothetical protein MT3116 68.5956221 80.1736286 79.8378673 99.3689214 1.201957863 0.265386321 6.36080667 0.123436005 Rv3032 Rv3032 conserved hypothetical protein MT3117 32.6110335 33.9335336 36.4635362 41.2931339 1.16766425 0.223625502 5.18034706 0.334052402 MT3118 83.9640402 84.3361421 113.027869 85.1622099 1.166270782 0.221902789 6.52033976 0.331834906 Rv3033 Rv3033 hypothetical protein MT3119 276.912655 182.155208 259.063877 226.526795 1.077815275 0.108109938 7.88468811 0.704237224 Rv3034c Rv3034c conserved hypothetical protein MT3120 68.689332 77.0969882 72.3814834 80.6347964 1.049728922 0.07001682 6.2265563 0.803054534 Rv3035 Rv3035 hypothetical protein MT3121 137.284954 170.120115 146.308802 154.556531 0.983157503 −0.024505539 7.25025944 0.933484698 Rv3036c Rv3036c probable secreted protein MT3122 131.100103 56.284421 122.575678 65.9597318 1.041183113 0.058223818 6.55659165 0.855750561 Rv3037c Rv3037c hypothetical protein MT3123 426.567311 248.755423 397.916295 263.838927 0.994099947 −0.008537187 8.38554844 0.97711178 Rv3038c Rv3038c hypothetical protein MT3124 76.7483805 101.438643 78.0192371 96.8710381 0.984411212 −0.022667006 6.46684309 0.938478232 Rv3039c echA17 enoyl-CoA hydratase/isomerase superfamily MT3125 53.4146238 90.0369757 54.5589071 71.8922047 0.898557295 −0.154317597 6.08020971 0.561617611 Rv3040c Rv3040c hypothetical protein MT3126 106.360698 143.606714 99.9337314 140.427879 0.959075817 −0.060283227 6.93980643 0.81765154 Rv3041c Rv3041c ABC transporter protein MT3127 365.937028 406.387998 327.717168 407.311101 0.947695361 −0.077504719 8.55849591 0.76492809 Rv3042c serB2 C-term similar to phosphoserine phosphatase MT3128 532.55317 809.06593 558.956003 742.886115 0.981387669 −0.027104951 9.3686198 0.930160958 Rv3043c ctaD cytochrome c oxidase polypeptide I MT3129 343.915209 409.917085 319.533332 371.482087 0.917533069 −0.12416794 8.49741392 0.559675434 Rv3044 fecB putative FellI-dicitrate transporter MT3130 544.079484 697.221003 552.136139 651.010844 0.97327497 −0.039080641 9.25572113 0.894736554 Rv3045 adhC alcohol dehydrogenase MT3131 58.1001171 58.4561671 57.74151 49.5673724 0.917851771 −0.123666912 5.81081404 0.651061634 Rv3046c Rv3046c conserved hypothetical protein MT3131.1 38.4210452 53.8412066 50.466989 62.8373776 1.235058938 0.30457989 5.68887019 0.121328869 MT3132 20.0539114 25.246549 23.9149876 23.9598349 1.16808996 0.224151387 4.62834812 0.365125626 MT3133 136.722695 152.203209 152.76494 157.36665 1.07447499 0.103631902 7.22828465 0.672785875 Rv3048c nrdG ribonucleoside-diphosphate small subunit MT3134 500.129556 625.010443 536.677782 633.447602 1.042748722 0.060391544 9.16490817 0.828256087 Rv3049c Rv3049c Probable monooxygenase MT3135 13.306801 11.763625 14.2762474 14.7531234 1.160740718 0.215045744 3.77670989 0.49025808 MT3136 645.379849 585.647545 680.89516 587.23676 1.028548533 0.040609871 9.28762204 0.891612606 Rv3050c Rv3050c putative transcriptional regulator MT3137 3636.41136 4122.96957 3706.91401 3868.75293 0.978015048 −0.032071432 11.9046112 0.926039217 Rv3051c nrdE ribonucleoside diphosphate reductase [alpha] chain MT3138 581.56343 776.851695 630.519103 682.390503 0.975616728 −0.0356136 9.38372633 0.907426106 MT3139 597.119258 634.602322 613.696773 639.69231 1.017826521 0.025491688 9.27950762 0.93032752 Rv3053c nrdH glutaredoxin electron transport component of NrdEF MT3139.1 884.808557 1029.49816 905.495994 932.64719 0.9627912 −0.05470514 9.87388774 0.866612316 MT3140 10.495505 36.6482162 7.36545245 32.1602479 0.814559055 −0.295908798 4.451522 0.241079618 Rv3054c Rv3054c conserved hypothetical protein MT3141 44.2310559 29.2280836 37.7365774 27.7889521 0.898679549 −0.154121324 5.12539039 0.572054672 Rv3055 Rv3055 putative transcriptional regulator MT3142 69.345301 67.1431517 63.8339213 65.5694375 0.948381835 −0.076460064 6.05847288 0.798287058 Rv3056 dinP DNA-damage-inducible protein MT3143 113.295228 115.916951 124.939897 122.552401 1.079617411 0.110520149 6.89910546 0.622290703 Rv3057c Rv3057c possible ketoacyl reductase MT3144 128.007677 124.422956 148.309296 144.564998 1.160230684 0.214411679 7.09282451 0.247779803 Rv3058c Rv3058c putative transcriptional regulator MT3145 200.070555 234.729563 198.048833 222.701911 0.968924161 −0.045544346 7.74191915 0.871382309 Rv3059 Rc3059 possible lanosterol 14-alpha- demethylases MT3146 221.623834 167.948369 217.599108 170.636655 0.998657954 −0.001937464 7.60449837 0.996920859 Rv3060c Rv3060c transcriptional regulator (GntR famny) MT3147 203.53783 128.766449 251.789356 149.404647 1.198706441 0.261478391 7.51992117 0.122137607 Rv3061c fadE22 acyl-CoA dehydrogenase MT3148 129.413325 131.390642 123.757788 122.552401 0.944374682 −0.082568731 6.98813796 0.745116768 Rv3062 ligB DNA ligase MT3149 84.9011388 99.3573863 72.5633464 92.9680953 0.895274411 −0.159598143 6.45331737 0.473546612 Rv3063 cstA starvation-induced stress response protein MT3149.1 2.62387626 4.61496056 4.36471256 3.59070729 1.101532368 0.139511889 1.99093612 0.854044262 MT3150 15.6495477 17.4644586 17.4588503 16.7826537 1.032910274 0.046714937 4.08876319 0.90313325 Rv3064c Rv3064c conserved hypothetical protein MT3150.1 24.7394017 18.3693528 24.3696452 23.1054208 1.110536292 0.151256541 4.51230951 0.624685486 MT3151 32.6110335 24.8845913 34.826769 26.5400104 1.067231245 0.09387281 4.9012631 0.76492809 Rv3066 Rv3066 putative transcriptional regulator MT3152 35.6097432 24.1606759 34.2811799 24.8227156 0.992986993 −0.010153274 4.90117157 0.977279079 MT3153 74.1245042 88.0462084 61.651565 72.3605578 0.826671112 −0.274614622 6.21374293 0.111712781 Rv3068c pgmA phosphoglucomutase MT3153.1 22.396658 29.6805307 19.550275 28.2573052 0.914957315 −0.128223655 4.65285912 0.674598293 Rv3069 Rv3069 unknown membrane protein MT3154 10.4017952 16.0166278 13.5487953 13.5822406 1.035841407 0.050803136 3.76202412 0.912188253 Rv3070 Rv3070 unknown membrane protein (3 TM segments) MT3155 31.5802249 46.2400951 32.5534812 39.5758391 0.934665282 −0.097478289 5.23530917 0.763236878 Rv3071 Rv3071 hypothetical protein MT3157 25.4890836 17.7359269 24.3696452 18.9683016 1.008434391 0.012117225 4.44668481 0.974932221 Rv3072c Rv3072c similar to alkanal monooxygenase beta chainschaims MT3158 41.0449214 23.1652922 34.3721114 28.4134229 1.006451283 0.009277341 4.99611084 0.982495673 Rv3073c Rv3073c conserved hypothetical protein MT3159 226.496747 93.8375315 153.40146 105.535571 0.869455229 −0.201816354 7.17958811 0.518774989 Rv3074 Rv3074 conserved hypothetical protein MT3160 271.852322 203.239244 240.150123 213.490966 0.962994723 −0.054400202 7.86016218 0.852607709 Rv3075c Rv3075c conserved hypothetical protein MT3161 33.0795828 44.4303066 29.6436728 47.0694891 0.979749406 −0.029515302 5.276021 0.930747689 Rv3076 Rv3076 conserved hypothetical protein MT3162 87.618725 127.861554 86.8395937 127.157874 0.992862031 −0.010334842 6.74899372 0.973114765 Rv3077 atsF proable arylsulfatase MT3163 23.6148853 43.5254124 22.4600834 42.0737224 0.959818948 −0.059165801 5.04943678 0.865029216 MT3164 34.3915209 38.8199624 24.1877821 27.867011 0.710927084 −0.492216498 4.97658249 0.00316678 Rv3079c Rv3079c probable monooxygenase MT3165 220.686735 124.332467 182.681407 102.17904 0.824884462 −0.277736034 7.30028163 0.087358903 Rv3080c pknK serine-threonine protein kinase MT3166 55.5699507 50.3121191 51.8309617 46.6791948 0.930267667 −0.10428221 5.67996326 0.725019493 Rv3081 Rv3081 hypothetical protein MT3167 38.8895945 58.4561671 32.0078921 36.9998969 0.717866188 −0.478213148 5.3840147 0.010626794 Rv3082c virS putative virutence regulating protein (AraC/XylS MT3168 318.144936 640.846092 283.979111 423.547343 0.766966607 −0.38276433 8.70324768 0.026391712 Rv3083 Rv3083 probable monooxygenase MT3169 107.110377 220.432234 93.9334848 144.096645 0.773750659 −0.370059362 7.15809551 0.053886432 Rv3084 lipR probable acetyl-hydrolase MT3170 136.254116 237.715714 121.666363 162.752711 0.779872838 −0.35868919 7.36435794 0.040070603 Rv3085 Rv3085 short chain alcohol dehydrogenase MT3171 322.36194 486.923584 298.437222 317.855654 0.776703799 −0.364563573 8.47802282 0.048868744 Rv3086 adhD zinc-containing alcohol dehydrogenase MT3172 264.824032 418.60407 238.695218 247.056274 0.728551313 −0.456897508 8.19210961 0.017760418 Rv3087 Rv3087 conserved hypothetical protein MT3173 173.269543 336.530164 160.039461 180.628189 0.702473624 −0.509484038 7.7332641 0.017771935 MT3174 202.600731 333.453523 184.318174 200.923491 0.739167784 −0.436026215 7.84858596 0.021173927 Rv3089 fadD13 acyl-CoA synthase MT3174.2 3.74839455 4.43398172 3.72819198 5.85441406 1.167620495 0.223571439 2.21193854 0.689539719 MT3175 20.5224607 37.6435999 19.9140011 27.5547755 0.832030609 −0.265291492 4.73285323 0.308884338 Rv3090 Rv3090 hypothetical protein MT3176 173.082123 129.128406 159.675735 129.343521 0.960968451 −0.057439028 7.20918565 0.839018102 Rv3091 Rv3091 hypothetical protein MT3176.1 721.75339 529.001166 780.828892 673.647912 1.173592215 0.230931206 9.40190698 0.250978723 MT3178 800.657097 743.18963 969.693641 909.385651 1.217355393 0.283750408 9.74131789 0.112616436 Rv3094c Rv3094c conserved hypothetical protein MT3179 170.739376 175.911438 216.416998 218.798968 1.255539813 0.328307777 7.61214211 0.025378065 Rv3095 Rv3095 putative transcriptional regulator MT3180 387.209157 442.855235 516.67285 543.523802 1.279543961 0.355629715 8.88494217 0.015352988 Rv3096 Rv3096 hypothetical protein MT3181 9.46469649 9.5013894 14.4581104 13.5822406 1.47640428 0.562087825 3.57748162 0.010790426 Rv3097c PE PE-family protein MT3182 64.0038337 89.3130603 66.6527981 87.5820344 1.009417841 0.013523491 6.26819058 0.969101493 Rv3098c Rv3098c hypothetical protein MT3183 262.200206 282.23651 262.155548 278.904286 0.993967711 −0.008729108 8.08508509 0.976589254 Rv3099c Rv3099c hypothetical protein MT3184 63.1604499 77.2779671 58.8326881 96.0904495 1.081196852 0.112629216 6.21017556 0.712880382 Rv3100c smpB probable small protein b MT3185 151.809933 244.59291 143.489926 235.425504 0.954033036 −0.06788887 7.60007983 0.801831984 Rv3101c ftsX membrane protein MT3186 96.6148721 155.27985 90.6587172 155.493238 0.970639589 −0.042992391 6.96239535 0.880578033 Rv3102c ftsE membrane protein MT3186.1 53.976883 53.5697383 59.1054826 57.4513167 1.083570054 0.115792428 5.81258872 0.661757712 Rv3103c Rv3103c hypothetical protein MT3187 238.679029 199.529177 218.872149 221.296852 1.008499534 0.012210417 7.77984429 0.972119393 Rv3104c Rv3104c conserved hypothetical protein MT3188 237.554511 257.08045 214.507436 234.801033 0.908181226 −0.138947882 7.88362855 0.507235719 Rv3105c prfB peptide chain release factor 2 MT3189 116.012814 139.896648 123.757788 139.256996 1.029952218 0.042577409 7.021402 0.883952145 Rv3106 fprA adrenodoxin and NADPH ferredoxin reductase MT3190 103.736822 162.157046 101.388636 134.027053 0.896705608 −0.157293674 6.97166367 0.470977168 Rv3107c Rv3107c Some similarity to D-lactate dehydrogenase MT3191 1.49935786 4.25300287 1.09117814 3.43458958 0.784784398 −0.349631734 1.46567738 0.59824312 Rv3108 Rv3108 hypothetical protein MT3192 2.99871572 5.1578971 2.27328779 4.83964896 0.867698102 −0.204734922 2.00260051 0.742457841 Rv3109 moaA molybdenum cofactor biosynthesis, protein A M13193 1.96790719 3.52908749 2.09142477 3.12235417 0.950828191 −0.072743417 1.51714813 0.926747303 Rv3110 moaB molybdenum cofactor biosynthesis, protein B MT3195 1.03080853 2.62419326 2.36421931 2.96623646 1.475291697 0.561000235 1.28543938 0.376255961 Rv3113 Rv3113 hypothetical protein MT3196 1.59306773 2.17174615 2.18235628 3.746825 1.567671209 0.648623012 1.39051323 0.226533034 Rv3114 Rv3114 hypothetical protein MT3198 172.332444 256.266045 181.953955 262.668044 1.040005507 0.056591168 7.77146968 0.831756973 Rv3116 moeB molybdopterin biosynthesis MT3199 19.6790719 21.7171615 20.3686586 23.9640682 1.070393702 0.098141532 4.4340337 0.764687847 MT3200 6.55969054 10.1348154 7.54731548 9.60123907 1.030568388 0.043440244 3.11211163 0.93032752 MT3201 69.0641714 116.459887 81.20184 132.075581 1.15373189 0.206308002 6.64242883 0.281588203 Rv3119 moaE molybdopterin-converting factor subunit 2 MT3202 42.5442793 69.9483238 47.1934546 73.0630875 1.074384174 0.103509959 5.86747559 0.716655179 Rv3120 Rv3120 Slight similarity to methyltransferases MT3203 84.3388795 109.944649 90.1131282 127.157874 1.112878544 0.15429615 6.68764618 0.483174937 Rv3121 Rv3121 probable cytochrome p450 MT3205 72.9999858 69.6768556 61.1969074 72.2044401 0.933315374 −0.099563434 6.11264525 0.741632985 Rv3122 Rv3122 hypothetical protein MT3206 35.7971639 64.9714056 32.2806867 62.9154365 0.937376449 −0.0993299547 5.62025745 0.764687847 MT3208 6.37227091 7.87257979 7.82011001 9.13288594 1.189902815 0.250843746 2.99749499 0.505322279 Rv3124 Rv3124 transcriptional regulator (AfsR/DndI/ RedD family) MT3209 10.6829248 18.0978846 9.63874025 16.4704182 0.906924621 −0.140945448 3.79834746 0.689967543 MT3210 1.59306773 6.42474902 0.72745209 4.05906042 0.590301302 −0.760476571 1.76271674 0.08038437 MT3211 2.34274656 5.61034422 1.09117814 3.746825 0.601830521 −0.732570822 1.75864426 0.089595629 Rv3126c Rv3126c hypothetical protein MT3212 1765.40017 2974.56831 1104.72694 1796.99288 0.614826388 −0.701749008 10.8998067 8.07E−07 Rv3127 Rv3127 conserved hypothetical protein MT3215 24.8331146 17.1929903 22.2782204 14.5189469 0.872368622 −0.196990216 4.3119716 0.476182576 Rv3129 Rv3129 conserved hypothetical protein MT3216 2535.41414 4431.71948 1754.15979 2924.55303 0.675679958 −0.565588033 11.507616 0.000320927 Rv3130c Rv3130c conserved hypothetical protein MT3217 1522.69162 2157.99176 988.24367 1362.82954 0.64019454 −0.643417722 10.5585249 4.82E−06 Rv3131 Rv3131 conserved hypothetical protein MT3218 1001.66476 1977.64634 638.339213 1218.42066 0.626553697 −0.674489937 10.239834 1.45E−06 Rv3132c Rv3132c sensor histidine kinase MT3219 312.428694 653.243143 201.68634 404.500982 0.63353862 −0.658495527 8.61984028 4.54E−08 Rv3133c Rv3133c two-component response regulator MT3220 1128.92276 1865.25847 672.165735 1229.27084 0.6265313 −0.674541511 10.2574848 2.40E−06 Rv3134c Rv3134c conserved hypothetical protein MT3220.1 13.0256714 9.95383651 11.2755075 12.5674755 1.045533759 0.064239645 3.57092745 0.894346121 MT3220.2 959.307901 976.471362 225.964807 478.188541 0.340057328 −1.556150112 9.36661886 1.02E−12 MT3221 1765.58759 1906.9741 397.370706 958.953024 0.336663001 −1.570622914 10.2962015 9.56E−11 Rv3136 PPE PPE-family protein MT3222 13.5879306 24.3416547 12.5485486 20.3733609 0.872483992 −0.196799434 4.16196668 0.494261547 MT3223 40.4826622 46.6925422 7.27452094 22.0125969 0.301748667 −1.728580698 4.87148205 5.26E−10 MT3224 235.680314 191.475619 56.7412633 109.67269 0.372818544 −1.423454472 7.21474753 1.13E−08 Rv3137 Rv3137 probable monophosphatase MT3225 216.469791 182.788634 88.7491555 140.583996 0.562769501 −0.829383951 7.29748509 8.86E−05 Rv3138 pflA similar to pyruvate lyase activating protein MT3226 460.021734 416.341834 520.037316 458.049356 1.115219944 0.157328267 8.85731925 0.4496021 Rv3139 fadE24 acyl-CoA dehydrogenase MT3227 467.987072 440.864468 530.221645 482.013425 1.112977051 0.054423845 8.90823527 0.464084488 Rv3140 fadE23 acyl-CoA dehydrogenase MT3228 268.759896 255.723109 237.785903 230.507796 0.893054968 −0.163179118 7.95631323 0.408863106 Rv3141 fadB4 3-hydroxyacyl-CoA dehydrogenase MT3229 125.85235 189.937299 153.674255 203.187198 1.141434726 0.19084836 7.39536636 0.352708891 Rv3142c Rv3142c hypothetical protein MT3230 14.2438997 25.7894855 14.4581104 26.4619516 1.021439478 0.030603725 4.35307632 0.932785035 Rv3143 Rv3143 putative sensory transduction protein MT3231 179.079554 248.212487 257.699904 290.300879 1.296012007 0.374079084 7.93082427 0.015352988 Rv3144c PPE PPE-family protein MT3233 149.373527 167.043475 167.132119 179.8476 1.097379371 0.134062361 7.37531388 0.544489057 Rv3145 nuoA NADH dehydrogenase chain A MT3234 153.590471 153.017614 158.675483 174.539598 1.085873419 0.118855937 7.32316916 0.617184719 Rv3146 nuoB NADH dehydrogenase chain B MT3235 164.648235 177.630737 168.587023 196.942489 1.065839591 0.091990328 7.46871304 0.715019493 Rv3147 nuoC NADH dehydrogenase chain C MT3236 318.051236 313.907808 322.534072 365.315438 1.086588514 0.119805702 8.36691226 0.616132609 Rv3148 nuoD NADH dehydrogenase chain D MT3237 192.854905 206.94931 211.052039 227.54156 1.096938422 0.13348254 7.71274447 0.52349722 Rv3149 nuoE NADH dehydrogenase chain E MT3238 434.62636 430.096227 416.739118 442.749821 0.993581064 −0.009290417 8.75231393 0.975415001 Rv3150 nuoF NADH dehydrogenase chain F MT3239 774.699454 681.747312 729.088861 732.894582 1.005862401 0.008432962 9.51132234 0.97876897 Rv3151 nuoG NADH dehydrogenase chain G MT3240 296.216837 284.679724 300.437715 330.735365 1.08571249 0.118642111 8.24412144 0.618053481 Rv3152 nuoH NADH dehydrogenase chain H MT3241 137.284954 134.105325 137.306583 141.130408 1.026067265 0.037125311 7.10469454 0.898649898 Rv3153 nuoI NADH dehydrogenase chain I MT3242 220.874155 210.387908 210.688313 247.836862 1.060523405 0.08477645 7.79850229 0.760272935 Rv3154 nuoJ NADH dehydrogenase chain J MT3243 113.195228 98.1810238 97.2967176 113.887868 0.998824433 −0.001696982 6.72580477 0.997032163 Rv3155 nuoK NADH dehydrogenase chain K MT3244 493.195026 434.892166 477.299505 492.785547 1.047233472 0.066583115 8.89093405 0.812642214 Rv3156 nuoL NADH dehydrogenase chain L MT3245 383.835612 337.616037 360.816239 393.026331 1.046218649 0.065184391 8.52748712 0.819552181 Rv3157 nuoM NADH dehydrogenase chain M MT3246 313.176873 294.452582 298.619085 323.475892 1.023638527 0.033706352 8.26495893 0.904909928 Rv3158 nuoN NADH dehydrogenase chain N MT3247 40.2015326 32.9381499 52.5584138 39.2636037 1.249576098 0.321438763 5.37201422 0.088623706 Rv3159c PPE PPE-family protein MT3248 51.3530057 50.7645662 68.7442229 54.7973156 1.202313387 0.265812988 5.82246667 0.218720987 MT3249 93.0538972 68.5909825 138.670555 77.5124422 1.301642753 0.380333543 6.56408728 0.02876032 Rv3160c Rv3160c putative transcritptional regulator MT3250 176.924228 119.35549 250.607246 149.482706 1.333190542 0.414882988 7.44508241 0.004369491 Rv3161c Rv3161c putative dioxgenasesdiooxygenases MT3251 20.6161705 14.2973288 20.8233162 13.3480641 0.974154034 −0.037778185 4.12357691 0.921052928 Rv3162c Rv3162c probable membrane protein MT3252 42.5442793 34.3859807 38.736824 29.6623646 0.886817646 −0.173290618 5.18960449 0.493625147 Rv3163c Rv3163c possible membrane protein MT3253 60.1617341 51.2170133 49.5576739 49.255137 0.890157127 −0.167868078 5.72021519 0.515423572 Rv3164c moxR3 transcriptional regulator, MoxR homologue MT3254 14.4313194 15.3832019 18.0953708 15.4556531 1.120908365 0.164668342 4.00150632 0.619926139 MT3255 31.2053855 33.1191288 35.7360841 32.2383068 1.054826787 0.077006113 5.05526587 0.816470736 MT3256 13.306801 10.9492202 11.2755075 10.0695922 0.88225966 −0.180724774 3.53199881 0.615784806 Rv3167c Rv3167c putative transcriptional regulator MT3257 18.2734239 37.8245787 17.3679188 24.1982448 0.76536188 −0.385786047 4.62032496 0.117330931 MT3258 37.7650751 70.400771 37.6456459 59.8711412 0.915659073 −0.127117555 5.68960372 0.657330385 Rv3168 Rv3168 conserved hypothetical protein MT3259 57.5378579 67.9575565 60.6513183 64.4766136 0.998984623 −0.001465624 5.97348773 0.997032163 Rv3170 Rv3170 Probable flavin-containing monoamine oxidase MT3260 596.838138 566.735255 750.730561 699.563451 1.246046948 0.317358427 9.3523696 0.047051878 Rv3171c hpx probable non-heme haloperoxidase MT3261 85.8382375 96.5522142 85.4756211 94.217037 0.985581483 −0.020952944 6.50302867 0.944171679 MT3262 144.969153 104.243815 141.125706 97.963862 0.956775472 −0.06374769 6.93352414 0.806148616 Rv3173c Rv3173c transcriptional regulator (TetR/AcrR family) MT3263 25.3953738 28.3231893 22.0963574 20.3733609 0.789627263 −0.340756293 4.5977254 0.111098322 Rv3174 Rv3174 putative oxidoreductase MT3264 26.5198922 27.4182951 20.8233162 19.6708313 0.750040098 −0.41496037 4.57122504 0.027112663 Rv3175 Rv3175 Probable amidase MT3265 137.378664 94.1089997 109.936198 76.1854417 0.804804315 −0.313290054 6.70813721 0.04636499 Rv3176c lipS probable esterase/lipase MT3266 15.6495477 15.4736913 11.4573705 10.5379453 0.705943224 −0.502375937 3.74865391 0.018568342 Rv3177 Rv3177 probable non-heme haloperoxidase MT3267 4.31065385 2.89566153 3.18260291 2.41982448 0.781918178 −0.354910446 1.75049554 0.52349722 Rv3178 Rv3178 conserved hypothetical protein MT3270 16.4929365 17.9612317 17.1860557 23.8860094 0.933038435 −0.099991583 4.43080192 0.773067208 Rv3179 Rv3179 conserved hypothetical protein MT3270.1 10.8703445 11.9446038 7.82011001 8.97676823 0.736600165 −0.441046374 3.33239537 0.093666119 MT3271 18.929393 21.3555038 20.0049326 18.6560662 0.958496212 −0.061155364 4.31539383 0.877756142 Rv3180c Rv3180c hypothetical protein MT3272 18.4608437 18.9122894 12.5485486 14.440888 0.722645508 −0.468639984 4.02316097 0.020608345 Rv3181c Rv3181c conserved hypothetical protein MT3274 96.8960017 45.6066691 88.0217034 50.6601964 0.999449817 −0.000793965 6.13849558 0.999355608 Rv3182 Rv3182 conserved hypothetical protein MT3775 11.0577642 6.06279133 14.0034528 8.3522974 1.312373779 0.392178675 3.32686971 0.171245612 Rv3183 Rv3183 putative transcriptional regulator MT3276 16.118097 20.9935461 14.5490419 17.3290656 0.860200089 −0.217255815 4.12305813 0.433613807 MT3277 43.8562174 43.2539441 34.463043 33.0969542 0.775375921 −0.367032162 5.27920565 0.038295456 Rv3189 Rv3189 conserved hypothetical protein MT3278 114.607156 153.289082 120.666116 161.113475 1.051931068 0.07304017 7.10442153 0.789228528 Rv3190c Rv3190c hypothetical protein MT3279 46.1989641 40.3582826 42.465016 49.4112547 1.062207456 0.087065562 5.48510662 0.803807978 MT3280 68.4082024 69.8578344 77.655511 86.2550339 1.18454094 0.244328062 6.24279023 0.197755898 MT3281 5.06033278 6.06279133 5.91054826 6.4788849 1.113118718 0.154607469 2.59940243 0.763576794 Rv3191c Rv3191c hypothetical protein MT3282 5.15404254 4.61496056 5.54682222 4.52741354 1.028552755 0.040615793 2.35949041 0.948443219 MT3285 717.630156 746.085291 680.076776 713.92628 0.952279028 −0.070543734 9.48100234 0.803054534 Rv3193c Rv3193c probable Integral membrane protein MT3286 98.2079398 132.657494 83.4751278 104.754982 0.818506753 −0.288933775 6.71357176 0.078972009 Rv3194c Rv3194c conserved hypothetical protein MT3287 56.1322099 28.7756365 54.1042495 33.2530719 1.049512936 0.069719949 5.43373318 0.839018102 Rv3195 Rv3195 conserved hypothetical protein MT3288 4.40436371 4.52447114 3.36446594 3.04429531 0.716604001 −0.480751997 1.99998984 0.282994004 Rv3196 Rv3196 hypothetical protein MT3289 6.74711037 11.5826461 4.54657559 7.18141459 0.641480627 −0.640522398 2.9429623 0.014675116 MT3290 1004.28854 799.383561 547.589564 460.937534 0.560705508 −0.834634852 9.45778622 3.70E−11 Rv3197 Rv3197 probable ABC transporter MT3290.1 63.7227091 143.154267 73.745456 149.482706 1.095589101 0.131706819 6.75131532 0.560683956 MT3290.2 133.25543 212.831123 118.210965 226.682913 0.974441844 −0.037352009 7.43416354 0.90313325 MT3291 236.523702 282.869936 261.337165 270.395871 1.02728103 0.03883098 8.03870328 0.894736554 Rv3198c uvrD2 putative UvrD MT3292 28.3940895 48.5023306 32.3716182 48.5526073 1.062665216 0.087687159 5.30922066 0.783679782 MT3293 117.605882 102.524516 110.299924 112.248632 1.013469136 0.019302154 6.79240374 0.949117634 Rv3199c Rv3199c conserved hypothetical protein MT3294 237.273381 218.350977 219.054012 210.758906 0.944015697 −0.083117246 7.79136395 0.740705091 Rv3200c Rv3200c putative potassium channel MT3295 105.892149 64.8809162 110.754581 78.6052662 1.123507483 0.168009734 6.49502188 0.459370243 Rv3201c Rv3201c probable ATP-dependent DNA helicase MT3296 147.12449 76.0111152 155.856611 93.8267427 1.140559425 0.189741615 6.88707694 0.344857224 Rv3202c Rv3202c similar to UvrD proteins MT3297 8.71501756 14.8402653 11.0027129 11.240475 0.958514249 −0.061128216 3.5394891 0.90313325 MT3298 66.1591656 76.9160094 73.8363876 78.3710896 1.065462696 0.091480083 6.20948669 0.739984204 Rv3203 lipV probable lipase MT3299 38.3273353 36.8291951 37.4637828 34.267837 0.953582674 −0.068570072 5.20527759 0.831756973 Rv3204 Rv3204 probable methyltransferase MT3300 478.295157 370.282718 427.923694 356.885081 0.928524507 −0.106988106 8.67423316 0.641879751 Rv3205c Rv3205c hypothetical protein MT3301 429.378607 667.449983 476.299259 680.204855 1.062935691 0.088054315 9.13833758 0.740705091 Rv3206c moeZ probably involved in molybdopterin biosynthesis MT3302 447.745741 491.900503 424.013639 473.739186 0.955032221 −0.066378687 8.84400342 0.803054534 MT3303 305.681584 243.416547 289.253139 263.604751 1.012158372 0.017435046 8.1067466 0.952996744 Rv3208 Rv3208 transcriptional regulator (TctR/AcrR family) MT3304 97.0834215 93.5660632 93.113868 118.181105 1.102204187 0.140391513 6.65353632 0.59824312 MT3305 307.087232 237.082288 395.824871 336.433662 1.352214706 0.435324242 8.31870566 0.001649509 Rv3209 Rv3209 conserved hypothetical protein MT3306 71.500628 82.0739065 83.6569908 103.740217 1.217131984 0.28348562 6.41674508 0.088172967 Rv3210c Rv3210c hypothetical protein MT3307 1451.56533 972.670806 1843.72733 1257.13785 1.281244234 0.357545512 10.4319609 0.03224823 Rv3211 rhlE probable ATP-dependent RNA helicase MT3308 618.578827 313.907808 754.27689 473.036656 1.354577051 0.437842459 9.07712194 0.004139784 Rv3212 Rv3212 hypothetical protein MT3309 925.29122 925.797285 764.92081 920.157773 0.918308666 −0.122948934 9.79639487 0.641869092 Rv3213c Rv3213c possible role in chromosome segregation MT3310 96.8022919 80.264118 93.9322516 86.9575636 1.025110809 0.035779866 6.48641857 0.90313325 Rv3214 entD weak similarity to many phosphoglycerate mutases MT3311 84.3388736 99.6288545 79.7469358 87.4259167 0.910283351 −0.1356124 6.45879847 0.553464721 MT3312 37.4839455 44.3398172 36.3726047 39.7319568 0.931297247 −0.102686381 5.30957967 0.733038419 Rv3216 Rv3216 possible acyltransferase MT3313 11.9948629 12.0350932 13.6397268 13.1919464 1.115900392 0.158208255 3.68860529 0.644492704 MT3314 20.8973032 43.0729653 21.3689053 33.4091896 0.877852712 −0.187949194 4.90087483 0.518774989 Rv3218 Rv3218 conserved hypothetical protein MT3315 1745.90852 1978.18927 1976.57827 1849.99484 1.028919239 0.041129748 10.8825228 0.90313325 Rv3219 whiB1 WhiB transcriptional activator homologue MT3316 372.028159 264.138625 348.813279 279.450698 0.995689317 −0.006232443 8.30502688 0.983253476 Rv3220c Rv3220c sensor histidine kinase MT3317 81.8087133 78.7257979 58.4689621 79.0736193 0.849554807 −0.235221073 6.22298939 0.337196914 MT3318 83.0269415 85.4220151 79.5650728 87.9723287 0.993923895 −0.008792706 6.3953275 0.97711178 MT3319 158.744513 178.535631 164.404173 160.09371 0.96327599 −0.053978888 7.37173375 0.857846065 Rv3222c Rv3222c conserved hypothetical protein MT3320 297.903655 378.336277 288.343824 346.73743 0.941653889 −0.086731209 8.35760118 0.734837124 Rv3223c sigH ECF subfamily sigma subunit MT3321 373.433817 360.419371 384.731226 384.439857 1.048318218 0.068076715 8.55433221 0.79743892 Rv3224 Rv3224 putative oxidoreductases MT3322 26.5198922 22.1699086 26.4610699 23.6518328 1.031317804 0.044488973 4.63648966 0.900323347 MT3323 154.902409 125.237361 151.128173 125.752814 0.989690065 −0.014951299 7.12332402 0.961758558 Rv3225c Rv3225c probable aminoglycoside 3′- phosphotransferases MT3323.1 50.9781673 47.9593941 52.2856193 46.2108417 0.994110646 −0.00852166 5.63022304 0.980042284 Rv3226c Rv3226c conserved hypothetical protein MT3324 135.035917 116.09793 127.122253 109.360455 0.941685542 −0.086682715 6.93158497 0.727349312 Rv3227 aroA 3-phosphoshikimate 1-carboxyvinyl transferase MT3325 74.0307944 71.0341969 72.8361409 74.390088 1.01529714 0.021902013 6.19474468 0.942756952 Rv3228 Rv3228 conserved hypothetical protein MT3326 1154.59926 547.551498 1323.50815 624.70501 1.143608122 0.193592771 9.83406259 0.375157468 Rv3229c desA3 acyl-[ACP] desaturase MT3327 607.427353 321.41843 587.781292 308.800827 0.964230079 −0.05255066 8.83449179 0.852607709 Rv3230c Rv3230c similar to various oxygenases MT3328 34.4852308 34.7479384 39.7370706 41.0589573 1.167050677 0.222867209 5.23609896 0.322355421 MT3329 147.31191 186.679679 169.04168 198.191431 1.103207847 0.141704624 7.45526533 0.521875569 Rv3232c pvdS alternative sigma factor for siderophore production MT3330 124.165573 127.861554 124.48524 143.706351 1.062105575 0.08692718 7.02500206 0.745116763 MT3331 126.695739 141.977904 129.759267 148.546 1.035291633 0.05003711 7.0972627 0.865029216 Rv3234c Rv3234c conserved hypothetical protein MT3332 47.5109022 56.1034422 46.556934 59.2466703 1.018502596 0.026449657 5.71533756 0.93458603 Rv3235 Rv3235 hypothetical protein MT3333 146.655941 99.9908122 152.76494 123.254931 1.131995396 0.178868091 7.0316216 0.409241084 Rv3236c kefB probable glutathione-regulated potassium- efflux MT3334 71.5943378 78.9067767 74.3819766 79.8542078 1.02515849 0.035846969 6.25481936 0.90313325 MT3335 48.354291 52.6648441 51.7400302 54.0167271 1.047208612 0.066548867 5.69692189 0.832160187 Rv3238c Rv3238c unknown, possible membrane protein MT3337 125.94606 179.711994 139.761734 164.704182 1.006949116 0.009990782 7.25469323 0.975497364 Rv3239c Rv3239c possible antibiotic efflux proteins MT3338 960.807259 1192.65059 1012.61332 1205.85318 1.032235499 0.045772151 10.0942954 0.886067917 Rv3240c secA SecA, preprotein translocase subunit MT3339 248.050016 398.062971 316.896319 403.095923 1.136174278 0.184184147 8.41666066 0.399096923 Rv3241c Rv3241c member of S30AE ribosomal protein family MT3340 38.4210452 29.4995518 37.0091253 30.2868354 0.993747026 −0.009049457 5.08624964 0.978929348 Rv3242c Rv3242c conserved hypothetical protein MT3341 132.037202 107.229966 130.032062 116.151575 1.032597696 0.046278284 6.92521839 0.873231353 Rv3243c Rv3243c hypothetical protein MT3342 572.473573 462.219972 578.870004 498.718019 1.044470803 0.062772164 9.04505223 0.819200333 Rv3244c lpqB lipoprotein MT3343 693.92156 632.249597 720.995957 702.529688 1.074490732 0.103653039 9.42542735 0.692019534 Rv3245c mtrB sensor histidine kinase MT3344 496.568531 718.305038 586.144525 793.546312 1.141755094 0.191253226 9.34170653 0.350424024 Rv3246c mtrA two-component response regulator MT3345 124.634122 76.2825834 139.761734 90.6263297 1.153249973 0.205705259 6.75474058 0.267466322 Rv3247c tmk thymidylate kinase MT3346 1981.58833 1150.75399 2224.27571 1363.06371 1.153014419 0.205410555 10.7143145 0.363381298 Rv3248c sahH adenosyihomocysteinase MT3347 1143.91634 417.06575 1355.06139 406.608572 1.075566538 0.105096777 9.69835622 0.721200634 Rv3249c Rv3249c transcriptional regulator (TetR/AcrR family) MT3348 151.997403 49.7691826 175.225023 51.9871969 1.102226997 0.140421369 6.74659345 0.531483649 MT3349 312.897244 112.9308 363.453253 108.97016 1.06252661 0.087498973 7.81185062 0.746856645 Rv3251c rubA rubredoxin A MT3350 2465.03803 826.25892 2586.45592 761.698299 0.983792206 −0.023574469 10.6969634 0.944598499 Rv3252c Rv3252c possible alkane-1 monooxygenase MT3351 37.3902356 49.226246 43.3743311 42.5420755 0.997811091 −0.00316139 5.43663256 0.99525661 Rv3253c Rv3253c probable cationic amino acid transport MT3352 128.101387 151.841252 136.033542 150.731647 1.026300498 0.03745311 7.14830517 0.89817502 Rv3254 Rv3254 slight similarity to squalene MT3353 213.658495 202.062881 219.599601 228.009913 1.077073198 0.107116299 7.75496734 0.641879751 Rv3255c manA mannose-6-phosphate Isomerase MT3354 184.889566 148.221675 189.046613 168.919361 1.079260779 0.110043501 7.43414661 0.648484588 Rv3256c Rv3256c hypothetical protein MT3355 716.411928 754.953255 752.821986 793.156017 1.050711901 0.071367145 9.55940623 0.802899283 Rv3257c pmmA phosphomannomutase MT3356 399.20403 507.374194 489.393396 619.162831 1.223102347 0.290545131 8.97721328 0.065406436 Rv3258c Rv3258c hypothetical protein MT3357 18.3003796 37.6435999 30.0983304 37.8585443 1.03257026 0.046239951 5.07301409 0.894346121 Rv3259 Rv3259 hypothetical protein M13358 740.870203 1057.4594 962.41912 1417.08044 1.31945615 0.399943406 10.0288172 0.011888969 Rv3260c whiB2 WhiB transcriptional activator homologue MT3359 90.7111505 117.907718 103.934718 126.377285 1.107302593 0.147049522 6.78031686 0.484421074 Rv3261 Rv3261 conserved hypothetical protein MT3361 75.7175719 102.524516 75.5640863 93.9828604 0.955283388 −0.065999318 6.44510056 0.814508736 Rv3262 Rv3262 conserved hypothetical protein MT3362 14.5250293 20.7220778 16.4586036 25.0568922 1.174758768 0.232364536 4.27705703 0.377431927 MT3363 92.6790577 120.71289 85.111895 113.731751 0.930516229 −0.103896783 6.68989824 0.673053573 Rv3263 RV3263 probable DNA methylase MT3364 370.435101 287.394407 339.720128 324.490657 1.017432601 0.024933227 8.36930308 0.913447653 Rv3264c rmlA2 glucose-1-phosphate thymldytransferase MT3365 148.811268 129.309385 150.94631 135.041818 1.029198011 0.041520574 7.14158829 0.886712512 Rv3265c wbbL dTDP-rhamnosyl transferase MT3366 345.414557 178.264163 315.623277 192.024781 0.990913468 −0.013169016 8.01114695 0.969499602 MT3367 699.263022 669.621729 787.285029 805.645434 1.163889098 0.218953596 9.53261982 0.273247448 Rv3267 Rv3267 conserved hypothetical protein MT3368 274.195069 236.901309 311.258565 300.370471 1.199677555 0.262646696 8.13371468 0.116754925 Rv3268 Rv3268 hypothetical protein MT3369 275.319537 307.935506 393.551583 376.165618 1.321104361 0.401744437 8.40270602 0.005069147 Rv3269 Rv3269 probable heat shock protein MT3370 2021.1344 1435.97665 2597.09491 1527.76789 1.169344419 0.225699924 10.8884804 0.335308461 Rv3270 ctpC cation transport ATPase MT3371 140.658509 186.317722 141.94409 181.486836 0.991151729 −0.012822167 7.34684169 0.969499602 Rv3271c Rv3271c hypothetical protein MT3372 187.700852 180.164441 214.689299 205.841199 1.143141439 0.193003917 7.62408542 0.296366668 Rv3272 Rv3272 conserved hypothetical protein MT3373 410.449214 433.172867 397.552569 416.678164 0.965235958 −0.051046433 8.69571319 0.855441655 Rv3273 Rv3273 C-term similar to carbonic anhydrase MT3374 220.686735 306.849633 231.60256 324.880951 1.054158979 0.076092458 8.08319284 0.768835739 Rv3274c fadE25 acyl-CoA dehydrogenase MT3375 94.0347057 79.9926498 95.2052928 87.4259167 1.051509419 0.072461773 6.48140564 0.797430088 Rv3275c purE phosphoribosylaminoimidazole carboxylase MT3376 290.500585 251.470106 272.794535 284.836759 1.031416079 0.044626442 8.10369406 0.884935749 Rv3276c purK phosphoribosylaminoimidazole carboxylase ATPase MT3377 391.238692 329.29101 423.46805 419.176047 1.17377732 0.231158738 8.61092632 0.20739922 Rv3277 Rv3277 conserved hypothetical protein MT3377.1 4.40436371 9.68236824 5.63775373 10.2257099 1.134756636 0.182382925 2.94245113 0.683091419 Rv3278c Rv3278c conserved hypothetical protein MT3378 22.1155284 11.8541144 21.3689053 16.4704182 1.143498835 0.193454896 4.17947518 0.565529532 MT3379 32.3299039 38.8199624 34.5539745 38.6391328 1.030049174 0.042713213 5.18059746 0.900042957 Rv3279c birA biotin apo-protein ligase MT3379.1 408.387597 479.503452 407.373173 484.35519 1.003826994 0.005510647 8.79794483 0.984096717 Rv3280 accD5 acetyl/propionyl CoA carboxylate [beta] subunit MT3380 138.503182 179.440526 127.031322 178.286423 0.955346749 −0.065903632 7.28542113 0.808331268 Rv3281 Rv3281 conserved hypothetical protein MT3381 72.3440158 69.6768556 71.4721682 85.5525042 1.102837691 0.141220479 6.22778784 0.584815826 Rv3282 Rv3282 conserved hypothetical protein MT3382 703.198836 571.712173 669.346858 508.085082 0.919800059 −0.120607804 9.26032694 0.614950649 Rv3283 sseA thiosulfate sulfurtransferase MT3383 200.257934 153.470061 192.047353 172.666186 1.038396693 0.054357694 7.4901022 0.85855125 Rv3284 Rv3284 conserved hypothetical protein MT3384 913.577436 716.042803 897.221227 731.723699 1.001777831 0.00256259 9.67031676 0.99525661 Rv3285 accA3 acetyl/propionyl CoA carboxylase [alpha] subunit MT3385 119.948629 64.5189585 124.848966 65.4133198 1.027881419 0.039673839 6.55204802 0.894346121 Rv3286c sigF ECF subfamily sigma subunit MT3386 87.2438855 56.1034422 110.208992 58.4660818 1.151494793 0.203507887 6.28841962 0.355489385 MT3387 191.636677 49.6786931 217.235382 44.7277235 1.021427617 0.030586972 6.97666032 0.92245505 Rv3288c Rv3288c conserved hypothetical protein MT3388 485.323397 86.23642 533.949837 87.1917401 1.05765754 0.080872571 8.33059817 0.763576794 Rv3289c Rv3289c hypothetical protein MT3389 2759.56814 637.678963 2810.78396 556.403513 0.94323474 −0.08431124 10.7238576 0.790412569 Rv3290c lat lysine-[epsilon] aminotransferase MT3390 22.5840778 23.6177394 24.5515082 25.4471865 1.082105451 0.113841096 4.59872533 0.719637416 MT3391 168.02179 117.455271 177.134585 115.214869 1.017506969 0.025038675 7.17609108 0.930747689 Rv3292 Rv3292 conserved hypothetical protein MT3392 269.509575 149.036079 263.610453 138.554466 0.954110548 −0.067771661 7.68178408 0.801337286 Rv3293 aldB aldehyde dehydrogenase MT3393 5.52888211 3.52908749 4.6375071 4.44935469 1.017429149 0.024928333 2.23530218 0.973097519 MT3394 285.627672 295.628944 307.530373 300.682706 1.046385783 0.065414845 8.21696053 0.806148616 Rv3295 Rv3295 transcriptional regulator (TetR/AcrR family) MT3395 441.27976 299.158032 490.848301 336.823956 1.119050783 0.162275508 8.61541557 0.420522227 Rv3296 lhr ATP-dependent helicase MT3396 64.2849683 38.729473 60.9241129 41.9956636 1.011086416 0.015906308 5.6905269 0.967251048 Rv3297 nel probable endonuclease VIII MT3397 25.3953738 30.9473826 30.6439195 28.0231287 1.041909928 0.059230563 4.85440863 0.880578033 Rv3298c lpqC similar to MTCI376.03c MT3398 268.010218 319.699131 270.612179 332.608778 1.025045146 0.035687452 8.21876767 0.900042957 Rv3299c atsB proable arylsulfatase MT3399 132.318331 99.085918 131.759761 111.70222 1.058893171 0.082557047 6.89344173 0.751431314 Rv3300c Rv3300c probable deaminase, riboflavin synthesis MT3400 263.418434 200.796029 252.698671 223.950853 1.034093969 0.048367291 7.87888832 0.870656307 Rv3301c phoY1 phosphate transport system regulator MT3401 557.479994 433.806293 534.313563 471.865774 1.020948012 0.029909404 8.96444631 0.917923192 Rv3302c glpD2 glycerol-3-phosphate dehydrogenase MT3402 846.106333 552.980863 740.909958 576.464638 0.955237536 −0.066068567 9.40785707 0.82588107 Rv3303c lpdA dihydrolipoamide dehydrogenase MT3403 131.849782 157.904043 127.213185 179.14507 1.047642567 0.067146585 7.22128004 0.813012054 Rv3304 Rv3304 conserved hypothetical protein MT3404 158.557094 109.492202 153.674255 113.653692 1.002535912 0.003653917 7.06616958 0.990596979 Rv3305c amiA probable aminohydrolase MT3405 226.215617 129.399875 222.418478 143.08188 1.041612907 0.058819231 7.4953541 0.837506926 Rv3306c amiB probable aminohydrolase MT3406 154.621279 143.244756 163.222064 137.305525 1.005988531 0.008613857 7.2265883 0.97711178 Rv3307 deoD probable purine nucleoside phosphorylase MT3407 76.4672509 73.3869219 72.9270724 89.3773881 1.07934796 0.110160035 6.28955088 0.703931527 Rv3308 pmmB phosphomannomutase MT3408 41.1386313 43.9778595 36.0088787 42.6981932 0.923308353 −0.115115556 5.36227008 0.69018019 Rv3309c upp uracil phophoribosyltransferase MT3409 103.268273 217.446083 116.210472 209.900259 1.039379302 0.055722235 7.33901798 0.852607709 Rv3310 Rv3310 probable acid phosphatase MT3410 114.888296 243.868995 134.578637 235.03521 1.059460387 0.083329647 7.5101135 0.767489209 Rv3311 Rv3311 conserved hypothetical protein MT3411 37.109107 56.4653998 31.098577 38.2488386 0.749282547 −0.416418248 5.35418428 0.022905567 Rv3312c Rv3312c conserved hypothetical protein MT3412 36.9216873 21.7174615 7.45638396 5.30800209 0.220692396 −2.17989117 4.16771802 5.99E−38 MT3413 197.634108 267.396244 21.3689053 47.5378422 0.140675641 −2.829555555 7.06193426 5.06E−65 MT3415 55.0076915 94.5614469 54.8317016 77.5905011 0.900235174 −0.15162616 6.14330215 0.546009693 Rv3314c deoA thymidine phosphorylase MT3416 14.4313194 17.1025009 11.0936444 11.7088281 0.723194214 −0.46754496 3.78153469 0.03224823 Rv3315c cdd probable cytidine deaminase MT3417 21.8343938 26.7848692 25.7336178 32.7847188 1.202333212 0.265836777 4.75360378 0.239799128 Rv3316 sdhC succinate dehydrogenase C subunit MT3418 41.1386313 44.8827537 41.1919748 53.4703151 1.094987559 0.130914478 5.50332179 0.651061634 Rv3317 sdhD succinate dehydrogenase D subunit MT3419 131.662352 172.020393 138.306829 176.178834 1.037005168 0.052423084 7.27359925 0.856419101 MT3420 84.9011388 110.397096 86.6577307 119.508106 1.052026753 0.073171393 6.65185623 0.793843734 Rv3319 sdhB succinate dehydrogenase B MT3421 61.7548019 48.7737989 72.5633464 69.7065568 1.295035491 0.372991636 5.98599156 0.038252471 Rv3320c Rv3320c conserved hypothetical protein MT3422 25.957633 13.5734134 39.5552076 19.3585958 1.480246711 0.565837658 4.63066649 0.000924471 Rv3321c Rv3321c conserved hypothetical protein MT3423 59.3183453 32.0332557 102.752608 46.9133714 1.601358412 0.679296244 5.91684551 4.18E−06 Rv3322c moaE3 molybdopterin-converting factor subunit 2 MT3424 132.599461 88.4081661 193.502257 103.037688 1.307432407 0.386736362 7.01734956 0.015153827 Rv3323c gphA phosphoglycolate phosphatase MT3425 83.9306631 52.3028864 149.218611 66.4280849 1.46792478 0.553778043 6.4818602 0.000368463 Rv3324c moaC3 molybdenum cofactor biosynthesis, protein C MT3426 50.3211982 28.8661259 82.9295387 42.307899 1.559694691 0.64126365 5.68006271 2.86E−05 MT3427 221.061575 116.640866 380.457445 175.007951 1.609554621 0.686661536 7.80382677 2.96E−08 MT3427.1 4.02952425 3.1671298 5.91054826 3.66876615 1.317313767 0.397599018 2.12566484 0.397669171 MT3428 67.6585234 87.4127825 89.02195 85.7866808 1.133926333 0.181326917 6.36895613 0.472451693 MT3429 10.4017952 17.8264163 14.6399734 18.4218896 1.18504562 0.244942599 3.95550849 0.426270599 MT3430 20.4287509 26.8753586 20.3686586 20.7636552 0.872499926 −0.196773086 4.47784448 0.495732 Rv3327 Rv3327 hypothetical protein MT3431 224.06029 173.377734 206.050806 171.65142 0.954004611 −0.067931856 7.5995487 0.801831984 MT3432 239.990968 195.638132 239.422671 215.208261 1.047451841 0.066883914 7.79919861 0.801831984 Rv3329 Rv3329 probable aminotransferase MT3433 202.507021 315.898575 231.511629 355.63614 1.134334386 0.18184599 8.1115858 0.356447417 Rv3330 Rv3330 probable penicillin binding protein MT3434 108.141136 125.689808 129.122747 138.008054 1.144365255 0.1945476 6.97067484 0.294305462 Rv3331 sugI probable sugar transport protein MT3435 68.0333629 54.0221854 83.5660593 63.4618485 1.201623223 0.2649846 6.07558444 0.161656981 Rv3332 nagA N-acetylglucosamine-6-P-deacetylase MT3436 2.15532692 1.62880961 1.90956175 2.88817761 1.272810604 0.34801776 1.22217391 0.641879751 MT3437 14.8061589 14.6592865 17.8225763 12.5674755 1.019133752 0.027343405 3.9193833 0.950509824 Rv3333c Rv3333c hypothetical protein MT3438 75.0616019 85.7839728 69.3807435 68.1453797 0.856048324 −0.224235856 6.22426047 0.272848973 Rv3334 Rv3334 transcriptional regulator (MerR family) MT3439 110.671352 57.7322518 97.023923 67.1306146 1.005359295 0.007711183 6.38020876 0.98219487 Rv3335c Rv3335c conserved hypothetical protein MT3440 344.946018 203.148754 303.984044 227.073207 0.991557878 −0.012231109 8.07654366 0.973097519 MT3441 26.7073119 90.6704017 31.1895085 75.4048532 0.967428802 −0.047772605 5.81246323 0.900042957 Rv3338 Rv3338 conserved hypothetical protein MT3442 300.621251 203.601201 243.059931 182.501601 0.850963303 −0.232831176 7.86172953 0.192254636 Rv3339c lcdI isocitrate dehydrogenase MT3443 995.573619 699.483238 851.755471 544.460508 0.816154837 −0.293085215 9.59426943 0.095446114 Rv3340 metC cystathionine [beta]-lyase MT3444 540.049959 412.179321 465.842135 324.022304 0.823627718 −0.279935713 8.76712222 0.080778165 Rv3341 metA homoserine o-acetyltransferase MT3445 230.526271 176.273396 189.683134 111.155808 0.721405084 −0.471118504 7.46807366 0.002888996 Rv3342 Rv3342 conserved hypothetical protein MT3448 11.4326037 12.0350932 13.5487953 9.44512136 0.967181826 −0.04814096 3.55838166 0.921052928 MT3449 39.4518537 33.8430441 51.9218932 36.3754261 1.191820848 0.253167389 5.34225522 0.266739001 Rv3345c PE_PGRS PE_PGRS-family protein MT3449.2 0.93709856 2.80517211 1.27304117 2.49788333 1.01675992 0.023979067 1.04866849 0.979541419 MT3450 7.87162877 7.51062209 8.45663059 8.27423854 1.088024046 0.121710441 3.03663591 0.79545701 Rv3346c Rv3346c conserved hypothetical protein MT3454 5.99743144 12.5780298 6.63800036 10.3037688 0.923940575 −0.11412803 3.1807816 0.808221041 MT3455 47.6983219 42.5300287 45.7385504 40.3564276 0.953918707 −0.06806177 5.46760993 0.811756973 Rv3348 Rv3348 weakly similar to transposases MT3456 3.37355519 4.43398172 4.45564408 4.21517813 1.107387814 0.147160551 2.10370319 0.814508736 Rv3349c Rv3349c hypothetical protein MT3456.1 5.62259198 9.68236824 4.45564408 8.19617969 0.825330796 −0.276955621 2.84327656 0.480991077 MT3459 4.87291305 8.3250269 4.72843861 8.50841511 1.001566854 0.002258723 2.76598659 0.997032163 Rv3351c Rv3351c conserved hypothetical protein MT3460 7.68420903 8.50600575 13.1850692 13.3480641 1.637002171 0.711056235 3.44269965 0.000966516 Rv3352c Rv3352c defective/truncated oxidoreductase MT3461 9.08985703 14.3878182 10.9117814 14.5189469 1.088341915 0.11213188 3.63420865 0.760272935 Rv3353c Rv3353c conserved hypothetical protein MT3462 27.9255402 47.4164576 43.5561941 48.162313 1.24835646 0.320029945 5.39076861 0.233546465 Rv3354 Rv3354 conserved hypothetical protein MT3463 16.6803552 16.1976067 16.6404667 13.8944761 0.925323924 −0.111969603 4.00190861 0.758755474 Rv3355c Rv3355c conserved hypothetical protein MT3464 189.38754 134.105325 169.678201 123.645225 0.908722605 −0.138088128 7.27018999 0.526678539 Rv3356c folD methylenetetrahydrofolate dehydrogenase MT3465 4.31065335 12.2160721 4.18284954 8.27423854 0.769377046 −0.378237306 2.89423729 0.297857769 Rv3357 Rv3357 conserved hypothetical protein MT3466 4.12323412 7.78209036 4.27378105 8.66453232 1.084124994 0.116531101 2.68036747 0.822804121 Rv3358 Rv3358 hypothetical protein MT3467 21.1784298 29.0471047 24.0968506 24.4324214 0.971878847 −0.041151614 4.63610006 0.916845409 Rv3359 Rv3359 probable oxidoreductase MT3468 79.5596765 25.1560595 64.9250994 27.3986578 0.92987362 −0.104893443 5.62640234 0.764687847 Rv3360 Rv3360 possible ABC transporter MT3469 42.4505694 41.6251345 47.7390437 43.6348995 1.085561602 0.118441597 5.46068036 0.682164707 Rv3361c Rv3361c conserved hypothetical protein MT3470 50.1347785 58.7276354 58.9236196 63.3057308 1.124460841 0.16923342 5.85689639 0.476182576 Rv3362c Rv3362c hypothetical protein MT3471 20.8973002 20.8125673 23.096604 22.7931854 1.100047472 0.137565784 4.46457155 0.637012172 MT3472 31.3928052 33.3001076 35.7360841 32.7066599 1.056402939 0.07916022 5.06433507 0.808331268 MT3474 367.155256 355.351963 434.834489 378.741561 1.123501871 0.168003811 8.58569851 0.406031587 Rv3365c Rv3365c conserved hypothetical protein MT3475 35.9845886 29.7710201 49.1030164 36.9998969 1.303509938 0.382401582 5.25319495 0.03317631 Rv3366 spoU probable rRNA methylase MT3476 135.598177 94.6519363 198.594422 119.430047 1.361229618 0.444910447 7.10051097 0.002115381 Rv3367 PE_PGRS PE_PGRS-family protein MT3477 19.3042325 29.2280836 23.9149876 26.6180693 1.052440028 0.073738036 4.64095166 0.851629288 Rv3368c Rv3368c conserved hypothetical protein MT3478 51.4467166 46.4210739 55.9228797 39.3416625 0.96140123 −0.056789446 5.59831526 0.879854448 Rv3369 Rv3369 conserved hypothetical protein MT3480 522.245035 139.353711 476.844848 130.514404 0.924296167 −0.113572895 8.31000958 0.626654945 Rv3370c dnaE2 DNA polymerase III [alpha] chain MT3481 1254.86832 707.08435 1327.23635 452.741354 0.823588818 −0.280003852 9.86977839 0.335308461 Rv3371 Rv3371 conserved hypothetical protein MT3482 231.55708 123.608552 251.971219 109.438514 0.984082588 −0.023148697 7.48615112 0.941730516 Rv3372 otsB2 trehalose-6-phosphate phosphatase MT3483 7.12194934 3.61957691 8.72942513 3.98100156 1.174729709 0.232328848 2.5897629 0.618065109 MT3485 54.3517224 63.9760219 47.6481122 64.0863193 0.939246619 −0.090424078 5.85048285 0.762826526 Rv3375 amlD probable amidase, v. similar MTCV50.19 MT3486 352.723937 285.31315 316.98725 368.359733 1.077284651 0.107399504 8.37080792 0.734837124 Rv3376 Rv3376 conserved hypothetical protein MT3487 102.237454 135.100708 105.935211 141.442644 1.041676121 0.058906783 6.92324024 0.822804121 Rv3377c Rv3377c similar to many cyclases Involved in steroid biosynthesis MT3488 34.4852308 58.637146 37.1000568 55.1095511 1.001015204 0.001463887 5.53991503 0.997032163 Rv3378c Rv3378c hypothetical protein MT3490 50.3221932 29.4995518 46.011345 31.613836 0.985855365 −0.020552091 5.30455129 0.952654537 Rv3382c lytB lytB protein homologue MT3491 77.6854791 56.6463787 72.9270724 43.1665464 0.848453561 −0.237092397 5.97175448 0.288882345 Rv3383c idsB transfergeranyl, similar geranyl pyrophosphate MT3491.1 12.7445418 5.70083364 13.0032062 7.80588542 1.153907513 0.206527595 3.31816931 0.601304701 MT3492 103.549402 64.8809162 98.6606903 71.8141459 1.024965797 0.035575768 6.40750301 0.903380374 Rv3384c Rv3384c conserved hypothetical protein MT3493 171.207926 129.580854 178.862284 139.725349 1.061212292 0.085713291 7.27623366 0.741632985 Rv3385c Rv3385c conserved hypothetical protein MT3494 29.7997375 41.3536662 34.644906 40.1222511 1.057559306 0.080738569 5.19631757 0.808331268 Rv3386 Rv3386 hypothetical protein MT3494.1 21.4595594 30.3139567 12.1872889 27.7108932 0.967887479 −0.047088757 4.67815287 0.897921476 Rv3387 Rv3387 hypothetical protein MT3495 30.7368351 47.0544999 50.3760575 53.3141974 1.354463971 0.437722018 5.50973656 0.040943437 Rv3388 PE_PGRS PE_PGRS-family protein MT3496 209.160422 286.399023 197.86697 288.739702 0.977057176 −0.033485106 7.94093486 0.90313325 Rv3389c Rv3389c putative dehydrogenase MT3497 153.121922 163.785855 194.138778 176.178834 1.167489732 0.223409862 7.42613898 0.249588935 Rv3390 lpqD lipoprotein MT3498 108.141186 113.926183 134.487706 114.200104 1.116212369 0.158611538 6.88097455 0.483174937 Rv3391 acrA1 fatty acyl-CoA reductase MT3499 94.8343847 90.2179546 90.4768542 88.3626229 0.966720782 −0.048828838 6.51011098 0.870656307 Rv3392c cmaA1 cyclopropane mycolic acid synthase 1 MT3500 79.184837 77.0064988 64.2885788 74.1559115 0.885233048 −0.175870784 6.20621627 0.448874833 Rv3393 lunH probable inosine-uridine preferring nucleoside MT3501 35.8908788 20.2696307 37.1000568 22.7151266 1.072705115 0.101253536 4.86556157 0.751431314 Rv3394c Rv3394c hypothetical protein MT3502 53.6957534 30.4044461 58.5598936 31.9260714 1.071459179 0.099576886 5.45292249 0.745116768 Rv3395c Rv3395c hypothetical protein MT3503 6.37227091 5.51985479 5.36495919 6.1664948 0.973890634 −0.038168326 2.5929374 0.948443219 MT3504 264.917792 260.066601 234.057711 251.037275 0.923650268 −0.114581404 7.98125032 0.617184719 Rv3396c guaA GMP synthase MT3505 40.4826622 47.8689047 35.3723581 38.1707797 0.833563642 −0.262635743 5.3450501 0.207303287 Rv3397c phyA phytoene synthase MT3506 33.5481321 30.7664038 31.098577 27.4767167 0.909936328 −0.136162498 4.94909287 0.625550995 Rv3398c ldsA geranylgeranyl pyrophosphate synthase MT3507 43.7625075 52.7553335 37.5547144 46.5230771 0.87039773 −0.200253301 5.50230664 0.402733156 Rv3399 Rv3399 conserved hypothetical protein MT3508 259.01407 169.758157 237.60404 189.604957 1.011408413 0.016365684 7.74254736 0.958106946 Rv3400 Rv3400 probable [beta]-phosphoglucomutase MT3509 486.447916 426.295671 442.381805 382.098091 0.902851273 −0.147439744 8.76311946 0.481104806 Rv3401 Rv3401 conserved hypothetical protein MT3510 258.451811 81.6214594 291.526427 105.847806 1.205545217 0.269685764 7.52750537 0.127414551 Rv3402c Rv3402c possible involved in LPS synthesis MT3510.1 28.7689289 19.3647365 27.0975905 20.5294787 0.996266393 −0.005396537 4.59122342 0.988617034 MT3511 362.563473 185.141359 399.007474 203.577492 1.100051672 0.137571292 8.16854673 0.52349722 Rv3403c Rv3403c hypothetical protein MT3512 151.809983 130.033301 127.667843 146.204234 0.972855672 −0.039702305 7.12004517 0.90313325 Rv3404c Rv3404c hypothetical protein MT3513 56.6944691 54.2936537 64.3795103 59.9492 1.119671881 0.163076013 5.88279967 0.494261547 MT3514 139.815121 101.800601 204.50497 102.257099 1.215527461 0.281582487 7.10069521 0.217482131 Rv3406 Rv3406 putative dioxygenasediooxygenase MT3515 67.0025544 49.3167354 72.3814834 50.0357255 1.047768627 0.067320169 5.90322365 0.823630484 Rv3407 Rv3407 conserved hypothetical protein MT3516 60.6302835 50.2216297 64.1976473 52.0652557 1.047840452 0.067419064 5.83157467 0.822461081 Rv3408 Rv3408 conserved hypothetical protein MT3517 457.866407 353.532664 459.022271 365.783791 1.018268806 0.026118459 8.67681435 0.924310616 Rv3409c choD cholesterol oxidase MT3518 177.955036 148.221675 170.769379 141.286526 0.956428171 −0.06427147 7.31944434 0.812642214 MT3519 984.890694 679.847034 919.135721 664.827261 0.955263107 −0.066029947 9.66593213 0.819552181 Rv3411c guaB2 Inosine-5′-monophosphate dehydrogenase MT3520 15.8369674 10.8587307 27.6431796 17.2510068 1.67156167 0.741196582 4.17566102 1.81E−05 MT3521 1097.43624 821.101023 1140.46302 862.003927 1.044489603 0.062798132 9.93725118 0.832160187 Rv3412 Rv3412 conserved hypothetical protein MT3522 162.399198 138.539306 237.785903 218.096439 1.51807608 0.602244095 7.56523119 2.12E−06 Rv3413c Rv3413c hypothetical protein MT3523 372.121879 273.368546 510.762302 424.796285 1.460087718 0.546055045 8.62732499 2.40E−05 Rv3414c sigD ECF subfamily sigma subunit MT3524 10.495505 13.3924346 11.4573705 12.9577698 1.022887601 0.032647624 3.61557151 0.939595615 Rv3415c Rv3415c conserved hypothetical protein MT3525 2548.3451 1407.20101 1243.57936 539.074447 0.432528515 −1.209132849 10.4865077 1.89E−17 Rv3416 whiB3 WhiB transcriptional activator homologue MT3526 432.002434 796.216431 461.659285 786.208779 1.026900048 0.038295766 9.27430682 0.897921476 Rv3417c groEL1 60 kD chaperonin 1 MT3527 348.600703 1096.36985 367.363308 906.341356 0.932065829 −0.101496243 9.40912311 0.734697142 Rv3418c groES 10 kD chaperone MT3528 226.965296 142.973288 212.143217 139.881467 0.955959325 −0.06497886 7.4970385 0.812642214 Rv3419c gcp glycoprotease MT3529 66.5340051 42.7110076 62.5608801 43.5568406 0.977869578 −0.032286034 5.75491092 0.921846482 Rv3420c rimI ribosomal protein S18 acetyltransferase MT3530 139.346571 80.6260757 133.942117 76.8099125 0.957088718 −0.063275433 6.75267007 0.812642214 Rv3421c Rv3421c conserved hypothetical protein MT3531 125.477511 63.5235748 119.756801 68.3795563 1.010963463 0.015730858 6.56128753 0.959849725 Rv3422c Rv3422c conserved hypothetical protein MT3532 256.109055 149.488527 231.875355 154.088178 0.965087053 −0.051269012 7.62970063 0.860243051 Rv3423c alr alanine racemase MT3532.2 65.9717459 25.6989961 81.20184 40.5125453 1.379294066 0.463930073 5.7415402 0.010709568 Rv3424c Rv3424c hypothetical protein MT3533 316.364509 145.235524 408.191556 204.514198 1.346665462 0.429391502 8.07003155 0.00193925 Rv3429 PPE PPE-family protein MT3534 46.6675134 34.9289172 48.6483588 37.46825 1.057065094 0.080064221 5.39559538 0.801831984 Rv3430c Rv3430c transposase MT3535 32.7047433 26.965848 35.0995635 32.0041302 1.127996304 0.173762341 4.99408811 0.507235719 MT3536 29.5186079 25.0655701 32.0988237 28.9598349 1.120527809 0.164178454 4.86225111 0.536432946 MT3537 49.6662291 59.8135085 65.56162 69.9407334 1.240691965 0.311144972 5.94093192 0.089666664 Rv3431c Rv3431c probable truncated transposase MT3538 62.9730301 71.8486017 59.4692087 65.7255552 0.929156469 −0.10600653 6.02638233 0.701057565 Rv3432c gadB glutamate decarboxylase MT3539 96.3337425 74.5632844 93.6592105 74.7023235 0.9814003 −0.027086382 6.40481499 0.924552662 Rv3433c Rv3433c conserved hypothetical protein MT3540 46.2926739 51.3979922 45.1020298 53.7044917 1.009890317 0.014198612 5.62371009 0.971262002 Rv3434c Rv3434c conserved hypothetical protein MT3541 128.569937 166.22907 119.756801 160.957357 0.950057804 −0.073912801 7.17055893 0.785634873 MT3542 249.080825 361.324265 230.056725 336.121426 0.926975278 −0.109397231 8.20130626 0.637037691 Rv3436c glmS glucosamine-fructose-6-phosphate aminotranferase MT3542.1 58.0064072 58.9086143 50.8307151 46.2108417 0.828863311 −0.70793891 5.74565264 0.190246509 Rv3437 Rv3437 hypothetical protein MT3543 89.3992124 137.272454 99.7518684 135.58823 1.04778346 0.067340593 6.85415926 0.802899283 Rv3438 Rv3438 conserved hypothetical protein MT3544 94.7406748 54.2936537 107.117321 56.202375 1.08411337 0.116515633 6.28988985 0.637790353 Rv3439c Rv3439c conserved hypothetical protein MT3545 63.4415795 39.815346 67.7439763 45.8205474 1.106929469 0.1465633 5.76470085 0.569416225 Rv3440c Rv3440c hypothetical protein MT3546 478.669997 378.426766 531.040029 435.256171 1.12955572 0.175755439 8.83295274 0.379061838 Rv3441c mrsA phosphoglucomutase or phosphomannomutase MT3547 325.829205 307.754527 376.365527 371.091793 1.180204163 0.239036452 8.43229626 0.142197629 Rv3442c rpsI 30S ribosomal protein S9 MT3548 866.347714 801.10286 867.759417 890.495409 1.055200618 0.077517315 9.74248462 0.795267516 Rv3443c rplM 50S ribosomal protein L13 MT3549 4.87291305 5.70083364 3.36446594 5.15188438 0.804721518 −0.313438484 2.30802475 0.505322279 Rv3444c Rv3444c conserved hypothetical protein MT3550 8.43388796 11.4921567 9.45687723 8.74259167 0.914075881 −0.129614161 3.27862141 0.786281637 Rv3445c Rv3445c hypothetical protein MT3551 5.24775251 6.51523844 4.72843861 4.6054724 0.792240001 −0.335990549 2.44473535 0.438953559 Rv3446c Rv3446c hypothetical protein MT3553 15.9306773 24.613123 14.7309049 12.6455344 0.682995387 −0.550052261 4.09950839 0.047355448 Rv3447c Rv3447c probable membrane protein MT3554 11.3388938 18.5503317 10.4571239 13.1138875 0.795273866 −0.330476332 3.75939641 0.233072634 Rv3448 Rv3448 probable membrane protein MT3555 9.37098653 10.4967731 7.36545245 8.11812084 0.779496723 −0.359385137 3.17134078 0.234801512 Rv3449 Rv3449 probable precursor of serine protease MT3556 31.0179657 39.0914307 30.6439195 35.2826021 0.942441365 −0.085525233 5.0954361 0.795952632 Rv3450c Rv3450c probable membrane spanning protein MT3557 104.486501 84.4266315 97.7513751 83.522974 0.961845751 −0.056122544 6.53472223 0.844723806 Rv3451 Rv3451 probable cutinase MT3559 57.5378579 71.3961546 57.1959209 68.9259683 0.97920671 −0.030314651 5.99878891 0.923557668 Rv3452 Rv3452 probable cutinase precursor MT3560 41.1386313 35.4718538 43.1015366 36.5315438 1.038833948 0.054965065 5.29394811 0.870656307 MT3561 109.265704 86.5078882 94.8415668 84.4596802 0.920234605 −0.119926386 6.55360165 0.619926139 Rv3453 Rv3453 hypothetical protein MT3562 315.52112 220.794192 321.533826 274.767167 1.125629055 0.170731473 8.14631781 0.448807051 Rv3455c truA probable pseudouridylate synthase MT3563 831.956193 582.480415 822.020866 693.865155 1.084736057 0.117344042 9.51717801 0.661238202 Rv3456c rplQ 50S ribosomal protein L17 MT3564 823.990854 709.980012 869.123389 794.483018 1.086411789 0.11957104 9.64307815 0.633618212 Rv3457c rpoA [alpha] subunit of RNA polymerase MT3565 902.144883 874.218314 947.233558 890.963762 1.034446825 0.048859486 9.819883 0.878901047 Rv3458c rpsD 30S ribosomal protein S4 MT3566 376.151403 450.275368 446.655586 434.007229 1.069515966 0.09695802 8.73792602 0.723313141 Rv3459c rpsK 30S ribosomal protein S11 MT3567 356.659751 383.856132 398.370953 385.454622 1.058920851 0.082594759 8.57464111 0.74702628 MT3567.1 557.854834 488.461904 617.424965 708.54022 1.267165357 0.341604799 9.21251804 0.059635375 MT3568 771.13849 723.191467 781.283549 752.331237 1.02663935 0.037929464 9.56445605 0.900501119 Rv3462c lnfA Initiation factor IF-1 MT3569 67.8459432 125.41834 83.7479223 123.567166 1.097890157 0.134733721 6.64875641 0.597362575 Rv3463 Rv3463 probable neuraminidase MT3570 250.955022 225.228173 240.695712 262.902221 1.058306521 0.031757541 7.93737425 0.764687847 Rv3464 rmlB dTDP-glucose 4,6-dehydratase MT3571 156.870316 139.172732 154.765433 151.512236 1.036405961 0.051589219 7.23606673 0.860475417 Rv3465 rmlC dTDP-4-dehydrorhamnose 3,5-epimerase MT3572 47.3234825 42.801497 49.1030164 42.2298401 1.011907817 0.017077869 5.50890961 0.963135739 MT3573 125.290091 92.661169 138.761487 94.3731547 1.062870035 0.087965199 6.81934762 0.728635818 Rv1586c Rv1586c phiRV1 integrase MT3573.1 137.753503 78.6353084 132.487213 83.6010328 1.009604994 0.013790952 6.75857296 0.966783763 Rv1584c Rv1584c phiRV1 phage related protein MT3573.11 85.3696831 42.801497 93.5685256 36.5315438 0.97499193 −0.036537817 6.01594423 0.916845409 MT3573.12 181.328591 68.7719613 191.86549 66.9744969 1.01783955 0.025510156 6.99292606 0.929988815 MT3573.13 2.06161706 3.80055576 2.00049326 2.49788333 0.771071494 −0.375063462 1.46812879 0.554227608 MT3573.14 14.712449 13.6639029 14.5490419 13.8944761 1.002905998 0.004186389 3.84588278 0.993327109 Rv1574 Rv1574 phIRV1 phage related protein MT3573.15 8.71501756 7.60111152 6.81986338 7.25947344 0.866318518 −0.207030539 2.95803434 0.619926139 Rv1573 Rv1573 phIRV1 phage related protein MT3573.16 4.49807358 6.15328075 4.18284954 4.52741354 0.817890937 −0.290019617 2.32601292 0.540028762 MT3573.2 20.8973002 7.32964325 19.186549 7.96200313 0.978419139 −0.03147547 3.80614329 0.941335885 MT3573.3 54.8202718 3.29381499 48.3755643 29.9746 0.895395382 −0.159403218 5.38131777 0.539842953 Rv1582c Rv1582c phiRV1 phage related protein MT3573.4 14.3376095 5.79132306 14.0034528 7.64976771 1.10448848 0.143378371 3.40617883 0.745116768 MT3573.5 16.6803562 10.9492202 14.6399734 10.8501807 0.92847295 −0.107068216 3.74865849 0.784640224 Rv1580c Rv1580c phiRV1 phage related protein MT3573.6 8.15275837 4.52447114 10.1843293 5.77635521 1.260124093 0.333565813 2.87245386 0.359345935 Rv1579c Rv1579c phIRV1 phage related protein MT3573.7 38.7021748 27.7802528 37.0091253 24.1982448 0.914741648 −0.128563757 5.00361802 0.654556372 Rv1578c Rv1578c phIRV1 phage related protein MT3573.8 156.870316 67.7765777 149.673268 66.5061438 0.966795645 −0.04871712 6.78594954 0.865029216 MT3573.9 2.06161706 4.3434923 4.27378105 1.8734125 0.937502262 −0.093105923 1.72272613 0.93032752 Rv1576c Rv1576c phiRV1 phage related protein MT3574 26.2337626 27.8708422 21.3689053 20.4514198 0.772266332 −0.372829619 4.59385943 0.057144453 Rv3468c rmlB3 dTDP-glucose 4,6-dehydratase MT3575 28.1129599 26.4229115 22.3691519 26.6180693 0.898069943 −0.155100286 4.70360577 0.617184719 Rv3469c mhpE probable 4-hydroxy-2-oxovalerate aldolase MT3576 23.3387557 30.9473826 21.4598368 26.4619516 0.884693991 −0.17674957 4.6853863 0.518433338 MT3577 3.09242559 3.71006634 3.54632896 3.66876615 1.058984324 0.082681234 1.88095998 0.90313325 Rv3471c Rv3471c conserved hypothetical protein MT3578 14.1501898 21.9889298 11.730165 16.5484771 0.785083391 −0.349082191 4.02537842 0.117274038 Rv3472 Rv3472 possible acyl carrier protein MT3579 39.0770142 38.6389836 41.4647694 36.9998969 1.007785686 0.01118887 5.29342944 0.974911666 MT3580 35.7971639 78.3638402 29.2799468 55.1876099 0.753793539 −0.407758666 5.63936804 0.02605996 MT3580.2 66.8151347 191.837576 24.0968506 36.2973672 0.257737722 −1.956024393 6.32027386 8.33E−24 MT3581 687.549239 1054.20178 254.244507 436.114818 0.391333715 −1.353528686 9.24836584 1.74E−29 Rv3477 PE PE-family protein MT3582 488.603243 700.297643 226.692259 322.695303 0.462370156 −1.112879814 8.76397847 1.17E−22 Rv1361c PPE PPE-family protein MT3583 860.631412 1176.3625 367.272376 563.038515 0.452086135 −1.145330424 9.53524669 1.03E−19 Rv3479 Rv3479 hypothetical protein MT3584 288.157839 329.29101 243.514589 304.273414 0.883960968 −0.177945428 8.18729317 0.377431927 Rv3480c Rv3480c conserved hypothetical protein MT3585 24.7394047 33.7525547 28.6434262 37.46825 1.13207022 0.178963448 4.97001581 0.48870294 Rv3481c Rv3481c possible membrane protein MT3586 131.193813 143.606714 146.490665 161.816005 1.121726788 0.16572133 7.18943703 0.423662019 MT3587 85.7445276 96.0092776 107.026389 111.858338 1.20536969 0.269475693 6.64881857 0.110386347 Rv3483c Rv3483c conserved hypothetical protein MT3588 477.545479 408.107297 407.645967 368.515851 0.877947501 −0.187793422 8.6991208 0.322018463 Rv3484 cpsA cpsA, CpsA : QS0160 MT3589 162.399198 67.2336412 20.7323847 35.2045432 0.259820655 −1.944411968 6.16025338 8.44E−07 Rv3485c Rv3485c short-chain alcohol dehydrogenase family MT3590 25.4890836 14.0258605 35.7360841 20.6855964 1.433750316 0.519793804 4.59394927 0.002838387 Rv3486 Rv3486 conserved hypothetical protein MT3591 1859.29746 1684.09865 151.219104 378.663501 0.135460473 −2.884056157 9.99215187 4.10E−24 Rv3487c lipF probable esterase MT3592 41.1386313 29.6805307 30.552988 26.4619516 0.812207717 −0.30007936 5.00539279 0.167258959 MT3593 400.328549 264.95303 310.803907 252.988746 0.860580196 −0.216618454 8.2641065 0.284807513 MT3594 861.099951 658.310551 782.738453 700.031804 0.983095769 −0.02459613 9.55211958 0.937911005 Rv3490 otsA probable [alpha],-trehalose- phosphate synthase MT3595 260.232299 240.792354 254.881028 226.604854 0.960071671 −0.058785986 7.9413261 0.822804121 Rv3491 Rv3491 hypothetical protein MT3596 68.7830418 108.315839 77.8373741 117.088281 1.104923509 0.143946499 6.54228977 0.518774989 Rv3492c Rv3492c conserved hypothetical protein MT3597 59.9743144 85.5125046 55.3772907 97.8077443 1.032731874 0.046465739 6.22624047 0.887972618 Rv3493c Rv3493c hypothetical protein MT3598 191.730336 273.820994 198.50349 324.490557 1.108874779 0.149096456 7.9503245 0.49025808 Rv3494c Rv3494c part of mce4 operon MT3599 137.191244 191.023172 134.669569 220.360145 1.065935485 0.092120122 7.41792096 0.735519493 Rv3495c lprN part of mce4 operon MT3600 121.166857 205.682458 134.214911 220.594322 1.089441796 0.123589122 7.41458761 0.589953244 Rv3496c Rv3496c part of mce4 operon MT3601 116.856203 171.115499 125.849212 179.379247 1.062174038 0.087020172 7.21424393 0.738873933 Rv3497c Rv3497c part of mce4 operon MT3602 92.8664775 140.168116 97.8423057 146.360352 1.048694746 0.0685948 6.90090011 0.794477304 Rv3498c Rv3498c part of mce4 operon MT3603 144.688034 226.223557 150.582584 220.282087 1.005971422 0.008589321 7.53632634 0.97711178 Rv3499c mce4 cell invasion protein MT3604 40.2952425 60.5374239 42.283153 61.9787302 1.035766705 0.050699089 5.68553506 0.880856541 Rv3500c Rv3500c part of mce4 operon MT3605 54.3517224 78.6353084 65.56162 88.5967995 1.164105242 0.219221492 6.16952877 0.272848973 MT3606 70.0012701 69.3148979 66.2890721 54.4070214 0.862246124 −0.213828356 6.02608394 0.353547417 Rv3502c Rv3502c putative dehydrogenase MT3607 23.146337 27.5087845 18.9137545 20.9978318 0.788444177 −0.342919481 4.51179673 0.08864668 Rv3503c fdxD probable forredoxin MT3608 33.4544223 35.743322 33.3718648 31.8480125 0.941932671 −0.086304154 5.07797344 0.795137008 Rv3504 fadE26 acyl-CoA dehydrogenase MT3609 31.7676447 52.4838652 38.6458925 40.1222511 0.957237841 −0.063050665 5.3551934 0.884925749 Rv3505 fadE27 acyl-CoA dehydrogenase MT3610 42.9191188 33.8430441 35.7360841 31.2235417 0.875881733 −0.191192014 5.17374439 0.446924852 Rv3506 fadD17 acyl-CoA synthase MT3612 79.7470952 75.6491575 103.661923 95.5440375 1.281233914 0.357533892 6.4730105 0.017771935 Rv3507 PE_PGRS PE_PGRS-family protein MT3612.1 264.168113 335.172822 374.365034 390.996801 1.285097599 0.361877932 8.41516587 0.018187722 MT3614 67.0025544 53.6602277 61.7424565 61.1981417 1.024849196 0.035411636 5.93251586 0.916845409 MT3615.2 14.0564799 17.554948 13.2760007 13.9725349 0.862610271 −0.213219201 3.89614739 0.479908014 Rv3513c fadD18 acyl-CoA synthase MT3615.3 85.463398 108.949265 125.758281 143.940527 1.392772351 0.477959468 6.86074237 0.000267118 Rv3514 PE_PGRS PE_PGRS-family protein MT3615.4 4.68549331 7.23915383 6.54706885 7.96200313 1.219565302 0.28636701 2.76504941 0.477752996 MT3616 54.2580126 65.2428739 57.1959209 57.6074344 0.963182121 −0.054119483 5.87656472 0.873880503 Rv3515c fadD19 acyl-CoA synthase MT3617 43.6687977 42.8919864 47.0115916 47.0694891 1.087004524 0.120357945 5.50268404 0.670900315 Rv3516 echA19 enoyl-CoA hydratase/isomerase superfamily MT3618 17.1489055 13.0304769 19.4593435 16.5484771 1.197911676 0.26052154 4.06364452 0.31688573 Rv3517 Rv3517 conserved hypothetical protein MT3619 83.5892007 90.1274651 84.0207169 79.4639136 0.940876795 −0.087922276 6.40041239 0.74702628 Rv3518c Rv3518c Probable Cytochrome P450 monooxygenasemonoxygenase MT3621 317.395317 285.584618 307.34851 270.161694 0.957114362 −0.063236778 8.20599658 0.813012054 Rv3520c Rv3520c probable coenzyme F420-dependent enzyme MT3622 44.4184766 50.6740768 41.2829063 52.2994323 0.981071665 −0.027569569 5.5653562 0.933484698 MT3622.1 28.6752191 32.1237451 25.2789603 32.3163656 0.944673568 −0.082112203 4.89629228 0.803950781 Rv3522 Rv3522 putative transcriptional regulator MT3623 428.066669 181.431293 368.272623 226.136501 1.033420673 0.04742765 8.2342415 0.894346121 Rv3523 Rv3523 lipid carrier protein MT3624 570.880505 624.01506 420.558242 502.855139 0.770607686 −0.37593152 9.0491647 0.01022971 Rv3524 Rv3524 possible membrane sensor protein MT3625 13.4005209 30.6759143 17.5497818 25.3691276 1.015164818 0.021713976 4.45549908 0.966222682 Rv3525c Rv3525c similar to ferripyochelin binding protein MT3626 1.31193813 2.26223557 1.81863024 2.02953021 1.075594344 0.105134074 1.02608399 0.905696211 MT3627 51.2592959 72.6630065 57.0140579 67.0525558 1.010021909 0.014386588 5.95839518 0.970173849 Rv3527 Rv3527 hypothetical protein MT3628 12.8382517 18.0978846 12.1848226 14.5189469 0.865779468 −0.207928507 3.86670313 0.497179783 MT3629 71.2194984 110.306606 74.4729081 105.925865 1.000371547 0.00053593 6.50256976 0.999355608 Rv3528c Rv3528c hypothetical protein MT3630 6.27856104 6.87719613 5.00123315 5.15188438 0.771556636 −0.374156034 2.5841728 0.323615741 MT3631 3.93581438 5.1578971 4.18284954 4.83964896 0.992060321 −0.01150025 2.23553456 0.985131579 MT3632 35.7971689 32.5761922 31.098577 25.9155396 0.831657805 −0.265938058 4.97774903 0.22614993 Rv3529c Rv3529c conserved hypothetical protein MT3633 27.363281 23.0748028 22.0054259 19.9050078 0.832732848 −0.264074362 4.53929726 0.249987045 Rv3530c Rv3530c probable cis-diol dehydrogenase MT3634 42.07573 35.5623432 38.0093719 30.1307177 0.875354431 −0.192060813 5.1940682 0.431856887 Rv3531c Rv3531c hypothetical protein MT3637 52.2901054 39.0009412 55.4682222 32.7847188 0.948152967 −0.076808265 5.49321536 0.822804121 Rv3533c PPE PPE-family protein MT3638 121.916536 77.2779671 133.578391 63.7740839 0.955042615 −0.066362986 6.6335221 0.836979867 MT3639 66.0654557 42.4395393 77.291785 37.3121323 1.020737148 0.029611403 5.80553189 0.933447653 Rv3535c Rv3535c acetaldehyde dehydrogenase MT3640 167.084692 117.998207 177.407379 90.7824474 0.906296056 −0.141945689 7.11341747 0.611538154 Rv3536c Rv3536c aromatic hydrocarbon degradation MT3641 56.2259198 54.1126749 52.5584138 48.8648427 0.91870723 −0.122322912 5.73092725 0.650390672 Rv3537 Rv3537 3-oxosteroid 1-dehydrogenase MT3642 28.8626368 25.3370384 27.6431796 22.9493031 0.931745947 −0.101991456 4.72054598 0.752487878 Rv3538 ufaA2 unknown fatty acid methyltransferase MT3643 37.3902356 54.3841431 36.0998102 35.2826021 0.787465103 −0.344712104 5.35608633 0.156602486 Rv3539 PE PE-family protein MT3644 47.6983219 43.3444335 52.1946878 37.3121323 0.972074411 −0.04086134 5.5014873 0.905823466 Rv3540c ltp2 non-specific lipid transport protein MT3645 16.3992256 14.11635 15.094631 13.8164172 0.948974572 −0.075558664 3.90948258 0.844610103 MT3646 38.8895945 39.4533884 40.7373173 34.6581313 0.959047286 −0.060326145 5.27068431 0.864827105 MT3647 61.0988328 53.8412066 58.0143045 51.1285495 0.949576083 −0.074644497 5.81223293 0.802899283 Rv3543c fadE29 acyl-CoA dehydragenase MT3648 69.7201405 58.5466566 63.2883322 57.1390813 0.941086075 −0.087601412 5.96214214 0.764687847 Rv3544c fadE28 acyl-CoA dehydrogenase MT3649 52.1963955 73.6583902 59.9238663 62.6032011 0.984372403 −0.022723882 5.96056268 0.950509824 Rv3545c Rv3545c cytochrome p450 MT3650 76.8420903 83.6122267 70.0172641 74.9365 0.903572937 −0.146287034 6.25789038 0.518177911 Rv3546 fadA5 acetyl-CoA C-acetyltransferase MT3651 56.788179 102.162558 69.7444695 82.7423854 0.991615702 −0.012146978 6.2862039 0.975905369 Rv3547 Rv3547 conserved hypothetical protein MT3652 103.268273 74.5632844 106.203006 84.2255037 1.077057015 0.107094622 6.52723458 0.668062711 Rv3548c Rv3548c short-chain alcohol dehydrogenase family MT3653 92.5853479 41.4441557 87.0218568 44.7277235 1.002736597 0.003942682 6.05731498 0.991084208 Rv3549c Rv3549c short-chain alcohol dehydrogenase family MT3654 52.2901054 32.8476605 59.3782772 31.5357771 1.04902409 0.069047809 5.46493203 0.839018102 Rv3550 echA20 enoyl-CoA hydratase/isomerase superfamily MT3655 60.4428637 27.599274 63.0155377 29.0378938 1.046882403 0.066099393 5.49736407 0.840411204 Rv3551 Rv3551 possible glutaconate CoA-transferase MT3656 50.3221932 22.3508874 51.1035096 26.8522458 1.095730094 0.13189247 5.24069531 0.648617706 Rv3552 Rv3552 hypothetical protein MT3657 61.8485117 28.2326999 61.5606335 25.0568922 0.945268412 −0.081204049 5.46980504 0.802899283 MT3658 112.732969 162.157046 117.30165 157.913062 1.005845022 0.008408035 7.10553262 0.977523735 Rv3554 fdxB ferredoxin MT3660 159.213053 108.587307 169.950996 122.005989 1.094720688 0.130562821 7.13035926 0.56234972 Rv3556c fadA6 acetyl-CoA C-acetyltransferase MT3661 55.9447902 37.2816422 54.2861125 45.0399589 1.080040152 0.111084947 5.59416586 0.732115651 Rv3557c Rv3557c transcriptional regulator (TctR/AcrR family) MT3663 31.6739348 55.0175691 48.7392903 57.6074344 1.2595938 0.332958561 5.59848832 0.179618934 Rv3558 PPE PPE-family protein MT3664 23.146337 14.6592865 21.0051792 14.5189469 0.944803051 −0.081914472 4.20884937 0.818068286 MT3665 24.7394047 18.9122894 32.6444127 25.7594219 1.339716291 0.421927516 4.68313604 0.023935198 Rv3560c fadE30 acyl-CoA dehydrogenase MT3666 55.6636606 32.9381499 64.0157843 39.5758391 1.174151923 0.23161909 5.5912703 0.304341874 MT3667 46.3863838 41.4441557 50.6488521 42.854311 1.062724103 0.087767103 5.50796079 0.780655736 Rv3562 fadE31 acyl-CoA dehydrogenase MT3668 32.6110335 26.1514432 34.5539745 30.4429531 1.109775476 0.150267828 4.95947093 0.584969964 Rv3563 fadE32 acyl-CoA dehydrogenase MT3669 30.2682868 19.6362048 31.098577 23.573774 1.106226596 0.145646933 4.71761855 0.624685486 Rv3564 fadE33 acyl-CoA dehydrogenase MT3671 49.759939 61.3518287 50.8307151 54.3289625 0.949461534 −0.074818542 5.76142364 0.813012054 Rv3566c nhoA N-hydroxyarylamine o-acetyltransferase MT3671.1 16.2118059 14.2068394 13.9125213 19.5147136 1.093994512 0.129605501 4.01342994 0.764687847 MT3671.2 23.2400458 20.7220778 19.7321381 19.5927724 0.896411229 −0.157767374 4.39180097 0.584815826 MT3672 43.2939582 49.9501614 45.1020298 44.1813115 0.958521848 −0.061116778 5.51747941 0.862436015 Rv3567c Rv3567c conserved hypothetical protein MT3673 52.7586547 64.6999373 57.1049894 66.4280849 1.053377464 0.0750225 5.91723695 0.801997347 Rv3568c Rv3568c putative dioxygenase MT3674 69.345301 63.8855325 71.7449628 62.1348479 1.003183637 0.004585721 6.06497714 0.988617034 MT3675 163.992256 144.692587 179.86253 144.40888 1.045426691 0.065471245 7.30750566 0.812642214 Rv3570c Rv3570c putative oxidoreductase MT3676 63.5352893 83.7932055 63.6520582 71.3457927 0.921665833 −0.117684325 6.14485596 0.657330385 MT3677 81.9024231 85.1505469 94.2050461 82.8985032 1.05785275 0.081138823 6.42983577 0.778848241 MT3678 27.4569908 29.318573 25.2789603 24.2763037 0.872242133 −0.197199415 4.74162657 0.45709859 Rv3573c fedE34 acyl-CoA dehydrogenase MT3679 116.856203 108.22535 130.668582 111.546103 1.073621769 0.102485329 6.870324 0.660006357 Rv3574 Rv3574 transcriptional regulator (TetR/AcrR family) MT3680 28.2066698 50.2216297 30.734851 44.8057823 0.978277358 −0.031684544 5.27359678 0.928752266 Rv3575c Rv3575c transcriptional regulator (LacI family) MT3681 78.9974173 71.9390911 84.6572375 92.4216834 1.173971497 0.231397381 6.3608518 0.245906231 Rv3576 pknM similar to ser-thr-protein kinases MT3682 63.3478696 68.048046 72.3814834 76.1854417 1.130844966 0.177401156 6.13284756 0.421550226 Rv3577 Rv3577 hypothetical protein MT3684 30.7368351 30.1329778 36.3726047 36.6096026 1.199171776 0.262038333 5.07233315 0.227121508 Rv3578 arsB2 probable arsenical pump MT3685 116.375074 134.376793 126.122007 142.457409 1.070806114 0.098697281 7.02310122 0.689343879 Rv3579c Rv3579c putative methyltransferase MT3686 306.150133 273.187568 320.806374 276.796697 1.030413475 0.043223365 8.20166468 0.880856541 Rv3580c cysS cystelnyl-tRNA synthase MT3687 387.021748 178.354652 402.917529 212.085907 1.111387777 0.152362279 8.20578054 0.491084358 Rv3581c Rv3581c conserved hypothetical protein MT3688 1415.30011 677.675288 1501.37019 824.535677 1.135822672 0.183737614 10.1096669 0.438953559 Rv3582c Rv3582c conserved hypothetical protein MT3689 3861.68938 2049.8569 3792.75336 2574.45907 1.110535551 0.151255578 11.5839523 0.617184719 Rv3583c Rv3583c putative transcriptional regulator MT3690 468.455621 588.995653 465.114683 582.319052 0.990754415 −0.013400604 9.04003046 0.967483076 MT3691 272.320871 197.628899 279.06881 226.604854 1.083624371 0.115864746 7.93118029 0.617184719 Rv3585 radA probable DNA repair RadA homologue MT3692 77.2169298 66.2382575 78.9285522 73.9997938 1.068504041 0.095592364 6.21472099 0.725019493 Rv3586 Rv3586 conserved hypothetical protein MT3693 403.514684 542.665069 499.668657 656.318846 1.223692899 0.291241541 9.03819631 0.068053722 Rv3587c Rv3587c hypothetical protein MT3694 93.2413169 105.420178 94.6597037 96.0123907 0.960947401 −0.05747063 6.60746294 0.84211886 Rv3588c Rv3588c putative carbonic anhydrase MT3695 92.1167935 106.506051 96.2055394 118.493341 1.078573925 0.109125061 6.69372292 0.651061634 Rv3589 mutY probable DNA glycosylase MT3696 72.9999858 60.5374239 87.9307719 69.0040271 1.172115918 0.229115254 6.1856719 0.233072634 Rv3590c PE_PGRS PE_PGRS-family protein MT3697 10.9640544 20.0886519 13.4578637 20.9197729 1.116058974 0.158413263 4.04910367 0.622324344 Rv3591c Rv3591c conserved hypothetical protein MT3698 233.243857 238.620608 242.514342 253.613217 1.051270434 0.072133843 7.91991901 0.7818709 Rv3592 Rv3592 conserved hypothetical protein MT3699 339.604555 374.7167 368.72728 406.530513 1.085323396 0.11812499 8.54139651 0.593366813 Rv3593 lpqF lipoprotein MT3700 51.4467166 43.0729653 51.8309617 45.1960766 1.02799206 0.039329122 5.58669513 0.90313325 Rv3594 Rv3594 hypothetical protein MT3701 173.550672 138.448817 204.686833 151.512236 1.13641394 0.184488434 7.38559028 0.359406788 Rv3595c PE_PGRS PE_PGRS-family protein MT3703 3039.57322 2482.39634 3278.62659 2716.83842 1.086513693 0.119706356 11.491617 0.676881026 Rv3596c clpC ATP-dependent Clp protease MT3704 187.232313 321.599409 186.682394 164.697575 0.904464658 −0.144863965 7.90832583 0.52349722 Rv3597c lsr2 #NAME? MT3705 149.560947 197.628899 139.670802 196.239959 0.96351013 −0.053628261 7.41753478 0.852389426 Rv3598c ylsS lysyl-tRNA synthase MT3706 173.082123 189.122894 178.407626 176.647187 0.980946174 −0.027754119 7.48776167 0.923772833 Rv3600c Rv3600c conserved hypothetical protein MT3T06.1 121.073147 125.41834 111.936691 113.731751 0.915568365 −0.127260479 6.88524634 0.548909973 Rv3601c panD aspartate 1-decarboxylase MT3707 164.835655 194.099812 177.316448 182.501601 1.005188195 0.007455777 7.49078134 0.980042284 Rv3602c panC pantoate-[beta]-alanine ligase MT3708 236.617412 282.326999 259.427603 288.115231 1.05750836 0.080669069 8.05963788 0.759681853 Rv3603c Rv3603c hypothetical protein MT3709 146.374811 168.129348 212.052285 236.049975 1.425935036 0.511908256 7.5762603 8.416−E05 Rv3604c Rv3604c unknown membrane protein MT3710 80.1219357 75.5586681 82.6567442 77.1221479 1.026132606 0.037217181 6.30449017 0.89957148 Rv3605c Rv3605c hypothetical protein MT3711 75.3427325 71.7581123 82.6567442 70.643263 1.039292498 0.055601743 6.23404184 0.857164899 MT3712 141.501898 117.63625 146.76346 114.43428 1.004702356 0.006768165 7.02514605 0.981898674 Rv3608c folP dihydropteroate synthase MT3712.1 94.3658353 82.9788007 87.4761143 82.6643266 0.960978299 −0.05742442 6.44365015 0.84211886 Rv3607c folX may be involved in folate biosynthesis MT3713 135.691886 116.278908 134.214911 126.221167 1.036125272 0.051198442 7.00310114 0.858854075 Rv3609c folE GTP cyclohydrolase I MT3714 800.844517 771.512819 821.02062 784.491485 1.020997287 0.029979033 9.63416089 0.921284174 Rv3610c ftsH Inner membrane protein, chaperone MT3715 253.297769 282.688957 181.499298 239.250388 0.779357169 −0.359643448 7.90303423 0.017512436 Rv3612c Rv3612c hypothetical protein MT3716 2189.71845 2894.30419 1598.49505 1957.40383 0.702608801 −0.509206446 11.076914 0.001216137 Rv3614c Rv3614c conserved hypothetical protein MT3717 1169.03058 1528.63782 820.656894 965.041614 0.665655705 −0.587151926 10.1305813 5.69E−05 Rv3615c Rv3615c conserved hypothetical protein MT3718 2905.66132 3735.2224 2150.0756 2405.46165 0.690287507 −0.53473072 11.4508356 0.001154986 Rv3616c Rv3616c conserved hypothetical protein MT3718.1 9.27727676 8.68698459 6.72893187 9.44512136 0.899655242 −0.152555844 3.12350376 0.746856645 MT3719 72.156597 99.6288545 86.6577307 98.2760974 1.085890907 0.118879172 6.48163436 0.64288872 Rv3617 ephA probable epoxide hydrolase MT3720 39.1707241 56.7368681 54.1042495 61.5103771 1.218631614 0.285262073 5.72982514 0.199662754 Rv3618 Rv3618 similar bacterial luciferase alpha chains MT3721 212.627637 286.037066 282.06955 296.623646 1.171941311 0.228900324 8.07427322 0.270897894 Rv1198 Rv1198 conserved hypothetical protein MT3722 221.248994 212.016718 270.612179 237.611152 1.170778986 0.227468757 7.87988402 0.195110476 MT3723 11.9948629 15.1117336 11.0936444 16.080124 0.99953801 −0.000666664 8.78219005 0.999355608 Rv3621c PPE PPE-family protein MT3724 3.84210452 5.24838652 3.27353442 5.46411979 0.958603539 −0.060993828 2.2155747 0.923772833 Rv3622c PE PE-family protein MT3725 60.3491539 106.144093 62.197154 110.921631 1.038230038 0.054126134 6.41112886 0.85222926 Rv3623 lpqG similar OMP28 MT3726 272.414581 212.831123 255.517548 218.798968 0.981808914 −0.026485829 7.90724189 0.924218684 Rv3624c hpt probable hypoxanthine-guanine MT3727 135.504467 82.4358642 121.848226 92.1094479 1.000275392 0.000397252 6.7567148 0.999355608 Rv3625c mesJ probable cell cycle protein MT3728 236.148853 177.268779 208.233162 149.014353 0.861143878 −0.215673795 7.59114233 0.236664882 Rv3626c Rv3626c hypothetical protein MT3729 438.468464 307.30208 385.185884 275.625814 0.887598796 −0.172020384 8.45862649 0.364078181 MT3730 72.0618872 140.439534 63.4701952 115.527104 0.849520622 −0.235279126 6.61568908 0.203989651 Rv3628 ppa probable inorganic pyrophosphatase MT3731 71.9691773 112.9308 73.6545245 110.843573 1.001349027 0.001944923 6.53202568 0.996920859 Rv3629c Rv3629c possible membrane protein MT3732 71.500628 73.2059431 65.925346 83.4449151 1.027109246 0.038589639 6.20366578 0.90313325 Rv3630 Rv3630 unknown membrane protein MT3733 67.5648136 87.1413142 62.3790171 90.5482709 0.981580206 −0.026821938 6.26860499 0.93032752 MT3734 24.4582751 37.5531105 22.4600834 36.6096026 0.948964469 −0.075574024 4.92892339 0.818068286 Rv3632 Rv3632 hypothetical protein MT3735 273.913939 562.120295 355.996869 540.94786 1.116728977 0.159279096 8.75969504 0.524235082 Rv3633 Rv3633 conserved hypothetical protein MT3736 139.815121 216.722168 129.395541 191.946723 0.904891789 −0.144182817 7.40647708 0.507926991 Rv3634c rmlB2 dTDP-glucose 4,6-dehydratase MT3737 50.6970377 80.897544 53.1949344 77.9807953 1.003526965 0.005079383 6.04184633 0.987820145 Rv3635 Rv3635 unknown transmembrane protein MT3741 5.52888211 5.33887595 4.00098652 6.00859063 0.927160549 −0.109108915 2.43890223 0.863840149 Rv3639c Rv3639c conserved hypothetical protein MT3742 11.1514741 8.68698459 9.54780873 9.3670625 0.959516619 −0.0596203 3.30163459 0.901225662 Rv3640c Rv3640c probable transposase highly related to IS1081 MT3743 81.8087133 54.2936537 84.4753744 64.4766136 1.105534472 0.144744011 6.158474 0.55335105 Rv3641c flc possible cell division protein MT3743.1 126.976859 126.866171 121.4845 85.4744453 0.803479347 −0.315667155 6.84998214 0.113391715 Rv3642c Rv3642c hypothetical protein MT3745 7.40307944 5.88181248 6.91079489 7.10335573 1.060999315 0.085423725 2.80764582 0.877734451 MT3747 85.5571079 87.5032719 94.0231832 96.7149203 1.102124263 0.140286895 6.50985448 0.525325512 MT3748 978.237294 444.212577 964.055888 600.740942 1.153701733 0.206270292 9.54490528 0.420522227 Rv3645 Rv3645 probable transmembrane protein MT3749 657.843261 694.325341 668.346611 773.953539 1.064272343 0.089867378 9.44873656 0.745116768 Rv3646c topA DNA topolsomerase MT3750 120.229758 134.105325 156.4022 155.727414 1.228518616 0.296919719 7.1477149 0.071467955 Rv3647c Rv3647c hypothetical protein MT3750.1 2140.61448 2540.30957 3095.30866 3061.3902 1.320030428 0.400571185 11.4038597 0.032349512 Rv3648c cspA cold shock protein, transcriptional regulator MT3751 36.5468478 40.3582826 33.9174539 39.0294171 0.948009212 −0.077027017 5.23426174 0.806148616 Rv3649 Rv3649 ATP-dependent DNA/RNA helicase MT3752 7.87162877 14.0258605 9.2750142 11.7088281 0.970211343 −0.043629049 3.44688796 0.928669788 Rv3650 PE PE-family protein MT3753 316.270799 422.223647 244.060178 337.604544 0.785658593 −0.348025567 8.36727513 0.015537798 Rv3651 Rv3651 hypothetical protein MT3755 2.81129599 2.08125673 3.18260291 2.57594219 1.179489005 0.23816197 1.50412136 0.741632985 MT3756 17.523745 22.893824 26.4610699 28.0231287 1.352164957 0.435271164 4.57985924 0.026823464 MT3756.1 6.84082024 9.04894228 8.54756211 8.27423854 1.058077731 0.081445618 3.06284892 0.877866393 MT3756.2 11.245184 10.9492202 12.8213432 12.8016521 1.154732585 0.207558788 3.60104999 0.52349722 Rv3655c Rv3655c hypothetical protein MT3756.3 3.09242559 4.16251345 4.45564408 3.35653073 1.067321108 0.093994282 1.97800385 0.897921476 MT3757 1.49935786 2.80517211 2.27328779 2.7320599 1.166240666 0.221865535 1.32901728 0.783679782 MT3758 69.8138504 74.7442633 82.6567442 77.2782657 1.105754661 0.145031324 6.25362999 0.540688432 Rv3658c Rv3658c probable transmembrane protein MT3759 25.1142442 10.4062836 28.4615632 14.2847703 1.227834581 0.296116208 4.30173277 0.234801512 Rv3659c trbB similar to conjugal transfer proteins MT3760 67.7522333 18.8218 84.1116484 23.4957151 1.244241874 0.315266965 5.60532873 0.118986382 Rv3660c Rv3660c involved in differentiation inhibition between MT3761 185.639245 170.663051 192.683873 182.657719 1.054001557 0.075876998 7.51637905 0.775693751 Rv3661 Rv3661 involved in differentiation inhibition between MT3762 24.3645652 45.154222 23.5512615 22.3248323 0.684628118 −0.54660755 4.85867172 0.058746039 MT3763 17.2426154 22.5318663 20.0958641 23.3395974 1.094236163 0.129924141 4.39147461 0.675826015 Rv3662c Rv3662c hypothetical protein MT3764 46.1052542 73.6583902 46.8297236 62.2909656 0.922759253 −0.115973795 5.84311746 0.689793351 Rv3663c dppD probable ABC-transporter MT3765 8.99614716 15.0212441 6.72893187 13.8164172 0.846786992 −0.239928987 3.50240528 0.484283855 Rv3664c dppC probable peptide transport system permease MT3766 16.2118059 22.7128451 13.8215898 21.5442438 0.905013232 −0.14398921 4.22956781 0.641869092 Rv3665c dppB probable peptide transport system permease MT3767 35.4223295 55.1080585 33.5537278 55.1876099 0.975937191 −0.035139792 5.49221222 0.916845409 Rv3666c dppA probable peptide transport system permease MT3767.1 5.90372158 5.79132306 6.27427431 5.6202375 1.015107516 0.02163254 2.60187051 0.973097519 MT3767.2 6.46598077 7.60111152 6.09241129 5.6202375 0.830441617 −0.268049349 2.7256226 0.518774989 MT3768 155.933218 162.428514 143.853652 145.267528 0.908252275 −0.13883502 7.24833939 0.52349722 Rv3667 acs acetyl-CoA synthase MT3769 84.3388796 91.6657853 103.752855 110.921632 1.21993272 0.286801585 6.61258484 0.079877706 Rv3668c Rv3668c probable alkaline serine protease MT3770 1.78048746 2.53370384 3.45539745 1.95147136 1.22159733 0.288768814 1.37890175 0.723313141 MT3771 45.6367049 53.2077806 47.5571807 54.094786 1.028953007 0.041177095 5.65265997 0.902972879 MT3772 88.8369532 117.455271 90.2040597 118.259164 1.010990487 0.015769422 6.69871383 0.958478014 Rv3671c Rv3671c probable serine protease MT3773 105.704729 123.337083 109.299677 154.166237 1.138958873 0.187715653 6.94626909 0.366108488 MT3774 147.2182 190.932682 153.492392 172.119774 0.96862091 −0.045995947 7.37608768 0.880578033 Rv3673c Rv3673c protein disulphide oxidoreductase MT3775 183.109079 246.493188 166.313735 216.066908 0.892045682 −0.164810502 7.66659532 0.412841331 Rv3674c nth probable endonuclease III MT3776 113.388938 94.380468 134.578637 116.307693 1.209230955 0.274089816 6.8434849 0.07862512 Rv3675 Rv3675 hypothetical protein MT3777 384.585291 486.652116 448.928874 551.095511 1.149635406 0.201176399 8.87037999 0.281197156 MT3778 332.951155 224.413769 284.888426 228.868561 0.933682488 −0.09899607 8.0657828 0.712116442 Rv3677c Rv3677c probable hydrolase MT3779 214.595534 151.841252 200.685846 187.34125 1.073546941 0.102385274 7.56062995 0.728805944 Rv3678c Rv3678c transcriptional regulator (LysR family) MT3780 270.540334 243.507037 238.058698 220.360145 0.892359138 −0.164303642 7.92650153 0.410988555 MT3781 1596.25336 1937.55952 1879.55435 1869.50956 1.065829935 0.091977258 10.8304344 0.771170966 Rv3679 Rv3679 possible anion transporter MT3782 1003.07041 1042.61913 1044.07562 1064.80083 1.031023032 0.044076562 10.0207285 0.890225316 Rv3680 Rv3680 probable anion transporter MT3783 273.63281 236.81082 260.42785 269.849459 1.041480888 0.058636365 8.02434914 0.839018102 Rv3681c whiB4 WhiB transcriptional activator homologue MT3784 1224.60053 1014.38643 1168.46993 1015.85793 0.977511458 −0.032814481 10.1111319 0.916845409 Rv3682 ponA′ class A penicillin binding protein MT3785 338.854876 333.634502 335.719141 335.028602 0.997453271 −0.00367884 8.39225122 0.989612622 Rv3683 Rv3683 conserved hypothetical protein MT3786 284.784234 257.17094 289.616865 252.832629 0.999920231 −0.000115087 8.0835946 0.999874639 Rv3684 Rv3684 Probable lyase, cysteine metabolism MT3787 216.750921 274.725888 132.123487 205.06061 0.675639532 −0.565674352 7.69585667 3.47E−05 Rv3685c Rv3685c Probable cytochrome P-450 MT3788 359.564757 492.26246 157.766173 303.024472 0.520783977 −0.941243033 8.3589805 6.54E−11 Rv3686c Rv3686c conserved hypothetical protein MT3789 78.8099975 114.921567 69.0170174 101.710687 0.880578577 −0.183476349 6.5125466 0.372558922 Rv3687c Rv3687c conserved hypothetical protein MT3790 150.591755 177.992695 128.395295 157.600827 0.86910617 −0.202395668 7.26512791 0.286557916 Rv3688c Rv3688c conserved hypothetical protein MT3791 191.917806 350.013088 223.600587 334.560249 1.05367522 0.075430246 8.10442656 0.796954742 Rv3689 Rv3689 hypothetical protein MT3792 54.0705928 95.9187882 56.9231264 82.6643266 0.94780741 −0.077334155 6.18155807 0.801831984 Rv3690 Rv3690 hypothetical protein MT3793 56.3196296 91.8467642 51.0125781 85.5525042 0.919303212 −0.121387313 6.15734012 0.626654945 Rv3691 Rv3691 hypothetical protein MT3794 92.7727676 136.277071 91.0224433 137.695819 0.996195936 −0.00549857 6.8408857 0.984096717 Rv3692 moxR2 transcriptional regulator, MoxR homologue MT3795 111.139901 136.096092 110.936444 154.868767 1.067211822 0.093846553 7.00507529 0.720596123 Rv3693 Rv3693 conserved hypothetical protein MT3796 328.359371 313.002914 282.615139 298.028705 0.905386478 −0.143394335 8.25585281 0.505322279 Rv3694c Rv3694c conserved hypothetical protein MT3797 131.943492 163.604877 119.484006 149.404647 0.909451236 −0.136931811 7.14251438 0.532682356 MT3798 78.3414482 114.921567 87.2942513 114.200104 1.050405393 0.070946229 6.62757925 0.801831984 Rv3696c glpK ATP:gycerol 3-phosphotransferase MT3799 51.2592969 83.7932055 53.6495919 82.7423854 1.014992437 0.021468977 6.08861548 0.947180673 Rv3697c Rv3697c conserved hypothetical protein MT3800 21.4595594 28.2326999 22.0963574 30.9113063 1.064257004 0.089846585 4.69294346 0.790605582 MT3801 33.0795828 33.0286393 35.9179471 32.0041302 1.025410402 0.036201438 5.07384874 0.916845409 Rv3698 Rv3698 hypothetical protein MT3802 134.567368 144.602098 144.581104 136.212701 1.005681432 0.008173378 7.13098606 0.978066048 Rv3699 Rv3699 Probable methyltransferase MT3803 76.1861213 81.2595017 78.2011001 82.976562 1.02374496 0.033856349 6.31894507 0.904814009 Rv3700c Rv3700c probable acetyltransferase MT3804 96.2400327 108.406329 87.4761143 93.8267427 0.886653086 −0.173558353 6.59487003 0.406290183 Rv3701c Rv3701c conserved hypothetical protein MT3805 20.2413311 23.1652922 18.0044393 16.7826537 0.600592066 −0.320860777 4.30127368 0.175761343 Rv3702c Rv3702c conserved hypothetical protein MT3806 149.467237 176.906822 137.033788 138.398349 0.846335299 −0.240698755 7.23479425 0.198891918 Rv3703c Rv3703c conserved hypothetical protein MT3807 249.830504 287.303918 229.238341 214.037378 0.826482993 −0.274942963 7.93822797 0.116914111 Rv3704c gshA possible [gamma]-glutamylcysteine synthase MT3808 63.7227081 76.9160094 74.9275657 82.0398558 1.118700786 0.161824216 6.22082674 0.476182576 Rv3705c Rv3705c hypothetical protein MT3808.1 64.472338 99.9003228 66.1072091 80.7128552 0.906699036 −0.141304344 6.28501669 0.584969964 MT3809 47.3234825 57.2798047 33.3718648 36.2973672 0.667468109 −0.583229187 5.45065119 0.000205318 Rv3706c Rv3706c hypothetical protein MT3810 137.378664 115.645482 112.027623 102.725452 0.851025279 −0.232726108 6.87171866 0.174860622 Rv3707c Rv3707c conserved hypothetical protein MT3811 344.946018 282.688957 333.900511 255.954983 0.936299859 −0.094957454 8.25046917 0.700160804 Rv3708c asd aspartate semialdehyde dehydrogenase MT3812 771.325909 492.624418 675.621132 479.5936 0.923267137 −0.115179959 9.24067032 0.636705647 Rv3709c ask aspartokinase MT3813 922.011374 642.474902 828.477004 579.04058 0.899906846 −0.152152427 9.53752633 0.506046901 Rv3710 leuA 2-isopropylmalate synthase MT3814 328.640501 372.273486 367.727034 409.496749 1.109373995 0.149745813 8.53028339 0.46928975 MT3815 95.0218044 171.748925 94.2050462 140.34982 0.897034349 −0.156764866 6.97175936 0.480578669 Rv3712 Rv3712 conserved hypothetical protein MT3816 60.8177082 106.777519 62.7427431 103.037688 0.995868388 −0.005973004 6.38437355 0.983889859 Rv3713 cobQ2 possible cobyric acid synthase MT3817 66.5340051 76.1016046 68.2895653 80.6347964 1.043225035 0.061050396 6.19127878 0.831756973 Rv3714c Rv3714c conserved hypothetical protein MT3818 164.741945 231.562433 165.586283 246.353744 1.03462445 0.049107191 7.66002142 0.864870852 Rv3715c recR RecBC-Independent process of DNA repair MT3819 168.958889 221.970554 164.858831 280.621581 1.112804157 0.154199714 7.70944709 0.52349722 Rv3716c Rv3716c conserved hypothetical protein MT3820 269.696995 277.259592 359.997855 341.117193 1.281392591 0.357712554 8.28633182 0.015153827 Rv3717 Rv3717 possible N-acetylmuramoyl-L-alanine amidase MT3821 87.618725 114.650099 81.5655661 112.326691 0.955742105 −0.065306717 6.63265113 0.812642214 MT3822 252.45438 259.704644 217.417245 239.016212 0.89044489 −0.16740177 7.92078449 0.403513993 Rv3719 Rv3719 conserved hypothetical protein MT3823 332.857445 357.614199 296.982317 341.97584 0.923848703 −0.114271491 8.37736256 0.61875146 Rv3720 Rv3720 C-term similar to cyclopropane fatty acid synthases MT3824 273.44539 259.161707 260.791576 276.172226 1.008271503 0.011884174 8.06377287 0.972119393 Rv3721c dnaZX DNA polymerase III, [gamma] (dnaZ) and t [dnaX] MT3825 662.341335 614.875628 599.602389 610.966652 0.94846475 −0.076333938 9.28104892 0.783679782 Rv3722c Rv3722c hypothetical protein MT3826 371.46591 313.726829 359.815992 339.399898 1.023636289 0.033703199 8.43577561 0.90313325 Rv3723 Rv3723 hypothetical protein MT3827 94.7406748 76.5540517 94.5687722 88.7529172 1.075404668 0.104879639 6.47295273 0.692019534 Rv3724 Rv3724 probable cutinase precursor MT3828 186.857473 257.532897 192.138284 265.087869 1.028805293 0.04096997 7.81758275 0.883952145 Rv3725 Rv3725 putative oxidoreductase MT3829 215.064143 260.881006 252.334945 294.047704 1.149779029 0.201356622 7.99869995 0.265020937 Rv3726 Rv3726 Putative alcohol dehydrogenase, zinc-type MT3830 101.956335 27.9612317 362.543937 36.2193083 2.187225071 1.129101685 7.04768187 0.000171968 Rv3727 Rv3727 similar to phytoene dehydrogenase precursor MT3831 108.141186 44.4303066 278.159495 63.3057308 1.936809735 0.953682236 6.95016764 6.50E−07 Rv3728 Rv3728 possible sugar transporter MT3833 117.699592 121.617784 137.306583 114.43428 1.047559448 0.067032118 6.94176906 0.813821128 Rv3729 Rv3729 probable transferase MT3835 35.7034591 36.9196845 30.3711249 33.8775427 0.884398722 −0.177231154 5.10402777 0.493828815 Rv3730c Rv3730c conserved hypothetical protein MT3836 53.227204 44.3398172 51.0125781 43.9471349 0.974492889 −0.037276437 5.59396327 0.907005419 Rv3731 ligC probable DNA ligase MT3837 86.869046 122.613168 84.5663059 101.008157 0.893688013 −0.162156822 6.62853214 0.477179718 Rv3732 Rv3732 conserved hypothetical protein MT3838 72.5314365 99.5383651 77.473648 84.5377391 0.950048622 −0.073926744 6.38713743 0.806205208 Rv3733c Rv3733c hypothetical protein MT3839 143.844645 242.692632 157.58431 194.912959 0.935928474 −0.095529815 7.53092525 0.760272935 Rv3734c Rv3734c conserved hypothetical protein MT3840 78.9037074 106.325072 76.7461959 99.3689214 0.952847874 −0.069682194 6.50016563 0.801831984 Rv3735 Rv3735 conserved hypothetical protein MT3841 63.6289992 87.5032719 61.3787704 77.3563245 0.922050095 −0.11708296 6.18286811 0.639005832 Rv3736 Rv3736 transcriptional regulator (AraC/XylS family) MT3842 116.293944 142.973288 113.846253 129.109345 0.939606901 −0.089870786 6.97423647 0.724775537 Rv3737 Rv3737 possible membrane protein MT3846 94.1784156 107.048987 105.84428 77.2002068 0.900299165 −0.151523614 6.58844104 0.629711772 MT3847 15.2747082 20.4506096 29.0980838 20.2172432 1.367165234 0.451187616 4.42199278 0.15276274 MT3848 293.405591 357.342731 462.386737 394.43139 1.318430691 0.398821732 8.55870048 0.02829659 Rv3740c Rv3740c conserved hypothetical protein MT3849 197.727818 249.569828 313.259058 280.075169 1.332518289 0.414155334 8.02426257 0.019386895 Rv3741c Rv3741c possible monooxygenasemonoxygenase-a MT3850 338.854876 373.721316 494.485561 407.38916 1.261068755 0.334646935 8.65746476 0.062154657 Rv3742c Rv3742c possible monooxygenase-b MT3851 10.7766346 3.89104518 13.4578637 5.54217865 1.308888538 0.388342246 3.09936018 0.22505943 Rv3743c Rv3743c probable cation-transporting ATPase MT3852 132.037202 103.881857 146.126939 119.820341 1.129612689 0.1758282 6.97313254 0.37144464 Rv3744 Rv3744 transcriptional regulator (ArsR family) MT3854 8.43388796 9.68236824 13.4578637 9.67929792 1.262107926 0.335835284 3.39062302 0.346464415 Rv3746c PE PE-family protein MT3855 8.24646823 5.51985479 6.54706885 4.37129584 0.793364954 −0.333943426 2.66189208 0.385970978 MT3856 34.3915209 22.6223557 34.2811799 27.2425401 1.09143267 0.126223134 4.89736741 0.688153512 Rv3749c Rv3749c hypothetical protein MT3857 75.6238621 52.3028864 72.7452094 54.2509037 0.997976426 −0.002922358 5.99761288 0.994942526 Rv3750c Rv3750c excisionase MT3858 19.3979423 13.482924 15.1855625 14.5970057 0.917086563 −0.12487018 3.98499264 0.748063474 MT3859 78.6225778 76.4635623 89.5675391 83.9913271 1.11854639 0.161625091 6.36349993 0.456226727 MT3860 92.6790577 144.783077 110.936444 133.246464 1.046491358 0.065560398 6.91405343 0.828256087 Rv3753c Rv3753c hypothetical protein MT3861 83.1206514 75.8301363 75.5640863 69.9407334 0.915705159 −0.127044944 6.253294 0.593366813 Rv3754 tyrA prephenate dehydrogenase MT3862 320.487743 255.723109 288.889413 242.372742 0.924240126 −0.11366037 8.11391691 0.622324844 Rv3755c Rv3755c hypothetical protein MT3863 47.8857417 35.2908749 49.1939479 40.2003099 1.080540608 0.111753292 5.43670668 0.712080008 Rv3756c proZ transport system permease MT3864 74.967893 54.565122 74.6547712 63.9302016 1.078926426 0.109596488 6.07039549 0.701897852 Rv3757c proW transport system permease MT3865 162.961457 111.844927 152.76494 129.811875 1.042107191 0.05950368 7.12426981 0.848091932 Rv3758c proV osmoprotection ABC transporter MT3866 187.981992 158.537469 179.135078 163.689417 0.991848629 −0.011808134 7.43051125 0.972119393 Rv3759c proX similar to osmoprotection proteins MT3867 21.3658495 38.2770259 23.5512615 35.0484255 0.995500796 −0.006505625 4.8949051 0.985374119 Rv3760 Rv3760 conserved hypothetical protein MT3868 67.4711037 92.661169 62.4699486 81.5715026 0.901998989 −0.148802278 6.25220514 0.51545697 Rv3761c fadE36 acyl-CoA dehydrogenase MT3869 86.6816263 129.037917 87.7489088 118.181105 0.961395961 −0.056797352 6.72244731 0.844643034 Rv3762c Rv3762c probable alkyl sulfatase MT3870 381.305446 552.437926 403.826844 491.536605 0.970226511 −0.043606494 8.83750119 0.088067917 Rv3763 lpqH 19 kDKD MT3871 98.2079998 116.821845 80.4743879 82.7423854 0.761038527 −0.393958604 6.56574038 0.008719115 Rv3764c Rv3764c sensor histidine kinase MT3872 55.0076915 109.76367 41.7375639 58.7783172 0.632503229 −0.660885249 6.05515372 0.000105371 Rv3765c Rv3765c two-component response regulator MT3873 88.4621138 150.936357 66.5618666 103.974394 0.718572938 −0.476793492 6.68177477 0.000547165 Rv3766 Rv3766 hypothetical protein MT3874 324.892106 540.583812 80.3834564 176.334952 0.285175589 −1.810077601 8.13288672 3.93E−43 Rv3767c Rv3767c conserved hypothetical protein MT3875 14.3438997 17.0120115 22.1872889 25.6033042 1.529198929 0.612776095 4.31889374 0.000384165 Rv3768 Rv3768 hypothetical protein MT3876 3.65468478 3.25761922 2.90980838 2.88817761 0.841272764 −0.249354457 1.74343031 0.697208218 MT3876.1 26.9884415 19.3647365 23.9149876 19.4366547 0.94084187 −0.08797583 4.49768216 0.798636571 MT3877 58.849796 65.695321 56.1956743 52.6116677 0.873628283 −0.194908532 5.87055762 0.412841331 Rv3770c Rv3770c hypothetical protein MT3878 6.09114131 6.87719613 6.63800036 5.85441406 0.959676825 −0.059379441 2.70872668 0.911298733 MT3879 16.9614858 14.2068394 14.5490419 17.6413011 1.035661668 0.050552777 4.00188092 0.904814009 MT3880 57.6315678 41.1726874 50.5579205 43.6348995 0.962749724 −0.054767291 5.59741563 0.879854448 Rv3771c Rv3771c conserved hypothetical protein MT3881 128.757356 121.708274 123.212198 107.487042 0.919317718 −0.121364549 6.91240072 0.584969964 Rv3772 hisC2 histidinol-phosphate aminotransferase MT3882 21.740689 21.1745249 22.8238095 21.0758906 1.021969109 0.031351588 4.45138499 0.93032752 Rv3773c Rv3773c conserved hypothetical protein MT3883 409.699535 340.964145 369.90939 328.159423 0.932147748 −0.101369451 8.50124305 0.657330385 Rv3774 echA21 enoyl-CoA hydratase/isomerase superfamily MT3884 144.313194 140.168116 138.306829 140.896232 0.981618065 −0.026766295 7.14053735 0.924988246 Rv3775 lipE probable hydrolase MT3885 301.55835 110.759054 212.961601 119.8984 0.870917351 −0.199375714 7.5425512 0.48135099 MT3886 107.953766 93.0231267 103.934718 92.2655657 0.977160341 −0.033332783 6.63610497 0.904814009 Rv3777 Rv3777 3-Hydroxyacyl-CoA Dehydrogenase MT3887 592.246355 679.485076 470.661505 498.327725 0.763357028 −0.389570121 9.13017996 0.007266187 Rv3778c Rv3778c conserved hypothetical protein MT3888 106.641828 92.7516584 115.48302 110.219102 1.134339247 0.181852172 6.7340538 0.380784281 Rv3779 Rv3779 unknown membrane protein MT3889 223.872871 197.266942 230.056725 203.733609 1.030193476 0.042915309 7.74082208 0.879854448 Rv3780 Rv3780 hypothetical protein MT3890 67.939653 67.2336412 75.2003602 83.8352094 1.175610527 0.233422454 6.20432711 0.233300069 Rv3781 Rv3781 ABC transporter MT3891 437.150236 321.056472 386.277062 334.091896 0.958582263 −0.061025849 8.53073996 0.828256087 Rv3782 rfbE similar to rhamnosyl transferase MT3892 186.107794 201.338966 195.957408 217.003615 1.065377805 0.091365131 7.64590297 0.714268263 Rv3783 Rv3783 integral membranememebrane protein, ABC-2 SUBFAMILY MT3893 221.155284 180.797867 246.242534 213.100672 1.145468419 0.195937684 7.75153293 0.286460873 Rv3784 eplB probable UDP-galactose 4-epimerase MT3894 64.0579485 65.7858104 62.6518116 62.6032011 0.96431725 −0.052420239 5.99907816 0.870656307 Rv3786c Rv3786c hypothetical protein MT3895 19.5853621 30.5854249 24.1877821 26.774187 1.029732942 0.042270228 4.67048625 0.917293811 Rv3787c Rv3787c conserved hypothetical protein MT3896 40.2015326 53.7507172 45.1929613 50.4260198 1.023911699 0.034091304 5.57212475 0.921846482 MT3897 55.7573704 76.0111152 54.7407701 83.7571506 1.042693971 0.060315792 6.08236044 0.848091932 Rv3789 Rv3789 conserved hypothetical protein MT3898 78.9974173 160.890194 88.0217034 153.30759 1.026514698 0.037754285 6.91292173 0.897921476 Rv3790 Rv3790 putative oxidoreductase MT3899 83.7766204 180.797867 82.6567442 161.894064 0.937505068 −0.093101606 6.99412517 0.719637416 Rv3791 Rv3791 putative oxidoreductase MT3899.1 69.9075602 128.404491 74.6547712 127.938462 1.029692953 0.0422142 6.64996311 0.887972618 Rv3792 Rv3792 unknown membrane protein MT3900 209.628971 313.002914 224.509903 348.064431 1.091613771 0.1264625 8.09802183 0.572054672 Rv3793 embC involved in arabinogalactan synthesis MT3901 295.467208 571.350216 287.52544 582.631288 0.996519505 −0.005030052 8.76303341 0.985374119 Rv3794 embA involved in arabinogalactan synthesis MT3902 300.246412 502.125807 294.254372 531.112444 1.018661019 0.026674044 8.66935995 0.923772833 Rv3795 embB involved in arabinogalactan synthesis MT3903 69.1578813 102.615006 75.5640863 112.795044 1.096036146 0.132295378 6.49550458 0.562810186 Rv3796 atsH proable arylsulfatase MT3904 106.829248 151.117336 118.938417 165.250594 1.103140465 0.141616504 7.08456002 0.518774989 Rv3797 fadE35 acyl-CoA dehydrogenase MT3905 5.62259198 3.25761922 4.27378105 3.12235417 0.842360146 −0.247490914 2.080852 0.654586496 MT3906 1293.85212 1115.55361 1357.9712 1295.69892 1.104098765 0.142869232 10.3059992 0.581076946 Rv3799c accD4 acetyl/propionyl CoA carboxylase [beta] subunit MT3907 4778.54721 3580.66646 5048.4266 3804.1201 1.059436433 0.083297028 12.0711623 0.801831984 Rv3800c pks13 polyketide synthase MT3908 2053.93235 1673.14943 2187.08472 1790.82623 1.067575201 0.094337698 10.9117048 0.750079277 Rv3801c fadD32 acyl-CoA synthase MT3909 437.812495 457.062075 448.565148 421.830048 0.972336572 −0.040472309 8.7862381 0.889814146 Rv3802c Rv3802c hypothetical protein MT3910 309.617398 290.652026 298.891879 296.701705 0.992739991 −0.010512184 8.22467855 0.973097519 Rv3803c fbpC1 antigen MPT51, mycolyltransferase MT3911 4076.37918 3338.87872 3182.14825 2667.81746 0.789769301 −0.340496805 11.6954305 0.075344841 Rv3804c fbpA antigen 85A, mycolyltransferase MT3912 293.686721 290.471047 324.989223 378.11709 1.200511011 0.263648636 8.33093392 0.138098627 Rv3805c Rv3805c weak similarity to Integral membrane proteins MT3913 120.792018 115.554993 122.484746 146.750646 1.135772693 0.183674131 6.98392734 0.404608908 Rv3806c Rv3806c possible integral membrane protein MT3914 184.327307 210.568887 199.594668 229.57109 1.086556961 0.119763807 7.68789992 0.590935767 Rv3807c Rv3607c possible membrane protein MT3915 528.804775 640.031688 538.95107 683.32721 1.043227507 0.061053815 9.22391752 0.825902812 Rv3808c Rv3808c hypothetical protein MT3916 169.240019 245.769272 168.768886 239.562624 0.985711646 −0.020762424 7.68666971 0.94164517 Rv3809c glf UDP-galactopyranose mutase MT3917 516.622493 608.722347 845.844922 795.73196 1.462712109 0.548645846 9.4344589 0.000284327 Rv3810 pirG cell surface protein precursor (Erp protein) MT3918 611.082038 656.319784 752.185465 812.592672 1.234502626 0.303929905 9.46807753 0.067854076 Rv3811 csp secreted protein MT3920 102.987143 126.323234 130.395788 142.925762 1.195860612 0.258049241 6.97550226 0.123801913 Rv3812 PE_PGRS PE_PGRS-family protein MT3921 24.7394047 14.2068394 19.8230696 16.5484771 0.956896786 −0.063564775 4.24744221 0.884925749 MT3922 104.299081 68.6814719 85.8393471 68.3795563 0.903625817 −0.146202605 6.35686806 0.543161321 Rv3813c Rv3813c conserved hypothetical protein MT3923 91.08599 79.8116709 79.0194837 72.6727933 0.888768244 −0.170120826 6.33655407 0.423478257 Rv3814c Rv3814c probable acyltransferase MT3924 85.3696882 71.2151758 81.8383606 72.5947344 0.988369169 −0.016878087 6.28400486 0.955304454 Rv3815c Rv3815c probable acyltransferase MT3925 293.967851 229.481176 248.333959 233.708209 0.92738675 −0.10875698 7.97465206 0.658932265 Rv3816c Rv3816c probable acyltransferase MT3925.1 23.5211764 26.4229115 27.188522 23.7298917 1.017014952 0.02434089 4.66611698 0.950509824 Rv3817 Rv3817 probable aminoglycoside 3′- phosphotransferase MT3926 216.282371 303.230056 189.774065 251.193393 0.852226032 −0.230691974 7.90869574 0.17946784 Rv3818 Rv3818 hypothetical protein MT3927 53.6020435 78.8162873 48.6483588 71.0335573 0.90427481 −0.145166819 5.9821093 0.552927263 MT3928 53.4146238 103.067453 42.646879 71.5019104 0.740841668 −0.432762851 6.08408385 0.007028907 Rv3820c papA2 PK5-associated protein, unknown function MT3929 146.84336 96.6427036 140.76198 110.765514 1.046793886 0.065977403 6.95325789 0.813012054 Rv3821 Rv3821 conserved hypothetical protein MT3930 1317.46701 1436.24812 242.42341 468.743419 0.245335793 −2.027170366 9.75882391 1.23E−27 Rv3822 Rv3822 conserved hypothetical protein MT3931 632.635307 1086.77797 132.578144 440.486114 0.292331754 −1.774321545 9.16309759 3.10E−19 Rv3823c mmpL8 conserved large membrane protein MT3932 481.793873 804.450969 57.5596469 262.668044 0.198835431 −2.330353238 8.64978071 8.55E−18 Rv3824c papA1 PK5-associated protein, unknown function MT3933 3993.9145 5457.05513 476.844848 1547.51678 0.184125775 −2.4412365 11.4863194 1.78E−21 Rv3825c pks2 polyketide synthase MT3334 141.220769 289.385174 92.568279 176.803305 0.632025145 −0.661946137 7.45265113 1.71E−07 Rv3826 fadD23 acyl-CoA synthase MT3935 117.231043 165.595644 107.481047 144.877233 0.895120816 −0.159845677 7.06586709 0.458731802 Rv3827c Rv3827c transposase MT3936 17.1489055 16.6310326 12.1848226 15.8459474 0.824103533 −0.279102498 3.97071789 0.322177831 Rv3828c Rv3828c resolvase MT3937 37.4839465 46.873521 43.2833996 46.8353125 1.071783954 0.100014122 5.4529023 0.750079277 Rv3829c Rv3829c probable ketoacyl reductase MT3938 17.0551957 22.7128451 20.5505217 22.7931854 1.093229537 0.128596345 4.38969267 0.692019534 Rv3830c Rv3830c transcriptional regulator (TetR/AcrR family) MT3939 21.9281087 37.0101739 28.4615632 35.9070729 1.110960763 0.151807865 4.95496932 0.626654945 Rv3831 Rv3831 hypothetical protein MT3940 20.8973002 19.2742472 30.6439195 19.5147136 1.224568431 0.292273397 4.50784482 0.284972246 Rv3832c Rv3832c hypothetical protein MT3941 48.0731614 55.0175691 53.0130714 53.1538464 1.079102652 0.109832111 5.74810867 0.703931527 Rv3833 Rv3833 transcriptional regulator (AraC/XylS family) MT3942 22.0218186 41.2631768 24.1877821 32.0041302 0.911063803 −0.134376004 4.9094592 0.705619372 Rv3834c serS seryl-tRNA synthase MT3943 217.969149 184.055486 223.78245 181.018483 1.004938614 0.007107378 7.65731262 0.980042284 Rv3835 Rv3835 hypothetical protein MT3944 59.9743144 53.7507172 63.8339213 49.6454313 0.992135191 −0.011391376 5.83208132 0.974110692 Rv3836 Rv3836 hypothetical protein MT3945 147.967879 172.563329 140.76198 148.780176 0.905218234 −0.143662449 7.25449135 0.518774989 Rv3837c Rv3837c putative phosphoglycerate mutase MT3946 146.655941 122.25121 140.216391 108.657925 0.922096668 −0.117010092 7.01802091 0.616132609 Rv3838c pheA prephenate dehydratase MT3947 66.2528755 19.1837576 85.6574841 22.3248323 1.237028883 0.306879186 5.59963849 0.143692242 Rv3839 Rv3839 hypothetical protein MT3948 16.118097 10.4967731 22.2782204 9.44512136 1.143346316 0.193262457 3.88148873 0.608154797 MT3949 1241.46831 4024.3361 707.174367 2865.2283 0.637152438 −0.650289517 11.1096699 5.40E−05 Rv3841 bfrB bacterioferritin MT3950 336.793259 233.824669 335.810073 248.227156 1.028613109 0.040700445 8.17406539 0.887972618 Rv3842c glpQ1 glycerophosphoryl diester phosphodiesterase MT3951 269.228446 219.979787 275.613412 240.265153 1.05731495 0.080405186 7.97408908 0.751374389 Rv3843c Rv3843c probable membrane protein MT3953 78.5288679 66.9621729 79.1104152 75.7951474 1.067745889 0.094568343 6.23409053 0.733387277 MT3954.1 18.6482634 29.7710201 15.3674255 22.5590089 0.78631006 −0.346829782 4.44409017 0.090319629 MT3955 49.6662291 43.6159018 47.8299752 42.5420755 0.969167375 −0.045182254 5.52617823 0.894346121 MT3957 26.1450527 22.5318663 25.7336178 25.4471865 1.05439812 0.076419703 4.65194059 0.825700001 MT3958 3.18613545 2.17174615 1.63676721 2.34176563 0.754627855 −0.406162741 1.32606602 0.554760335 MT3959 38.2336254 31.9427663 32.3716182 34.3458958 0.954623024 −0.066996962 5.10424093 0.857550145 MT3960 311.116756 456.24767 309.985524 376.477854 0.906058897 −0.142323262 8.50635668 0.52349722 Rv3846 sodA superoxide dismutase MT3961 139.440281 103.5199 131.486966 91.4069183 0.912998112 −0.131316218 6.86570369 0.538270037 Rv3847 Rv3847 hypothetical protein MT3962 47.6046121 53.1172912 55.1954276 44.8838412 0.989160462 −0.015723521 5.65449892 0.972119393 MT3963 721.94081 254.999194 767.825685 285.305112 1.090395614 0.124851664 8.98771368 0.584969964 Rv3848 Rv3848 probable membrane proteinprot MT3964 343.25924 373.449848 227.9653 202.953021 0.600672054 −0.735350551 8.16521701 1.89E−08 Rv3849 Rv3849 hypothetical protein MT3965 66.4402952 114.559609 52.2856193 74.390088 0.711696359 −0.490666239 6.26857308 0.001154067 Rv3850 Rv3850 hypothetical protein MT3966 29.424898 36.8291951 22.914741 26.5400104 0.747704658 −0.419459574 4.8628603 0.020183082 MT3967 302.026899 356.709305 289.071276 399.89551 1.036452336 0.051653772 8.39709641 0.862205654 Rv3852 hns HU-histone protein MT3968 71.5943378 95.9187882 67.3802502 107.799278 1.031877471 0.04527167 6.42404205 0.884925749 Rv3853 menG 5-adenosylmethionine:2- demethylmenaquinone MT3969 640.975485 1375.25825 977.42282 1535.18349 1.304013106 0.382958369 10.1451866 0.055854463 Rv3854c Rv3854c probable monooxygenase MT3970 149.186107 255.361151 211.324833 256.345277 1.189909201 0.250851489 7.76981075 0.253351936 Rv3855 Rv3855 putative transcriptional regulator MT3971 416.727775 232.376838 393.096925 239.874859 0.986282612 −0.019926995 8.32496286 0.946497216 Rv3856c Rv3856c conserved hypothetical protein MT3972 49.8536489 43.0729653 92.8410735 60.3394943 1.618636407 0.694778951 5.94727295 1.28E−05 Rv3857c Rv3857c hypothetical protein MT3972.1 149.186107 143.968672 255.244754 248.773568 1.719384102 0.781891872 7.64015524 1.87E−11 MT3973 373.527527 350.375045 383.094459 379.912443 1.054580637 0.076669413 8.53878708 0.764687847 Rv3858c gltD small subunit of NADH-dependent glutamate synthase MT3974 1552.49135 1428.37554 1493.82288 1359.08271 0.956834458 −0.06365875 10.5103814 0.83350394 Rv3859c gltB ferredoxin-dependent glutamate synthase MT3974.1 69.5327208 69.6768556 72.3814834 74.7803823 1.057140095 0.080166579 6.16534256 0.7768186 MT3975 60.8177032 75.3776892 62.5608801 65.8036141 0.946048234 −0.080014354 6.05130074 0.797567796 Rv3860 Rv3860 conserved hypothetical protein MT3976 340.822784 586.823907 128.031569 221.452969 0.376547817 −1.409095015 8.31939981 1.02E−34 Rv3862c Rv3862c hypothetical protein MT3977 262.387626 243.507037 269.975658 234.957151 0.996405042 −0.005195773 7.98229424 0.985115966 MT3978 727.563402 764.183176 570.322442 662.017142 0.824149688 −0.279021701 9.41192306 0.112872066 Rv3864 Rv3864 conserved hypothetical protein MT3979 400.703388 467.106401 350.540978 390.762624 0.855388833 −0.225347721 8.65267466 0.195397535 MT3981 1043.64678 1092.20733 958.690928 963.792673 0.900317285 −0.151494577 9.98691763 0.523451386 MT3982 688.392678 604.469345 687.442229 581.616523 0.980249486 −0.028779114 9.32338947 0.921846482 Rv3869 Rv3869 conserved hypothetical protein MT3983 1479.67879 1220.7928 1427.26101 1193.59794 0.971124363 −0.042272034 10.3777523 0.896513559 Rv3870 Rv3870 conserved hypothetical protein MT3984 130.256714 95.5568305 132.94187 117.244399 1.118158129 0.161124227 6.89691316 0.465870125 MT3985 969.334857 781.376166 912.315858 763.493653 0.958962819 −0.060453215 9.74280884 0.839018102 Rv3871 Rv3871 conserved hypothetical protein MT3986 373.340107 478.508068 232.966533 301.77553 0.627364297 −0.672624667 8.43802094 9.07E−09 Rv3872 PE PE-family protein MT3987 1214.19874 1260.97011 803.288975 940.218899 0.702404108 −0.509626813 10.0428028 0.000740921 Rv3873 PPE PPE-family protein MT3988 4014.34325 6228.38697 2335.39402 3897.79083 0.603403874 −0.728804137 12.0081313 2.18E−06 Rv3874 Rv3874 conserved hypothetical protein MT3989 6841.85105 11147.392 4135.56516 7726.57762 0.647293873 −0.627507247 12.8655446 0.000264459 Rv3875 esat6 early secretory antigen target MT3990 607.521063 657.134189 613.242115 679.033973 1.021326214 0.03044374 9.32060441 0.916845409 Rv3876 Rv3876 conserved hypothetical protein MT3991 383.554483 399.87276 426.46879 453.521943 1.122997715 0.167354992 8.7005675 0.395975151 Rv3877 Rv3877 conserved hypothetical protein MT3992 441.842019 395.981714 365.271883 371.716264 0.880990641 −0.182801401 8.62158775 0.363602402 Rv3878 Rv3878 hypothetical protein MT3993 1095.46834 1016.92013 889.58298 828.516678 0.813395344 −0.297971363 9.90356087 0.090433444 Rv3879c Rv3879c hypothetical protein MT3994 81.5275837 83.0692902 53.7405235 57.6074344 0.676404138 −0.564042609 6.1116475 6.62E−05 MT3995 250.299053 328.476605 189.228476 221.921323 0.714282967 −0.485432376 7.95216431 0.000214724 Rv3880c Rv3880c conserved hypothetical protein MT3996 527.211708 676.589414 407.282241 492.941664 0.750124956 −0.414797155 9.03940807 0.003214405 Rv3881c Rv3881c conserved hypothetical protein MT3997 270.540384 257.894855 280.796508 273.20599 1.048598941 0.068462994 8.081007 0.800875065 Rv3882c Rv3882c conserved hypothetical protein MT3998 433.220712 363.315033 458.203888 378.819619 1.050157795 0.070606121 8.67440293 0.788018169 Rv3883c Rv3883c probable secreted protease MT3999 101.112946 102.072069 106.238937 101.710687 1.023356749 0.033309166 6.68613447 0.905590819 Rv3884c Rv3884c conserved hypothetical protein MT4000 74.967893 69.4958767 72.8361409 70.4090865 0.992207915 −0.011285629 6.1719466 0.973097519 Rv3885c Rv3885c hypothetical protein MT4002 53.5083336 66.3287469 56.0138112 72.6727933 1.071765314 0.099989031 5.96160546 0.725019493 MT4003 86.0256572 125.961277 100.843047 128.875168 1.093017905 0.128317035 6.78941435 0.572355347 Rv3888c Rv3888c conserved hypothetical protein MT4004 36.1720084 70.5817498 42.646879 65.5694375 1.038651244 0.05471131 5.75320193 0.880578033 Rv3889c Rv3889c hypothetical protein MT4005 72.906276 190.480235 101.479567 183.828602 1.15136736 0.203348219 7.10200915 0.433613807 Rv3890c Rv3890c hypothetical protein MT4006 108.141186 264.048136 136.942857 216.769438 1.015056973 0.021560705 7.50517627 0.955506358 Rv3891c Rv3891c hypothetical protein MT4007 62.5981907 112.659331 74.2910451 99.2128037 1.017024021 0.024353754 6.4492175 0.944598499 Rv3892c PPE PPE-family protein MT4008 96.8960017 135.734134 102.116088 117.16634 0.951802851 −0.071265319 6.8222016 0.801831984 Rv3893c PE PE-family protein MT4010 388.708525 406.840445 382.276075 421.361695 1.00931998 0.013383618 8.64377009 0.966783763 Rv3894c Rv3894c transmembrane ATP/GTP binding protein MT4011 55.6636606 79.2687344 71.4721682 70.3310276 1.063837646 0.089277996 6.11610621 0.801997347 Rv3895c Rv3895c conserved hypothetical protein MT4012 187.981992 181.340803 180.408119 164.391947 0.932715305 −0.100491304 7.48140083 0.689343879 Rv3896c Rv3896c putative p60 homologue MT4013 109.171994 115.645482 124.394308 119.820341 1.086167603 0.119246738 6.87573084 0.596256999 Rv3897c Rv3897c conserved hypothetical protein MT4014 63.9101238 74.1108373 76.7461959 77.9807953 1.122869629 0.167190433 6.19708936 0.467943625 Rv3898c Rv3898c conserved hypothetical protein MT4016 43.3876681 47.506947 47.5571807 56.3584927 1.141403601 0.19080902 5.61145037 0.437644413 Rv3899c Rv3899c conserved hypothetical protein MT4017 65.6906153 75.9206258 69.289812 78.0588542 1.041096395 0.058103654 6.17835712 0.84211886 Rv3900c Rv3900c conserved hypothetical protein MT4018 53.8831731 51.3979922 48.5574273 51.9871969 0.955345994 −0.065904772 5.69019765 0.839018102 Rv3901c Rv3901c membrane protein TM stretch MT4019 10.0269557 8.23453748 9.82060327 9.83541563 1.081102818 0.112503737 3.27145844 0.803054534 MT4020 25.7702132 23.5272499 27.6431796 31.3796594 1.198113867 0.260765026 4.76901576 0.292971938 Rv3902c Rv3902c hypothetical protein MT4022 38.6084649 34.2954913 43.1015366 32.8627776 1.035422283 0.050219272 5.22438449 0.886067917 MT4023 11.0577642 7.51062209 11.0936444 5.38606094 0.867677723 −0.204768805 3.15605513 0.619926139 Rv3904c Rv3904c hypothetical protein MT4024 11.5263136 11.0397096 10.9117814 11.240475 0.982672538 −0.025217357 3.50527981 0.955286813 Rv3905c Rv3905c hypothetical protein MT4025 134.286238 86.5078882 125.758281 86.8795047 0.969014107 −0.045410426 6.76178252 0.877734451 Rv3906c Rv3906c conserved hypothetical protein MT4026 187.232313 164.328792 161.858091 180.081777 0.973640386 −0.038539083 7.43922536 0.90313325 Rv3907c pcnA polynucleotide polymerase MT4027 114.513457 144.059161 109.754335 134.963759 0.947377383 −0.077988864 6.97733138 0.762656558 Rv3908 Rv3908 conserved hypothetical protein MT4028 294.904949 378.969703 296.891386 408.872278 1.042527116 0.060084908 8.43086756 0.81765154 Rv3909 Rv3909 conserved hypothetical protein MT4029 716.037088 776.942184 764.643082 836.634799 1.072352677 0.10077946 9.59571623 0.707679183 MT4030 72.7188552 92.4801901 85.5665526 86.9575636 1.049870328 0.070211148 6.40276378 0.814508736 MT4031 31.5802219 27.0563374 32.6444127 29.2720703 1.057314176 0.080404131 4.92178754 0.803807978 Rv3912 Rv3912 hypothetical protein MT4032 132.037202 259.523665 151.764693 212.007848 0.966087189 −0.049774698 7.56240857 0.887972618 Rv3913 trxB2 thioredoxin reductase MT4033 65.1283571 146.864333 71.1993737 131.060816 0.98225638 −0.025828461 6.69712943 0.933447653 Rv3914 trxC thioredoxin MT4034 887.994693 711.337353 912.679584 795.02943 1.071750281 0.099968796 9.69162468 0.719940528 Rv3915 cwlM hydrolase MT4035 292.374783 206.134905 350.995635 239.718741 1.181707784 0.240873326 8.08996643 0.161656981 Rv3916c Rv3916c conserved hypothetical protein MT4035.1 234.836925 145.235524 263.519521 197.56696 1.234174168 0.303546004 7.71739691 0.065900388 MT4036 249.268244 184.688912 274.24944 239.328447 1.193576803 0.255291402 7.88910139 0.142032411 MT4037 298.840764 211.65476 304.165907 288.583584 1.177539708 0.23577571 8.10846258 0.277296766 Rv3918c parB possibly involved in chromosome partitioning MT4038 77.9666087 60.7184027 85.3846895 79.9322667 1.199904862 0.262920022 6.25131467 0.176635335 Rv3919c gid glucose inhibited division protein B MT4039 416.634065 388.923539 428.923941 506.992258 1.158709906 0.212519419 8.7667108 0.308884338 Rv3920c Rv3920c conserved hypothetical protein MT4040 530.210423 632.249597 537.405235 768.021066 1.109986691 0.150542378 9.26951193 0.523182712 Rv3921c Rv3921c unknown membrane protein MT4040.1 157.994835 181.340803 139.761734 206.621787 1.005581733 0.008030347 7.42307147 0.980042284 Rv3922c Rv3922c possible hemolysin MT4041 223.123192 308.297464 222.145683 301.697471 0.986963341 −0.018931596 8.04441183 0.948443219 Rv3923c rnpA ribonuclease P protein component MT4041.1 146.562231 217.084125 152.128419 196.942489 0.969279118 −0.045015924 7.47868537 0.880856541 Rv3924c rpmH 50S ribosomal protein L34 MT4041.2 2.34274666 2.17174615 3.00073989 2.65400104 1.250051946 0.321988048 1.44365445 0.626654945 

1. A method for inhibiting growth of one or more bacterial cells in which the PhoPR regulon is conserved, the method comprising contacting the one or more bacterial cells with an effective amount of an inhibitor of the PhoP/R regulon to thereby inhibit the growth of the one or more bacterial cells.
 2. A method for preventing or reducing the likelihood of a productive bacterial infection in a subject, the method comprising administering to a subject an effective amount of an inhibitor of the PhoP/R regulon to thereby prevent or reduce the likelihood of a productive bacterial infection in the subject, wherein the subject has been identified as being at risk of developing an infection with bacterial cells in which the PhoPR regulon is conserved.
 3. A method for treating a subject who is infected with bacterial cells in which the PhoPR regulon is conserved, the method comprising administering to the subject an effective amount of an inhibitor of the PhoP/R regulon to thereby treat the infection.
 4. A method for ameliorating the signs or symptoms of an infection of a subject by bacterial cells in which the PhoPR regulon is conserved, the method comprising administering to the subject an effective amount of an inhibitor of the PhoP/R regulon to thereby ameliorate the signs and symptoms of the infection.
 5. The method according to claim 3, further comprising identifying the subject as having an infection with bacterial cells in which the PhoPR regulon is conserved.
 6. The method according to claim 3, wherein the bacteria or bacterial cells are selected from the group consisting of Mycobacterium, Mycobacterium tuberculosis, multi-drug resistant Mycobacterium tuberculosis, extensively drug resistant Mycobacterium tuberculosis, nontuberculosis mycobacterium (NTM), Clostridium, Bacillus, C. acetobutylicum, B. subtilis, Echerichia coli, Vibrio cholera, Streptomyces coelicolor, and Enterobacteriaceae.
 7. (canceled)
 8. (canceled)
 9. (canceled)
 10. (canceled)
 11. (canceled)
 12. (canceled)
 13. (canceled)
 14. (canceled)
 15. (canceled)
 16. (canceled)
 17. The method of claim 3, wherein the inhibitor of the PhoP/R regulon is a carbonic anhydrase inhibitor, and wherein the carbonic anhydrase inhibitor is selected from the group consisting of a sulfonamide, ethoxzolamide, an analog of ethoxzolamide, acetazolamide, methazolamide, dorzolamide, and brinzolamide.
 18. (canceled)
 19. (canceled)
 20. (canceled)
 21. (canceled)
 22. The method according to claim 3, wherein the inhibitor is orally administered, parenterally administered, intravenously administered, administered as an aerosol, administered using a nebulizer or inhaler, topically administered, administered as an eye drop, administered as a cream, an ointment, or a lotion, or present on a bandage or dressing applied to an infected site to the subject.
 23. (canceled)
 24. (canceled)
 25. (canceled)
 26. (canceled)
 27. (canceled)
 28. (canceled)
 29. (canceled)
 30. (canceled)
 31. The method according to claim 3, wherein the subject has a lung infection, skin infection, or eye infection.
 32. (canceled)
 33. (canceled)
 34. The method according to claim 3 wherein the subject is afflicted with tuberculosis, multi-resistant tuberculosis, or extensively multidrug resistant tuberculosis.
 35. (canceled)
 36. (canceled)
 37. (canceled)
 38. (canceled)
 39. (canceled)
 40. The method according to claim 3, wherein the subject is a human.
 41. The method according to claim 3 for eliminating dormant Mycobacterium tuberculosis cells in a subject afflicted with latent tuberculosis.
 42. (canceled)
 43. (canceled)
 44. (canceled)
 45. (canceled)
 46. (canceled)
 47. (canceled)
 48. (canceled)
 49. The method according to claim 3, wherein the effective amount of the carbonic anhydrase inhibitor is between 0.01 and 100 mg/kg body weight of the subject.
 50. The method according to claim 3, wherein the inhibitor is administered in combination with one or more antibiotics selected from the group consisting of isoniazid, rifampicin, ethambutol, and pyrazinamide.
 51. (canceled)
 52. The method according to claim 3, wherein the inhibitor is administered for less than 6 weeks or between 2 to 4 weeks.
 53. (canceled)
 54. A pharmaceutical composition for use in topical treatment of an infection with bacterial cells in which the PhoPR regulon is conserved, wherein the pharmaceutical composition comprises a carbonic anhydrase inhibitor.
 55. The pharmaceutical composition of claim 54, formulated as an eye drop, an ointment, a lotion, a cream, or a gel.
 56. (canceled)
 57. (canceled)
 58. (canceled)
 59. (canceled)
 60. A sterile bandage or dressing for use in treating a wound, wherein the bandage or dressing comprises a carbonic anhydrase inhibitor in an amount effective to inhibit the growth or viability of bacterial cells in which the PhoPR regulon is conserved.
 61. The sterile bandage or dressing according to claim 60, wherein the carbonic anhydrase inhibitor is selected from the group consisting of ethoxzolamide an analog of ethoxzolamide, acetazolamide, methazolamide, dorzolamide, and brinzolamide.
 62. (canceled)
 63. (canceled) 